22 articles for thisTarget
The following articles (labelled with PubMed ID or TBD) are for your review
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Article Title
Organization
Non-peptide renin inhibitors containing 2-(((3-phenylpropyl)phosphoryl)oxy)alkanoic acid moieties as P2-P3 replacements.
E. Merck Darmstadt
Potent and selective inhibitors of an aspartyl protease-like endothelin converting enzyme identified in rat lung.
Abbott Laboratories
Structure-activity relationships of a series of 2-amino-4-thiazole-containing renin inhibitors.
Parke-Davis Pharmaceutical Research Division Of Warner-Lambert
Design and synthesis of potent, selective, and orally active fluorine-containing renin inhibitors.
Warner-Lambert
Renin inhibitors containing esters at the P2-position. Oral activity in a derivative of methyl aminomalonate.
Warner-Lambert
Substrate analogue renin inhibitors containing replacements of histidine in P2 or isosteres of the amide bond between P3 and P2 sites.
E. Merck Darmstadt
Orally potent human renin inhibitors derived from angiotensinogen transition state: design, synthesis, and mode of interaction.
Kissei Pharmaceutical
Inhibition of cathepsin D by substrate analogues containing statine and by analogues of pepstatin.
TBA
Design and synthesis of a potent and specific renin inhibitor with a prolonged duration of action in vivo.
TBA
Design and synthesis of potent and specific renin inhibitors containing difluorostatine, difluorostatone, and related analogues.
TBA
Difluorostatine- and difluorostatone-containing peptides as potent and specific renin inhibitors.
TBA
The P1N-isopropyl motif bearing hydroxyethylene dipeptide isostere analogues of aliskiren are in vitro potent inhibitors of the human aspartyl protease renin.
Nagasaki International University
Novel low molecular renin inhibitors which show good oral blood pressure lowering effects in marmosets
TBA
Renin inhibitors. Dipeptide analogues of angiotensinogen incorporating transition-state, nonpeptidic replacements at the scissile bond.
Abbott Laboratories
Renin inhibitors. Design and synthesis of a new class of conformationally restricted analogues of angiotensinogen.
Abbott Laboratories
Synthesis and biological activity of some transition-state inhibitors of human renin.
Ciba-Geigy
Inhibition of porcine pepsin by two substrate analogues containing statine. The effect of histidine at the P2 subsite on the inhibition of aspartic proteinases.
University Of Wisconsin
New inhibitors of human renin that contain novel replacements at the P2 site.
Warner-Lambert