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Fragment-based discovery of novel pentacyclic triterpenoid derivatives as cholesteryl ester transfer protein inhibitors.

China Pharmaceutical University

Design, synthesis and biological evaluation of novel cholesteryl ester transfer protein inhibitors bearing a cycloalkene scaffold.

Shenyang Pharmaceutical University

Discovery of hydroxyl 1,2-diphenylethanamine analogs as potent cholesterol ester transfer protein inhibitors.

Bristol-Myers Squibb Pharmaceutical Research Institute

Discovery of Novel Indoline Cholesterol Ester Transfer Protein Inhibitors (CETP) through a Structure-Guided Approach.

Merck Research Laboratories

Design, synthesis and biological evaluation of N,N-3-phenyl-3-benzylaminopropanamide derivatives as novel cholesteryl ester transfer protein inhibitor.

Shenyang Pharmaceutical University

Discovery of novel N,N-3-phenyl-3-benzylaminopropionanilides as potent inhibitors of cholesteryl ester transfer protein in vivo.

Shenyang Pharmaceutical University

Applications of Fluorine in Medicinal Chemistry.

Bristol-Myers Squibb Research And Development

Some molecular targets for antihyperlipidemic drug research.

Banasthali University

Potent cholesteryl ester transfer protein inhibitors of reduced lipophilicity: 1,1'-spiro-substituted hexahydrofuroquinoline derivatives.

Boehringer Ingelheim Pharma

Diphenylpyridylethanamine (DPPE)-based aminoheterocycles as cholesteryl ester transfer protein inhibitors.

Bristol-Myers Squibb

Diphenylpyridylethanamine (DPPE) derivatives as cholesteryl ester transfer protein (CETP) inhibitors.

Bristol-Myers Squibb

Identification of a potent and metabolically stable series of fluorinated diphenylpyridylethanamine-based cholesteryl ester transfer protein inhibitors.

Bristol-Myers Squibb

Design and synthesis of new tetrahydroquinolines derivatives as CETP inhibitors.

Eli Lilly

Design, synthesis and structure-activity-relationship of 1,5-tetrahydronaphthyridines as CETP inhibitors.

Eli Lilly

2-Arylbenzoxazoles as novel cholesteryl ester transfer protein inhibitors: optimization via array synthesis.

Bristol-Myers Squibb Pharmaceutical Research Institute

The biology and chemistry of hyperlipidemia.

Sinhgad College Of Pharmacy

bis(2-(Acylamino)phenyl) disulfides, 2-(acylamino)benzenethiols, and S-(2-(acylamino)phenyl) alkanethioates as novel inhibitors of cholesteryl ester transfer protein.

Research Triangle Institute

 

CETP inhibitory activity of ceramides, isolated from the gorgonian Acabaria Undulata

TBA

 

Wiedendiol-A and -B, cholesteryl ester transfer protein inhibitors from the marine sponge Xestospongia wiedenmayeri

TBA

Discovery of substituted biphenyl oxazolidinone inhibitors of cholesteryl ester transfer protein.

TBA

SAR studies on the central phenyl ring of substituted biphenyl oxazolidinone-potent CETP inhibitors.

Merck Sharp & Dohme

Biphenyl-substituted oxazolidinones as cholesteryl ester transfer protein inhibitors: modifications of the oxazolidinone ring leading to the discovery of anacetrapib.

Merck Research Laboratories

2-(4-Carbonylphenyl)benzoxazole inhibitors of CETP: attenuation of hERG binding and improved HDLc-raising efficacy.

Merck Research Laboratories

2-(4-carbonylphenyl)benzoxazole inhibitors of CETP: scaffold design and advancement in HDLc-raising efficacy.

Merck Research Laboratories

2-Arylbenzoxazoles as CETP inhibitors: raising HDL-C in cynoCETP transgenic mice.

Merck Research Laboratories

Design of a novel class of biphenyl CETP inhibitors.

Merck Sharp & Dohme

Synthesis of a series of novel 2,4,5-trisubstituted selenazole compounds as potential PLTP inhibitors.

Beijing Institute Of Pharmacology And Toxicology

Novel tetrahydrochinoline derived CETP inhibitors.

Bayer Healthcare

2-Arylbenzoxazoles as CETP inhibitors: substitution and modification of the alpha-alkoxyamide moiety.

Merck Research Laboratories

Synthesis and discovery of 2,3-dihydro-3,8-diphenylbenzo[1,4]oxazines as a novel class of potent cholesteryl ester transfer protein inhibitors.

Johnson & Johnson Pharmaceutical Research And Development

 

Substituted 1,3,5-triazines as cholesteryl ester transfer protein inhibitors

TBA

 

Phosphonate-containing analogs of cholesteryl ester as novel inhibitors of cholesteryl ester transfer protein

TBA

 

Novel inhibitors of cholesteryl ester transfer protein

TBA

Design and synthesis of potent inhibitors of cholesteryl ester transfer protein (CETP) exploiting a 1,2,3,4-tetrahydroquinoline platform.

Johnson & Johnson Pharmaceutical Research & Development

Design, synthesis, and biological evaluation of (2R,alphaS)-3,4-dihydro-2-[3-(1,1,2,2-tetrafluoroethoxy)phenyl]-5-[3-(trifluoromethoxy)-phenyl]-alpha-(trifluoromethyl)-1(2H)-quinolineethanol as potent and orally active cholesteryl ester transfer protein inhibitor.

Johnson And Johnson Pharmaceutical Research And Development

2D Quantitative structure-activity relationship studies on a series of cholesteryl ester transfer protein inhibitors.

Universidade Federal Da Bahia

Tetrazole and ester substituted tetrahydoquinoxalines as potent cholesteryl ester transfer protein inhibitors.

Array Biopharma

Dibenzodioxocinones--a new class of CETP inhibitors.

Bayer Healthcare Pharma Research

S-(2-(acylamino)phenyl) 2,2-dimethylpropanethioates as CETP inhibitors.

Central Pharmaceutical Research Institute

Discovery of a simple picomolar inhibitor of cholesteryl ester transfer protein.

Pfizer

Chiral N,N-disubstituted trifluoro-3-amino-2-propanols are potent inhibitors of cholesteryl ester transfer protein.

Pharmacia

Novel heteroaryl replacements of aromatic 3-tetrafluoroethoxy substituents in trifluoro-3-(tertiaryamino)-2-propanols as potent inhibitors of cholesteryl ester transfer protein.

Pharmacia

Discovery of chiral N,N-disubstituted trifluoro-3-amino-2-propanols as potent inhibitors of cholesteryl ester transfer protein.

Pfizer

Discovery of a Lead Triphenylethanamine Cholesterol Ester Transfer Protein (CETP) Inhibitor.

Bristol-Myers Squibb

A depsipeptide fungal metabolite inhibitor of cholesteryl ester transfer protein.

Schering-Plough Research Institute

Combinatorial synthesis of cholesterol ester transfer protein-mRNA ligands and screening by nondenaturating gel-electrophoresis.

Johann Wolfgang Goethe-Universit£T Frankfurt/Main

Discovery of pentacyclic triterpene 3?-ester derivatives as a new class of cholesterol ester transfer protein inhibitors.

China Pharmaceutical University

Discovery of a Novel Piperidine-Based Inhibitor of Cholesteryl Ester Transfer Protein (CETP) That Retains Activity in Hypertriglyceridemic Plasma.

Novartis Institutes For Biomedical Research

Phenolic compounds with pancreatic lipase inhibitory activity from Korean yam (Dioscorea opposita).

Seoul National University

4-Acylamino-6-arylfuro[2,3-d]pyrimidines: potent and selective glycogen synthase kinase-3 inhibitors.

Tsukuba Research Laboratories