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281 articles for thisTarget

The following articles (labelled with PubMed ID or TBD) are for your review
PMIDDataArticle TitleOrganization
27721146 22 (+)-and (-)-Phenazocine enantiomers: Evaluation of their dual opioid agonist/sEBI University of Catania
28435535 8 Opioid Receptor Activity and Analgesic Potency of DPDPE Peptide Analogues Containing a Xylene Bridge.EBI Universit£ di Chieti-Pescara"G. d'Annunzio"
2153204 6 Assessment of the in vivo and in vitro opioid activity of bridged hexahydroaporphine and isoquinoline molecules.EBI Creighton University
2709383 39 Synthesis and pharmacological evaluation of 4,4-disubstituted piperidines.EBI Anaquest Pharmaceuticals
2536439 10 Synthesis and biological evaluation of 14-alkoxymorphinans. 2. (-)-N-(cyclopropylmethyl)-4,14-dimethoxymorphinan-6-one, a selective mu opioid receptor antagonist.EBI University of Innsbruck
3039139 3 X-ray crystal structure of the opioid ligand naltrexonazine.EBI TBA
3012085 3 Probes for narcotic receptor mediated phenomena. 12. cis-(+)-3-Methylfentanyl isothiocyanate, a potent site-directed acylating agent for delta opioid receptors. Synthesis, absolute configuration, and receptor enantioselectivity.EBI TBA
3009813 3 Probes for narcotic receptor mediated phenomena. 9. Synthesis of (+/-)-(3 alpha,6a alpha,11a beta)-1,3,4,5,6,11a-hexahydro-2-methyl-2H-3,6a- methanobenzofuro[2,3-c]azocin-10-ol, an oxide-bridged 5-(m-hydroxyphenyl)morphan.EBI TBA
3023609 14 Probes for narcotic receptor mediated phenomena. 13. Potential irreversible narcotic antagonist-based ligands derived from 6,14-endo-ethenotetrahydronororipavine with 7-(methoxyfumaroyl)amino, (bromoacetyl)amino, or isothiocyanate electrophiles: chemistry, biochemistry, and pharmacology.EBI TBA
2876106 6 3,7-Diazabicyclane: a new narcotic analgesic.EBI TBA
3020246 11 Irreversible blockage of opioid receptor types by ester homologues of beta-funaltrexamine.EBI TBA
2863378 7 Acylmorphinans. A novel class of potent analgesic agents.EBI TBA
2409280 35 Opioid agonists and antagonists. 6-Desoxy-6-substituted lactone, epoxide, and glycidate ester derivatives of naltrexone and oxymorphone.EBI TBA
2999399 4 Novel nonnarcotic analgesics with an improved therapeutic ratio. Structure-activity relationships of 8-(methylthio)- and 8-(acylthio)-1,2,3,4,5,6-hexahydro-2,6-methano-3-benzazocines.EBI TBA
6088771 5 Potential synthetic codeine substitutes: (-)-3-O-aryl-N-methylmorphinans.EBI TBA
6094809 32 Synthesis and biological evaluation of 14-alkoxymorphinans. 1. Highly potent opioid agonists in the series of (-)-14-methoxy-N-methylmorphinan-6-ones.EBI TBA
6315939 2 14 beta-(2-bromoacetamido)morphine and 14 beta-(2-bromoacetamido)morphinone.EBI TBA
6600791 32 Synthesis and pharmacological studies of 4,4-disubstituted piperidines: a new class of compounds with potent analgesic properties.EBI TBA
6288945 28 Potential affinity labels for the opiate receptor based on fentanyl and related compounds.EBI TBA
6276546 12 Common anionic receptor site hypothesis: its relevance to the antagonist action of naloxone.EBI TBA
6268789 22 Synthesis of analogues of acetylmethadol and methadol as potential narcotic antagonists.EBI TBA
6268786 27 Opiate receptor interaction of compounds derived from or structurally related to fentanyl.EBI TBA
6273560 16 Preparation and analgesic properties of amino acid derivatives of (-)-5,9 alpha-diethyl-2'-hydroxybenzomorphan.EBI TBA
6249930 7 Synthesis and analgesic activity of some 5-(4-hydroxyphenyl)-2-azabicyclo[3.2.1]octanes.EBI TBA
6248644 4 Some spiro analogues of the potent analgesic ketobemidone.EBI TBA
6252322 19 Novel analogues of enkephalin: indentification of functional groups required for biological activity.EBI TBA
28105278 10 Hydrazone Linker as a Useful Tool for Preparing Chimeric Peptide/Nonpeptide Bifunctional Compounds.EBI Mossakowski Medical Research Centre Polish Academy of Sciences
27676089 35 A Cyclic Tetrapeptide ("Cyclodal") and Its Mirror-Image Isomer Are Both High-Affinityµ Opioid Receptor Antagonists.EBI Clinical Research Institute of Montreal
27301366 30 [Dmt(1)]DALDA analogues modified with tyrosine analogues at position 1.EBI Nanjing Medical University
27148755 75 Effects of N-Substitutions on the Tetrahydroquinoline (THQ) Core of Mixed-Efficacyµ-Opioid Receptor (MOR)/d-Opioid Receptor (DOR) Ligands.EBI University of Michigan
27234885 31 Evaluation of N-substituent structural variations in opioid receptor profile of LP1.EBI University of Catania
26713106 59 Dual Alleviation of Acute and Neuropathic Pain by Fused Opioid Agonist-Neurokinin 1 Antagonist Peptidomimetics.EBI Vrije Universiteit Brussel
26713104 24 Rapid Synthesis of Boc-2',6'-dimethyl-l-tyrosine and Derivatives and Incorporation into Opioid Peptidomimetics.EBI University of Michigan
26944625 26 Synthesis, biological evaluation and structural analysis of novel peripherally active morphiceptin analogs.EBI Medical University of Lodz
26785295 35 Synthesis of mixed MOR/KOR efficacy cyclic opioid peptide analogs with antinociceptive activity after systemic administration.EBI Medical University of Lodz
26656913 85 Multitarget opioid ligands in pain relief: New players in an old game.EBI University of Catania
26789491 44 Potentµ-Opioid Receptor Agonists from Cyclic Peptides Tyr-c[D-Lys-Xxx-Tyr-Gly]: Synthesis, Biological, and Structural Evaluation.EBI Torrey Pines Institute for Molecular Studies
26524472 75 Further Optimization and Evaluation of Bioavailable, Mixed-Efficacyµ-Opioid Receptor (MOR) Agonists/d-Opioid Receptor (DOR) Antagonists: Balancing MOR and DOR Affinities.EBI University of Michigan
26411794 46 Conformationally restrictedż-opioid receptor agonists: Synthesis and pharmacological evaluation of diastereoisomeric and enantiomeric decahydroquinoxalines.EBI Mercachem
25129170 20 'Carba'-carfentanil (trans isomer): aµ opioid receptor (MOR) partial agonist with a distinct binding mode.EBI Clinical Research Institute of Montreal
25996309 49 Parallel Synthesis of Hexahydrodiimidazodiazepines Heterocyclic Peptidomimetics and Their in Vitro and in Vivo Activities atµ (MOR),d (DOR), andż (KOR) Opioid Receptors.EBI Torrey Pines Institute for Molecular Studies
26005537 72 Synthesis of mixed opioid affinity cyclic endomorphin-2 analogues with fluorinated phenylalanines.EBI Medical University of Lodz
25898137 61 C7ß-methyl analogues of the orvinols: the discovery of kappa opioid antagonists with nociceptin/orphanin FQ peptide (NOP) receptor partial agonism and low, or zero, efficacy at mu opioid receptors.EBI University of Bath
25559207 92 Synthesis and biological evaluations of novel endomorphin analogues containinga-hydroxy-ß-phenylalanine (AHPBA) displaying mixedµ/d opioid receptor agonist andd opioid receptor antagonist activities.EBI Zhejiang University
25544687 60 Synthesis and biological evaluation of compact, conformationally constrained bifunctional opioid agonist - neurokinin-1 antagonist peptidomimetics.EBI Vrije Universiteit Brussel
25047937 9 Antinociceptive and antidepressant-like action of endomorphin-2 analogs with proline surrogates in position 2.EBI Medical University of Lodz
25456075 16 Cyclic side-chain-linked opioid analogs utilizing cis- and trans-4-aminocyclohexyl-D-alanine.EBI TBA
25221662 24 Novel cyclic biphalin analogue with improved antinociceptive properties.EBI Universit£ di Chieti-Pescara"G. d'Annunzio"
24761755 76 Selectively promiscuous opioid ligands: discovery of high affinity/low efficacy opioid ligands with substantial nociceptin opioid peptide receptor affinity.EBI University of Bath
24839540 26 In Vitro Membrane Permeation Studies and in Vivo Antinociception of Glycosylated DmtEBI Vrije Universiteit Brussel
24613457 64 Endomorphin analogues with mixedµ-opioid (MOP) receptor agonism/d-opioid (DOP) receptor antagonism and lackingß-arrestin2 recruitment activity.EBI Nanjing Medical University
24602401 40 [Dmt(1)]DALDA analogues with enhancedµ opioid agonist potency and with a mixedµ/ż opioid activity profile.EBI Nanjing Medical University
24641190 16 Development of a bioavailableµ opioid receptor (MOPr) agonist,d opioid receptor (DOPr) antagonist peptide that evokes antinociception without development of acute tolerance.EBI University of Michigan
15743203 272 3D-QSAR comparative molecular field analysis on opioid receptor antagonists: pooling data from different studies.EBI University of Medicine& Dentistry of New Jersey-Robert Wood Johnson Medical School (UMDNJ-RWJMS)
23547584 19 Biological active analogues of the opioid peptide biphalin: mixeda/ß(3)-peptides.EBI Universit£ di Chieti-Pescara"G. d'Annunzio"
23419026 40 Opioid peptidomimetics: leads for the design of bioavailable mixed efficacyµ opioid receptor (MOR) agonist/d opioid receptor (DOR) antagonist ligands.EBI University of Michigan
2415705 4 Opioid receptor interactions and conformations of the 6 alpha and 6 beta epimers of oxymorphamine. Solid-state conformation of 6 alpha-oxymorphamine.EBI TBA
22325949 28 Novel TIPP (H-Tyr-Tic-Phe-Phe-OH) analogues displaying a wide range of efficacies at thed opioid receptor. Discovery of two highly potent and selectived opioid agonists.EBI Clinical Research Institute of Montreal
23102273 60 Variation of the net charge, lipophilicity, and side chain flexibility in Dmt(1)-DALDA: Effect on Opioid Activity and Biodistribution.EBI Vrije Universiteit Brussel
22957923 20 The effect of Pro(2) modifications on the structural and pharmacological properties of endomorphin-2.EBI Biological Research Center of the Hungarian Academy of Sciences
22695132 56 Identification of a duald OR antagonist/µ OR agonist as a potential therapeutic for diarrhea-predominant Irritable Bowel Syndrome (IBS-d).EBI Janssen Research and Development, L.L.C.
21978284 42 Superpotent [Dmt¹] dermorphin tetrapeptides containing the 4-aminotetrahydro-2-benzazepin-3-one scaffold with mixedµ/d opioid receptor agonistic properties.EBI Vrije Universiteit Brussel
22677527 38 Deconstructing 14-phenylpropyloxymetopon: minimal requirements for binding to mu opioid receptors.EBI University of Maryland
20599386 46 Evaluation of N-substitution in 6,7-benzomorphan compounds.EBI University of Catania
20580236 60 Morphinans and isoquinolines: acetylcholinesterase inhibition, pharmacophore modeling, and interaction with opioid receptors.EBI University of Innsbruck and Center for Molecular Biosciences Innsbruck-CMBI
20218625 27 "Carba"-analogues of fentanyl are opioid receptor agonists.EBI Clinical Research Institute of Montreal
19595591 37 Synthesis and opioid receptor activity of indolopropellanes.EBI Chinese Academy of Sciences
19362480 22 Design and synthesis of novel delta opioid receptor agonists and their pharmacologies.EBI Kitasato University
18403056 8 Ligand binding to nucleic acids and proteins: Does selectivity increase with strength?EBI Universit£t des Saarlandes
18370374 12 Blood-brain barrier penetration by two dermorphin tetrapeptide analogues: role of lipophilicity vs structural flexibility.EBI Vrije Universiteit Brussel
18311909 10 Synthesis of a potent and selective (18)F-labeled delta-opioid receptor antagonist derived from the Dmt-Tic pharmacophore for positron emission tomography imaging.EBI Stanford University School of Medicine
18178091 24 Role of benzimidazole (Bid) in the delta-opioid agonist pseudopeptide H-Dmt-Tic-NH-CH(2)-Bid (UFP-502).EBI University of Ferrara
18062664 13 Endomorphin-2 with a beta-turn backbone constraint retains the potent micro-opioid receptor agonist properties.EBI Biological Research Center of the Hungarian Academy of Sciences
17659872 15 3-Hydroxy-4-methoxyindolomorphinans as delta opioid selective ligands.EBI University of Maryland
17395470 40 Differential receptor binding characteristics of consecutive phenylalanines in micro-opioid specific peptide ligand endomorphin-2.EBI Kyushu University
17267226 46 Novel piperazines: potent melanocortin-4 receptor antagonists with anxiolytic-like activity.EBI Taisho Pharmaceutical Co., Ltd
16942034 19 Effect of lysine at C-terminus of the Dmt-Tic opioid pharmacophore.EBI University of Cagliari
15857143 48 Synthesis and biological evaluation of 14-alkoxymorphinans. 22.(1) Influence of the 14-alkoxy group and the substitution in position 5 in 14-alkoxymorphinan-6-ones on in vitro and in vivo activities.EBI University La Sapienza
16033285 24 Effect of a 6-cyano substituent in 14-oxygenated N-methylmorphinans on opioid receptor binding and antinociceptive potency.EBI University of Innsbruck
14998329 142 Identification of opioid ligands possessing mixed micro agonist/delta antagonist activity among pyridomorphinans derived from naloxone, oxymorphone, and hydromorphone [correction of hydropmorphone].EBI Southern Research Institute
14761209 15 Importance of phenolic address groups in opioid kappa receptor selective antagonists.EBI Research Triangle Institute
12699394 30 Synthesis and biological evaluation of 14-alkoxymorphinans. 18. N-substituted 14-phenylpropyloxymorphinan-6-ones with unanticipated agonist properties: extending the scope of common structure-activity relationships.EBI University of Innsbruck
12570383 46 3-(alphaR)-alpha-((2S,5R)-4-allyl-2,5-dimethyl-1-piperazinyl)-3-hydroxybenzyl)-N-alkyl-N-arylbenzamides: potent, non-peptidic agonists of both the micro and delta opioid receptors.EBI GlaxoSmithKline Research and Development
13678399 54 Peptide science: exploring the use of chemical principles and interdisciplinary collaboration for understanding life processes.EBI University of Arizona
12954070 24 Synthesis and biological evaluation of 14-alkoxymorphinans. 20. 14-phenylpropoxymetopon: an extremely powerful analgesic.EBI University of Innsbruck
12825951 54 Identification of (3R)-7-hydroxy-N-((1S)-1-[[(3R,4R)-4-(3-hydroxyphenyl)- 3,4-dimethyl-1-piperidinyl]methyl]-2-methylpropyl)-1,2,3,4-tetrahydro- 3-isoquinolinecarboxamide as a novel potent and selective opioid kappa receptor antagonist.EBI Research Triangle Institute
11806723 20 Evaluation of the Dmt-Tic pharmacophore: conversion of a potent delta-opioid receptor antagonist into a potent delta agonist and ligands with mixed properties.EBI University of Cagliary
12459023 46 Potent delta-opioid receptor agonists containing the Dmt-Tic pharmacophore.EBI University of Cagliari
12431065 72 Synthesis and biological evaluation of 14-alkoxymorphinans. 17. Highly delta opioid receptor selective 14-alkoxy-substituted indolo- and benzofuromorphinans.EBI University of Innsbruck
12139463 24 Discovery of an opioid kappa receptor selective pure antagonist from a library of N-substituted 4beta-methyl-5-(3-hydroxyphenyl)morphans.EBI Research Triangle Institute
11300879 77 Factors influencing agonist potency and selectivity for the opioid delta receptor are revealed in structure-activity relationship studies of the 4-[(N-substituted-4-piperidinyl)arylamino]-N,N-diethylbenzamides.EBI Research Triangle Institute
11689075 20 Pseudoproline-containing analogues of morphiceptin and endomorphin-2: evidence for a cis Tyr-Pro amide bond in the bioactive conformation.EBI University of Lausanne
11495579 24 Identification of the first trans-(3R,4R)- dimethyl-4-(3-hydroxyphenyl)piperidine derivative to possess highly potent and selective opioid kappa receptor antagonist activity.EBI Research Triangle Institute
10691681 17 Novel ligands lacking a positive charge for the delta- and mu-opioid receptors.EBI Clinical Research Institute of Montr£al
11052799 10 Synthesis and evaluation of N,N-dialkyl enkephalin-based affinity labels for delta opioid receptors.EBI University of Maryland
10956208 121 Nonpeptide analogues of dynorphin A(1-8): design, synthesis, and pharmacological evaluation of kappa-selective agonists.EBI University of Catania
10229636 30 delta Opioid affinity and selectivity of 4-hydroxy-3-methoxyindolomorphinan analogues related to naltrindole.EBI National Institute of Diabetes
10639287 62 Probes for narcotic receptor mediated phenomena. 26. Synthesis and biological evaluation of diarylmethylpiperazines and diarylmethylpiperidines as novel, nonpeptidic delta opioid receptor ligands.EBI National Institute of Diabetes and Digestive and Kidney Diseases
10479286 53 Synthesis, opioid receptor binding, and biological activities of naltrexone-derived pyrido- and pyrimidomorphinans.EBI Southern Research Institute
9719602 24 3-Alkyl ethers of clocinnamox: delayed long-term mu-antagonists with variable mu efficacy.EBI University of Bristol
9667975 86 Synthesis, opioid receptor binding, and bioassay of naltrindole analogues substituted in the indolic benzene moiety.EBI Southern Research Institute
9057856 53 Probes for narcotic receptor mediated phenomena. 23. Synthesis, opioid receptor binding, and bioassay of the highly selective delta agonist (+)-4-[(alpha R)-alpha-((2S,5R)-4-Allyl-2,5-dimethyl-1-piperazinyl)-3-methoxybenzyl]- N,N-diethylbenzamide (SNC 80) and related novel nonpeptide delta opioid rEBI National Institute of Diabetes and Digestive and Kidney Diseases
9397176 28 Cyclic enkephalin analogues with exceptional potency and selectivity for delta-opioid receptors.EBI University of Arizona
9301674 60 Evolution of the Dmt-Tic pharmacophore: N-terminal methylated derivatives with extraordinary delta opioid antagonist activity.EBI University of Ferrara
9288177 20 Synthesis and pharmacological activity of deltorphin and dermorphin-related glycopeptides.EBI University of Ferrara
9288176 95 Probes for narcotic receptor-mediated phenomena. 25. Synthesis and evaluation of N-alkyl-substituted (alpha-piperazinylbenzyl)benzamides as novel, highly selective delta opioid receptor agonists.EBI National Institute of Diabetes and Digestive and Kidney Diseases
8642567 64 Probes for narcotic receptor-mediated phenomena. 21. Novel derivatives of 3-(1,2,3,4,5,11-hexahydro-3-methyl-2,6-methano-6H-azocino[4,5-b]indol- 6-yl)-phenols with improved delta opioid receptor selectivity.EBI National Institute of Diabetes and Digestive and Kidney Diseases
7739013 26 Enantiomers of diastereomeric cis-N-[1-(2-hydroxy-2-phenylethyl)- 3-methyl-4-piperidyl]-N-phenylpropanamides: synthesis, X-ray analysis, and biological activities.EBI Research Triangle Institute
7739011 90 Probes for narcotic receptor-mediated phenomena. 20. Alteration of opioid receptor subtype selectivity of the 5-(3-hydroxyphenyl)morphans by application of the message-address concept: preparation of delta-opioid receptor ligands.EBI National Institute of Diabetes and Digestive and Kidney Diseases
8164255 23 Cyclic beta-casomorphin analogues with mixed mu agonist/delta antagonist properties: synthesis, pharmacological characterization, and conformational aspects.EBI Clinical Research Institute of Montreal
8126697 30 Synthesis of naltrexone-derived delta-opioid antagonists. Role of conformation of the delta address moiety.EBI University of Minnesota
8201592 27 [L-Ala3]DPDPE: a new enkephalin analog with a unique opioid receptor activity profile. Further evidence of delta-opioid receptor multiplicity.EBI University of Arizona
8289188 30 Cyclic enkephalin analogs with exceptional potency at peripheral delta opioid receptors.EBI University of Arizona
8230106 16 TIPP[psi]: a highly potent and stable pseudopeptide delta opioid receptor antagonist with extraordinary delta selectivity.EBI Clinical Research Institute of Montreal
1311764 4 Systemic analgesic activity and delta-opioid selectivity in [2,6-dimethyl-Tyr1,D-Pen2,D-Pen5]enkephalin.EBI Searle Research and Development
1323677 18 Analogs of the delta opioid receptor selective cyclic peptide [2-D-penicillamine,5-D-penicillamine]-enkephalin: 2',6'-dimethyltyrosine and Gly3-Phe4 amide bond isostere substitutions.EBI G.D. Searle and Company
1322988 60 Probes for narcotic receptor mediated phenomena. 18. Epimeric 6 alpha- and 6 beta-iodo-3,14-dihydroxy-17-(cyclopropylmethyl)-4,5 alpha-epoxymorphinans as potential ligands for opioid receptor single photon emission computed tomography: synthesis, evaluation, and radiochemistry of [125I]-6 beta-iodoEBI National Institute of Diabetes and Digestive and Kidney Diseases
1648137 30 Topographically designed analogues of [D-Pen,D-Pen5]enkephalin.EBI University of Arizona
1851843 96 Synthesis and structure-activity relationships of deltorphin analogues.EBI University of Ferrara
1849997 42 Function of negative charge in the"address domain" of deltorphins.EBI National Institute of Environmental Health Sciences
2167979 43 Photoactivatable opiate derivatives as irreversible probes of the mu-opioid receptor.EBI Universit£ Louis Pasteur
2153205 10 [D-Pen2,D-Pen5]enkephalin analogues with increased affinity and selectivity for delta opioid receptors.EBI University of Arizona
2537426 12 Synthesis of highly mu and delta opioid receptor selective peptides containing a photoaffinity group.EBI University of Arizona
2536436 24 Cyclic enkephalin analogues containing alpha-amino-beta-mercapto-beta,beta-pentamethylenepropionic acid at positions 2 or 5.EBI Smith Kline and French Laboratories
2828622 71 Investigation of the structural parameters involved in the mu and delta opioid receptor discrimination of linear enkephalin-related peptides.EBI INSERM
2845084 22 Effects of addition of a 2-methyl group to ethyl nipecotates (beta-meperidines) on receptor affinities and opiate agonist/antagonist activities.EBI SRI International
2888899 34 Combined analgesic/neuroleptic activity in N-butyrophenone prodine-like compounds.EBI Istituto Superiore di Sanit£
3007760 93 N-substituent modulation of opiate agonist/antagonist activity in resolved 3-methyl-3-(m-hydroxyphenyl)piperidines.EBI TBA
2878079 22 Design and synthesis of conformationally constrained somatostatin analogues with high potency and specificity for mu opioid receptors.EBI TBA
2999408 11 Hybromet: a ligand for purifying opioid receptors.EBI TBA
2999401 20 Synthesis and activity profiles of novel cyclic opioid peptide monomers and dimers.EBI TBA
6150112 24 Probes for narcotic receptor mediated phenomena. 7. Synthesis and pharmacological properties of irreversible ligands specific for mu or delta opiate receptors.EBI TBA
6296388 68 Synthesis and pharmacological characterization in vitro of cyclic enkephalin analogues: effect of conformational constraints on opiate receptor selectivity.EBI TBA
15115401 24 Oral bioavailability of a new class of micro-opioid receptor agonists containing 3,6-bis[Dmt-NH(CH(2))(n)]-2(1H)-pyrazinone with central-mediated analgesia.EBI National Institutes of Environmental Health Sciences
12565965 45 Synthesis, opioid receptor binding, and functional activity of 5'-substituted 17-cyclopropylmethylpyrido[2',3':6,7]morphinans.EBI Southern Research Institute
11425550 62 Piperazinyl benzamidines: synthesis and affinity for the delta opioid receptor.EBI R. W. Johnson Pharmaceutical Research Institute
10782696 67 ORL1 receptor ligands: structure-activity relationships of 8-cycloalkyl-1-phenyl-1,3,8-triaza-spiro[4.5]decan-4-ones.EBI F. Hoffmann-La Roche Ltd.
11078198 12 N-Cyclohexylethyl-N-noroxymorphindole: a mu-opioid preferring analogue of naltrindole.EBI University of Maryland
10091684 10 The LMC delta opioid recognition pharmacophore: comparison of SNC80 and oxymorphindole.EBI National Institute of Diabetes
10617086 21 Delta opioid binding selectivity of 3-ether analogs of naltrindole.EBI National Institute of Diabetes
9871544 24 Synthesis and biological activity of 3-substituted 3-desoxynaltrindole derivatives.EBI National Institute of Diabetes
9873480 35 Syntheses of potent Leu-enkephalin analogs possessing beta-hydroxy-alpha,alpha-disubstituted-alpha-amino acid and their characterization to opioid receptors.EBI Institute for Bioorganic Research
 17 Synthesis and biological evaluation of 14-alkoxymorphinans. 14.1 14-ethoxy-5-methyl substituted indolomorphinans with opioid receptor selectivityEBI TBA
 51 EMD 61 753 as a favourable representative of structurally novel arylacetamido-type K opiate receptor agonistsEBI TBA
22197670 51 Synthesis of quinolinomorphinan-4-ol derivatives asd opioid receptor agonists.EBI Kitasato University
22047797 16 Effect of 2',6'-dimethyl-L-tyrosine (Dmt) on pharmacological activity of cyclic endomorphin-2 and morphiceptin analogs.EBI Medical University of Lodz
21870874 30 Synthesis, biological evaluation, and automated docking of constrained analogues of the opioid peptide H-Dmt-D-Ala-Phe-Gly-NH2 using the 4- or 5-methyl substituted 4-amino-1,2,4,5-tetrahydro-2-benzazepin-3-one scaffold.EBI Vrije Universiteit Brussel
21481987 27 Synthesis of 7,9-diazabicyclo[4.2.2]decanes as conformationally restricted κ receptor agonists: fine tuning of the dihedral angle of the ethylenediamine pharmacophore.EBI Institut f£r Pharmazeutische und Medizinische Chemie der Universit£t M£nster
21413804 21 Design of novel neurokinin 1 receptor antagonists based on conformationally constrained aromatic amino acids and discovery of a potent chimeric opioid agonist-neurokinin 1 receptor antagonist.EBI Vrije Universiteit Brussel
21287991 43 Design, synthesis, pharmacological evaluation, and structure-activity study of novel endomorphin analogues with multiple structural modifications.EBI Hungarian Academy of Sciences
21235243 35 Synthesis and pharmacological activities of 6-glycine substituted 14-phenylpropoxymorphinans, a novel class of opioids with high opioid receptor affinities and antinociceptive potencies.EBI University of Innsbruck
20637637 46 Role of 2',6'-dimethyl-l-tyrosine (Dmt) in some opioid lead compounds.EBI University of Cagliari
20413312 17 Synthesis and opioid activity of novel 6-substituted-6-demethoxy-ethenomorphinans.EBI University of Debrecen
20137938 28 Novel multiple opioid ligands based on 4-aminobenzazepinone (Aba), azepinoindole (Aia) and tetrahydroisoquinoline (Tic) scaffolds.EBI Vrije Universiteit Brussel
20045339 16 Design, synthesis and SAR analysis of novel selective sigma1 ligands (Part 2).EBI University of Pavia
19932964 26 Highly selective and potent mu opioid ligands by unexpected substituent on morphine skeleton.EBI Fudan University
19621878 19 Discovery of dermorphin-based affinity labels with subnanomolar affinity for mu opioid receptors.EBI The University of Kansas
19827750 39 Agonist vs antagonist behavior of delta opioid peptides containing novel phenylalanine analogues in place of Tyr(1).EBI Clinical Research Institute of Montreal
19788201 32 Pentapeptides displaying mu opioid receptor agonist and delta opioid receptor partial agonist/antagonist properties.EBI University of Michigan
19576786 129 Identification, structure-activity relationships and molecular modeling of potent triamine and piperazine opioid ligands.EBI Institute for Molecular Studies
19642675 60 Influence of the side chain next to C-terminal benzimidazole in opioid pseudopeptides containing the Dmt-Tic pharmacophore.EBI University of Cagliari
19560919 28 Synthesis and evaluation of new endomorphin analogues modified at the Pro(2) residue.EBI Universit£ di Roma
1317407 7 Akuammine and Dihydroakuammine, Two Indolomonoterpene Alkaloids Displaying Affinity for Opioid ReceptorsEBI TBA
15984054 21 Structure-activity relationships of novel endomorphin-2 analogues with N-O turns induced by alpha-aminoxy acids.EBI TBA
 35 Stereoselective synthesis and evaluation of all stereoisomers of Z4349, a novel and selective μ-opioid analgesicEBI TBA
 8 Specific affinity labeling of μ opioid receptors in rat brain by S-activated sulfhydryldihydromorphine analogsEBI TBA
 16 Synthesis and biological properties of quaternized N-methylation analogs of D-Arg-2-dermorphin tetrapeptideEBI TBA
 4 A new approach to enhance bioavailability of biologically active peptides: conjugation of a δ opioid agonist to β-cyclodextrinEBI TBA
 8 Topographical requirements for delta opioid ligands: The synthesis and biological properties of a cyclic analogue of deltorphin IEBI TBA
 6 New potent enkephalin analogs containing trifluoromethylamino acid residuesEBI TBA
 4 Dermorphin sequence with high δ-afinity by fixing the phe sidechain to trans at ξ1EBI TBA
19435668 20 Biological activity of endomorphin and [Dmt1]endomorphin analogs with six-membered proline surrogates in position 2.EBI Medical University of Lodz
19062273 41 Conformationally constrained opioid ligands: the Dmt-Aba and Dmt-Aia versus Dmt-Tic scaffold.EBI Vrije Universiteit Brussel
18800771 26 Novel opioid peptide derived antagonists containing (2S)-2-methyl-3-(2,6-dimethyl-4-carbamoylphenyl)propanoic acid [(2S)-Mdcp].EBI National University of Singapore
18680274 44 Further studies on lead compounds containing the opioid pharmacophore Dmt-Tic.EBI University of Cagliari
18572932 64 New endomorphin analogues containing alicyclic beta-amino acids: influence on bioactive conformation and pharmacological profile.EBI Hungarian Academy of Sciences
18490168 32 Structure-activity study of endomorphin-2 analogs with C-terminal modifications by NMR spectroscopy and molecular modeling.EBI Lanzhou University
18468445 26 Synthesis and in vitro evaluation of a library of modified endomorphin 1 peptides.EBI University of Queensland
18207400 17 Novel highly potent mu-opioid receptor antagonist based on endomorphin-2 structure.EBI Medical University of Lodz
17851080 6 A new opioid designed multiple ligand derived from the micro opioid agonist endomorphin-2 and the delta opioid antagonist pharmacophore Dmt-Tic.EBI University of Ferrara
17497839 72 Bifunctional [2',6'-dimethyl-L-tyrosine1]endomorphin-2 analogues substituted at position 3 with alkylated phenylalanine derivatives yield potent mixed mu-agonist/delta-antagonist and dual mu-agonist/delta-agonist opioid ligands.EBI Kobe Gakuin University
17339114 27 Further studies on the effect of lysine at the C-terminus of the Dmt-Tic opioid pharmacophore.EBI University of Cagliari
17315860 40 Dicarba analogues of the cyclic enkephalin peptides H-Tyr-c[D-Cys-Gly-Phe-D(or L)-Cys]NH(2) retain high opioid activity.EBI Clinical Research Institute of Montreal
17266203 29 Synthesis and characterization of potent and selective mu-opioid receptor antagonists, [Dmt(1), D-2-Nal(4)]endomorphin-1 (Antanal-1) and [Dmt(1), D-2-Nal(4)]endomorphin-2 (Antanal-2).EBI Medical University
17234422 118 Structure-activity relationships of novel piperazines as antagonists for the melanocortin-4 receptor.EBI Taisho Pharmaceutical Co., Ltd
17228874 18 Beta-methyl substitution of cyclohexylalanine in Dmt-Tic-Cha-Phe peptides results in highly potent delta opioid antagonists.EBI Hungarian Academy of Sciences
17188879 16 Endomorphin-1 analogs with enhanced metabolic stability and systemic analgesic activity: design, synthesis, and pharmacological characterization.EBI Lanzhou University
17142049 40 Transformation of mu-opioid receptor agonists into biologically potent mu-opioid receptor antagonists.EBI Kobe Gakuin University
16949282 12 Synthesis of 3,6-bis[H-Tyr/H-Dmt-NH(CH2)m,n]-2(1H)pyrazinone derivatives: function of alkyl chain length on opioid activity.EBI Kobe Gakuin University
16913729 9 Replacement of the N-terminal tyrosine residue in opioid peptides with 3-(2,6-dimethyl-4-carbamoylphenyl)propanoic acid (Dcp) results in novel opioid antagonists.EBI National University of Singapore
16759107 18 6-N,N-dimethylamino-2,3-naphthalimide: a new environment-sensitive fluorescent probe in delta- and mu-selective opioid peptides.EBI Universidad de Santiago de Compostela
16682191 21 Opioid receptor binding and antinociceptive activity of the analogues of endomorphin-2 and morphiceptin with phenylalanine mimics in the position 3 or 4.EBI Lanzhou University
16483774 66 Identification of potent phenyl imidazoles as opioid receptor agonists.EBI Johnson & Johnson Pharmaceutical Research & Development
16366592 33 Conversion of the potent delta-opioid agonist H-Dmt-Tic-NH-CH(2)-bid into delta-opioid antagonists by N(1)-benzimidazole alkylation(1).EBI University of Cagliari
16335927 48 Potent Dmt-Tic pharmacophoric delta- and mu-opioid receptor antagonists.EBI Kobe Gakuin University
16183273 12 New series of potent delta-opioid antagonists containing the H-Dmt-Tic-NH-hexyl-NH-R motif.EBI Kobe Gakuin University
15887972 8 A new structural motif for mu-opioid antagonists.EBI Vrije Universiteit Brussel
15863298 20 6-Hydroxy-1,2,3,4-tetrahydro-isoquinoline-3-carboxylic acid mimics active conformation of tyrosine in opioid peptides.EBI University of Catania
15658871 28 Development of potent mu-opioid receptor ligands using unique tyrosine analogues of endomorphin-2.EBI Kobe Gakuin University
15588089 10 Highly selective fluorescent analogue of the potent delta-opioid receptor antagonist Dmt-Tic.EBI University of Cagliary
15456245 44 Rationale, design, and synthesis of novel phenyl imidazoles as opioid receptor agonists for gastrointestinal disorders.EBI Johnson & Johnson Pharmaceutical Research & Development
15214786 64 Development of potent bifunctional endomorphin-2 analogues with mixed mu-/delta-opioid agonist and delta-opioid antagonist properties.EBI Kobe Gakuin University
15163203 45 Synthesis and biological evaluation of 14-alkoxymorphinans. 21. Novel 4-alkoxy and 14-phenylpropoxy derivatives of the mu opioid receptor antagonist cyprodime.EBI University of Innsbruck
14736254 70 Structure-activity study on the Phe side chain arrangement of endomorphins using conformationally constrained analogues.EBI Biological Research Center of the Hungarian Academy of Sciences
12852751 34 Unique high-affinity synthetic mu-opioid receptor agonists with central- and systemic-mediated analgesia.EBI Kobe Gakuin University
12672238 3 Mechanism of action of the diazabicyclononanone-type kappa-agonists.EBI Universität Würzburg
12672226 9 A novel N-terminal cyclic dynorphin A analogue cyclo(N,5)[Trp(3),Trp(4),Glu(5)] dynorphin A-(1-11)NH(2) that lacks the basic N-terminus.EBI University of Maryland
12657261 32 Dermorphin tetrapeptide analogues with 2',6'-dimethylphenylalanine (Dmp) substituted for aromatic amino acids have high mu opioid receptor binding and biological activities.EBI Tohoku Pharmaceutical University
12459018 6 Crystal structures of dipeptides containing the Dmt-Tic pharmacophore.EBI National Institute of Environmental Health Sciences
12372513 102 Indoline and piperazine containing derivatives as a novel class of mixed D(2)/D(4) receptor antagonists. Part 2: asymmetric synthesis and biological evaluation.EBI Neurogen Corporation
11958984 24 Dermorphin and deltorphin heptapeptide analogues: replacement of Phe residue by Dmp greatly improves opioid receptor affinity and selectivity.EBI Tohoku Pharmaceutical University
11755345 45 Synthesis and biological activity of 8beta-substituted hydrocodone indole and hydromorphone indole derivatives.EBI NIDDK
11212102 24 Enkephalin analogues with 2',6'-dimethylphenylalanine replacing phenylalanine in position 4.EBI Tohoku Pharmaceutical University
10956228 13 Probes for narcotic receptor-mediated phenomena. 27. Synthesis and pharmacological evaluation of selective delta-opioid receptor agonists from 4-[(alphaR)-alpha-(2S,5R)-4-substituted-2, 5-dimethyl-1-piperazinyl-3-methoxybenzyl]-N,N-diethylbenzamides and their enantiomers.EBI National Institute of Diabetes and Digestive and Kidney Diseases
10893314 24 Potent and selective indolomorphinan antagonists of the kappa-opioid receptor.EBI University of Minnesota
10866400 18 4-[(8-Alkyl-8-azabicyclo[3.2.1]octyl-3-yl)-3-arylanilino]-N,N-diethylbenzamides: high affinity, selective ligands for the delta opioid receptor illustrate factors important to antagonist activity.EBI Research Triangle Institute
10843229 92 Synthesis and binding affinities of 4-diarylaminotropanes, a new class of delta opioid agonists.EBI R. W. Johnson Pharmaceutical Research Institute
10841790 24 Synthesis, molecular modeling, and opioid receptor affinity of 9, 10-diazatricyclo[,5)]decanes and 2,7-diazatricyclo[4.4.0. 0(3,8)]decanes structurally related to 3,8-diazabicyclo[3.2. 1]octanes.EBI Istituto di Chimica Farmaceutica e Tossicologica
10753473 14 Deltorphin II analogues with 6-hydroxy-2-aminotetralin-2-carboxylic acid in position 1.EBI Hungarian Academy of Sciences
10691683 22 Opiate aromatic pharmacophore structure-activity relationships in CTAP analogues determined by topographical bias, two-dimensional NMR, and biological activity assays.EBI University of Arizona
10639279 26 Exploring the structure-activity relationships of [1-(4-tert-butyl-3'-hydroxy)benzhydryl-4-benzylpiperazine] (SL-3111), a high-affinity and selective delta-opioid receptor nonpeptide agonist ligand.EBI The University of Arizona
10585210 60 Further studies on the Dmt-Tic pharmacophore: hydrophobic substituents at the C-terminus endow delta antagonists to manifest mu agonism or mu antagonism.EBI University of Ferrara
10479285 17 The opioid mu agonist/delta antagonist DIPP-NH(2)[Psi] produces a potent analgesic effect, no physical dependence, and less tolerance than morphine in rats.EBI Clinical Research Institute of Montreal
9873693 24 N-substituted octahydro-4a-(3-hydroxyphenyl)-10a-methyl-benzo[g]isoquinolines are opioid receptor pure antagonists.EBI Research Triangle Institute
9822547 41 De novo design, synthesis, and biological activities of high-affinity and selective non-peptide agonists of the delta-opioid receptor.EBI The University of Arizona
9767649 24 N-Substituted 9beta-methyl-5-(3-hydroxyphenyl)morphans are opioid receptor pure antagonists.EBI Research Triangle Institute
9599247 57 Investigation of the N-substituent conformation governing potency and mu receptor subtype-selectivity in (+)-(3R, 4R)-dimethyl-4-(3-hydroxyphenyl)piperidine opioid antagonists.EBI Research Triangle Institute
9276018 47 Synthesis and opioid activity of [D-Pro10]dynorphin A-(1-11) analogues with N-terminal alkyl substitution.EBI Oregon State University
9258365 28 Helix-inducing alpha-aminoisobutyric acid in opioid mimetic deltorphin C analogues.EBI National Institute of Environmental Health Sciences
9083489 30 Conformationally constrained deltorphin analogs with 2-aminotetralin-2-carboxylic acid in position 3.EBI Hungarian Academy of Sciences
8576920 34 Design and synthesis of 1-aminocycloalkane-1-carboxylic acid-substituted deltorphin analogues: unique delta and mu opioid activity in modified peptides.EBI University of Ferrara
8411007 392 Chemistry, binding affinities, and behavioral properties of a new class of"antineophobic" mitochondrial DBI receptor complex (mDRC) ligands.EBI Mayo Foundation for Medical Education and Research
8410999 81 3,4-Dimethyl-4-(3-hydroxyphenyl)piperidines: opioid antagonists with potent anorectant activity.EBI Lilly Research Laboratories
8289187 47 Design of cyclic deltorphins and dermenkephalins with a disulfide bridge leads to analogues with high selectivity for delta-opioid receptors.EBI University of Arizona
8254604 50 Phe3-substituted analogues of deltorphin C. Spatial conformation and topography of the aromatic ring in peptide recognition by delta opioid receptors.EBI University of Ferrara
8246239 84 Development of high-affinity 5-HT3 receptor antagonists. Structure-affinity relationships of novel 1,7-annelated indole derivatives.EBI Solvay Duphar B.V.
8097539 10 Synthesis and opioid activity of dynorphin A-(1-13)NH2 analogues containing cis- and trans-4-aminocyclohexanecarboxylic acid.EBI Oregon State University
8057274 18 Discovery of a potent, peripherally selective trans-3,4-dimethyl-4-(3-hydroxyphenyl)piperidine opioid antagonist for the treatment of gastrointestinal motility disorders.EBI Lilly Research Laboratories
7932540 38 A marked change of receptor affinity of the 2-methyl-5-(3-hydroxyphenyl)morphans upon attachment of an (E)-8-benzylidene moiety: synthesis and evaluation of a new class of sigma receptor ligands.EBI National Institute of Diabetes and Digestive and Kidney Diseases
7908696 45 Enkephalin analogs as systemically active antinociceptive agents: O- and N-alkylated derivatives of the dipeptide amide L-2,6-dimethyltyrosyl-N-(3-phenylpropyl)-D-alaninamide.EBI Searle
7608905 24 Synthesis and opioid activity of conformationally constrained dynorphin A analogues. 1. Conformational constraint in the"message" sequence.EBI Oregon State University
7562933 24 Novel deltorphin heptapeptide analogs with potent delta agonist, delta antagonist, or mixed mu antagonist/delta agonist properties.EBI Tohoku College of Pharmacy
7490727 72 (E)-8-benzylidene derivatives of 2-methyl-5-(3-hydroxyphenyl)morphans: highly selective ligands for the sigma 2 receptor subtype.EBI National Institute of Diabetes and Digestive and Kidney Diseases
6313921 10 Synthesis and pharmacological characterization of (+/-)-5,9 alpha-dimethyl-2-[2-(4-fluorophenyl)ethyl]-2'-hydroxy-6,7-benzomorphan (fluorophen), a ligand suitable for visualization of opiate receptors in vivo.EBI TBA
3746815 15 In vitro labeling of serotonin-S2 receptors: synthesis and binding characteristics of [3H]-7-aminoketanserin.EBI TBA
2903246 58 Design and synthesis of somatostatin analogues with topographical properties that lead to highly potent and specific mu opioid receptor antagonists with greatly reduced binding at somatostatin receptors.EBI University of Arizona
2876099 51 Synthesis and biological activities of dynorphin A analogues with opioid antagonist properties.EBI TBA
2845081 24 Development of conformationally constrained linear peptides exhibiting a high affinity and pronounced selectivity for delta opioid receptors.EBI UA 498 CNRS
2822930 48 Structure-activity relationships of cyclic opioid peptide analogues containing a phenylalanine residue in the 3-position.EBI Clinical Research Institute of Montreal
2542560 4 Probes for narcotic receptor mediated phenomena. 15. (3S,4S)-(+)-trans-3-methylfentanyl isothiocyanate, a potent site-directed acylating agent for the delta opioid receptors in vitro.EBI National Institutes of Health
2537427 24 Dermorphin analogues carrying an increased positive net charge in their"message" domain display extremely high mu opioid receptor selectivity.EBI Clinical Research Institute of Montreal
2153212 87 Cholecystokinin-A receptor ligands based on the kappa-opioid agonist tifluadom.EBI Merck Sharp & Dohme Research Laboratories
1714957 12 Pseudopeptide analogues of substance P and leucine enkephalinamide containing the psi (CH2O) modification: synthesis and biological activity.EBI Hebrew University of Jerusalem
1656045 26 Conformational restriction of the phenylalanine residue in a cyclic opioid peptide analogue: effects on receptor selectivity and stereospecificity.EBI Clinical Research Institute of Montreal
1360025 27 Effect of modification of the basic residues of dynorphin A-(1-13) amide on kappa opioid receptor selectivity and opioid activity.EBI Oregon State University
1346276 25 Preparation and opioid activity of analogues of the analgesic dipeptide 2,6-dimethyl-L-tyrosyl-N-(3-phenylpropyl)-D-alaninamide.EBI G. D. Searle and Company
1335080 20 Para-substituted Phe3 deltorphin analogues: enhanced selectivity of halogenated derivatives for delta opioid receptor sites.EBI University of Ferrara
1331455 9 Delta opioid antagonist activity and binding studies of regioisomeric isothiocyanate derivatives of naltrindole: evidence for delta receptor subtypes.EBI University of Minnesota
1331451 68 Conformationally restricted deltorphin analogues.EBI Clinical Research Institute of Montreal
1323682 61 Novel indolodioxanes with antihypertensive effects: potent ligands for the 5-HT1A receptor.EBI Upjohn Company
1320122 55 Ring substituted and other conformationally constrained tyrosine analogues of [D-Pen2,D-Pen5]enkephalin with delta opioid receptor selectivity.EBI University of Arizona
1313878 36 Stereospecificity of amino acid side chains in deltorphin defines binding to opioid receptors.EBI National Institute of Environmental Health Sciences
27863747 21 Symmetrical aryl linked bis-iminothiazolidinones as new chemical entities for the inhibition of monoamine oxidases: Synthesis, in vitro biological evaluation and molecular modelling analysis.BDB Quaid-i-Azam University
27128978 8 Inhibitor Discovery for the Human GLUT1 from Homology Modeling and Virtual Screening.BDB Icahn School of Medicine at Mount Sinai
26032047 15 Novel 4-heteroaryl-antipyrines as DPP-IV inhibitors.BDB Cairo University
7774675 35 Characterisation of melanocortin receptor subtypes by radioligand binding analysis.BDB Uppsala