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121 articles for thisTarget

The following articles (labelled with PubMed ID or TBD) are for your review
PMIDDataArticle TitleOrganization
27816515 143 Structure guided design of a series of selective pyrrolopyrimidinone MARK inhibitors.EBI Merck & Co.
27676471 200 Further investigation of Paprotrain: Towards the conception of selective and multi-targeted CNS kinase inhibitors.EBI CNRS
27171036 164 Cyclin Dependent Kinase 9 Inhibitors for Cancer Therapy.EBI University of Nebraska Medical Center
27128181 9 Discovery of pyrido[3,4-g]quinazoline derivatives as CMGC family protein kinase inhibitors: Design, synthesis, inhibitory potency and X-ray co-crystal structure.EBI Universit£ Clermont Auvergne
27019296 52 Novel optimization of valmerins (tetrahydropyrido[1,2-a]isoindolones) as potent dual CDK5/GSK3 inhibitors.EBI Universit£ d'Orl£ans
26741853 95 Synthesis, biological evaluation and molecular modeling of a novel series of 7-azaindole based tri-heterocyclic compounds as potent CDK2/Cyclin E inhibitors.EBI University of Tours
26762835 342 Discovery of 2-(1H-indol-5-ylamino)-6-(2,4-difluorophenylsulfonyl)-8-methylpyrido[2,3-d]pyrimidin-7(8H)-one (7ao) as a potent selective inhibitor of Polo like kinase 2 (PLK2).EBI Icahn School of Medicine at Mount Sinai
24798019 30 Acridone alkaloids from Glycosmis chlorosperma as DYRK1A inhibitors.EBI Institut de Chimie des Substances Naturelles
24998602 17 Synthesis and biological evaluation of tetrahydro[1,4]diazepino[1,2-a]indol-1-ones as cyclin-dependent kinase inhibitors.EBI Universit£ de Lyon
24973661 10 9- and 11-substituted 4-azapaullones are potent and selective inhibitors of African trypanosoma.EBI Technische Universit£t Braunschweig
24530227 30 Synthesis, biological evaluation and molecular modelling studies of 4-anilinoquinazoline derivatives as protein kinase inhibitors.EBI Rajiv Gandhi Proudyogiki Vishwavidyalaya
24176400 78 Synthesis of novel 7-substituted pyrido[2',3':4,5]furo[3,2-d]pyrimidin-4-amines and their N-aryl analogues and evaluation of their inhibitory activity against Ser/Thr kinases.EBI COBRA
23454515 66 Chemical synthesis and biological validation of immobilized protein kinase inhibitory Leucettines.EBI Universit£ de Rennes1
23994326 9 6-Cyclohexylmethoxy-5-(cyano-NNO-azoxy)pyrimidine-4-amine: a new scaffold endowed with potent CDK2 inhibitory activity.EBI Universit£ degli Studi di Torino
23981088 10 Synthesis, resolution, and biological evaluation of atropisomeric (aR)- and (aS)-16-methyllamellarins N: unique effects of the axial chirality on the selectivity of protein kinases inhibition.EBI Nagasaki University
23927974 12 Potential neuroprotective flavonoid-based inhibitors of CDK5/p25 from Rhus parviflora.EBI Kyung Hee University
23829517 30 A novel series of highly potent 2,6,9-trisubstituted purine cyclin-dependent kinase inhibitors.EBI Palack£ University
23600925 12 Development of highly potent and selective diaminothiazole inhibitors of cyclin-dependent kinases.EBI H. Lee Moffitt Cancer Center and Research Institute
23453843 84 Design, synthesis, and molecular modelling of pyridazinone and phthalazinone derivatives as protein kinases inhibitors.EBI University of Strasburg
22770608 35 Synthesis and in vitro biological evaluation of 2,6,9-trisubstituted purines targeting multiple cyclin-dependent kinases.EBI Palack£ University
23394126 170 Discovery of a novel class of highly potent, selective, ATP-competitive, and orally bioavailable inhibitors of the mammalian target of rapamycin (mTOR).EBI Exelixis Inc
23237976 162 Synthesis and biological evaluation of N-aryl-7-methoxybenzo[b]furo[3,2-d]pyrimidin-4-amines and their N-arylbenzo[b]thieno[3,2-d]pyrimidin-4-amine analogues as dual inhibitors of CLK1 and DYRK1A kinases.EBI Universit£ de Rouen
23218601 100 Potent inhibitors of CDK5 derived from roscovitine: synthesis, biological evaluation and molecular modelling.EBI University of Paris
22982525 32 Synthesis and biological evaluation of selective and potent cyclin-dependent kinase inhibitors.EBI TBA
21420204 129 Studying synergism of methyl linked cyclohexyl thiophenes with triazole: synthesis and their cdk5/p25 inhibition activity.EBI Dr. Reddy's Laboratories, Ameerpet, Hyderabad, India.
19700321 29 Potent and cellularly active 4-aminoimidazole inhibitors of cyclin-dependent kinase 5/p25 for the treatment of Alzheimer's disease.EBI Pfizer Inc
17643991 48 A novel approach to cyclin-dependent kinase 5/p25 inhibitors: A potential treatment for Alzheimer's disease.EBI Dr. Reddy's Laboratories
24936234 42 Synthesis and biological evaluation of a selective N- and p/q-type calcium channel agonist.EBI TBA
23083119 57 Novel tetrahydropyrido[1,2-a]isoindolone derivatives (valmerins): potent cyclin-dependent kinase/glycogen synthase kinase 3 inhibitors with antiproliferative activities and antitumor effects in human tumor xenografts.EBI Universit£ d'Orl£ans
22998443 69 Selectivity, cocrystal structures, and neuroprotective properties of leucettines, a family of protein kinase inhibitors derived from the marine sponge alkaloid leucettamine B.EBI CNRS
23039927 44 Multitargeted drug development: Discovery and profiling of dihydroxy substituted 1-aza-9-oxafluorenes as lead compounds targeting Alzheimer disease relevant kinases.EBI Martin-Luther-University Halle-Wittenberg
21413800 56 A one-pot synthesis and biological activity of ageladine A and analogues.EBI Macquarie University
23124214 100 Synthesis and biological evaluation of N-arylbenzo[b]thieno[3,2-d]pyrimidin-4-amines and their pyrido and pyrazino analogues as Ser/Thr kinase inhibitors.EBI Universit£ de Rouen
23063566 70 Synthesis and biological evaluation of new 5-benzylated 4-oxo-3,4-dihydro-5H-pyridazino[4,5-b]indoles as PI3Ka inhibitors.EBI Universit£ de Nantes
22889803 19 Synthesis and structure-activity relationship of 4-(1,3-benzothiazol-2-yl)-thiophene-2-sulfonamides as cyclin-dependent kinase 5 (cdk5)/p25 inhibitors.EBI AstraZeneca
22533818 84 Identification of glycogen synthase kinase-3 inhibitors with a selective sting for glycogen synthase kinase-3a.EBI Technische Universit£t Darmstadt
22809559 31 Synthesis and biological evaluation of analogs of the marine alkaloids granulatimide and isogranulatimide.EBI Universit£ Paul Sabatier
22352892 42 Synthesis, biological evaluation, and molecular modeling of natural and unnatural flavonoidal alkaloids, inhibitors of kinases.EBI Institut de Chimie des Substances Naturelles (ICSN)
22320327 250 Structure-based design of novel class II c-Met inhibitors: 2. SAR and kinase selectivity profiles of the pyrazolone series.EBI Amgen Inc
20153204 109 Optimization of 6,6-dimethyl pyrrolo[3,4-c]pyrazoles: Identification of PHA-793887, a potent CDK inhibitor suitable for intravenous dosing.EBI Nerviano Medical Sciences srl
18345612 35 9-cyano-1-azapaullone (cazpaullone), a glycogen synthase kinase-3 (GSK-3) inhibitor activating pancreatic beta cell protection and replication.EBI Technische Universit£t Braunschweig
18077363 314 A systematic interaction map of validated kinase inhibitors with Ser/Thr kinases.EBI University of Oxford
18232649 60 Meriolins (3-(pyrimidin-4-yl)-7-azaindoles): synthesis, kinase inhibitory activity, cellular effects, and structure of a CDK2/cyclin A/meriolin complex.EBI University of Oxford
17708655 10 Glycogen synthase kinase-3 (GSK-3) inhibitory activity and structure-activity relationship (SAR) studies of the manzamine alkaloids. Potential for Alzheimer's disease.EBI University of Mississippi
16854069 74 3'-Substituted 7-halogenoindirubins, a new class of cell death inducing agents.EBI CNRS
15163202 16 Generation of new protein kinase inhibitors utilizing cytochrome p450 mutant enzymes for indigoid synthesis.EBI Vanderbilt University School of Medicine
12593668 6 Evaluation of the first cytostatically active 1-aza-9-oxafluorenes as novel selective CDK1 inhibitors with P-glycoprotein modulating properties.EBI Martin-Luther-University Halle-Wittenberg
22305342 33 Synthesis of chromeno[3,4-b]indoles as Lamellarin D analogues: a novel DYRK1A inhibitor class.EBI Universit£ d'Orl£ans
22154349 123 5-(2-amino-pyrimidin-4-yl)-1H-pyrrole and 2-(2-amino-pyrimidin-4-yl)-1,5,6,7-tetrahydro-pyrrolo[3,2-c]pyridin-4-one derivatives as new classes of selective and orally available Polo-like kinase 1 inhibitors.EBI Nerviano Medical Sciences srl
22014550 337 Discovery of a novel class of non-ATP site DFG-out state p38 inhibitors utilizing computationally assisted virtual fragment-based drug design (vFBDD).EBI Ansaris
21944287 39 Synthesis and biological evaluation of new 3-(6-hydroxyindol-2-yl)-5-(Phenyl) pyridine or pyrazine V-Shaped molecules as kinase inhibitors and cytotoxic agents.EBI Universit£ d'Orl£ans
21807510 31 Synthesis and biological evaluation of glycogen synthase kinase 3 (GSK-3) inhibitors: an fast and atom efficient access to 1-aryl-3-benzylureas.EBI Technische Universit£t Darmstadt
21623630 108 Synthesis, protein kinase inhibitory potencies, and in vitro antiproliferative activities of meridianin derivatives.EBI Clermont Universite£
21615147 230 Leucettines, a class of potent inhibitors of cdc2-like kinases and dual specificity, tyrosine phosphorylation regulated kinases derived from the marine sponge leucettamine B: modulation of alternative pre-RNA splicing.EBI Universite£? de Rennes 1
20621478 37 Concise synthesis and CDK/GSK inhibitory activity of the missing 9-azapaullones.EBI Trinity College
21470862 110 NMS-P937, a 4,5-dihydro-1H-pyrazolo[4,3-h]quinazoline derivative as potent and selective Polo-like kinase 1 inhibitor.EBI Nerviano Medical Sciences srl
21417417 8 Pyrazolo[4,3-d]pyrimidine bioisostere of roscovitine: evaluation of a novel selective inhibitor of cyclin-dependent kinases with antiproliferative activity.EBI Palacky£? University and Institute of Experimental Botany ASCR
21353545 39 Structure-activity relationship study of 2,4-diaminothiazoles as Cdk5/p25 kinase inhibitors.EBI Harvard Medical School
21144757 15 Design, synthesis, and testing of an 6-O-linked series of benzimidazole based inhibitors of CDK5/p25.EBI Duquesne University
21035334 55 Discovery and selectivity-profiling of 4-benzylamino 1-aza-9-oxafluorene derivatives as lead structures for IGF-1R inhibitors.EBI Martin-Luther-University Halle-Wittenberg
20965724 57 Identification of potent ITK inhibitors through focused compound library design including structural information.EBI Nycomed GmbH
20873740 111 Cdc7 kinase inhibitors: 5-heteroaryl-3-carboxamido-2-aryl pyrroles as potential antitumor agents. 1. Lead finding.EBI Nerviano Medical Sciences srl
20397705 208 Identification of 4,5-dihydro-1H-pyrazolo[4,3-h]quinazoline derivatives as a new class of orally and selective Polo-like kinase 1 inhibitors.EBI Nerviano Medical Sciences srl
20363627 56 Identification and structure-activity relationship of 8-hydroxy-quinoline-7-carboxylic acid derivatives as inhibitors of Pim-1 kinase.EBI Universit£ Paris-Sud
19879673 18 Synthesis and preliminary biological evaluation of new derivatives of the marine alkaloid leucettamine B as kinase inhibitors.EBI TBA
20141146 234 Identification of potent pyrazolo[4,3-h]quinazoline-3-carboxamides as multi-cyclin-dependent kinase inhibitors.EBI Nerviano Medical Sciences srl
19926477 100 2,4-Diaminopyrimidine MK2 inhibitors. Part II: Structure-based inhibitor optimization.EBI Abbott Laboratories
19665384 38 Synthesis and kinase inhibitory activity of novel substituted indigoids.EBI Universit£ de La Rochelle
19864130 26 Design and synthesis of 6-oxo-1,6-dihydropyridines as CDK5 inhibitors.EBI Amgen Inc
17291769 133 Clubbed thiazoles by MAOS: a novel approach to cyclin-dependent kinase 5/p25 inhibitors as a potential treatment for Alzheimer's disease.EBI Dr. Reddys Laboratories
17064911 17 A Pd(0) based cross-coupling approach to the synthesis of 2-amidopurines and their evaluation as CDK inhibitors.EBI Institut Curie
16644220 29 Thiazolo[5,4-f]quinazolin-9-ones, inhibitors of glycogen synthase kinase-3.EBI Université de La Rochelle
16420063 12 Synthesis and biological evaluation of novel phenylcarbazoles as potential anticancer agents.EBI Université d'Orléans
15999992 25 Synthesis and identification of [1,3,5]triazine-pyridine biheteroaryl as a novel series of potent cyclin-dependent kinase inhibitors.EBI Johnson & Johnson Pharmaceutical Research and Development LLC
15689152 3 Mechanism of CDK5/p25 binding by CDK inhibitors.EBI European Institute of Oncology
14505655 61 A catch-and-release strategy for the combinatorial synthesis of 4-acylamino-1,3-thiazoles as potential CDK5 inhibitors.EBI Pharmacia Corporation
11909733 30 Beta-carbolines as specific inhibitors of cyclin-dependent kinases.EBI Institute of Molecular and Cell Biology
30639897 48 Recent development of CDK inhibitors: An overview of CDK/inhibitor co-crystal structures.EBI The First Affiliated Hospital of Zhengzhou University
32502343 79 Discovery of MFH290: A Potent and Highly Selective Covalent Inhibitor for Cyclin-Dependent Kinase 12/13.EBI Harvard Medical School
31757666 314 Discovery and optimization of heteroaryl piperazines as potent and selective PI3K? inhibitors.EBI Merck & Co.
27491711 422 Optimization of microtubule affinity regulating kinase (MARK) inhibitors with improved physical properties.EBI Merck and Co.
31098000 63 Discovery of CDK5 Inhibitors through Structure-Guided Approach.EBI University of South Australia
30909021 21 Insights into the chemistry and therapeutic potential of furanones: A versatile pharmacophore.EBI Jamia Hamdard
30798053 66 Design, biological evaluation and X-ray crystallography of nanomolar multifunctional ligands targeting simultaneously acetylcholinesterase and glycogen synthase kinase-3.EBI CNRS
30943029 59 3,5,7-Substituted Pyrazolo[4,3- d]pyrimidine Inhibitors of Cyclin-Dependent Kinases and Their Evaluation in Lymphoma Models.EBI Palack£ University and Institute of Experimental Botany
31693351 473 Discovery of 4EBI TBA
30543440 86 Cyclin-Dependent Kinase 2 Inhibitors in Cancer Therapy: An Update.EBI University of South Australia Cancer Research Institute
30502116 8 An insight into medicinal chemistry of anticancer quinoxalines.EBI India; Academy of Scientific and Innovative Research (AcSIR)
30384048 365 ASR352, A potent anticancer agent: Synthesis, preliminary SAR, and biological activities against colorectal cancer bulk, 5-fluorouracil/oxaliplatin resistant and stem cells.EBI University of Florida
30343954 16 Synthesis of aminopyrazole analogs and their evaluation as CDK inhibitors for cancer therapy.EBI Eppley Institute for Research in Cancer and Allied Diseases
31710489 55 Discovery of a Potent and Selective Oral Inhibitor of ERK1/2 (AZD0364) That Is Efficacious in Both Monotherapy and Combination Therapy in Models of Nonsmall Cell Lung Cancer (NSCLC).EBI AstraZeneca
31526603 379 Structure-based rational design of staurosporine-based fluorescent probe with broad-ranging kinase affinity for kinase panel application.EBI Takeda Pharmaceutical Company Limited
30234987 232 How Selective Are Pharmacological Inhibitors of Cell-Cycle-Regulating Cyclin-Dependent Kinases?EBI Palack£ University and Institute of Experimental Botany ASCR
26509640 234 Discovery of A-971432, An Orally Bioavailable Selective Sphingosine-1-Phosphate Receptor 5 (S1P5) Agonist for the Potential Treatment of Neurodegenerative Disorders.EBI AbbVie Bioresearch Center
26479029 79 Development of new highly potent imidazo[1,2-b]pyridazines targeting Toxoplasma gondii calcium-dependent protein kinase 1.EBI Universit£ Fran£ois-Rabelais de Tours
31200237 95 Discovery of 6-(2-(dimethylamino)ethyl)-N-(5-fluoro-4-(4-fluoro-1-isopropyl-2-methyl-1H-benzo[d]imidazole-6-yl)pyrimidin-2-yl)-5,6,7,8-tetrahydro-1,6-naphthyridin-2-amine as a highly potent cyclin-dependent kinase 4/6 inhibitor for treatment of cancer.EBI Shanghai Pharmaceuticals Holding Co., Ltd.
30199702 24 A ?-glucuronidase-responsive albumin-binding prodrug for potential selective kinase inhibitor-based cancer chemotherapy.EBI Universit£ de Poitiers
29046238 17 1,3,5-Triazines: A promising scaffold for anticancer drugs development.EBI Universit£ degli Studi di Palermo
30253346 46 Discovery of 4-(((4-(5-chloro-2-(((1s,4s)-4-((2-methoxyethyl)amino)cyclohexyl)amino)pyridin-4-yl)thiazol-2-yl)amino)methyl)tetrahydro-2H-pyran-4-carbonitrile (JSH-150) as a novel highly selective and potent CDK9 kinase inhibitor.EBI Chinese Academy of Sciences
30082069 359 ROCK inhibitors 3: Design, synthesis and structure-activity relationships of 7-azaindole-based Rho kinase (ROCK) inhibitors.EBI Vertex Pharmaceuticals Inc
30026041 139 Synthesis and anticancer activity of novel bisindolylhydroxymaleimide derivatives with potent GSK-3 kinase inhibition.EBI University College Cork
29273417 26 An appraisal on synthetic and pharmaceutical perspectives of pyrazolo[4,3-d]pyrimidine scaffold.EBI University of KwaZulu-Natal
29853332 50 Benzofuro[3,2-d]pyrimidines inspired from cercosporamide CaPkc1 inhibitor: Synthesis and evaluation of fluconazole susceptibility restoration.EBI Universit£ de Nantes
29370702 41 Discovery and Preclinical Development of IIIM-290, an Orally Active Potent Cyclin-Dependent Kinase Inhibitor.EBI CSIR-Indian Institute of Integrative Medicine
28827110 54 Synthesis and biological evaluation of N9-cis-cyclobutylpurine derivatives for use as cyclin-dependent kinase (CDK) inhibitors.EBI Korea Research Institute of Chemical Technology
27721154 660 Exploration of the imidazo[1,2-b]pyridazine scaffold as a protein kinase inhibitor.EBI University of Paris
28487075 36 N-(1H-Pyrazol-3-yl)quinazolin-4-amines as a novel class of casein kinase 1?/? inhibitors: Synthesis, biological evaluation and molecular modeling studies.EBI Rajiv Gandhi Proudyogiki Vishwavidyalaya
28557430 45 Identification of a Water-Soluble Indirubin Derivative as Potent Inhibitor of Insulin-like Growth Factor 1 Receptor through Structural Modification of the Parent Natural Molecule.EBI University of Kaiserslautern
23603658 33 Structure-guided design of a selective BCL-X(L) inhibitor.BDB Walter and Eliza Hall Institute of Medical Research, Parkville, Victoria, Australia
19200745 35 Design, synthesis and structure-activity relationships of 1,3,4-oxadiazole derivatives as novel inhibitors of glycogen synthase kinase-3beta.BDB Takeda Pharmaceutical Co., Ltd
19603809 59 Identification of N,1,4,4-Tetramethyl-8-{[4-(4-methylpiperazin-1-yl)phenyl]amino}-4,5-dihydro-1H-pyrazolo[4,3-h]quinazoline-3-carboxamide (PHA-848125), a Potent, Orally Available Cyclin Dependent Kinase Inhibitor.BDB Nerviano Medical Sciences srl
18656911 39 Identification of N-(4-piperidinyl)-4-(2,6-dichlorobenzoylamino)-1H-pyrazole-3-carboxamide (AT7519), a novel cyclin dependent kinase inhibitor using fragment-based X-ray crystallography and structure based drug design.BDB Astex
16290148 44 3-Amino-1,4,5,6-tetrahydropyrrolo[3,4-c]pyrazoles: a new class of CDK2 inhibitors.BDB Nerviano Medical Sciences
10465404 61 Synthesis and in vitro evaluation of novel 2,6,9-trisubstituted purines acting as cyclin-dependent kinase inhibitors.BDB Institut Curie