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47 articles for thisTarget

The following articles (labelled with PubMed ID or TBD) are for your review
PMIDDataArticle TitleOrganization
2795605 59 Potential antiatherosclerotic agents. 6. Hypocholesterolemic trisubstituted urea analogues.EBI American Cyanamid Company
25897973 29 Discovery of a Novel Series of N-Phenylindoline-5-sulfonamide Derivatives as Potent, Selective, and Orally Bioavailable Acyl CoA:Monoacylglycerol Acyltransferase-2 Inhibitors.EBI Takeda Pharmaceutical Co., Ltd
25349648 29 Discovery of a Potent and Selective DGAT1 Inhibitor with a Piperidinyl-oxy-cyclohexanecarboxylic Acid Moiety.EBI Merck Research Laboratories
24900877 107 Development of novel benzomorpholine class of diacylglycerol acyltransferase I inhibitors.EBI Merck Research Laboratories
24618302 49 Discovery of novel quinoline carboxylic acid series as DGAT1 inhibitors.EBI Merck Research Laboratories
24670009 65 Discovery of 6-phenylpyrimido[4,5-b][1,4]oxazines as potent and selective acyl CoA:diacylglycerol acyltransferase 1 (DGAT1) inhibitors with in vivo efficacy in rodents.EBI Amgen Inc
23871442 88 Defining the key pharmacophore elements of PF-04620110: discovery of a potent, orally-active, neutral DGAT-1 inhibitor.EBI Pfizer Inc
23711919 62 Synthesis and structure-activity relationship of pyripyropene A derivatives as potent and selective acyl-CoA:cholesterol acyltransferase 2 (ACAT2) inhibitors: part 3.EBI Kitasato University
23665143 8 Manzamine A, a marine-derived alkaloid, inhibits accumulation of cholesterol ester in macrophages and suppresses hyperlipidemia and atherosclerosis in vivo.EBI Kumamoto University
23535327 44 Synthesis and structure-activity relationship of pyripyropene A derivatives as potent and selective acyl-CoA:cholesterol acyltransferase 2 (ACAT2) inhibitors: part 2.EBI Kitasato University
23419736 58 Synthesis of a novel series of 2-alkylthio substituted naphthoquinones as potent acyl-CoA: cholesterol acyltransferase (ACAT) inhibitors.EBI Dongguk University-Seoul
23369538 88 Synthesis and structure-activity relationship of pyripyropene A derivatives as potent and selective acyl-CoA:cholesterol acyltransferase 2 (ACAT2) inhibitors: part 1.EBI Kitasato University
23317570 42 Lead optimization of a pyridine-carboxamide series as DGAT-1 inhibitors.EBI Merck Research Laboratories
23116186 68 Design and optimization of pyrazinecarboxamide-based inhibitors of diacylglycerol acyltransferase 1 (DGAT1) leading to a clinical candidate dimethylpyrazinecarboxamide phenylcyclohexylacetic acid (AZD7687).EBI AstraZeneca
23025824 6 Inhibition of Acyl-CoA: cholesterol acyltransferase (ACAT), overexpression of cholesterol transporter gene, and protection of amyloidß (Aß) oligomers-induced neuronal cell death by tricyclic pyrone molecules.EBI Kansas State University
18284184 4 Biphenyl versus phenylpyridazine derivatives: the role of the heterocycle in a series of acyl-CoA:cholesterol acyl transferase inhibitors.EBI Universita di Milano
15261286 18 Acyl-CoA: cholesterol acyltransferase inhibitory activities of fatty acid amides isolated from Mylabris phalerate Pallas.EBI Korea Research Institute of Bioscience and Biotechnology
7241506 40 New analgesic drugs derived from phencyclidine.EBI TBA
22079027 8 Conformationally restricted analog and biotin-labeled probe based on beauveriolide III.EBI Tohoku University
21413799 63 Discovery of orally active carboxylic acid derivatives of 2-phenyl-5-trifluoromethyloxazole-4-carboxamide as potent diacylglycerol acyltransferase-1 inhibitors for the potential treatment of obesity and diabetes.EBI Hoffmann-La Roche Inc
20833038 98 Discovery of pyrrolopyridazines as novel DGAT1 inhibitors.EBI Amgen Inc
 12 RP 73163: A bioavailable alkylsulphinyl-diphenylimidazole ACAT inhibitorEBI TBA
 9 Synthesis and pharmacological profile of FCE 28654: A water-soluble and injectable ACAT inhibitorEBI TBA
 29 RP 70676: A potent systematically available inhibitor of acyl-CoA:cholesterol O-acyl transferase (ACAT)EBI TBA
19167888 20 Novel 1,4-diarylpiperidine-4-methylureas as anti-hyperlipidemic agents: dual effectors on acyl-CoA:cholesterol O-acyltransferase and low-density lipoprotein receptor expression.EBI Dainippon Sumitomo Pharma Co., Ltd
18620381 9 Novel indoline-based acyl-CoA:cholesterol acyltransferase inhibitor with antiperoxidative activity: improvement of physicochemical properties and biological activities by introduction of carboxylic acid.EBI Kyoto Pharmaceutical Industries
17157006 21 Human ACAT inhibitory effects of shikonin derivatives from Lithospermum erythrorhizon.EBI National Research Laboratory of Lipid Metabolism and Atherosclerosis
16919944 25 Anti-atherosclerotic and anti-inflammatory activities of catecholic xanthones and flavonoids isolated from Cudrania tricuspidata.EBI National Research Laboratory of Lipid Metabolism and Atherosclerosis
16302810 9 Mono- or diphenylpyridazines connected to N-(2,4-difluorophenyl)-N'-heptylurea as acyl-CoA:cholesterol acyltransferase inhibitors.EBI Università di Milano
15603959 12 Saucerneol B derivatives as human acyl-CoA: cholesterol acyltransferase inhibitors.EBI Korea Research Institute of Bioscience and Biotechnology
15324887 2 Synthesis of cinnamic acid derivatives and their inhibitory effects on LDL-oxidation, acyl-CoA:cholesterol acyltransferase-1 and -2 activity, and decrease of HDL-particle size.EBI National Research Laboratory of Lipid Metabolism and Atherosclerosis
15149654 7 Human ACAT-1 and -2 inhibitory activities of saucerneol B, manassantin A and B isolated from Saururus chinensis.EBI Korea Research Institute of Bioscience and Biotechnology
11708931 44 5,6-Diphenylpyridazine derivatives as acyl-CoA:cholesterol acyltransferase inhibitors.EBI Università di Firenze
32035699 8 Inhibition of cholesteryl ester synthesis by polyacetylenes from Atractylodes rhizome.EBI Kitasato University
10890154 14 Synthetic conversion of ACAT inhibitor to acetylcholinesterase inhibitor.EBI Kitasato University
10450977 27 Polyunsaturated fatty acid anilides as inhibitors of acyl-coA: cholesterol acyltransferase (ACAT).EBI Azwell Inc.
30952592 206 Accelerating the discovery of DGAT1 inhibitors through the application of parallel medicinal chemistry (PMC).EBI Merck & Co. Inc
30926247 18 Benzimidazole-based DGAT1 inhibitors with a [3.1.0] bicyclohexane carboxylic acid moiety.EBI Merck & Co.
8691472 49 Acyl-CoA:Cholesterol O-acyltransferase (ACAT) inhibitors. 2. 2-(1,3-Dioxan-2-yl)-4,5-diphenyl-1H-imidazoles as potent inhibitors of ACAT.EBI Rhône-Poulenc Rorer
30433781 23 Discovery of Clinical Candidate 2-(4-(2-((1 H-Benzo[ d]imidazol-2-yl)thio)ethyl)piperazin-1-yl)- N-(6-methyl-2,4-bis(methylthio)pyridin-3-yl)acetamide Hydrochloride [K-604], an Aqueous-Soluble Acyl-CoA:Cholesterol O-Acyltransferase-1 Inhibitor.EBI Kowa Company, Ltd.
29945757 70 Design, synthesis and pharmacology of aortic-selective acyl-CoA: Cholesterol O-acyltransferase (ACAT/SOAT) inhibitors.EBI Kowa Co., Ltd.
3100794 6 Potential antiatherosclerotic agents. 5. An acyl-CoA:cholesterol O-acyltransferase inhibitor with hypocholesterolemic activity.EBI TBA
29456796 51 Discovery of Tetralones as Potent and Selective Inhibitors of Acyl-CoA:Diacylglycerol Acyltransferase 1.EBI GlaxoSmithKline
28242547 2 Vicinal diaryl azole-based urea derivatives as potential cholesterol lowering agents acting through inhibition of SOAT enzymes.EBI The Maharaja Sayajirao University of Baroda
19152636 26 Probing the active site of Candida glabrata dihydrofolate reductase with high resolution crystal structures and the synthesis of new inhibitors.BDB University of Connecticut