PMID

Data

Article Title

Organization

Quinoxaline N-oxide containing potent angiotensin II receptor antagonists: synthesis, biological properties, and structure-activity relationships.

Bristol-Myers Squibb Pharmaceutical Research Institute

Nonpeptide angiotensin II receptor antagonists. 2. Design, synthesis, and structure-activity relationships of 2-alkyl-4-(1H-pyrrol-1-yl)-1H-imidazole derivatives: profile of 2-propyl-1-[[2'-(1H-tetrazol-5-yl)-[1,1' -biphenyl]-4-yl]-methyl]-4-[2-(trifluoroacetyl)-1H-pyrrol-1-yl]-1H- imidazole-5-car

Warner-Lambert

Potent nonpeptide angiotensin II receptor antagonists. 2. 1-(Carboxybenzyl)imidazole-5-acrylic acids.

Smithkline Beecham Pharmaceuticals

Conformationally restricted polysubstituted biphenyl derivatives with angiotensin II receptors antagonist properties.

Searle R & D And Mcr

Nonpeptide angiotensin II receptor antagonists: the discovery of a series of N-(biphenylylmethyl)imidazoles as potent, orally active antihypertensives.

E. I. Du Pont De Nemours

Synthesis and structure-activity relationships of a novel series of non-peptide angiotensin II receptor binding inhibitors specific for the AT2 subtype.

Warner-Lambert

Nonpeptide angiotensin II receptor antagonists: N-[(benzyloxy)benzyl]imidazoles and related compounds as potent antihypertensives.

E. I. Du Pont De Nemours And

The discovery of potent nonpeptide angiotensin II receptor antagonists: a new class of potent antihypertensives.

E. I. Du Pont De Nemours

Topographic probes of angiotensin and receptor: potent angiotensin II agonist containing diphenylalanine and long-acting antagonists containing biphenylalanine and 2-indan amino acid in position 8.

Washington State University

Angiotensin II pseudopeptides containing 1,3,5-trisubstituted benzene scaffolds with high AT2 receptor affinity.

Uppsala University

Vinyl sulfide cyclized analogues of angiotensin II with high affinity and full agonist activity at the AT(1) receptor.

Uppsala University

Dihydropyrimidine angiotensin II receptor antagonists.

Bristol-Myers Squibb Pharmaceutical Research Institute

 

1,4-substituted indoles: a potent and selective class of angiostensin II receptor antagonists

TBA

 

Acyliminothiadiazoline derivatives: New, highly potent, and orally active angiotensin II receptor antagonists

TBA

 

4,5-Dihydro-4-oxo-3H-imidazo[4,5-c]pyridines: potent arylacetic acid-derived AT₁ antagonists with improved affinity for the AT₂ receptor

TBA

 

Balanced AT₁ and AT₂ angiotensin II antagonists. II. Potent 5 α-hydroxyacid imidazolyl biphenyl sulfonylureas

TBA

 

Uracil-based angiotensin II receptor antagonists

TBA

 

The SAR of 6-(N-alkyl-N-acyl)-2-propyl-3-[(2′-tetrazol-5-yl)biphen-4-yl)methyl]-quinazolinones as balanced affinity antagonists of the human AT₁ and AT₂ receptors

TBA

 

2,3,6-Substituted quinazolinones as angiotensin II receptor antagonists

TBA

 

Potent triazolinone-based angiotensin II receptor antagonists with equivalent affinity for both the AT₁ and AT₂ subtypes

TBA

 

Discovery of nonpeptide potent conformationally restricted angiotensin II receptor antagonists

TBA

 

Development of angiotensin II antagonists with equipotent affinity for human AT₁ and AT₂ receptor subtypes.

TBA

 

Balanced angiotensin II receptor antagonists. I. The effects of biphenyl “ortho”-substitution on AT₁/AT₂ affinities

TBA

 

Synthesis and biological evaluation of the potent isoxazolidinyl angiotensin II receptor antagonist CL332,877 and its enantiomers.

TBA

 

6-isoxazolinyl and isoxazolidinyl substituted quinazolinones as angiotensin II receptor antagonists

TBA

 

A potent long-acting imidazole-5-acrylic acid angiotensin II AT-1 receptor antagonist

TBA

 

Orally active prodrugs of quinoline-4-carboxylic acid angiotensin II receptor antagonists

TBA

 

Quinoline-4-carboxylic acids as angiotensin II receptor antagonists

TBA

 

Dihydro-imidazolone derivatives as angiotensin II receptor antagonists: chiral effect on the activity

TBA

 

Cyclopentanespiro-3H-dihydro-pyrimidinones as Angiotensin II AT₁ receptor antagonists

TBA

 

Triazolinones as nonpeptide angiotensin II antagonists. 2. discovery of a potent and orally active triazolinone acylsulfonamide

TBA

Design, synthesis, structural studies, biological evaluation, and computational simulations of novel potent AT(1) angiotensin II receptor antagonists based on the 4-phenylquinoline structure.

Università

Discovery of 4'-[(imidazol-1-yl)methyl]biphenyl-2-sulfonamides as dual endothelin/angiotensin II receptor antagonists.

Bristol-Myers Squibb Pharmaceutical Research Institute

Discovery of N-isoxazolyl biphenylsulfonamides as potent dual angiotensin II and endothelin A receptor antagonists.

Bristol-Myers Squibb Pharmaceutical Research Institute

Multiple binding modes for the receptor-bound conformations of cyclic AII agonists.

Washington University

Nonpeptide angiotensin II receptor antagonists. 1. Synthesis and in vitro structure-activity relationships of 4-[[[(1H-pyrrol-1-ylacetyl)amino]phenyl]methyl]imidazole derivatives as angiotensin II receptor antagonists.

Warner-Lambert

Nonpeptide angiotensin II antagonists derived from 4H-1,2,4-triazoles and 3H-imidazo[1,2-b][1,2,4]triazoles.

Merck Research Laboratories

Nonpeptide angiotensin II antagonists: N-phenyl-1H-pyrrole derivatives are angiotensin II receptor antagonists.

Searle

Synthesis and structure-activity relationships of nonpeptide, potent triazolone-based angiotensin II receptor antagonists.

Searle R&D

6-Substituted benzimidazoles as new nonpeptide angiotensin II receptor antagonists: synthesis, biological activity, and structure-activity relationships.

Dr. Karl Thomae

A novel series of selective, non-peptide inhibitors of angiotensin II binding to the AT2 site.

Dupont Pharmaceuticals

A new series of imidazolones: highly specific and potent nonpeptide AT1 angiotensin II receptor antagonists.

Sanofi Recherche

Non-peptide angiotensin II receptor antagonists: synthesis and biological activity of a series of novel 4,5-dihydro-4-oxo-3H-imidazo[4,5-c]pyridine derivatives.

E. Merck

Synthesis and SAR studies of novel triazolopyrimidine derivatives as potent, orally active angiotensin II receptor antagonists.

Carpibem

Conformational restriction of angiotensin II: cyclic analogues having high potency.

G.D. Searle And

Nonpeptidic angiotensin II antagonists: synthesis and in vitro activity of a series of novel naphthalene and tetrahydronaphthalene derivatives.

Ciba-Geigy

Nonpeptide angiotensin II receptor antagonists: synthetic and computational chemistry of N-[[4-[2-(2H-tetrazol-5-yl)-1-cycloalken-1- yl]phenyl]methyl]imidazole derivatives and their in vitro activity.

Eli Lilly

Imidazole-5-acrylic acids: potent nonpeptide angiotensin II receptor antagonists designed using a novel peptide pharmacophore model.

Smithkline Beecham Pharmaceuticals

Discovery of a novel class of orally active, non-peptide angiotensin II antagonists.

Abbott Laboratories