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248 articles for thisTarget


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PMIDDataArticle TitleOrganization
28218838 69 Design and Synthesis of Enantiomerically Pure Decahydroquinoxalines as Potent and Selective┐-Opioid Receptor Agonists with Anti-Inflammatory Activity in Vivo.EBI Dr. August Wolff GmbH& Co. KG Arzneimittel
28011222 16 Benzylideneoxymorphone: A new lead for development of bifunctional mu/delta opioid receptor ligands.EBI West Virginia University School of Pharmacy
27721146 22 (+)-and (-)-Phenazocine enantiomers: Evaluation of their dual opioid agonist/sEBI University of Catania
27676089 35 A Cyclic Tetrapeptide ("Cyclodal") and Its Mirror-Image Isomer Are Both High-AffinityÁ Opioid Receptor Antagonists.EBI Clinical Research Institute of Montreal
27301366 30 [Dmt(1)]DALDA analogues modified with tyrosine analogues at position 1.EBI Nanjing Medical University
26944625 26 Synthesis, biological evaluation and structural analysis of novel peripherally active morphiceptin analogs.EBI Medical University of Lodz
26785295 35 Synthesis of mixed MOR/KOR efficacy cyclic opioid peptide analogs with antinociceptive activity after systemic administration.EBI Medical University of Lodz
26789491 44 PotentÁ-Opioid Receptor Agonists from Cyclic Peptides Tyr-c[D-Lys-Xxx-Tyr-Gly]: Synthesis, Biological, and Structural Evaluation.EBI Torrey Pines Institute for Molecular Studies
26411794 46 Conformationally restricted┐-opioid receptor agonists: Synthesis and pharmacological evaluation of diastereoisomeric and enantiomeric decahydroquinoxalines.EBI Mercachem
25283554 43 Design, synthesis, and structure-activity relationship of novel opioid┐ receptor selective agonists:a-iminoamide derivatives with an azabicyclo[2.2.2]octene skeleton.EBI Kitasato University
25168746 28 Synthesis and analgesic activity of alkylated, reduced and constrained oligoheterocyclic peptidomimetic analogs of Leu-enkephalin.EBI University of Monastir
25147605 52 Synthesis and Pharmacology of a Novel┐ Opioid Receptor (KOR) Agonist with a 1,3,5-Trioxazatriquinane Skeleton.EBI Kitasato University
25129170 20 'Carba'-carfentanil (trans isomer): aÁ opioid receptor (MOR) partial agonist with a distinct binding mode.EBI Clinical Research Institute of Montreal
25996309 49 Parallel Synthesis of Hexahydrodiimidazodiazepines Heterocyclic Peptidomimetics and Their in Vitro and in Vivo Activities atÁ (MOR),d (DOR), and┐ (KOR) Opioid Receptors.EBI Torrey Pines Institute for Molecular Studies
26005537 72 Synthesis of mixed opioid affinity cyclic endomorphin-2 analogues with fluorinated phenylalanines.EBI Medical University of Lodz
25559207 92 Synthesis and biological evaluations of novel endomorphin analogues containinga-hydroxy-▀-phenylalanine (AHPBA) displaying mixedÁ/d opioid receptor agonist andd opioid receptor antagonist activities.EBI Zhejiang University
25062506 102 Synthesis and pharmacological evaluation of 5-pyrrolidinylquinoxalines as a novel class of peripherally restricted┐-opioid receptor agonists.EBI Westf£lische Wilhelms-Universit£t M£nster
25047937 9 Antinociceptive and antidepressant-like action of endomorphin-2 analogs with proline surrogates in position 2.EBI Medical University of Lodz
25456075 16 Cyclic side-chain-linked opioid analogs utilizing cis- and trans-4-aminocyclohexyl-D-alanine.EBI TBA
25248680 67 Synthesis of a novel universal opioid receptor agonist with the 1,3,5-trioxazatriquinane skeleton and its pharmacologies.EBI Kitasato University
24856182 23 Combination of cyclohexane and piperazine based┐-opioid receptor agonists: Synthesis and pharmacological evaluation of trans,trans-configured perhydroquinoxalines.EBI Institut f£r Pharmazeutische und Medizinische Chemie der Universit£t M£nster
24761755 76 Selectively promiscuous opioid ligands: discovery of high affinity/low efficacy opioid ligands with substantial nociceptin opioid peptide receptor affinity.EBI University of Bath
24690494 92 Antagonists of the kappa opioid receptor.EBI The Scripps Research Institute
24900842 71 Novel delta opioid receptor agonists with oxazatricyclodecane structure.EBI Kitasato University
24602401 40 [Dmt(1)]DALDA analogues with enhancedÁ opioid agonist potency and with a mixedÁ/┐ opioid activity profile.EBI Nanjing Medical University
15743203 272 3D-QSAR comparative molecular field analysis on opioid receptor antagonists: pooling data from different studies.EBI University of Medicine& Dentistry of New Jersey-Robert Wood Johnson Medical School (UMDNJ-RWJMS)
23438330 174 Orvinols with mixed kappa/mu opioid receptor agonist activity.EBI University of Bath
23360448 18 Development of¿ opioid receptor antagonists.EBI Research Triangle Institute
23200250 36 The effect of 17-N substituents on the activity of the opioid¿ receptor in nalfurafine derivatives.EBI Kitasato University
16290934 51 Highly potent and selective zwitterionic agonists of the delta-opioid receptor. Part 1.EBI Pfizer Global Research and Development
23131341 50 Synthesis of novel triplet drugs with 1,3,5-trioxazatriquinane skeletons and their pharmacologies. 3: synthesis of novel triplet drugs with the bis(epoxymethano) or bis(dimethylepoxymethano) structure (double-capped triplet).EBI Kitasato University
23103094 39 Essential structure of opioid¿ receptor agonist nalfurafine for binding to the¿ receptor 3: synthesis of decahydro(iminoethano)phenanthrene derivatives with an oxygen functionality at the 3-position and their pharmacologies.EBI Kitasato University
22325949 28 Novel TIPP (H-Tyr-Tic-Phe-Phe-OH) analogues displaying a wide range of efficacies at thed opioid receptor. Discovery of two highly potent and selectived opioid agonists.EBI Clinical Research Institute of Montreal
23134120 72 Discovery and pharmacological evaluation of a diphenethylamine derivative (HS665), a highly potent and selective¿ opioid receptor agonist.EBI University of Innsbruck
23102273 60 Variation of the net charge, lipophilicity, and side chain flexibility in Dmt(1)-DALDA: Effect on Opioid Activity and Biodistribution.EBI Vrije Universiteit Brussel
23043264 20 Fumaroylamino-4,5-epoxymorphinans and related opioids with irreversibleµ opioid receptor antagonist effects.EBI University of Bristol
22695132 56 Identification of a duald OR antagonist/µ OR agonist as a potential therapeutic for diarrhea-predominant Irritable Bowel Syndrome (IBS-d).EBI Janssen Research and Development, L.L.C.
22967810 102 Synthesis of quinolinomorphinan derivatives as highly selectived opioid receptor ligands.EBI Kitasato University
22742909 24 Essential structure of opioid¿ receptor agonist nalfurafine for binding to the¿ receptor 2: synthesis of decahydro(iminoethano)phenanthrene derivatives and their pharmacologies.EBI Kitasato University
22583618 8 Kappa agonist CovX-Bodies.EBI Pfizer Inc.
22460026 39 Synthesis of new opioid derivatives with a propellane skeleton and their pharmacology. Part 2: Propellane derivatives with an amide side chain.EBI Kitasato University
22445285 26 Design and synthesis of novel opioid ligands with an azabicyclo[2.2.2]octane skeleton and their pharmacologies.EBI Kitasato University
21641798 16 Synthesis of new opioid derivatives with a propellane skeleton and their pharmacology: part 1.EBI Kitasato University
20931963 112 Discovery of a novel 5-HT(3) antagonist/5-HT(1A) agonist 3-amino-5,6,7,8-tetrahydro-2-{4-[4-(quinolin-2-yl)piperazin-1-yl]butyl}quinazolin-4(3H)-one (TZB-30878) as an orally bioavailable agent for irritable bowel syndrome.EBI ASKA Pharmaceutical Co, Ltd
20599386 46 Evaluation of N-substitution in 6,7-benzomorphan compounds.EBI University of Catania
20580236 60 Morphinans and isoquinolines: acetylcholinesterase inhibition, pharmacophore modeling, and interaction with opioid receptors.EBI University of Innsbruck and Center for Molecular Biosciences Innsbruck-CMBI
20441176 76 Conformationally constrained kappa receptor agonists: stereoselective synthesis and pharmacological evaluation of 6,8-diazabicyclo[3.2.2]nonane derivatives.EBI Wilhelms-Universit£t M£nster
20218625 27 "Carba"-analogues of fentanyl are opioid receptor agonists.EBI Clinical Research Institute of Montreal
19962305 2 Drug design and synthesis of a novel kappa opioid receptor agonist with an oxabicyclo[2.2.2]octane skeleton and its pharmacology.EBI Kitasato University
19362480 22 Design and synthesis of novel delta opioid receptor agonists and their pharmacologies.EBI Kitasato University
19349178 4 Synthesis of a new opioid ligand having the oxabicyclo[3.2.1]octane skeleton using a new rearrangement reaction.EBI Kitasato University
19464172 74 Nascent structure-activity relationship study of a diastereomeric series of kappa opioid receptor antagonists derived from CJ-15,208.EBI Adolor Corporation
19253983 37 14 beta-O-cinnamoylnaltrexone and related dihydrocodeinones are mu opioid receptor partial agonists with predominant antagonist activity.EBI University of Bath
18755589 2 Synthesis of N-isobutylnoroxymorphone from naltrexone by a selective cyclopropane ring opening reaction.EBI Kitasato University
19027293 149 Syntheses and opioid receptor binding properties of carboxamido-substituted opioids.EBI Rensselaer Polytechnic Institute
18990576 11 Synthesis of a novel 6,14-epoxymorphinan derivative and its pharmacology.EBI Kitasato University
18829333 28 Design, synthesis, and structure-activity relationship of novel opioid kappa-agonists.EBI Toray Industries, Inc.
18637671 21 Structure-antitussive activity relationships of naltrindole derivatives. Identification of novel and potent antitussive agents.EBI Toray Industries, Inc
18468907 64 Conformation-opioid activity relationships of bicyclic guanidines from 3D similarity analysis.EBI Torrey Pines Institute for Molecular Studies
18337104 7 Syntheses of 4,6'-epoxymorphinan derivatives and their pharmacologies.EBI Kitasato University
17420073 31 Synthesis of bridged piperazines with sigma receptor affinity.EBI Institut f£r Pharmazeutische und Medizinische Chemie
17402725 9 Indium-labeled macrocyclic conjugates of naltrindole: high-affinity radioligands for in vivo studies of peripheral delta opioid receptors.EBI University of Missouri-Columbia
17004724 146 Structural determinants of opioid activity in derivatives of 14-aminomorphinones: effects of changes to the chain linking of the C14-amino group to the aryl ring.EBI University of Bristol
16913723 78 Structural determinants of opioid activity in derivatives of 14-aminomorphinones: effect of substitution in the aromatic ring of cinnamoylaminomorphinones and codeinones.EBI University of Bristol
16777416 80 Opiate receptor binding properties of morphine-, dihydromorphine-, and codeine 6-O-sulfate ester congeners.EBI University of Kentucky
15857143 48 Synthesis and biological evaluation of 14-alkoxymorphinans. 22.(1) Influence of the 14-alkoxy group and the substitution in position 5 in 14-alkoxymorphinan-6-ones on in vitro and in vivo activities.EBI University La Sapienza
14998329 142 Identification of opioid ligands possessing mixed micro agonist/delta antagonist activity among pyridomorphinans derived from naloxone, oxymorphone, and hydromorphone [correction of hydropmorphone].EBI Southern Research Institute
14761209 15 Importance of phenolic address groups in opioid kappa receptor selective antagonists.EBI Research Triangle Institute
12593647 49 2,6-Dimethyltyrosine analogues of a stereodiversified ligand library: highly potent, selective, non-peptidic mu opioid receptor agonists.EBI Harvard University
12930147 96 Synthesis, biological evaluation, and receptor docking simulations of 2-[(acylamino)ethyl]-1,4-benzodiazepines as kappa-opioid receptor agonists endowed with antinociceptive and antiamnesic activity.EBI Universit£ degli Studi di Siena
12825951 54 Identification of (3R)-7-hydroxy-N-((1S)-1-[[(3R,4R)-4-(3-hydroxyphenyl)- 3,4-dimethyl-1-piperidinyl]methyl]-2-methylpropyl)-1,2,3,4-tetrahydro- 3-isoquinolinecarboxamide as a novel potent and selective opioid kappa receptor antagonist.EBI Research Triangle Institute
12801235 5 Synthesis and biological evaluation of 18-methoxycoronaridine congeners. Potential antiaddiction agents.EBI University of Vermont
12723940 145 2002 Medicinal Chemistry Division Award address: monoamine transporters and opioid receptors. Targets for addiction therapy.EBI Research Triangle Institute
12431065 72 Synthesis and biological evaluation of 14-alkoxymorphinans. 17. Highly delta opioid receptor selective 14-alkoxy-substituted indolo- and benzofuromorphinans.EBI University of Innsbruck
12139463 24 Discovery of an opioid kappa receptor selective pure antagonist from a library of N-substituted 4beta-methyl-5-(3-hydroxyphenyl)morphans.EBI Research Triangle Institute
11311071 53 Effect of N-alkyl and N-alkenyl substituents in noroxymorphindole, 17-substituted-6,7-dehydro-4,5alpha-epoxy-3,14-dihydroxy-6,7:2',3'-indolomorphinans, on opioid receptor affinity, selectivity, and efficacy.EBI National Institute of Diabetes and Digestive and Kidney Diseases
11543672 24 [2',6'-Dimethyltyrosine]dynorphin A(1-11)-NH2 analogues lacking an N-terminal amino group: potent and selective kappa opioid antagonists.EBI Clinical Research Institute of Montreal
11495592 12 Methylated analogues of methyl (R)-4-(3,4-dichlorophenylacetyl)- 3-(pyrrolidin-1-ylmethyl)piperazine-1-carboxylate (GR-89,696) as highly potent kappa-receptor agonists: stereoselective synthesis, opioid-receptor affinity, receptor selectivity, and functional studies.EBI Pharmazeutisches Institut der Universit£t Freiburg
11495579 24 Identification of the first trans-(3R,4R)- dimethyl-4-(3-hydroxyphenyl)piperidine derivative to possess highly potent and selective opioid kappa receptor antagonist activity.EBI Research Triangle Institute
10794701 48 Structural determinants of opioid activity in the orvinols and related structures: ethers of orvinol and isoorvinol.EBI University of Bristol
10753461 13 Isosteric replacement of acidic with neutral residues in extracellular loop-2 of the kappa-opioid receptor does not affect dynorphin A(1-13) affinity and function.EBI University of Minnesota
11000010 27 Selective protection and functionalization of morphine: synthesis and opioid receptor binding properties of 3-amino-3-desoxymorphine derivatives.EBI Rensselaer Polytechnic Institute
10956208 121 Nonpeptide analogues of dynorphin A(1-8): design, synthesis, and pharmacological evaluation of kappa-selective agonists.EBI University of Catania
10841791 8 Modeling of kappa-opioid receptor/agonists interactions using pharmacophore-based and docking simulations.EBI Universit£ di Napoli"Federico II"
10633042 30 Synthesis and opioid receptor affinity of morphinan and benzomorphan derivatives: mixed kappa agonists and mu agonists/antagonists as potential pharmacotherapeutics for cocaine dependence.EBI Harvard Medical School
10229636 30 delta Opioid affinity and selectivity of 4-hydroxy-3-methoxyindolomorphinan analogues related to naltrindole.EBI National Institute of Diabetes
10639287 62 Probes for narcotic receptor mediated phenomena. 26. Synthesis and biological evaluation of diarylmethylpiperazines and diarylmethylpiperidines as novel, nonpeptidic delta opioid receptor ligands.EBI National Institute of Diabetes and Digestive and Kidney Diseases
10479286 53 Synthesis, opioid receptor binding, and biological activities of naltrexone-derived pyrido- and pyrimidomorphinans.EBI Southern Research Institute
9857089 32 Identification of an opioid kappa receptor subtype-selective N-substituent for (+)-(3R,4R)-dimethyl-4-(3-hydroxyphenyl)piperidine.EBI Research Triangle Institute
9857087 63 Side chain methyl substitution in the delta-opioid receptor antagonist TIPP has an important effect on the activity profile.EBI Vrije Universiteit Brussel
9667975 86 Synthesis, opioid receptor binding, and bioassay of naltrindole analogues substituted in the indolic benzene moiety.EBI Southern Research Institute
9057861 33 (E)- and (Z)-7-arylidenenaltrexones: synthesis and opioid receptor radioligand displacement assays.EBI University of Washington
9288176 95 Probes for narcotic receptor-mediated phenomena. 25. Synthesis and evaluation of N-alkyl-substituted (alpha-piperazinylbenzyl)benzamides as novel, highly selective delta opioid receptor agonists.EBI National Institute of Diabetes and Digestive and Kidney Diseases
8627605 10 Opioid antagonist activity of naltrexone-derived bivalent ligands: importance of a properly oriented molecular scaffold to guide"address" recognition at kappa opioid receptors.EBI University of Minnesota
8648612 30 Arylacetamide-derived fluorescent probes: synthesis, biological evaluation, and direct fluorescent labeling of kappa opioid receptors in mouse microglial cells.EBI University of Minnesota
8642567 64 Probes for narcotic receptor-mediated phenomena. 21. Novel derivatives of 3-(1,2,3,4,5,11-hexahydro-3-methyl-2,6-methano-6H-azocino[4,5-b]indol- 6-yl)-phenols with improved delta opioid receptor selectivity.EBI National Institute of Diabetes and Digestive and Kidney Diseases
7739013 26 Enantiomers of diastereomeric cis-N-[1-(2-hydroxy-2-phenylethyl)- 3-methyl-4-piperidyl]-N-phenylpropanamides: synthesis, X-ray analysis, and biological activities.EBI Research Triangle Institute
7739011 90 Probes for narcotic receptor-mediated phenomena. 20. Alteration of opioid receptor subtype selectivity of the 5-(3-hydroxyphenyl)morphans by application of the message-address concept: preparation of delta-opioid receptor ligands.EBI National Institute of Diabetes and Digestive and Kidney Diseases
7853350 33 Isothiocyanate-substituted benzyl ether opioid receptor ligands derived from 6 beta-naltrexol.EBI University of Washington
7853332 27 7'-Substituted amino acid conjugates of naltrindole. Hydrophilic groups as determinants of selective antagonism of delta 1 opioid receptor-mediated antinociception in mice.EBI University of Minnesota
7636870 18 Synthesis and biological evaluation of 14-alkoxymorphinans. 11. 3-Hydroxycyprodime and analogues: opioid antagonist profile in comparison to cyprodime.EBI University of Innsbruck
8126697 30 Synthesis of naltrexone-derived delta-opioid antagonists. Role of conformation of the delta address moiety.EBI University of Minnesota
7996538 42 Synthesis and opioid receptor affinity of a series of aralkyl ethers of 6 alpha- and 6 beta-naltrexol.EBI University of Washington
8071934 30 Isothiocyanate-substituted kappa-selective opioid receptor ligands derived from N-methyl-N-[(1S)-1-phenyl-2-(1-pyrrolidinyl)ethyl] phenylacetamide.EBI University of Washington
8021929 13 Synthesis and delta-opioid receptor antagonist activity of a naltrindole analogue with a regioisomeric indole moiety.EBI University of Minnesota
8182708 18 Structure-activity relationship of N17'-substituted norbinaltorphimine congeners. Role of the N17' basic group in the interaction with a putative address subsite on the kappa opioid receptor.EBI University of Minnesota
8394935 4 A selective delta 1 opioid receptor agonist derived from oxymorphone. Evidence for separate recognition sites for delta 1 opioid receptor agonists and antagonists.EBI University of Minnesota
8360887 9 Synthesis and kappa-opioid antagonist selectivity of a norbinaltorphimine congener. Identification of the address moiety required for kappa-antagonist activity.EBI University of Minnesota
8390575 28 Non-peptide ligands for opioid receptors. Design of kappa-specific agonists.EBI Universit£ di Catania
8380614 6 A remarkable change of opioid receptor selectivity on the attachment of a peptidomimetic kappa address element to the delta antagonist, natrindole: 5'-[N2-alkylamidino)methyl]naltrindole derivatives as a novel class of kappa opioid receptor antagonists.EBI University of Minnesota
1315870 39 Substitution on the Phe3 aromatic ring in cyclic delta opioid receptor-selective dermorphin/deltorphin tetrapeptide analogues: electronic and lipophilic requirements for receptor affinity.EBI University of Michigan
1361580 25 N-terminal alkylated derivatives of [D-Pro10]dynorphin A-(1-11) are highly selective for kappa-opioid receptors.EBI Oregon State University
1335078 76 O3-(2-carbomethoxyallyl) ethers of opioid ligands derived from oxymorphone, naltrexone, etorphine, diprenorphine, norbinaltorphimine, and naltrindole. Unexpected O3-dealkylation in the opioid radioligand displacement assay.EBI University of Washington
1333014 12 Incorporation of a novel conformationally restricted tyrosine analog into a cyclic, delta opioid receptor selective tetrapeptide (JOM-13) enhances delta receptor binding affinity and selectivity.EBI University of Michigan
1333013 29 Opioid agonist and antagonist activities of morphindoles related to naltrindole.EBI University of Minnesota
1323679 21 Substituted 1-(aminomethyl)-2-(arylacetyl)-1,2,3,4-tetrahydroisoquinolines: a novel class of very potent antinociceptive agents with varying degrees of selectivity for kappa and mu opioid receptors.EBI Zambeletti Research Laboratories
1322988 60 Probes for narcotic receptor mediated phenomena. 18. Epimeric 6 alpha- and 6 beta-iodo-3,14-dihydroxy-17-(cyclopropylmethyl)-4,5 alpha-epoxymorphinans as potential ligands for opioid receptor single photon emission computed tomography: synthesis, evaluation, and radiochemistry of [125I]-6 beta-iodoEBI National Institute of Diabetes and Digestive and Kidney Diseases
1320121 48 Electrophilic opioid ligands. Oxygen tethered alpha-methylene-gamma-lactone, acrylate, isothiocyanate, and epoxide derivatives of 6 beta-naltrexol.EBI University of Washington
1319495 21 Selective reversible and irreversible ligands for the kappa opioid receptor.EBI National Taiwan University
1319493 31 Synthesis and receptor binding properties of fluoro- and iodo-substituted high affinity sigma receptor ligands: identification of potential PET and SPECT sigma receptor imaging agents.EBI National Institute of Diabetes and Digestive and Kidney Diseases
1648136 12 An approach to the design of receptor-type-selective non-peptide antagonists of peptidergic receptors: delta opioid antagonists.EBI University of Minnesota
1851846 23 Role of spacer and address components in peptidomimetic delta opioid receptor antagonists related to naltrindole.EBI University of Minnesota
1849995 12 Role of the spacer in conferring kappa opioid receptor selectivity to bivalent ligands related to norbinaltorphimine.EBI University of Minnesota
1659636 51 Structure/activity studies related to 2-(3,4-dichlorophenyl)-N-methyl-N-[2-(1-pyrrolidinyl)-1-substituted- ethyl]acetamides: a novel series of potent and selective kappa-opioid agonists.EBI ICI Pharmaceuticals
1846919 26 Highly selective kappa opioid analgesics. 4. Synthesis of some conformationally restricted naphthalene derivatives with high receptor affinity and selectivity.EBI Parke-Davis Research Unit
2167979 43 Photoactivatable opiate derivatives as irreversible probes of the mu-opioid receptor.EBI Universit£ Louis Pasteur
2160538 84 Design of peptidomimetic delta opioid receptor antagonists using the message-address concept.EBI University of Minnesota
2172538 58 Synthesis and evaluation of N-substituted cis-N-methyl-2-(1-pyrrolidinyl)cyclohexylamines as high affinity sigma receptor ligands. Identification of a new class of highly potent and selective sigma receptor probes.EBI National Institute of Diabetes and Digestive and Kidney Diseases
2153208 3 Highly selective kappa-opioid analgesics. 3. Synthesis and structure-activity relationships of novel N-[2-(1-pyrrolidinyl)-4- or -5-substituted-cyclohexyl]arylacetamide derivatives.EBI Parke-Davis Research Unit
2547074 16 Alterations in the stereochemistry of the kappa-selective opioid agonist U50,488 result in high-affinity sigma ligands.EBI National Institute of Digestive
2542556 65 Synthesis, opioid receptor binding profile, and antinociceptive activity of 1-azaspiro[4.5]decan-10-yl amides.EBI Ciba-Geigy Corporation
2832603 68 Highly selective kappa opioid analgesics. Synthesis and structure-activity relationships of novel N-[(2-aminocyclohexyl)aryl]acetamide and N-[(2-aminocyclohexyl)aryloxy]acetamide derivatives.EBI Parke-Davis Research Unit
2831363 19 Synthesis and analgesic properties of N-substituted trans-4a-aryldecahydroisoquinolines.EBI Eli Lilly and Company
2845084 22 Effects of addition of a 2-methyl group to ethyl nipecotates (beta-meperidines) on receptor affinities and opiate agonist/antagonist activities.EBI SRI International
2887656 48 Synthesis and activity profiles of new dermorphin-(1-4) peptide analogues.EBI TBA
2879914 30 Peptides as receptor selectivity modulators of opiate pharmacophores.EBI TBA
2409281 9 10-Ketonaltrexone and 10-ketooxymorphone.EBI TBA
12565965 45 Synthesis, opioid receptor binding, and functional activity of 5'-substituted 17-cyclopropylmethylpyrido[2',3':6,7]morphinans.EBI Southern Research Institute
11294396 57 Selective delta-opioid receptor ligands: potential PET ligands based on naltrindole.EBI University of Bristol
11591513 87 Mixed kappa agonists and mu agonists/antagonists as potential pharmacotherapeutics for cocaine abuse: synthesis and opioid receptor binding affinity of N-substituted derivatives of morphinan.EBI Harvard Medical School
11425545 22 3-Carboxamido analogues of morphine and naltrexone. synthesis and opioid receptor binding properties.EBI Pharmacia
11055333 21 Selective kappa-opioid antagonists related to naltrindole. Effect of side-chain spacer in the 5'-amidinoalkyl series.EBI University of Bristol
10673107 63 8-Aminocyclazocine analogues: synthesis and structure-activity relationships.EBI Institute
10340622 47 Synthesis of novel analogues of the delta opioid ligand SNC-80 using REM resin.EBI Organon Laboratories Ltd.
10206545 40 Ring constrained analogues of the orvinols: the furanomorphides.EBI University of Bristol
10617086 21 Delta opioid binding selectivity of 3-ether analogs of naltrindole.EBI National Institute of Diabetes
10612597 31 Optically pure (-)-4-[(N-allyl-3-methyl-4-piperidinyl)phenyl-amino]-N,N-diethylbenzami de displays selective binding and full agonist activity for the delta opioid receptor.EBI Research Triangle Institute
10571174 25 (+/-)-4-[(N-allyl-cis-3-methyl-4-piperidinyl)phenylamino]-N,N-diethylbenzamide displays selective binding for the delta opioid receptor.EBI Research Triangle Institute
9871544 24 Synthesis and biological activity of 3-substituted 3-desoxynaltrindole derivatives.EBI National Institute of Diabetes
9873603 23 Design of a high affinity peptidomimetic opioid agonist from peptide pharmacophore models.EBI University of Michigan
 9 Synthesis and biological evaluation of 14-alkoxymorphinans.12.1 A phenethyl analogue of the -selective opioid receptor antagonist cyprodimeEBI TBA
 51 EMD 61 753 as a favourable representative of structurally novel arylacetamido-type K opiate receptor agonistsEBI TBA
 21 Neurotensin receptor binding and antinociceptive activity for lipophilic N-amido neurotensin(913) analogsEBI TBA
22197670 51 Synthesis of quinolinomorphinan-4-ol derivatives asd opioid receptor agonists.EBI Kitasato University
21967807 36 Identification of a potent and selectives¿? receptor agonist potentiating NGF-induced neurite outgrowth in PC12 cells.EBI University of Pavia
21889335 27 Synthesis of novel triplet drugs with 1,3,5-trioxazatriquinane skeletons and their pharmacologies. Part 2: Synthesis of novel triplet drugs with the epoxymethano structure (capped homotriplet).EBI Kitasato University
21641219 12 Synthesis of novel triplet drugs with 1,3,5-trioxazatriquinane skeletons and their pharmacologies. 1: Synthesis of triplet drugs with morphinan skeletons.EBI Kitasato University
21481987 27 Synthesis of 7,9-diazabicyclo[4.2.2]decanes as conformationally restricted κ receptor agonists: fine tuning of the dihedral angle of the ethylenediamine pharmacophore.EBI Institut f£r Pharmazeutische und Medizinische Chemie der Universit£t M£nster
21413804 21 Design of novel neurokinin 1 receptor antagonists based on conformationally constrained aromatic amino acids and discovery of a potent chimeric opioid agonist-neurokinin 1 receptor antagonist.EBI Vrije Universiteit Brussel
21256034 58 Synthesis of 6,14-epoxymorphinan derivatives and their pharmacologies.EBI Kitasato University
20850307 27 Design and synthesis of KNT-127, ad-opioid receptor agonist effective by systemic administration.EBI Kitasato University
20685120 20 Synthesis of pyrrolomorphinan derivatives as kappa opioid agonists.EBI Kitasato University
20483601 22 Investigation of Beckett-Casy model 2: synthesis of novel 15-16 nornaltrexone derivatives and their pharmacology.EBI Kitasato University
19818611 100 Rapid access towards follow-up NOP receptor agonists using a knowledge based approach.EBI Schering-Plough Research Institute
20056539 14 Investigation of Beckett-Casy model 1: synthesis of novel 16,17-seco-naltrexone derivatives and their pharmacology.EBI Kitasato University
20045339 16 Design, synthesis and SAR analysis of novel selective sigma1 ligands (Part 2).EBI University of Pavia
19827750 39 Agonist vs antagonist behavior of delta opioid peptides containing novel phenylalanine analogues in place of Tyr(1).EBI Clinical Research Institute of Montreal
19576786 129 Identification, structure-activity relationships and molecular modeling of potent triamine and piperazine opioid ligands.EBI Institute for Molecular Studies
19620007 4 Aerobic oxidation of indolomorphinan without the 4,5-epoxy bridge and subsequent rearrangement of the oxidation product to spiroindolinonyl-C-normorphinan derivative.EBI Kitasato University
 21 Arylacetamide kappa-selective opioid ligandsEBI TBA
 26 6N-Cinnamoyl-β-naltrexamine and its p-nitro derivative. High efficacy κ-opioid agonists with weak antagonist actionsEBI TBA
 24 Morphinan cyclic imines and pyrrolidines containing a constrained phenyl group: High affinity opioid agonistsEBI TBA
 9 Octahydro-1,2,3,4,4a,5,11,11a-pyrido[3,4-c][1,5]benzoxazepines: conformationally restricted fentanyl analogsEBI TBA
 22 Palladium-catalyzed synthesis of C3-substituted 3-deoxymorphines.EBI TBA
 6 New potent enkephalin analogs containing trifluoromethylamino acid residuesEBI TBA
18800771 26 Novel opioid peptide derived antagonists containing (2S)-2-methyl-3-(2,6-dimethyl-4-carbamoylphenyl)propanoic acid [(2S)-Mdcp].EBI National University of Singapore
17497839 72 Bifunctional [2',6'-dimethyl-L-tyrosine1]endomorphin-2 analogues substituted at position 3 with alkylated phenylalanine derivatives yield potent mixed mu-agonist/delta-antagonist and dual mu-agonist/delta-agonist opioid ligands.EBI Kobe Gakuin University
17315860 40 Dicarba analogues of the cyclic enkephalin peptides H-Tyr-c[D-Cys-Gly-Phe-D(or L)-Cys]NH(2) retain high opioid activity.EBI Clinical Research Institute of Montreal
17166723 141 Synthesis and evaluation of N-3 substituted phenoxypropyl piperidine benzimidazol-2-one analogues as NOP receptor agonists with analgesic and sedative properties.EBI Organon Laboratories Ltd.
16913729 9 Replacement of the N-terminal tyrosine residue in opioid peptides with 3-(2,6-dimethyl-4-carbamoylphenyl)propanoic acid (Dcp) results in novel opioid antagonists.EBI National University of Singapore
15456245 44 Rationale, design, and synthesis of novel phenyl imidazoles as opioid receptor agonists for gastrointestinal disorders.EBI Johnson & Johnson Pharmaceutical Research & Development
15324897 3 A novel cyclic enkephalin analogue with potent opioid antagonist activity.EBI Clinical Research Institute of Montreal
14695830 111 10-Ketomorphinan and 3-substituted-3-desoxymorphinan analogues as mixed kappa and micro opioid ligands: synthesis and biological evaluation of their binding affinity at opioid receptors.EBI Harvard Medical School
12749896 47 Redefining the structure-activity relationships of 2,6-methano-3-benzazocines. Part 2: 8-formamidocyclazocine analogues.EBI Rensselaer Polytechnic Institute
12672226 9 A novel N-terminal cyclic dynorphin A analogue cyclo(N,5)[Trp(3),Trp(4),Glu(5)] dynorphin A-(1-11)NH(2) that lacks the basic N-terminus.EBI University of Maryland
12593663 146 Syntheses and opioid receptor binding affinities of 8-amino-2,6-methano-3-benzazocines.EBI Rensselaer Polytechnic Institute
12383009 2 Kappa-opioid receptor model in a phospholipid bilayer: molecular dynamics simulation.EBI University of Catania
12190304 10 Solid phase synthesis and evaluation of Tyr-Tic-Phe-Phe(p-NHCOCH(2)Br) ([Phe(p-bromoacetamide)(4)]TIPP), a potent affinity label for delta opioid receptors.EBI University of Maryland
11755345 45 Synthesis and biological activity of 8beta-substituted hydrocodone indole and hydromorphone indole derivatives.EBI NIDDK
11266156 42 8-Carboxamidocyclazocine analogues: redefining the structure-activity relationships of 2,6-methano-3-benzazocines.EBI Rensselaer Polytechnic Institute
10866400 18 4-[(8-Alkyl-8-azabicyclo[3.2.1]octyl-3-yl)-3-arylanilino]-N,N-diethylbenzamides: high affinity, selective ligands for the delta opioid receptor illustrate factors important to antagonist activity.EBI Research Triangle Institute
10841790 24 Synthesis, molecular modeling, and opioid receptor affinity of 9, 10-diazatricyclo[4.2.1.1(2,5)]decanes and 2,7-diazatricyclo[4.4.0. 0(3,8)]decanes structurally related to 3,8-diazabicyclo[3.2. 1]octanes.EBI Istituto di Chimica Farmaceutica e Tossicologica
10479285 17 The opioid mu agonist/delta antagonist DIPP-NH(2)[Psi] produces a potent analgesic effect, no physical dependence, and less tolerance than morphine in rats.EBI Clinical Research Institute of Montreal
10340623 31 Synthesis of novel analogues of the delta opioid ligand SNC-80 using AlCl3-promoted aminolysis.EBI Organon Laboratories Ltd.
9873693 24 N-substituted octahydro-4a-(3-hydroxyphenyl)-10a-methyl-benzo[g]isoquinolines are opioid receptor pure antagonists.EBI Research Triangle Institute
9873439 18 C-alkylated spiro[benzofuran-3(2H),4'-1'-methyl-piperidine-7-ols] as potent opioids: a conformation-activity study.EBI National Taiwan University
9767649 24 N-Substituted 9beta-methyl-5-(3-hydroxyphenyl)morphans are opioid receptor pure antagonists.EBI Research Triangle Institute
9599247 57 Investigation of the N-substituent conformation governing potency and mu receptor subtype-selectivity in (+)-(3R, 4R)-dimethyl-4-(3-hydroxyphenyl)piperidine opioid antagonists.EBI Research Triangle Institute
9276018 47 Synthesis and opioid activity of [D-Pro10]dynorphin A-(1-11) analogues with N-terminal alkyl substitution.EBI Oregon State University
9111295 48 Synthesis and opioid activity of conformationally constrained dynorphin A analogues. 2. Conformational constraint in the"address" sequence.EBI Oregon State University
8893842 6 Aspartic acid conjugates of 2-(3,4-dichlorophenyl)-N-methyl-N-[(1S)-1(3-aminophenyl)-2-(1-pyrrolidi nyl) ethyl]acetamide: kappa opioid receptor agonists with limited access to the central nervous system.EBI University of Minnesota
8691442 52 Effects of modifications of residues in position 3 of dynorphin A(1-11)-NH2 on kappa receptor selectivity and potency.EBI University of Arizona
8676350 39 Design, synthesis, and biological activities of cyclic lactam peptide analogues of dynorphine A(1-11)-NH2.EBI University of Arizona
8642554 42 Asymmetric syntheses, opioid receptor affinities, and antinociceptive effects of 8-amino-5,9-methanobenzocyclooctenes, a new class of structural analogues of the morphine alkaloids.EBI Institute
8632410 33 Synthesis, biological evaluation, and quantitative receptor docking simulations of 2-[(acylamino)ethyl]-1,4-benzodiazepines as novel tifluadom-like ligands with high affinity and selectivity for kappa-opioid receptors.EBI Universitá di Siena
8558529 195 Synthesis and structure-activity relationships of N-propyl-N-(4-pyridinyl)-1H-indol-1-amine (besipirdine) and related analogs as potential therapeutic agents for Alzheimer's disease.EBI Hoechst-Roussel Pharmaceuticals Inc.
8410999 81 3,4-Dimethyl-4-(3-hydroxyphenyl)piperidines: opioid antagonists with potent anorectant activity.EBI Lilly Research Laboratories
8410998 129 Structure-activity relationships of trans-3,4-dimethyl-4-(3-hydroxyphenyl)piperidine antagonists for mu- and kappa-opioid receptors.EBI Lilly Research Laboratories
8201586 3 2-(3,4-Dichlorophenyl)-N-methyl-N-[(1S)-1-(3-isothiocyanatophenyl)-2-(1-pyrrolidinyl)ethyl]acetamide: an opioid receptor affinity label that produces selective and long-lasting kappa antagonism in mice.EBI University of Minnesota
8097539 10 Synthesis and opioid activity of dynorphin A-(1-13)NH2 analogues containing cis- and trans-4-aminocyclohexanecarboxylic acid.EBI Oregon State University
8096246 70 Design and synthesis of highly potent and selective cyclic dynorphin A analogs. 2. New analogs.EBI University of Arizona
8057274 18 Discovery of a potent, peripherally selective trans-3,4-dimethyl-4-(3-hydroxyphenyl)piperidine opioid antagonist for the treatment of gastrointestinal motility disorders.EBI Lilly Research Laboratories
7966152 57 Design, synthesis, and biological properties of highly potent cyclic dynorphin A analogues. Analogues cyclized between positions 5 and 11.EBI University of Arizona
7932540 38 A marked change of receptor affinity of the 2-methyl-5-(3-hydroxyphenyl)morphans upon attachment of an (E)-8-benzylidene moiety: synthesis and evaluation of a new class of sigma receptor ligands.EBI National Institute of Diabetes and Digestive and Kidney Diseases
7932535 40 Synthesis and opioid activity of 7-oxygenated 2,3,4,4a,5,6,7,7a-octahydro-1H-benzofuro[3,2-e]isoquinolin-9-ols.EBI National Taiwan University
7861405 9 Highly kappa receptor-selective dynorphin A analogues with modifications in position 3 of dynorphin A(1-11)-NH2.EBI University of Arizona
7799399 8 kappa Opioid receptor selective affinity labels: electrophilic benzeneacetamides as kappa-selective opioid antagonists.EBI University of Minnesota
7731019 16 Electrophilic N-benzylnaltrindoles as delta opioid receptor-selective antagonists.EBI University of Minnesota
7707326 39 Opioid receptor binding requirements for the delta-selective peptide deltorphin. I: Phe3 replacement with ring-substituted and heterocyclic amino acids.EBI Eastern Michigan University
7658433 27 Synthesis using a Fmoc-based strategy and biological activities of some reduced peptide bond pseudopeptide analogues of dynorphin A1.EBI University of Arizona
7608905 24 Synthesis and opioid activity of conformationally constrained dynorphin A analogues. 1. Conformational constraint in the"message" sequence.EBI Oregon State University
7490727 72 (E)-8-benzylidene derivatives of 2-methyl-5-(3-hydroxyphenyl)morphans: highly selective ligands for the sigma 2 receptor subtype.EBI National Institute of Diabetes and Digestive and Kidney Diseases
3020244 45 Opioid agonist and antagonist bivalent ligands. The relationship between spacer length and selectivity at multiple opioid receptors.EBI TBA
2876099 51 Synthesis and biological activities of dynorphin A analogues with opioid antagonist properties.EBI TBA
1972964 40 Design and synthesis of highly potent and selective cyclic dynorphin A analogues.EBI University of Arizona
1895300 15 Modification of the enkephalin"message" with an artificial polycationic C-terminus.EBI Case Western Reserve University
1847432 13 New 1-(heterocyclylalkyl)-4-(propionanilido)-4-piperidinyl methyl ester and methylene methyl ether analgesics.EBI Anaquest, Inc.
1846921 56 (2S)-1-(arylacetyl)-2-(aminomethyl)piperidine derivatives: novel, highly selective kappa opioid analgesics.EBI Zambeletti Research Laboratories
1846918 12 2-(3,4-Dichlorophenyl)-N-methyl-N-[2-(1-pyrrolidinyl)-1-substituted- ethyl]-acetamides: the use of conformational analysis in the development of a novel series of potent opioid kappa agonists.EBI ICI Pharmaceuticals
1652025 45 (1S)-1-(aminomethyl)-2-(arylacetyl)-1,2,3,4-tetrahydroisoquinoline and heterocycle-condensed tetrahydropyridine derivatives: members of a novel class of very potent kappa opioid analgesics.EBI Zambeletti Research Laboratories
1652019 12 Electrophilic gamma-lactone kappa-opioid receptor probes. Analogues of 2'-hydroxy-2-tetrahydrofurfuryl-5,9-dimethyl-6,7-benzomorphan diastereomers.EBI University of Washington
1360025 27 Effect of modification of the basic residues of dynorphin A-(1-13) amide on kappa opioid receptor selectivity and opioid activity.EBI Oregon State University
1315868 44 Phenylmorphans and analogues: opioid receptor subtype selectivity and effect of conformation on activity.EBI Harvard Medical School
26496515 11 Iminothiazoline-Sulfonamide Hybrids as Jack Bean Urease Inhibitors; Synthesis, Kinetic Mechanism and Computational Molecular Modeling.BDB Quaid-i-Azam University
26520885 21 Synthesis of 4-thiazolidinone analogs as potent in vitro anti-urease agents.BDB Hazara University
25996453 4 Synthesis of novel 3-aryl-1-oxa-2,8-diazaspiro[4.5]dec-2-ene derivatives and their biological evaluation against protein tyrosine phosphatase 1B.BDB Jiangnan University