PMID

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Article Title

Organization

Terminal functionalized thiourea-containing dipeptides as multidrug-resistance reversers that target 20S proteasome and cell proliferation.

Guangxi Normal University

Discovery of Highly Selective Inhibitors of the Immunoproteasome Low Molecular Mass Polypeptide 2 (LMP2) Subunit.

Kezar Life Sciences

Identification of noncovalent proteasome inhibitors with high selectivity for chymotrypsin-like activity by a multistep structure-based virtual screening.

University Of Naples Federico Ii

Substituted quinolines as noncovalent proteasome inhibitors.

Michigan State University

Development of novel proteasome inhibitors based on phthalazinone scaffold.

Peking University Health Science Center

Optimization of peptidomimetic boronates bearing a P3 bicyclic scaffold as proteasome inhibitors.

Universit£

Identification of a new series of amides as non-covalent proteasome inhibitors.

Universit£

Structurally novel highly potent proteasome inhibitors created by the structure-based hybridization of nonpeptidic belactosin derivatives and peptide boronates.

Hokkaido University

New C(4)- and C(1)-derivatives of furo[3,4-c]pyridine-3-ones and related compounds: evidence for site-specific inhibition of the constitutive proteasome and its immunoisoform.

Yerevan State University

A novel tamoxifen derivative, ridaifen-F, is a nonpeptidic small-molecule proteasome inhibitor.

Institute Of Bio-Science And Technology

Development of peptidomimetic boronates as proteasome inhibitors.

Universit£

Potent proteasome inhibitors derived from the unnatural cis-cyclopropane isomer of Belactosin A: synthesis, biological activity, and mode of action.

Hokkaido University

Dimerized linear mimics of a natural cyclopeptide (TMC-95A) are potent noncovalent inhibitors of the eukaryotic 20S proteasome.

University Paris 6

Incorporation of non-natural amino acids improves cell permeability and potency of specific inhibitors of proteasome trypsin-like sites.

Leiden Institute Of Chemistry And Netherlands Proteomics Centre

Molecular mechanisms of acquired proteasome inhibitor resistance.

University Of California San Diego

Incorporation of fluorinated phenylalanine generates highly specific inhibitor of proteasome's chymotrypsin-like sites.

Gorlaeus Laboratories

Optimization of subsite binding to the beta5 subunit of the human 20S proteasome using vinyl sulfones and 2-keto-1,3,4-oxadiazoles: syntheses and cellular properties of potent, selective proteasome inhibitors.

Celera

LMP2 Inhibitors as a Potential Treatment for Alzheimer's Disease.

University Of Kentucky

Discovery of Fluoromethylketone-Based Peptidomimetics as Covalent ATG4B (Autophagin-1) Inhibitors.

Roche Pharma Research And Early Development

Structure-Based Design of ?5c Selective Inhibitors of Human Constitutive Proteasomes.

Leiden Institute Of Chemistry

Another look at phenolic compounds in cancer therapy the effect of polyphenols on ubiquitin-proteasome system.

Institute Of Agricultural And Food Biotechnology

Covalent docking modelling-based discovery of tripeptidyl epoxyketone proteasome inhibitors composed of aliphatic-heterocycles.

Hangzhou Institute Of Innovative Medicine

Exploration of novel macrocyclic dipeptide N-benzyl amides as proteasome inhibitors.

Zhejiang University

Required Immunoproteasome Subunit Inhibition Profile for Anti-Inflammatory Efficacy and Clinical Candidate KZR-616 ((2 S,3 R)- N-(( S)-3-(Cyclopent-1-en-1-yl)-1-(( R)-2-methyloxiran-2-yl)-1-oxopropan-2-yl)-3-hydroxy-3-(4-methoxyphenyl)-2-(( S)-2-(2-morpholinoacetamido)propanamido)propenamide).

Kezar Life Sciences

Identification of neomacrophorins isolated from Trichoderma sp. 1212-03 as proteasome inhibitors.

Iwate University

Immunoproteasome-selective inhibitors: An overview of recent developments as potential drugs for hematologic malignancies and autoimmune diseases.

Hangzhou Xixi Hospital

Synthesis and Biological Activity of Peptide ?-Ketoamide Derivatives as Proteasome Inhibitors.

University Of Ferrara

Analysis of chain length, substitution patterns, and unsaturation of AM-404 derivatives as 20S proteasome stimulators.

Purdue University

Structure-Based Design of Inhibitors Selective for Human Proteasome ?2c or ?2i Subunits.

Leiden Institute Of Chemistry And Netherlands Proteomics Centre

Novel Cell-Penetrating Peptide Conjugated Proteasome Inhibitors: Anticancer and Antifungal Investigations.

University Of Auckland

Design, synthesis, and biological evaluation of novel phenol ether derivatives as non-covalent proteasome inhibitors.

Zhejiang University

Tetradehydrohalicyclamine B, a new proteasome inhibitor from the marine sponge Acanthostrongylophora ingens.

Kumamoto University

Cinnabaramides A-G: analogues of lactacystin and salinosporamide from a terrestrial streptomycete.

Intermed Discovery Gmbh (Imd)

Structure-based design of derivatives of tyropeptin A as the potent and selective inhibitors of mammalian 20S proteasome.

Numazu Bio-Medical Research Institute

Potent inhibitors of proteasome.

Cephalon

Structure-based optimisation of 2-aminobenzylstatine derivatives: potent and selective inhibitors of the chymotrypsin-like activity of the human 20S proteasome.

Novartis Pharma

Structure-based design of human immuno- and constitutive proteasomes inhibitors.

Universit£

Design, synthesis, in vitro and in vivo evaluation, and structure-activity relationship (SAR) discussion of novel dipeptidyl boronic acid proteasome inhibitors as orally available anti-cancer agents for the treatment of multiple myeloma and mechanism studies.

Nanjing Forestry University

Synthesis and biological evaluation of curcumin derivatives modified with ?-amino boronic acid as proteasome inhibitors.

Peking University

Reviewing Hit Discovery Literature for Difficult Targets: Glutathione Transferase Omega-1 as an Example.

Monash University

Ridaifen-F conjugated with cell-penetrating peptides inhibits intracellular proteasome activities and induces drug-resistant cell death.

Nagahama Institute Of Bio-Science And Technology

Neomacrophorin X, a [4.4.3]Propellane-Type Meroterpenoid from Trichoderma sp. 1212-03.

Hirosaki University

Synthesis and biological activity of peptide proline-boronic acids as proteasome inhibitors.

Peking University

Urea-containing peptide boronic acids as potent proteasome inhibitors.

Peking University

A strategy for dual inhibition of the proteasome and fatty acid synthase with belactosin C-orlistat hybrids.

Baylor University