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65 articles for thisTarget


The following articles (labelled with PubMed ID or TBD) are for your review

PMID
Data
Article Title
Organization
Discovery of a series of (4,5-dihydroimidazol-2-yl)-biphenylamine 5-HT7 agonists.EBI
Pfizer
Tactical Approaches to Interconverting GPCR Agonists and Antagonists.EBI
University Of Minnesota
Synthesis and pharmacological evaluation of piperidine (piperazine)-substituted benzoxazole derivatives as multi-target antipsychotics.EBI
Huazhong University Of Science And Technology
Novel spirohydantoin derivative as a potent multireceptor-active antipsychotic and antidepressant agent.EBI
Jagiellonian University Medical College
Selective 5-HT Receptor Modulators May Deliver Focused Targeting with Fewer Adverse Effects.EBI
Therachem Research Medilab (India)
Discovery and SAR of org 24598-a selective glycine uptake inhibitor.EBI
Organon Research And Development Group
First pharmacophoric hypothesis for 5-HT7 antagonism.EBI
Universidad Complutense
Investigations on the 1-(2-biphenyl)piperazine motif: identification of new potent and selective ligands for the serotonin(7) (5-HT(7)) receptor with agonist or antagonist action in vitro or ex vivo.EBI
Universit£
7-Arylpiperazinylalkyl and 7-tetrahydroisoquinolinylalkyl derivatives of 8-alkoxy-purine-2,6-dione and some of their purine-2,6,8-trione analogs as 5-HT(1A), 5-HT(2A), and 5-HT(7) serotonin receptor ligands.EBI
Jagiellonian University Medical College
Higher-end serotonin receptors: 5-HT(5), 5-HT(6), and 5-HT(7).EBI
Virginia Commonwealth University
(R)-(+)-2-[[[3-(Morpholinomethyl)-2H-chromen-8-yl]oxy]methyl] morpholine methanesulfonate: a new selective rat 5-hydroxytryptamine1B receptor antagonist.EBI
Astra Arcus
Buspirone analogues. 2. Structure-activity relationships of aromatic imide derivatives.EBI
TBA
New serotonin 5-HT(1A) receptor agonists with neuroprotective effect against ischemic cell damage.EBI
Universidad Complutense De Madrid
Novel tetrahydropyrido[3,2-c]pyrroles as 5-HT(7) antagonists.EBI
Johnson & Johnson Pharmaceutical Research And Development
Synthesis and structure-activity relationships of a new model of arylpiperazines. 8. Computational simulation of ligand-receptor interaction of 5-HT(1A)R agonists with selectivity over alpha1-adrenoceptors.EBI
TBA
Structural modifications of N-(1,2,3,4-tetrahydronaphthalen-1-yl)-4-aryl-1-piperazinehexanamides: influence on lipophilicity and 5-HT7 receptor activity. Part III.EBI
Università
Bivalent ligand approach on 4-[2-(3-methoxyphenyl)ethyl]-1-(2-methoxyphenyl)piperazine: synthesis and binding affinities for 5-HT(7) and 5-HT(1A) receptors.EBI
Università
Phenylpyrroles, a new chemolibrary virtual screening class of 5-HT7 receptor ligands.EBI
Université
Novel 3-aminochromans as potential pharmacological tools for the serotonin 5-HT(7) receptor.EBI
Uppsala University
Structure-affinity relationship study on N-(1,2,3,4-tetrahydronaphthalen-1-yl)-4-aryl-1-piperazinealkylamides, a new class of 5-hydroxytryptamine7 receptor agents.EBI
Università
The impact of spacer structure on 5-HT7 and 5-HT1A receptor affinity in the group of long-chain arylpiperazine ligands.EBI
Polish Academy Of Sciences
Novel 5-HT7 receptor inverse agonists. Synthesis and molecular modeling of arylpiperazine- and 1,2,3,4-tetrahydroisoquinoline-based arylsulfonamides.EBI
State University Of Groningen
Synthesis and structure--activity relationship in a class of indolebutylpiperazines as dual 5-HT(1A) receptor agonists and serotonin reuptake inhibitors.EBI
Merck
Novel 2-aminotetralin and 3-aminochroman derivatives as selective serotonin 5-HT7 receptor agonists and antagonists.EBI
Uppsala University
Design and synthesis of S-(-)-2-[[4-(napht-1-yl)piperazin-1-yl]methyl]-1,4-dioxoperhydropyrrolo[1,2-a]pyrazine (CSP-2503) using computational simulation. A 5-HT1A receptor agonist.EBI
Universidad Complutense
Synthesis and structure-affinity relationships of 1-[omega-(4-aryl-1-piperazinyl)alkyl]-1-aryl ketones as 5-HT(7) receptor ligands.EBI
Università
Atropisomeric derivatives of 2',6'-disubstituted (R)-11-phenylaporphine: selective serotonin 5-HT(7) receptor antagonists.EBI
Uppsala University
Serotonergic and dopaminergic activities of rigidified (R)-aporphine derivatives.EBI
Uppsala University
Derivatives of (R)-1,11-methyleneaporphine: synthesis, structure, and interactions with G-protein coupled receptors.EBI
Uppsala University
3-[3-(Piperidin-1-yl)propyl]indoles as highly selective h5-HT(1D) receptor agonists.EBI
Merck Sharp & Dohme Research Laboratories
N-Substituted (2,3-dihydro-1,4-benzodioxin-2-yl)methylamine derivatives as D(2) antagonists/5-HT(1A) partial agonists with potential as atypical antipsychotic agents.EBI
Knoll Pharmaceuticals
Structure-activity relationships of serotonin 5-HTEBI
Normandie Univ
Design, synthesis, radiolabeling and in vivo evaluation of potential positron emission tomography (PET) radioligands for brain imaging of the 5-HT? receptor.EBI
Universit£
Development of high-affinity 5-HT3 receptor antagonists. Structure-affinity relationships of novel 1,7-annelated indole derivatives.EBI
Solvay Duphar
Synthesis and evaluation of 1-[2-(4-[(11)C]methoxyphenyl)phenyl]piperazine for imaging of the serotonin 5-HT7 receptor in the rat brain.EBI
National Institute Of Radiological Sciences
Synthesis and evaluation of a novel series of N,N-dimethylisotryptamines.EBI
TBA
Optimization of the pharmacophore model for 5-HT7R antagonism. Design and synthesis of new naphtholactam and naphthosultam derivatives.EBI
Universidad Complutense
Characterization of the 5-HT(7) receptor. Determination of the pharmacophore for 5-HT(7) receptor agonism and CoMFA-based modeling of the agonist binding site.EBI
State University Of Groningen
Synthesis and Biological Evaluation of Fused Tricyclic Heterocycle Piperazine (Piperidine) Derivatives As Potential Multireceptor Atypical Antipsychotics.EBI
Huazhong University Of Science And Technology
Structure-Activity Relationships and Therapeutic Potentials of 5-HTEBI
Universit£
Highly Potent Cell-Permeable and Impermeable NanoLuc Luciferase Inhibitors.BDB
Promega Biosciences
Benzimidazole derivatives as new a-glucosidase inhibitors and in silico studies.BDB
Universiti Teknologi Mara (Uitm)
Small Molecule Inhibitors of 8-Oxoguanine DNA Glycosylase-1 (OGG1).BDB
Oregon Health & Science University
Inhibitor recognition specificity of MERS-CoV papain-like protease may differ from that of SARS-CoV.BDB
University Of Illinois At Chicago
Characterization of I2 imidazoline and sigma binding sites in the rat and human stomach.BDB
University Of Bonn