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58 articles for thisTarget


The following articles (labelled with PubMed ID or TBD) are for your review

PMID
Data
Article Title
Organization
Biosynthetic approaches to creating bioactive fungal metabolites: Pathway engineering and activation of secondary metabolism.EBI
Riken Csrs
Functional 1,3a,6a-triazapentalene scaffold: Design of fluorescent probes for kinesin spindle protein (KSP).EBI
University Of Shizuoka
Structure-Guided Design of Novel l-Cysteine Derivatives as Potent KSP Inhibitors.EBI
University Of Shizuoka
Discovery of novel spiro 1,3,4-thiadiazolines as potent, orally bioavailable and brain penetrant KSP inhibitors.EBI
Merck Research Laboratories
Synthetic studies on mitotic kinesin Eg5 inhibitors: synthesis and structure-activity relationships of novel 2,4,5-substituted-1,3,4-thiadiazoline derivatives.EBI
Kyowa Hakko Kirin
Design, synthesis and anticancer evaluation of tetrahydro-ß-carboline-hydantoin hybrids.EBI
TBA
Optimization of diaryl amine derivatives as kinesin spindle protein inhibitors.EBI
Kyoto University
Synthesis, biological evaluation and molecular docking studies of flavone and isoflavone derivatives as a novel class of KSP (kinesin spindle protein) inhibitors.EBI
Nanjing University
Resistance by allostery: a novel perspective for eg5-targeted drug design.EBI
Korea Institute Of Science And Technology
Mitotic kinesin Eg5 overcomes inhibition to the phase I/II clinical candidate SB743921 by an allosteric resistance mechanism.EBI
The Beatson Institute For Cancer Research
Advances in the discovery of kinesin spindle protein (Eg5) inhibitors as antitumor agents.EBI
Cairo University
Optimized S-trityl-L-cysteine-based inhibitors of kinesin spindle protein with potent in vivo antitumor activity in lung cancer xenograft models.EBI
The Beatson Institute For Cancer Research
Discovery of coumarin-monastrol hybrid as potential antibreast tumor-specific agent.EBI
Csir-Central Drug Research Institute
Doing the methylene shuffle--further insights into the inhibition of mitotic kinesin Eg5 with S-trityl L-cysteine.EBI
University Of Strathclyde
Receptor-ligand interaction-based virtual screening for novel Eg5/kinesin spindle protein inhibitors.EBI
Korea Institute Of Science And Technology
Triphenylbutanamines: kinesin spindle protein inhibitors with in vivo antitumor activity.EBI
The Beatson Institute For Cancer Research
The discovery and optimization of hexahydro-2H-pyrano[3,2-c]quinolines (HHPQs) as potent and selective inhibitors of the mitotic kinesin-5.EBI
Merck Serono
Pharmacophore identification of KSP inhibitors.EBI
China Pharmaceutical University
Synthesis and SAR of pyrrolotriazine-4-one based Eg5 inhibitors.EBI
Bristol-Myers Squibb Pharmaceutical Research Institute
Recent progress in biological activities of synthesized phenothiazines.EBI
The Medical University Of Silesia
Discovery of (+)-N-(3-aminopropyl)-N-[1-(5-benzyl-3-methyl-4-oxo-[1,2]thiazolo[5,4-d]pyrimidin-6-yl)-2-methylpropyl]-4-methylbenzamide (AZD4877), a kinesin spindle protein inhibitor and potential anticancer agent.EBI
Astrazeneca
De novo design, synthesis and biological evaluation of 1,4-dihydroquinolin-4-ones and 1,2,3,4-tetrahydroquinazolin-4-ones as potent kinesin spindle protein (KSP) inhibitors.EBI
China Pharmaceutical University
Synthesis and characterization of tritylthioethanamine derivatives with potent KSP inhibitory activity.EBI
New Mexico State University
Synthesis and biological evaluation of conformationally flexible as well as restricted dimers of monastrol and related dihydropyrimidones.EBI
Indian Institute Of Chemical Technology
Structure-activity relationships of carboline and carbazole derivatives as a novel class of ATP-competitive kinesin spindle protein inhibitors.EBI
Kyoto University
Structure-activity relationship and multidrug resistance study of new S-trityl-L-cysteine derivatives as inhibitors of Eg5.EBI
Institute For Cancer Research
Design, synthesis and bioevaluation of dihydropyrazolo[3,4-b]pyridine and benzo[4,5]imidazo[1,2-a]pyrimidine compounds as dual KSP and Aurora-A kinase inhibitors for anti-cancer agents.EBI
China Pharmaceutical University
Structural basis for inhibition of Eg5 by dihydropyrimidines: stereoselectivity of antimitotic inhibitors enastron, dimethylenastron and fluorastrol.EBI
Institute For Cancer Research
Kinesin spindle protein (KSP) inhibitors with 2,3-fused indole scaffolds.EBI
Kyoto University
Discovery of tetrahydro-beta-carbolines as inhibitors of the mitotic kinesin KSP.EBI
China Pharmaceutical University
The discovery of tetrahydro-beta-carbolines as inhibitors of the kinesin Eg5.EBI
Novartis Institutes For Biomedical Research
Substituted benzimidazoles: A novel chemotype for small molecule hKSP inhibitors.EBI
Schering-Plough Research Institute
Bis(hetero)aryl derivatives as unique kinesin spindle protein inhibitors.EBI
University Of Shizuoka
Structure of human Eg5 in complex with a new monastrol-based inhibitor bound in the R configuration.EBI
Cnrs-Commissariat à
Kinesin spindle protein (KSP) inhibitors. Part 7: Design and synthesis of 3,3-disubstituted dihydropyrazolobenzoxazines as potent inhibitors of the mitotic kinesin KSP.EBI
Merck Research Laboratories
Kinesin spindle protein (KSP) inhibitors. Part 6: Design and synthesis of 3,5-diaryl-4,5-dihydropyrazole amides as potent inhibitors of the mitotic kinesin KSP.EBI
Merck Research Laboratories
Novel ATP-competitive kinesin spindle protein inhibitors.EBI
Glaxosmithkline
New chemical tools for investigating human mitotic kinesin Eg5.EBI
Cnrs-Université
Synthesis and biological evaluation of L-cysteine derivatives as mitotic kinesin Eg5 inhibitors.EBI
University Of Shizuoka
Kinesin spindle protein (KSP) inhibitors. Part V: discovery of 2-propylamino-2,4-diaryl-2,5-dihydropyrroles as potent, water-soluble KSP inhibitors, and modulation of their basicity by beta-fluorination to overcome cellular efflux by P-glycoprotein.EBI
Merck Research Laboratories
Inhibition of kinesin motor proteins by adociasulfate-2.EBI
University Of Georgia
Kinesin spindle protein (KSP) inhibitors. Part 3: synthesis and evaluation of phenolic 2,4-diaryl-2,5-dihydropyrroles with reduced hERG binding and employment of a phosphate prodrug strategy for aqueous solubility.EBI
Merck Research Laboratories
Kinesin spindle protein (KSP) inhibitors. Part 1: The discovery of 3,5-diaryl-4,5-dihydropyrazoles as potent and selective inhibitors of the mitotic kinesin KSP.EBI
Merck Research Laboratories
Design, synthesis, and bioactivity of dihydropyrimidine derivatives as kinesin spindle protein inhibitors.EBI
Tanta University
Why Some Targets Benefit from beyond Rule of Five Drugs.EBI
Boston University
Design and synthesis of novel phenyl -1, 4-beta-carboline-hybrid molecules as potential anticancer agents.EBI
Karnatak University
Crystal structure of the Eg5 - K858 complex and implications for structure-based design of thiadiazole-containing inhibitors.EBI
University College London
Synthesis and anticancer activity of new dihydropyrimidinone derivatives.EBI
Mansoura University
Design and synthesis of novel thiadiazole-thiazolone hybrids as potential inhibitors of the human mitotic kinesin Eg5.EBI
University Of Kwazulu-Natal (Ukzn)
Synthesis of N-(1-(6-acetamido-5-phenylpyrimidin-4-yl) piperidin-3-yl) amide derivatives as potential inhibitors for mitotic kinesin spindle protein.EBI
Alagappa University
Evaluation of multifunctional synthetic tetralone derivatives for treatment of Alzheimer's disease.BDB
Wuhan University Of Technology
Characterization of two distinct modes of drug binding to human intestinal fatty acid binding protein.BDB
Monash University
Inhibitor binding to type 4 phosphodiesterase (PDE4) assessed using [3H]piclamilast and [3H]rolipram.BDB
University Of Tennessee