The first public molecular recognition database, BindingDB supports research, education and practice in drug discovery, pharmacology and related fields.

BindingDB contains 2.8M data for 1.2M Compounds and 9.2K Targets. Of those, 1,346K data for 622K Compounds and 4.5K Targets were curated by BindingDB curators. BindingDB is a FAIRsharing resource.

If BindingDB was of value to your research, please take a moment to donate to this nonprofit project. Your donation will let us provide you with more data and improved service.

Advanced Search

51 articles for thisTarget


The following articles (labelled with PubMed ID or TBD) are for your review

PMID
Data
Article Title
Organization
Discovery of phenoxyindazoles and phenylthioindazoles as ROR¿ inverse agonists.EBI
Galderma R & D
2-(3-Methoxyphenyl)quinazoline Derivatives: A New Class of Direct Constitutive Androstane Receptor (CAR) Agonists.EBI
Palacky University In Olomouc
Synthesis and Biological Evaluation of Vitamin D3 Metabolite 20S,23S-Dihydroxyvitamin D3 and Its 23R Epimer.EBI
University Of Tennessee Health Science Center
SAR Exploration Guided by LE and Fsp(3): Discovery of a Selective and Orally Efficacious ROR¿ Inhibitor.EBI
Central Pharmaceutical Research Institute
Synthesis and evaluation of vitamin D receptor-mediated activities of cholesterol and vitamin D metabolites.EBI
University Of Wisconsin
Synthesis, Biological Activities, and X-ray Crystal Structural Analysis of 25-Hydroxy-25(or 26)-adamantyl-17-[20(22),23-diynyl]-21-norvitamin D Compounds.EBI
Rikkyo University
Effects of alkyl side chains and terminal hydrophilicity on vitamin D receptor (VDR) agonistic activity based on the diphenylpentane skeleton.EBI
National Institute Of Health Sciences
Fine tuning of agonistic/antagonistic activity for vitamin D receptor by 22-alkyl chain length of ligands: 22S-Hexyl compound unexpectedly restored agonistic activity.EBI
Showa Pharmaceutical University
Chemical Synthesis and Biological Activities of 20S,24S/R-Dihydroxyvitamin D3 Epimers and Their 1a-Hydroxyl Derivatives.EBI
Veterans Affairs Medical Center
Structural development of stapled short helical peptides as vitamin D receptor (VDR)-coactivator interaction inhibitors.EBI
National Institute Of Health Sciences
Identification of the first inverse agonist of retinoid-related orphan receptor (ROR) with dual selectivity for RORß and ROR¿t.EBI
Phenex Pharmaceuticals
Structural insights into the molecular mechanism of vitamin D receptor activation by lithocholic acid involving a new mode of ligand recognition.EBI
Institute Of Genetics And Molecular And Cellular Biology (Igbmc)
Combination of triple bond and adamantane ring on the vitamin D side chain produced partial agonists for vitamin D receptor.EBI
Rikkyo University
A mixed population of antagonist and agonist binding conformers in a single crystal explains partial agonism against vitamin D receptor: active vitamin D analogues with 22R-alkyl group.EBI
Showa Pharmaceutical University
Development of novel Vitamin D Receptor-Coactivator Inhibitors.EBI
University Of Wisconsin-Milwaukee
Novel acetamidothiazole derivatives: synthesis and in vitro anticancer evaluation.EBI
University Of Mansoura
Novel nonsecosteroidal VDR agonists with phenyl-pyrrolyl pentane skeleton.EBI
China Pharmaceutical University
Synthesis of VS-105: A novel and potent vitamin D receptor agonist with reduced hypercalcemic effects.EBI
Vidasym
Development of stapled short helical peptides capable of inhibiting vitamin D receptor (VDR)-coactivator interactions.EBI
National Institute Of Health Sciences
Synthesis of 2?-heteroarylalkyl active vitamin d3 with therapeutic effect on enhancing bone mineral density in vivo.EBI
Teikyo University
Synthesis and evaluation of methylsulfonylnitrobenzamides (MSNBAs) as inhibitors of the thyroid hormone receptor-coactivator interaction.EBI
St. Jude Children'S Research Hospital
Development of silicon-containing bis-phenol derivatives as androgen receptor antagonists: selectivity switching by C/Si exchange.EBI
The University Of Tokyo
Structure-activity relationship of benzodiazepine derivatives as LXXLL peptide mimetics that inhibit the interaction of vitamin D receptor with coactivators.EBI
The University Of Tokyo
Synthesis and biological evaluation of halogenated curcumin analogs as potential nuclear receptor selective agonists.EBI
Arizona State University
Further synthetic and biological studies on vitamin D hormone antagonists based on C24-alkylation and C2alpha-functionalization of 25-dehydro-1alpha-hydroxyvitamin D(3)-26,23-lactones.EBI
Teikyo University
Practical synthesis and evaluation of the biological activities of 1alpha,25-dihydroxyvitamin D3 antagonists, 1alpha,25-dihydroxyvitamin D3-26,23-lactams. Designed on the basis of the helix 12-folding inhibition hypothesis.EBI
University Of Tokyo
Synthesis and biological evaluation of 1a,25-dihydroxyvitamin D3 analogues with a long side chain at C12 and short C17 side chains.EBI
Universidad De Santiago De Compostela
Structural basis for the accommodation of bis- and tris-aromatic derivatives in vitamin D nuclear receptor.EBI
Institute Of Genetics And Molecular And Cellular Biology (Igbmc)
The many faces of the adamantyl group in drug design.EBI
University Of Sydney
Discovery of the first irreversible small molecule inhibitors of the interaction between the vitamin D receptor and coactivators.EBI
University Of Wisconsin-Milwaukee
Butyl pocket formation in the vitamin D receptor strongly affects the agonistic or antagonistic behavior of ligands.EBI
Showa Pharmaceutical University
Novel selective anti-androgens with a diphenylpentane skeleton.EBI
The University Of Tokyo
Vitamin D receptor agonist/histone deacetylase inhibitor molecular hybrids.EBI
Mcgill University
2-Methylene 19-nor-25-dehydro-1alpha-hydroxyvitamin D3 26,23-lactones: synthesis, biological activities and molecular basis of passive antagonism.EBI
Tokyo Medical And Dental University
(2S,2'R)-analogue of LG190178 is a major active isomer.EBI
National Institute Of Health Sciences
22-Alkyl-20-epi-1alpha,25-dihydroxyvitamin D3 compounds of superagonistic activity: syntheses, biological activities and interaction with the receptor.EBI
Tokyo Medical And Dental University
New dermatological agents for the treatment of psoriasis.EBI
Allergan
Design, synthesis and X-ray crystallographic study of new nonsecosteroidal vitamin D receptor ligands.EBI
National Institute Of Health Sciences
An o-aminoanilide analogue of 1a,25-dihydroxyvitamin D(3) functions as a strong vitamin D receptor antagonist.EBI
Mcgill University
Synthesis and pharmacological validation of a novel series of non-steroidal FXR agonists.EBI
Phenex Pharmaceuticals
LXXLL peptide mimetics as inhibitors of the interaction of vitamin D receptor with coactivators.EBI
The University Of Tokyo
Synthesis and anti-inflammatory properties of 1alpha,25-dihydroxy-16-ene-20-cyclopropyl-24-oxo-vitamin D3, a hypocalcemic, stable metabolite of 1alpha,25-dihydroxy-16-ene-20-cyclopropyl-vitamin D3.EBI
Bioxell
Crystal structures of rat vitamin D receptor bound to adamantyl vitamin D analogs: structural basis for vitamin D receptor antagonism and partial agonism.EBI
Tokyo Medical And Dental University
Structure-activity relationship studies on vitamin D lactam derivatives as vitamin D receptor antagonist.EBI
Tokyo University Of Agriculture And Technology
Low-calcemic, highly antiproliferative, 23-oxa ether analogs of the natural hormone 1 alpha,25-dihydroxyvitamin D3: design, synthesis, and preliminary biological evaluation.EBI
The Johns Hopkins University
Low-calcemic, highly antiproliferative, 1-difluoromethyl hybrid analogs of the natural hormone 1alpha,25-dihydroxyvitamin D3: design, synthesis, and preliminary biological evaluation.EBI
The University Of Texas
Structure-activity relationships of 19-norvitamin D analogs having a fluoroethylidene group at the C-2 position.EBI
Tokyo Medical And Dental University
Vitamin D receptor: ligand recognition and allosteric network.EBI
Tokyo Medical And Dental University
Crystal structures of the vitamin D nuclear receptor liganded with the vitamin D side chain analogues calcipotriol and seocalcitol, receptor agonists of clinical importance. Insights into a structural basis for the switching of calcipotriol to a receptor antagonist by further side chain modificatioEBI
Institute Of Genetics And Molecular And Cellular Biology (Igbmc)
Bicyclic hydroxy-1H-pyrrolopyridine-trione containing HIV-1 integrase inhibitors.BDB
National Institutes Of Health