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37 articles for thisTarget

The following articles (labelled with PubMed ID or TBD) are for your review
PMIDDataArticle TitleOrganization
28146629 65 Identification of High-Potency Human TLR8 and Dual TLR7/TLR8 Agonists in Pyrimidine-2,4-diamines.EBI University of Minnesota
27270029 39 Incorporation of Phosphonate into Benzonaphthyridine Toll-like Receptor 7 Agonists for Adsorption to Aluminum Hydroxide.EBI Genomics Institute of Novartis Research Foundation
26351878 24 Structure-Based Design of Human TLR8-Specific Agonists with Augmented Potency and Adjuvanticity.EBI University of Kansas
25698055 12 Structural requirements for TLR7-selective signaling by 9-(4-piperidinylalkyl)-8-oxoadenine derivatives.EBI GlaxoSmithKline
25102141 25 Human Toll-like receptor 8-selective agonistic activities in 1-alkyl-1H-benzimidazol-2-amines.EBI University of Kansas
25408837 24 Dihydropyrrolo[2,3-d]pyrimidines: Selective Toll-Like Receptor 9 Antagonists from Scaffold Morphing Efforts.EBI Sumitomo Dainippon Pharma Co., Ltd
23961878 1 Identification and optimization of pteridinone Toll-like receptor 7 (TLR7) agonists for the oral treatment of viral hepatitis.EBI Gilead Sciences Inc
23899291 3 Exquisite selectivity for human toll-like receptor 8 in substituted furo[2,3-c]quinolines.EBI University of Kansas
22837811 12 Discovery of Imidazoquinolines with Toll-Like Receptor 7/8 Independent Cytokine Induction.EBI TBA
22924757 16 Structure-activity relationships in human Toll-like receptor 8-active 2,3-diamino-furo[2,3-c]pyridines.EBI University of Kansas
22239408 31 Toll-like receptor (TLR)-7 and -8 modulatory activities of dimeric imidazoquinolines.EBI University of Kansas
20232824 17 Synthesis and biological evaluation of 8-oxoadenine derivatives as toll-like receptor 7 agonists introducing the antedrug concept.EBI Dainippon Sumitomo Pharma Co., Ltd
32001135 24 Optimization of 8-oxoadenines with toll-like-receptor 7 and 8 activity.EBI University of Montana
32944143 89 Discovery of Potent and Orally Bioavailable Small Molecule Antagonists of Toll-like Receptors 7/8/9 (TLR7/8/9).EBI Princ
32786235 87 Target-Based Identification and Optimization of 5-Indazol-5-yl Pyridones as Toll-like Receptor 7 and 8 Antagonists Using a Biochemical TLR8 Antagonist Competition Assay.EBI Genomics Institute of the Novartis Research Foundation
31784317 25 Further exploration of the structure-activity relationship of imidazoquinolines; identification of potent C7-substituted imidazoquinolines.EBI University of Kansas
27513008 16 Human Toll-like Receptor (TLR) 8-Specific Agonistic Activity in Substituted Pyrimidine-2,4-diamines.EBI University of Minnesota
32233366 32 Rationally Designed Small-Molecule Inhibitors Targeting an Unconventional Pocket on the TLR8 Protein-Protein Interface.EBI The University of Tokyo
31687820 45 Discovery of Novel Small Molecule Dual Inhibitors Targeting Toll-Like Receptors EBI University of Colorado Boulder
31284084 3 Identification and characterization of a novel chemotype for human TLR8 inhibitors.EBI Freie Universit£t Berlin
24383475 22 Structure-activity relationship analysis of imidazoquinolines with Toll-like receptors 7 and 8 selectivity and enhanced cytokine induction.EBI University of Minnesota
30344900 36 NLRP3 Modulators for the Treatment of Autoinflammatory Disorders.EBI Usona Institute
29152046 28 Design and Synthesis of N1-Modified Imidazoquinoline Agonists for Selective Activation of Toll-like Receptors 7 and 8.EBI University of Minnesota
28537730 9 Discovery of Small Molecules as Multi-Toll-like Receptor Agonists with Proinflammatory and Anticancer Activities.EBI University of Colorado Boulder
17827 156 Binding characteristics of a radiolabeled agonist and antagonist at central nervous system alpha noradrenergic receptors.BDB TBA
18173230 5 Inhibition of adenosine deaminase by analogues of adenosine and inosine, incorporating a common heterocyclic base, 4(7)-amino-6(5)H-imidazo[4,5-d]pyridazin-7(4)one.BDB University of Maryland Baltimore County
17485205 18 Benzopyrans as selective estrogen receptor beta agonists (SERBAs). Part 2: structure-activity relationship studies on the benzopyran scaffold.BDB Eli Lilly and Company
16183021 19 Methylxanthine drugs are chitinase inhibitors: investigation of inhibition and binding modes.BDB University of Dundee