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40 articles for thisTarget


The following articles (labelled with PubMed ID or TBD) are for your review

PMID
Data
Article Title
Organization
Evaluation of bisbenzamidines as inhibitors for matriptase-2.EBI
University Of Bonn
Synthesis of 3,4-diaminobenzoyl derivatives as factor Xa inhibitors.EBI
Southeast University
Synthesis and pharmacological characterization of 2-aminobenzaldehyde oxime analogs as dual inhibitors of neutrophil elastase and proteinase 3.EBI
Chang Gung University
How aß-D-glucoside side chain enhances binding affinity to thrombin of inhibitors bearing 2-chlorothiophene as P1 moiety: crystallography, fragment deconstruction study, and evaluation of antithrombotic properties.EBI
Consiglio Nazionale Delle Ricerche
Novel bis(benzamidino) compounds with an aromatic central link. Inhibitors of thrombin, pancreatic kallikrein, trypsin, and complement.EBI
TBA
Diarylamidine derivatives with one or both of the aryl moieties consisting of an indole or indole-like ring. Inhibitors of arginine-specific esteroproteases.EBI
TBA
Inactivation of trypsin-like proteases by sulfonylation. Variation of positively charged group and inhibitor length.EBI
TBA
Synthesis and biological evaluation of direct thrombin inhibitors bearing 4-(piperidin-1-yl)pyridine at the P1 position with potent anticoagulant activity.EBI
University Of Bari &Quot;Aldo Moro&Quot
Thrombin inhibitors. 2. Amide derivatives of N alpha-substituted L-arginine.EBI
TBA
Thrombin inhibitors. 1. Ester derivatives of N alpha-(arylsulfonyl)-L-arginine.EBI
TBA
Thrombin inhibitors from the freshwater cyanobacterium Anabaena compacta.EBI
Hokkaido University
Development of tryptase inhibitors derived from thalidomide.EBI
The University Of Tokyo
Simple, intuitive calculations of free energy of binding for protein-ligand complexes. 1. Models without explicit constrained water.EBI
University Of Parma
Estimation of binding affinities for selective thrombin inhibitors via Monte Carlo simulations.EBI
Yale University
GRID/CPCA: a new computational tool to design selective ligands.EBI
Boehringer Ingelheim Pharma
Design and synthesis of thrombin inhibitors: analogues of MD-805 with reduced stereogenicity and improved potency.EBI
Novartis Horsham Research Centre
Synthesis and structure-activity relationships of potent thrombin inhibitors: piperazides of 3-amidinophenylalanine.EBI
Klinikum Der Friedrich-Schiller-Universit£T Jena
Inhibition studies of some serine and thiol proteinases by new leupeptin analogues.EBI
University Of Arkansas
Anticoagulant peptides: nature of the interaction of the C-terminal region of hirudin with a noncatalytic binding site on thrombin.EBI
TBA
Fluorinated benzyloxyphenyl piperidine-4-carboxamides with dual function against thrombosis: inhibitors of factor Xa and platelet aggregation.EBI
University Of Bari
 
Rational design of selective thrombin inhibitorsEBI
TBA
 
(N-acyl-N-alkyl)glycyl borolysine analogs: A new class of potent thrombin inhibitorsEBI
TBA
 
Characterization of LY806303 as a potent and selective inhibitor of thrombinEBI
TBA
Effects of tannins from Geum japonicum on the catalytic activity of thrombin and factor Xa of blood coagulation cascade.EBI
National University Of Singapore
Synthesis and evaluation of the sunflower derived trypsin inhibitor as a potent inhibitor of the type II transmembrane serine protease, matriptase.EBI
National Cancer Institute-Frederick
Optimization of Cyclic Plasmin Inhibitors: From Benzamidines to Benzylamines.EBI
Philipps University Marburg
Structural and functional analyses of benzamidine-based inhibitors in complex with trypsin: implications for the inhibition of factor Xa, tPA, and urokinase.EBI
Institut FüR Biochemie
Discovery of LB30057, a benzamidrazone-based selective oral thrombin inhibitor.EBI
Biotech Research Institute
Design of benzamidine-type inhibitors of factor Xa.EBI
Institut FüR Biochemie
Structure-activity study of tripeptide thrombin inhibitors using alpha-alkyl amino acids and other conformationally constrained amino acid substitutions.EBI
Eli Lilly
Aromatic amidines: comparison of their ability to block respiratory syncytial virus induced cell fusion and to inhibit plasmin, urokinase, thrombin, and trypsin.EBI
TBA
Three-dimensional quantitative structure-activity relationship analyses using comparative molecular field analysis and comparative molecular similarity indices analysis to elucidate selectivity differences of inhibitors binding to trypsin, thrombin, and factor Xa.EBI
University Of Marburg
Design of Small-Molecule Active-Site Inhibitors of the S1A Family Proteases as Procoagulant and Anticoagulant Drugs.EBI
University Of Nottingham
Natural-Products-Inspired Use of the gem-Dimethyl Group in Medicinal Chemistry.EBI
St. John'S University