PMID

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Article Title

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Discovery, design and synthesis of 6H-anthra[1,9-cd]isoxazol-6-one scaffold as G9a inhibitor through a combination of shape-based virtual screening and structure-based molecular modification.

China Pharmaceutical University

Targeting DNA methylation with small molecules: what's next?

Cnrs-Pierre Fabre

Selective inhibitors of protein methyltransferases.

Icahn School Of Medicine At Mount Sinai

SAH derived potent and selective EZH2 inhibitors.

Pfizer

Discovery of a selective, substrate-competitive inhibitor of the lysine methyltransferase SETD8.

University Of North Carolina At Chapel Hill

Identifying novel selective non-nucleoside DNA methyltransferase 1 inhibitors through docking-based virtual screening.

Chinese Academy Of Sciences

Analogues of the Natural Product Sinefungin as Inhibitors of EHMT1 and EHMT2.

University Of Copenhagen

Using 'biased-privileged' scaffolds to identify lysine methyltransferase inhibitors.

Rockefeller University

On the histone lysine methyltransferase activity of fungal metabolite chaetocin.

Imperial College

Discovery and development of potent and selective inhibitors of histone methyltransferase g9a.

Abbvie

A medicinal chemistry perspective for targeting histone H3 lysine-79 methyltransferase DOT1L.

Baylor College Of Medicine

Discovery of an in vivo chemical probe of the lysine methyltransferases G9a and GLP.

University Of North Carolina At Chapel Hill

Exploiting an allosteric binding site of PRMT3 yields potent and selective inhibitors.

University Of North Carolina At Chapel Hill

Epidithiodiketopiperazine as a pharmacophore for protein lysine methyltransferase G9a inhibitors: reducing cytotoxicity by structural simplification.

Riken Advanced Science Institute

Identification of Potent, Selective, Cell-Active Inhibitors of the Histone Lysine Methyltransferase EZH2.

TBA

Oncoepigenomics: making histone lysine methylation count.

TBA

Gliotoxin analogues from a marine-derived fungus, Penicillium sp., and their cytotoxic and histone methyltransferase inhibitory activities.

The University Of Tokyo

Optimization of cellular activity of G9a inhibitors 7-aminoalkoxy-quinazolines.

University Of North Carolina At Chapel Hill

Computer- and structure-based lead design for epigenetic targets.

Martin-Luther University Of Halle-Wittenberg

Chemical probes for histone-modifying enzymes.

Johns Hopkins University School Of Medicine

Protein lysine methyltransferase G9a inhibitors: design, synthesis, and structure activity relationships of 2,4-diamino-7-aminoalkoxy-quinazolines.

University Of North Carolina At Chapel Hill

Discovery of a 2,4-diamino-7-aminoalkoxyquinazoline as a potent and selective inhibitor of histone lysine methyltransferase G9a.

University Of North Carolina