BindingDB logo
myBDB logout

81 articles for thisTarget


The following articles (labelled with PubMed ID or TBD) are for your review
PMIDDataArticle TitleOrganization
27876467 9 A review on tacrine-based scaffolds as multi-target drugs (MTDLs) for Alzheimer's disease.EBI Tehran University of Medical Sciences
27951485 59 Aurone Mannich base derivatives as promising multifunctional agents with acetylcholinesterase inhibition, anti--amyloid aggragation and neuroprotective properties for the treatment of Alzheimer's disease.EBI Sichuan University
27552582 42 Development of Multifunctional Pyrimidinylthiourea Derivatives as Potential Anti-Alzheimer Agents.EBI East China University of Science and Technology
27392529 32 Novel series of tacrine-tianeptine hybrids: Synthesis, cholinesterase inhibitory activity, S100B secretion and a molecular modeling approach.EBI Universidade Federal do Rio Grande do Sul
25678013 63 Design, synthesis and evaluation of chromone-2-carboxamido-alkylbenzylamines as multifunctional agents for the treatment of Alzheimer's disease.EBI Sichuan University
25082512 38 Design, synthesis and evaluation of rivastigmine and curcumin hybrids as site-activated multitarget-directed ligands for Alzheimer's disease therapy.EBI Zhejiang University
25778991 116 Design, synthesis and evaluation of scutellarein-O-alkylamines as multifunctional agents for the treatment of Alzheimer's disease.EBI Sichuan University
25614117 37 Multifunctional scutellarin-rivastigmine hybrids with cholinergic, antioxidant, biometal chelating and neuroprotective properties for the treatment of Alzheimer's disease.EBI Sichuan University
25205193 10 Synthesis and acetylcholinesterase inhibitory activity of Mannich base derivatives flavokawain B.EBI Hunan University
23422935 29 Synthesis of tacrine-lophine hybrids via one-pot four component reaction and biological evaluation as acetyl- and butyrylcholinesterase inhibitors.EBI Universidade Federal do Rio Grande do Sul
23380475 7 Synthesis, biological evaluation and molecular modeling of aloe-emodin derivatives as new acetylcholinesterase inhibitors.EBI Hainan University
23273608 20 Design, synthesis and evaluation of novel heterodimers of donepezil and huperzine fragments as acetylcholinesterase inhibitors.EBI The Hong Kong University of Science and Technology
18976927 83 Synthesis and structure-activity relationships for biphenyl H3 receptor antagonists with moderate anti-cholinesterase activity.EBI Universit£ degli Studi di Parma
 1 A New Diterpene from a Soft Coral, Sinularia dissectaEBI TBA
3351860 56 Approaches to protection against nerve agent poisoning. (Naphthylvinyl)pyridine derivatives as potential antidotes.EBI Dynamac Corporation
3336013 52 Evaluation of the side arm of (naphthylvinyl)pyridinium inhibitors of choline acetyltransferase.EBI University of Pittsburgh
3965704 22 Synthesis of some quaternary ammonium alkylating agents and their effects on soman-inhibited acetylcholinesterase.EBI TBA
23033965 37 Combining galantamine and memantine in multitargeted, new chemical entities potentially useful in Alzheimer's disease.EBI Istituto Italiano di Tecnologia
22172310 47 Synthesis and evaluation of novel 4-[(3H,3aH,6aH)-3-phenyl)-4,6-dioxo-2-phenyldihydro-2H-pyrrolo[3,4-d]isoxazol-5(3H,6H,6aH)-yl]benzoic acid derivatives as potent acetylcholinesterase inhibitors and anti-amnestic agents.EBI Punjabi University
22831800 32 Synthesis of phenserine analogues and evaluation of their cholinesterase inhibitory activities.EBI Meiji Pharmaceutical University
18517184 47 Novel donepezil-based inhibitors of acetyl- and butyrylcholinesterase and acetylcholinesterase-induced beta-amyloid aggregation.EBI Laboratori de Qu�mica Farmac�utica (Unitat Associada al CSIC)
18479118 113 Exploiting protein fluctuations at the active-site gorge of human cholinesterases: further optimization of the design strategy to develop extremely potent inhibitors.EBI Universit£ di Siena
15568781 2 Indole glucoalkaloids from Chimarrhis turbinata and their evaluation as antioxidant agents and acetylcholinesterase inhibitors.EBI Instituto de Qu£mica da Universidade Estadual Paulista
17888667 33 Synthesis and screening for acetylcholinesterase inhibitor activity of some novel 2-butyl-1,3-diaza-spiro[4,4]non-1-en-4-ones: derivatives of irbesartan key intermediate.EBI University of Mysore
15993600 54 Design, synthesis, and evaluation of 2-phenoxy-indan-1-one derivatives as acetylcholinesterase inhibitors.EBI Zhejiang University
15214773 76 Fragment-based drug discovery.EBI Sunesis Pharmaceuticals Inc.
10052979 45 Aminopyridazines as acetylcholinesterase inhibitors.EBI Universit£ Louis Pasteur
7658452 52 Synthesis and evaluation of 5-amino-5,6,7,8-tetrahydroquinolinones as potential agents for the treatment of Alzheimer's disease.EBI Hoechst-Roussel Pharmaceuticals, Inc
1766006 8 Delineating the pharmacophoric elements of huperzine A: importance of the unsaturated three-carbon bridge to its AChE inhibitory activity.EBI Mayo Clinic Jacksonville
11551765 7 Synthesis and acetylcholinesterase inhibition of 5-desamino huperzine A derivatives.EBI Universit£t Wien
10476864 22 Potent, easily synthesized huperzine A-tacrine hybrid acetylcholinesterase inhibitors.EBI Hong Kong University of Science and Technology
9873409 2 Synthesis and acetylcholinesterase inhibitory activity of (+/-)-14-fluorohuperzine A.EBI Chinese Academy of Sciences
 32 Acetylcholinesterase inhibition by fused dihydroquinazoline compoundsEBI TBA
21438612 4 Amidine-oximes: reactivators for organophosphate exposure.EBI Human BioMolecular Research Institute
22257528 5 A review on coumarins as acetylcholinesterase inhibitors for Alzheimer's disease.EBI Punjabi University
22019465 28 Searching for the Multi-Target-Directed Ligands against Alzheimer's disease: discovery of quinoxaline-based hybrid compounds with AChE, H3R and BACE 1 inhibitory activities.EBI Zhejiang University
20144867 32 Synthesis of physostigmine analogues and evaluation of their anticholinesterase activities.EBI Zhejiang University
19692250 52 Design, synthesis and evaluation of flavonoid derivatives as potent AChE inhibitors.EBI Zhejiang University
19954865 10 Synthesis and AChE inhibitory activity of new chiral tetrahydroacridine analogues from terpenic cyclanones.EBI Universidade Federal do Rio Grande do Sul
19493592 30 Active site directed docking studies: synthesis and pharmacological evaluation of cis-2,6-dimethyl piperidine sulfonamides as inhibitors of acetylcholinesterase.EBI University of Mysore
 18 Acetylcholinesterase inhibition by tacrine analoguesEBI TBA
 11 Synthesis and preliminary structure-activity relationships of 1-[(3-fluoro-4-pyridinyl)amino]-3-methyl-1H-indol-5-yl methyl carbamate (P10358), a novel acetylcholinesterase inhibitorEBI TBA
 7 Synthesis and in vitro gastrointestinal motility enhancing activity of 3-aryl-2-imidazolidinylidene propanedinitrile derivativesEBI TBA
 26 Synthesis and in vitro acetylcholinesterase inhibitory activity of some 1-substituted analogues of velnacrineEBI TBA
 27 Synthesis and anti-acetylcholinesterase activity of 1-benzyl-4-[(5,6-dimethoxy-1-indanon-2-yl)methyl]piperidine hydrochloride (E2020) and related compoundsEBI TBA
 12 Synthesis and biological activity of putative mono-hydroxylated metabolites of velnacrineEBI TBA
 15 Synthesis and biological activity of galanthamine derivatives as acetylcholinesterase (AChE) inhibitorsEBI TBA
19485411 2 Site-activated multifunctional chelator with acetylcholinesterase and neuroprotective-neurorestorative moieties for Alzheimer's therapy.EBI Institute of Science
19162488 57 Design, synthesis and biological evaluation of novel dual inhibitors of acetylcholinesterase and beta-secretase.EBI Chinese Academy of Sciences
18662884 56 2-Phenoxy-indan-1-one derivatives as acetylcholinesterase inhibitors: a study on the importance of modifications at the side chain on the activity.EBI Zhejiang University
18550228 40 Design, synthesis and evaluation of galanthamine derivatives as acetylcholinesterase inhibitors.EBI Zhejiang University
18436348 68 Design, synthesis and AChE inhibitory activity of indanone and aurone derivatives.EBI Zhejiang University
17624631 9 Chemiluminescent high-throughput microassay applied to imidazo[2,1-b]thiazole derivatives as potential acetylcholinesterase and butyrylcholinesterase inhibitors.EBI Università di Bologna
17126020 58 Study on dual-site inhibitors of acetylcholinesterase: Highly potent derivatives of bis- and bifunctional huperzine B.EBI Chinese Academy of Sciences
16942022 20 Complexes of alkylene-linked tacrine dimers with Torpedo californica acetylcholinesterase: Binding of Bis5-tacrine produces a dramatic rearrangement in the active-site gorge.EBI Institute of Science
16735118 23 Synthesis and efficacy of 1-[bis(4-fluorophenyl)-methyl]piperazine derivatives for acetylcholinesterase inhibition, as a stimulant of central cholinergic neurotransmission in Alzheimer's disease.EBI University of Mysore
15664805 15 Synthesis and acetylcholinesterase inhibition of derivatives of huperzine B.EBI Chinese Academy of Sciences
12646025 12 Design, synthesis, and pharmacological profile of novel fused pyrazolo[4,3-d]pyridine and pyrazolo[3,4-b][1,8]naphthyridine isosteres: a new class of potent and selective acetylcholinesterase inhibitors.EBI Universidade Federal do Rio de Janeiro
10612585 4 Synthesis and acetylcholinesterase inhibitory activity of huperzine A-E2020 combined compound.EBI Institute of Materia Medica
9357518 74 Novel tacrine analogues for potential use against Alzheimer's disease: potent and selective acetylcholinesterase inhibitors and 5-HT uptake inhibitors.EBI University of Strathclyde
8709135 20 Identification of a 3-hydroxylated tacrine metabolite in rat and man: metabolic profiling implications and pharmacology.EBI Warner-Lambert Company
8558530 4 Substituted (pyrroloamino)pyridines: potential agents for the treatment of Alzheimer's disease.EBI Hoechst-Roussel Pharmaceuticals Inc.
8558529 195 Synthesis and structure-activity relationships of N-propyl-N-(4-pyridinyl)-1H-indol-1-amine (besipirdine) and related analogs as potential therapeutic agents for Alzheimer's disease.EBI Hoechst-Roussel Pharmaceuticals Inc.
8126709 49 Novel [2-(4-piperidinyl)ethyl](thio)ureas: synthesis and antiacetylcholinesterase activity.EBI Centre de Recherche Pierre Fabre Médicament
8057278 43 Central cholinergic agents. 6. Synthesis and evaluation of 3-[1-(phenylmethyl)-4-piperidinyl]-1-(2,3,4,5-tetrahydro-1H-1-benzazepi n-8-yl)-1-propanones and their analogs as central selective acetylcholinesterase inhibitors.EBI Takeda Chemical Industries, Ltd.
7932538 54 Docking analysis of a series of benzylamino acetylcholinesterase inhibitors with a phthalimide, benzoyl, or indanone moiety.EBI Takeda Chemical Industries, Ltd.
7636858 25 Flexible 1-[(2-aminoethoxy)alkyl]-3-ar(o)yl(thio)ureas as novel acetylcholinesterase inhibitors. Synthesis and biochemical evaluation.EBI Centre de Recherche Pierre Fabre
6827532 2 In vitro and in vivo protection of acetylcholinesterase against organophosphate poisoning by pretreatment with a novel derivative of 1,3,2-dioxaphosphorinane 2-oxide.EBI TBA
3385720 2 (+/-)-9-Amino-1,2,3,4-tetrahydroacridin-1-ol. A potential Alzheimer's disease therapeutic of low toxicity.EBI Hoechst-Roussel Pharmaceuticals, Inc.
14709324 20 Pharmacological profile of YM348, a novel, potent and orally active 5-HT2C receptor agonist.BDB Yamanouchi Pharmaceutical Co., Ltd.
19154150 19 Design, synthesis, and evaluation of oxygen-containing macrocyclic peptidomimetics as inhibitors of HCV NS3 protease.BDB Schering-Plough Research Institute
17723305 34 Inhibition of the Mycobacterium tuberculosis enoyl acyl carrier protein reductase InhA by arylamides.BDB Incyte Corporation
18585390 20 The molecular structure of epoxide hydrolase B from Mycobacterium tuberculosis and its complex with a urea-based inhibitor.BDB University of Alberta
18287029 12 Discovery of a selective inhibitor of oncogenic B-Raf kinase with potent antimelanoma activity.BDB Plexxikon
18473434 57 Novel inhibitors of the v-raf murine sarcoma viral oncogene homologue B1 (BRAF) based on a 2,6-disubstituted pyrazine scaffold.BDB Cancer Research UK Centre for Cancer Therapeutics
18459730 144 Novel 3-carboxamide-coumarins as potent and selective FXIIa inhibitors.BDB University of Namur
14709046 4 A highly potent non-nucleoside adenosine deaminase inhibitor: efficient drug discovery by intentional lead hybridization.BDB Fujisawa Pharmaceutical Co., Ltd.
17824681 55 Discovery and synthesis of HIV integrase inhibitors: development of potent and orally bioavailable N-methyl pyrimidones.BDB IRBM-MRL