PMID

Data

Article Title

Organization

Phenyltetrazolyl-phenylamides: Substituent impact on modulation capability and selectivity toward the efflux protein ABCG2 and investigation of interaction with the transporter.

Rheinische Friedrich-Wilhelms-Universit£T Bonn

New, highly potent and non-toxic, chromone inhibitors of the human breast cancer resistance protein ABCG2.

Universit£

Halogenated naphthochalcones and structurally related naphthopyrazolines with antitumor activity.

University Bayreuth

The combination of quinazoline and chalcone moieties leads to novel potent heterodimeric modulators of breast cancer resistance protein (BCRP/ABCG2).

University Of Bonn

Pyrrolopyrimidine Derivatives as Novel Inhibitors of Multidrug Resistance-Associated Protein 1 (MRP1, ABCC1).

University Of Bonn

Flavonoid derivatives as selective ABCC1 modulators: Synthesis and functional characterization.

University Of Regensburg

Potent and Nontoxic Chemosensitizer of P-Glycoprotein-Mediated Multidrug Resistance in Cancer: Synthesis and Evaluation of Methylated Epigallocatechin, Gallocatechin, and Dihydromyricetin Derivatives.

The Hong Kong Polytechnic University

Mechanistic studies on the absorption and disposition of scutellarin in humans: selective OATP2B1-mediated hepatic uptake is a likely key determinant for its unique pharmacokinetic characteristics.

Chinese Academy Of Sciences

In vitro investigations into the roles of drug transporters and metabolizing enzymes in the disposition and drug interactions of dolutegravir, a HIV integrase inhibitor.

Glaxosmithkline

HM30181 Derivatives as Novel Potent and Selective Inhibitors of the Breast Cancer Resistance Protein (BCRP/ABCG2).

University Of Bonn

Thieno[2,3-b]pyridines--a new class of multidrug resistance (MDR) modulators.

Institute Of Organic Synthesis

Potent nonimmunosuppressive cyclophilin inhibitors with improved pharmaceutical properties and decreased transporter inhibition.

Novartis Institutes For Biomedical Research

Converting potent indeno[1,2-b]indole inhibitors of protein kinase CK2 into selective inhibitors of the breast cancer resistance protein ABCG2.

Bmssi Umr 5086 Cnrs/Universit£

Symmetric bis-chalcones as a new type of breast cancer resistance protein inhibitors with a mechanism different from that of chromones.

Bmssi Umr 5086 Cnrs/Universit£

Investigation of quinazolines as inhibitors of breast cancer resistance protein (ABCG2).

University Of Bonn

Synthesis and biological evaluation of flavones and benzoflavones as inhibitors of BCRP/ABCG2.

University Of Bonn

Activity-lipophilicity relationship studies on P-gp ligands designed as simplified tariquidar bulky fragments.

Universit£

Potent and selective tariquidar bioisosters as potential PET radiotracers for imaging P-gp.

Universit£

Naphthalenyl derivatives for hitting P-gp/MRP1/BCRP transporters.

Universit£

Benzanilide-Biphenyl Replacement: A Bioisosteric Approach to Quinoline Carboxamide-Type ABCG2 Modulators.

University Of Regensburg

Imatinib mesylate is a potent inhibitor of the ABCG2 (BCRP) transporter and reverses resistance to topotecan and SN-38 in vitro.

St. Jude Children'S Research Hospital

Mechanism of the pharmacokinetic interaction between methotrexate and benzimidazoles: potential role for breast cancer resistance protein in clinical drug-drug interactions.

The Netherlands Cancer Institute

Functional characterization of the human multidrug transporter, ABCG2, expressed in insect cells.

Hungarian Academy Of Sciences

High-affinity interaction of tyrosine kinase inhibitors with the ABCG2 multidrug transporter.

Membrane Research Group Of The Hungarian Academy Of Sciences

Transport of glyburide by placental ABC transporters: implications in fetal drug exposure.

Hospital For Sick Children

HIV protease inhibitors are inhibitors but not substrates of the human breast cancer resistance protein (BCRP/ABCG2).

University Of Washington

Reversal of breast cancer resistance protein-mediated drug resistance by estrogen antagonists and agonists.

Japanese Foundation For Cancer Research

Structure-activity relationships of new inhibitors of breast cancer resistance protein (ABCG2).

University Of Bonn

Classification of inhibitors of hepatic organic anion transporting polypeptides (OATPs): influence of protein expression on drug-drug interactions.

Uppsala University

4-Substituted-2-phenylquinazolines as inhibitors of BCRP.

University Of Bonn

Investigation of chalcones as selective inhibitors of the breast cancer resistance protein: critical role of methoxylation in both inhibition potency and cytotoxicity.

Bmssi Umr 5086 Cnrs/Universit£

Discovery of GS-9451: an acid inhibitor of the hepatitis C virus NS3/4A protease.

Gilead Sciences

Substituted chromones as highly potent nontoxic inhibitors, specific for the breast cancer resistance protein.

Cnrs/Universit£

Inhibition of ABCG2-mediated drug efflux by naphthopyrones from marine crinoids.

Nci-Frederick

Potent and selective inhibitors of breast cancer resistance protein (ABCG2) derived from the p-glycoprotein (ABCB1) modulator tariquidar.

University Of Regensburg

Synthesis and biological evaluation of (hetero)arylmethyloxy- and arylmethylamine-phenyl derivatives as potent P-glycoprotein modulating agents.

Universita Degli Studi Di Bari

Acridone derivatives: design, synthesis, and inhibition of breast cancer resistance protein ABCG2.

Umr 5063 Cnrs/Universit£

Nonprenylated rotenoids, a new class of potent breast cancer resistance protein inhibitors.

Umr 5086 Cnrs/Universit£

Investigation of chalcones and benzochalcones as inhibitors of breast cancer resistance protein.

University Of Bonn

Solid phase synthesis of tariquidar-related modulators of ABC transporters preferring breast cancer resistance protein (ABCG2).

Universidad Nacional De Colombia

Flavonoids from eight tropical plant species that inhibit the multidrug resistance transporter ABCG2.

National Cancer Institute-Frederick

Interaction potential of etravirine with drug transporters assessed in vitro.

University Hospital Heidelberg

Structure-activity relationships of flavonoids as inhibitors of breast cancer resistance protein (BCRP).

University Of Bonn

Synthesis and structure-activity relationship of botryllamides that block the ABCG2 multidrug transporter.

Ritsumeikan University

Novel lead for potent inhibitors of breast cancer resistance protein (BCRP).

University Of Bonn

Aromatic 2-(thio)ureidocarboxylic acids as a new family of modulators of multidrug resistance-associated protein 1: synthesis, biological evaluation, and structure-activity relationships.

University Of Bonn

2-[(3-Methoxyphenylethyl)phenoxy]-based ABCB1 inhibitors: effect of different basic side-chains on their biological properties.

Universita Degli Studi Di Bari

Synthesis and Investigation of Tetrahydro-?-carboline Derivatives as Inhibitors of the Breast Cancer Resistance Protein (ABCG2).

University Of Bonn

Structure-Activity Relationship Studies on Tetrahydroisoquinoline Derivatives: [4'-(6,7-Dimethoxy-3,4-dihydro-1H-isoquinolin-2-ylmethyl)biphenyl-4-ol] (MC70) Conjugated through Flexible Alkyl Chains with Furazan Moieties Gives Rise to Potent and Selective Ligands of P-glycoprotein.

Universit£

Synthesis and Biological Evaluation of 4-Anilino-quinazolines and -quinolines as Inhibitors of Breast Cancer Resistance Protein (ABCG2).

University Of Bonn

Novel chalcone and flavone derivatives as selective and dual inhibitors of the transport proteins ABCB1 and ABCG2.

Rheinische Friedrich-Wilhelms-University Of Bonn

Design, Biological Evaluation, and Molecular Modeling of Tetrahydroisoquinoline Derivatives: Discovery of A Potent P-Glycoprotein Ligand Overcoming Multidrug Resistance in Cancer Stem Cells.

Universit£

Optimization of the chromone scaffold through QSAR and docking studies: Identification of potent inhibitors of ABCG2.

Univ. Grenoble Alpes

Modulation of the spacer in N,N-bis(alkanol)amine aryl ester heterodimers led to the discovery of a series of highly potent P-glycoprotein-based multidrug resistance (MDR) modulators.

University Of Florence

Design, synthesis and biological evaluation of stereo- and regioisomers of amino aryl esters as multidrug resistance (MDR) reversers.

University Of Florence

Identification of Thienopyrimidine Scaffold as an Inhibitor of the ABC Transport Protein ABCC1 (MRP1) and Related Transporters Using a Combined Virtual Screening Approach.

Rheinische Friedrich-Wilhelms-University Of Bonn

Synthesis and biological evaluation of quinazoline derivatives - A SAR study of novel inhibitors of ABCG2.

University Of Bonn

Triazole Bridged Flavonoid Dimers as Potent, Nontoxic, and Highly Selective Breast Cancer Resistance Protein (BCRP/ABCG2) Inhibitors.

Hong Kong Polytechnic University

Synthesis of a new inhibitor of breast cancer resistance protein with significantly improved pharmacokinetic profiles.

Takeda Pharmaceuticals International

Structure-activity relationships of chromone derivatives toward the mechanism of interaction with and inhibition of breast cancer resistance protein ABCG2.

Bmssi Umr 5086 Cnrs/Universit£

Tariquidar-Related Chalcones and Ketones as ABCG2 Modulators.

Universidad Nacional De Colombia-Sede Bogot£

Structure activity relationships, multidrug resistance reversal and selectivity of heteroarylphenyl ABCG2 inhibitors.

Rheinische Friedrich-Wilhelms-Universit£T Bonn

Natural alkaloids as P-gp inhibitors for multidrug resistance reversal in cancer.

Csir - Indian Institute Of Integrative Medicine

2,4,6-Substituted Quinazolines with Extraordinary Inhibitory Potency toward ABCG2.

University Of Bonn

Synthesis and biological investigation of 2,4-substituted quinazolines as highly potent inhibitors of breast cancer resistance protein (ABCG2).

University Of Bonn

Discovery of a Novel and Selective Indoleamine 2,3-Dioxygenase (IDO-1) Inhibitor 3-(5-Fluoro-1H-indol-3-yl)pyrrolidine-2,5-dione (EOS200271/PF-06840003) and Its Characterization as a Potential Clinical Candidate.

Iteos Therapeutics

New Inhibitors of Breast Cancer Resistance Protein (ABCG2) Containing a 2,4-Disubstituted Pyridopyrimidine Scaffold.

University Of Bonn

Design, synthesis and biological evaluation of benzamide and phenyltetrazole derivatives with amide and urea linkers as BCRP inhibitors.

St. John'S University

Dual inhibitors of the human blood-brain barrier drug efflux transporters P-glycoprotein and ABCG2 based on the antiviral azidothymidine.

Purdue University

4-Anilino-2-pyridylquinazolines and -pyrimidines as Highly Potent and Nontoxic Inhibitors of Breast Cancer Resistance Protein (ABCG2).

University Of Bonn

Biological profile of the less lipophilic and synthetically more accessible bryostatin 7 closely resembles that of bryostatin 1.

National Cancer Institute-Bethesda

Characterization of a tropane radioligand, [(3)H]2beta-propanoyl-3beta-(4-tolyl) tropane ([(3)H]PTT), for dopamine transport sites in rat brain.

Wake Forest University

18F-labeled FECNT: a selective radioligand for PET imaging of brain dopamine transporters.

Emory University

 

Cycloalkylpiperazines as HIV-1 Protease Inhibitors: Enhanced Oral Absorption

Merck Research Laboratories