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18 articles for thisTarget


The following articles (labelled with PubMed ID or TBD) are for your review

PMID
Data
Article Title
Organization
[3H]Batrachotoxinin A 20 alpha-benzoate binding to voltage-sensitive sodium channels: a rapid and quantitative assay for local anesthetic activity in a variety of drugs.EBI
TBA
Sulfonamides as Selective NaEBI
Amgen
Discovery of Aryl Sulfonamides as Isoform-Selective Inhibitors of NaV1.7 with Efficacy in Rodent Pain Models.EBI
Xenon Pharmaceuticals
Voltage-Gated Sodium Channels: Structure, Function, Pharmacology, and Clinical Indications.EBI
Merck Research Laboratories
Discovery and Optimization of Selective Nav1.8 Modulator Series That Demonstrate Efficacy in Preclinical Models of Pain.EBI
Pfizer
Simulation of multiple ion channel block provides improved early prediction of compounds' clinical torsadogenic risk.EBI
University Of Oxford
Engineering potent and selective analogues of GpTx-1, a tarantula venom peptide antagonist of the Na(V)1.7 sodium channel.EBI
Amgen
Imidazol-1-ylethylindazole voltage-gated sodium channel ligands are neuroprotective during optic neuritis in a mouse model of multiple sclerosis.EBI
University College London
Ion channels as therapeutic targets: a drug discovery perspective.EBI
Pfizer
A-803467, a potent and selective Nav1.8 sodium channel blocker, attenuates neuropathic and inflammatory pain in the rat.EBI
Abbott Laboratories
Joys of molecules. 2. Endeavors in chemical biology and medicinal chemistry.EBI
The Scripps Research Institute
Identification and characterization of a potential ischemia-selective N-methyl-D-aspartate (NMDA) receptor ion-channel blocker, CNS 5788.EBI
Cambridge Neuroscience
 
Batrachotoxin binding site antagonistsEBI
TBA
Identification of a potent, state-dependent inhibitor of Nav1.7 with oral efficacy in the formalin model of persistent pain.EBI
Amgen
Sodium channel blockers.EBI
Purdue Pharma
Anticonvulsant activity of piperidinol and (dialkylamino)alkanol esters.EBI
TBA
Inhibitors of HIV-1 proteinase containing 2-heterosubstituted 4-amino-3-hydroxy-5-phenylpentanoic acid: synthesis, enzyme inhibition, and antiviral activity.BDB
Sandoz Forschungsinstitut Ges.M.B.H.