BindingDB logo
myBDB logout

167 articles for thisTarget

The following articles (labelled with PubMed ID or TBD) are for your review
PMIDDataArticle TitleOrganization
8421282 22 Synthesis and structure-activity relationship of some 5-[[[(dialkylamino)alkyl]-1-piperidinyl]acetyl]-10,11-dihydro-5H- benzo[b,e][1,4]diazepin-11-ones as M2-selective antimuscarinics.EBI George Washington University Medical Center
1560440 42 Synthesis and muscarinic activities of quinuclidin-3-yltriazole and -tetrazole derivatives.EBI SmithKline Beecham Pharmaceuticals
1732545 27 Phenyl-substituted analogues of oxotremorine as muscarinic antagonists.EBI University of Uppsala
1619616 94 Substituent variation in azabicyclic triazole- and tetrazole-based muscarinic receptor ligands.EBI SmithKline Beecham Pharmaceuticals
1895293 44 Comparison of azabicyclic esters and oxadiazoles as ligands for the muscarinic receptor.EBI SmithKline Beecham Pharmaceuticals
1875333 132 Cholinergic activity of acetylenic imidazoles and related compounds.EBI Upjohn Company
1995893 81 Muscarinic cholinergic agonists and antagonists of the 3-(3-alkyl-1,2,4-oxadiazol-5-yl)-1,2,5,6-tetrahydropyridine type. Synthesis and structure-activity relationships.EBI Ferrosan A/S
2299626 18 Beta-lactam analogues of oxotremorine. 3- and 4-methyl-substituted 2-azetidinones.EBI University of Uppsala
2258905 135 Chemical and biochemical studies of 2-propynylpyrrolidine derivatives. Restricted-rotation analogues of N-methyl-N-(1-methyl-4-pyrrolidino-2-butynyl)acetamide (BM-5).EBI American Cyanamid Company
2296026 12 Synthesis of some 3-(1-azabicyclo[2.2.2]octyl) 3-amino-2-hydroxy-2-phenylpropionates: profile of antimuscarinic efficacy and selectivity.EBI Nova Pharmaceutical Corporation
2724292 120 Regional differences in the binding of selective muscarinic receptor antagonists in rat brain: comparison with minimum-energy conformations.EBI University of Toledo
2785211 18 Synthesis and biological evaluation of [125I]- and [123I]-4-iododexetimide, a potent muscarinic cholinergic receptor antagonist.EBI Johns Hopkins Medical Institutions
2704032 10 Conformationally restricted analogues of the muscarinic agent N-methyl-N-(1-methyl-4-pyrrolidino-2-butynyl)acetamide.EBI University of Uppsala
3351856 3 Synthesis and antiulcer activity of 5,11-dihydro[1]benzoxepino[3,4-b]pyridines.EBI Kyowa Hakko Kogyo Co., Ltd.
3336015 8 Dimethylsulfonium and thiolanium analogues of the muscarinic agent oxotremorine.EBI University of California
3039133 9 Tricyclic compounds as selective antimuscarinics. 1. Structural requirements for selectivity toward the muscarinic acetylcholine receptor in a series of pirenzepine and imipramine analogues.EBI TBA
3806613 2 Molecular modification of anticholinergics as probes for muscarinic receptors. 3. Conformationally restricted analogues of benactyzine.EBI TBA
2866248 8 Examination of a series of 8-[3-[bis(4-fluorophenyl)amino]propyl]-1-aryl-1,3,8- triazaspiro[4.5]decan-4-ones as potential antipsychotic agents.EBI TBA
7108902 18 Affinity of 10-(4-methylpiperazino)dibenz[b,f]oxepins for clozapine and spiroperidol binding sites in rat brain.EBI TBA
6128416 29 Effects of conformationally restricted 4-piperazinyl-10H-thienobenzodiazepine neuroleptics on central dopaminergic and cholinergic systems.EBI TBA
7288815 18 Synthesis of clozapine analogues and their affinity for clozapine and spiroperidol binding sites in rat brain.EBI TBA
6249933 12 Conformationally restricted tricyclic antidepressants. 1. Octahydrodibenzazepinonaphthyridines as rigid imipramine analogues.EBI TBA
27939174 84 Challenges in the development of an MEBI Vanderbilt University Medical Center
25147929 105 Development of a highly potent, novel M5 positive allosteric modulator (PAM) demonstrating CNS exposure: 1-((1H-indazol-5-yl)sulfoneyl)-N-ethyl-N-(2-(trifluoromethyl)benzyl)piperidine-4-carboxamide (ML380).EBI Vanderbilt University Medical Center
24837158 60 Novel quinuclidinyl heteroarylcarbamate derivatives as muscarinic receptor antagonists.EBI Astellas Pharma Inc
23375092 16 The effect of absolute configuration on activity, subtype selectivity (M3/M2) of 3a-acyloxy-6ß-acetoxyltropane derivatives as muscarinic M3 receptor antagonists.EBI Shanghai Jiao Tong University School of Medicine
23200253 67 Further exploration of M1 allosteric agonists: subtle structural changes abolish M1 allosteric agonism and result in pan-mAChR orthosteric antagonism.EBI Vanderbilt University Medical Center
23177787 59 Discovery of a selective M4 positive allosteric modulator based on the 3-amino-thieno[2,3-b]pyridine-2-carboxamide scaffold: development of ML253, a potent and brain penetrant compound that is active in a preclinical model of schizophrenia.EBI Vanderbilt University Medical Center
9767650 48 Universal template approach to drug design: polyamines as selective muscarinic receptor antagonists.EBI University of Bologna
12392730 10 Synthesis and muscarinic M(2) subtype antagonistic activity of enantiomeric pairs of 3-demethylhimbacine (3-norhimbacine) and its C(4)-epimer.EBI Kyorin Pharmaceutical Co. Ltd.
12270166 8 Synthesis and muscarinic M2 subtype antagonistic activity of unnatural ent-himbacine and an enantiomeric pair of (2'S,6'R)-diepihimbacine.EBI Kyorin Pharmaceutical Company Ltd.
 20 Design, synthesis and biological activity of some 4-DAMP- related compoundsEBI TBA
18178088 64 Synthesis and SAR of selective muscarinic acetylcholine receptor subtype 1 (M1 mAChR) antagonists.EBI Vanderbilt Institute of Chemical Biology
17629699 42 Synthesis and optimization of novel and selective muscarinic M(3) receptor antagonists.EBI Ranbaxy Research Laboratories
16220976 66 Synthesis and antimuscarinic properties of quinuclidin-3-yl 1,2,3,4-tetrahydroisoquinoline-2-carboxylate derivatives as novel muscarinic receptor antagonists.EBI Astellas Pharma Inc.
10354408 58 1-(1,2,5-Thiadiazol-4-yl)-4-azatricyclo[,6)]heptanes as new potent muscarinic M1 agonists: structure-activity relationship for 3-aryl-2-propyn-1-yloxy and 3-aryl-2-propyn-1-ylthio derivatives.EBI Novo Nordisk A/S
9464362 19 5-HT3 antagonists derived from aminopyridazine-type muscarinic M1 agonists.EBI Universit£ Louis Pasteur
9622546 109 6beta-Acetoxynortropane: a potent muscarinic agonist with apparent selectivity toward M2-receptors.EBI National Institute of Diabetes and Digestive and Kidney Diseases
9572883 32 (+)-cis-N-ethyleneamino-N-normetazocine derivatives. Novel and selective sigma ligands with antagonist properties.EBI University of Catania
9016336 15 Stereoselective synthesis and biodistribution of potent [11C]-labeled antagonists for positron emission tomography imaging of muscarinic receptors in the airways.EBI Groningen University Hospital
8765504 34 (S)-(-)-5-ethynyl-3-(1-methyl-2-pyrrolidinyl)pyridine maleate (SIB-1508Y): a novel anti-parkinsonian agent with selectivity for neuronal nicotinic acetylcholine receptors.EBI SIBIA Neurosciences Inc.
7562926 81 Novel 4'-substituted and 4',4"-disubstituted 3 alpha-(diphenylmethoxy)tropane analogs as potent and selective dopamine uptake inhibitors.EBI National Institutes of Health
7562924 10 Resolution and in vitro and initial in vivo evaluation of isomers of iodine-125-labeled 1-azabicyclo[2.2.2]oct-3-yl alpha-hydroxy-alpha-(1-iodo-1-propen-3-yl)-alpha-phenylacetate: a high-affinity ligand for the muscarinic receptor.EBI Oak Ridge National Laboratory (ORNL)
8027978 50 Novel (4-phenylpiperidinyl)- and (4-phenylpiperazinyl)alkyl-spaced esters of 1-phenylcyclopentanecarboxylic acids as potent sigma-selective compounds.EBI Albany Molecular Research
8464039 12 Synthesis and biodistribution of iodine-125-labeled 1-azabicyclo[2.2.2]oct-3-yl alpha-hydroxy-alpha-(1-iodo-1-propen-3-yl)-alpha-phenylacetate. A new ligand for the potential imaging of muscarinic receptors by single photon emission computed tomography.EBI Oak Ridge National Laboratory
8246221 90 The synthesis and biochemical pharmacology of enantiomerically pure methylated oxotremorine derivatives.EBI Medical Research Division of American Cyanamid Company
8394936 11 Design of potent non-peptide competitive antagonists of the human bradykinin B2 receptor.EBI Sterling Winthrop Pharmaceutical Research Division
8360873 25 Synthesis and structure-activity studies of a series of spirooxazolidine-2,4-diones: 4-oxa analogues of the muscarinic agonist 2-ethyl-8-methyl-2,8-diazaspiro[4.5]decane-1,3-dione.EBI Institute for Drug Discovery Research
1319493 31 Synthesis and receptor binding properties of fluoro- and iodo-substituted high affinity sigma receptor ligands: identification of potential PET and SPECT sigma receptor imaging agents.EBI National Institute of Diabetes and Digestive and Kidney Diseases
1956033 121 Synthesis, molecular modeling studies, and muscarinic receptor activity of azaprophen analogues.EBI Research Triangle Institute
1920350 22 Muscarinic receptor binding profile of para-substituted caramiphen analogues.EBI Virginia Commonwealth University
2374141 33 Synthesis and biological evaluation of new antimuscarinic compounds with amidine basic centers. A useful bioisosteric replacement of classical cationic heads.EBI Istituto De Angeli
2738887 22 Binary antidotes for organophosphate poisoning: aprophen analogues that are both antimuscarinics and carbamates.EBI Institute of Research
2573732 84 Synthesis and pharmacological evaluation of a series of 4-piperazinylpyrazolo[3,4-b]- and -[4,3-b][1,5]benzodiazepines as potential anxiolytics.EBI Lilly Research Centre Limited
2571731 33 Synthesis and pharmacological evaluation of CNS activities of [1,2,3]triazolo[4,5-b][1,5]-, imidazolo[4,5-b][1,5]-, and pyrido[2,3-b][1,5]benzodiazepines. 10-Piperazinyl-4H-1,2,3-triazolo[4,5-b][1,5]benzodiazepines with neuroleptic activity.EBI Lilly Research Centre Limited
3385735 32 Affinity and selectivity of the optical isomers of 3-quinuclidinyl benzilate and related muscarinic antagonists.EBI Nova Pharmaceutical Corporation
3385727 48 Heterocyclic muscarinic agonists. Synthesis and biological activity of some bicyclic sulfonium arecoline bioisosteres.EBI Royal Danish School of Pharmacy
3039136 328 Pyrroloisoquinoline antidepressants. 2. In-depth exploration of structure-activity relationships.EBI TBA
2869146 72 Synthesis and biological evaluation of 1-(1,2-benzisothiazol-3-yl)- and (1,2-benzisoxazol-3-yl)piperazine derivatives as potential antipsychotic agents.EBI TBA
6134835 76 Synthesis and receptor binding studies relevant to the neuroleptic activities of some 1-methyl-4-piperidylidene-9-substituted-pyrrolo[2,1-b][3]benzazepine derivatives.EBI TBA
9873644 74 Identification of side chains on 1,2,5-thiadiazole-azacycles optimal for muscarinic m1 receptor activation.EBI Novo Nordisk A/S
 28 Design of dual acting anticonvulsant-antimuscarinic succinimide and hydantoin derivativesEBI TBA
 40 Structure activity relationships of non-peptide bradykinin B2 receptor antagonistsEBI TBA
21930376 92 Development of a highly selective, orally bioavailable and CNS penetrant M1 agonist derived from the MLPCN probe ML071.EBI Vanderbilt University Medical Center
20004578 28 Chemical lead optimization of a pan G(q) mAChR M(1), M(3), M(5) positive allosteric modulator (PAM) lead. Part I: Development of the first highly selective M(5) PAM.EBI Vanderbilt University Medical Center
 20 Synthesis and binding affinity of new muscarinic ligands structurally related to oxotremorineEBI TBA
 16 Identification of novel (isoxazole)methylene-1-azabicyclic compounds with high affinity for the central nicotinic cholinergic receptorEBI TBA
 8 Synthesis and biological activity of enantiomers of a conformationally restricted muscarone analogEBI TBA
 14 Chemical modification of ring c of himbacine: Discovery of a pharmacophoric element for M2-selectivityEBI TBA
 24 Simplified analogs of himbacine displaying potent binding affinity for muscarinic receptorsEBI TBA
 3 Muscarinic receptor probes based on amine congeners of pirenzepine and telenzepineEBI TBA
 88 A rationale for the design and synthesis of m1 selective muscarinic agonists.EBI TBA
 21 Synthesis and structure-activity relationships of heterocyclic analogues of the functional M1 selective muscarinic agonist hexyloxy-TZTPEBI TBA
 40 Cholinergic agents: aldehyde, ketone, and oxime analogues of the muscarinic agonist UH5EBI TBA
 8 Alzheimer's therapy: an approach to novel muscarinic ligands based upon the naturally occurring alkaloid himbacine.EBI TBA
 14 Cholinergic agents: 2-oxazolidinone analogues of the acetylcholine-receptor muscarinic agonist pilocarpineEBI TBA
19438238 45 Discovery of the first highly M5-preferring muscarinic acetylcholine receptor ligand, an M5 positive allosteric modulator derived from a series of 5-trifluoromethoxy N-benzyl isatins.EBI Vanderbilt University Medical Center
15808475 40 Design, synthesis and activity of novel derivatives of oxybutynin and tolterodine.EBI Ranbaxy Research Laboratories
12419388 25 Enhancement of pharmacokinetic properties and in vivo efficacy of benzylidene ketal M(2) muscarinic receptor antagonists via benzamide modification.EBI Schering-Plough Research Institute
10636243 6 Synthesis and binding studies of some epibatidine analogues.EBI Institute of Pharmacy and Biochemistry
10571170 27 Quinolizidinyl derivatives of 5,11-dihydro-6H-pyrido[2,3-b][1,4]benzodiazepin-6-one as ligands for muscarinic receptors.EBI Dipartimento di Scienze Farmaceutiche - Università di Genova
9572880 44 1'-Benzyl-3,4-dihydrospiro[2H-1- benzothiopyran-2,4'-piperidine] (spipethiane), a potent and highly selective sigma1 ligand.EBI University of Camerino
8709107 99 Dopamine D3 and D4 receptor antagonists: synthesis and structure--activity relationships of (S)-(+)-N-(1-Benzyl-3-pyrrolidinyl)-5-chloro-4- [(cyclopropylcarbonyl) amino]-2-methoxybenzamide (YM-43611) and related compounds.EBI Yamanouchi Pharmaceutical Company Limited
8558529 195 Synthesis and structure-activity relationships of N-propyl-N-(4-pyridinyl)-1H-indol-1-amine (besipirdine) and related analogs as potential therapeutic agents for Alzheimer's disease.EBI Hoechst-Roussel Pharmaceuticals Inc.
8410999 81 3,4-Dimethyl-4-(3-hydroxyphenyl)piperidines: opioid antagonists with potent anorectant activity.EBI Lilly Research Laboratories
8355251 8 Synthesis and binding properties of MK-801 isothiocyanates; (+)-3-isothiocyanato-5-methyl-10,11-dihydro-5H-dibenzo[a,d]cyclohepten- 5,10-imine hydrochloride: a new, potent and selective electrophilic affinity ligand for the NMDA receptor-coupled phencyclidine binding site.EBI National Institute of Diabetes and Digestive and Kidney Diseases
8246239 84 Development of high-affinity 5-HT3 receptor antagonists. Structure-affinity relationships of novel 1,7-annelated indole derivatives.EBI Solvay Duphar B.V.
8101877 80 New pyridobenzodiazepine derivatives as potential antipsychotics: synthesis and neurochemical study.EBI University of Liège
7966137 52 Construction of a molecular shape analysis-three-dimensional quantitative structure-analysis relationship for an analog series of pyridobenzodiazepinone inhibitors of muscarinic 2 and 3 receptors.EBI College of Pharmacy
7837240 19 Preparation of 18F-labeled muscarinic agonist with M2 selectivity.EBI National Institutes of Health
7752195 30 Syntheses and biological properties of chiral fluoroalkyl quinuclidinyl benzilates.EBI National Institutes of Health
3746815 15 In vitro labeling of serotonin-S2 receptors: synthesis and binding characteristics of [3H]-7-aminoketanserin.EBI TBA
3712371 49 A novel class of conformationally restricted heterocyclic muscarinic agonists.EBI TBA
3373484 36 Tricyclic compounds as selective antimuscarinics. 2. Structure-activity relationships of M1-selective antimuscarinics related to pirenzepine.EBI Dr. Karl Thomae GmbH
2892936 21 Synthesis and potential antipsychotic activity of 1H-imidazo[1,2-c]pyrazolo[3,4-e]pyrimidines.EBI Warner-Lambert Company
2875184 57 (5-Amino-1,3-dimethyl-1H-pyrazol-4-yl)(2-fluorophenyl)methanones . A series of novel potential antipsychotic agents.EBI TBA
2754696 56 Tricyclic compounds as selective muscarinic receptor antagonists. 3. Structure-selectivity relationships in a series of cardioselective (M2) antimuscarinics.EBI Dr. Karl Thomae GmbH
2571728 21 Sterically hindered 5,11-dicarbo analogues of clozapine as potential chiral antipsychotic agents.EBI Vanderbilt University
2066986 137 Functionalized congener approach to muscarinic antagonists: analogues of pirenzepine.EBI NIDDK
1967652 27 Chloro-substituted, sterically hindered 5,11-dicarbo analogues of clozapine as potential chiral antipsychotic agents.EBI Vanderbilt University
1732522 42 Muscarinic activity of the thiolactone, lactam, lactol, and thiolactol analogues of pilocarpine and a hypothetical model for the binding of agonists to the m1 receptor.EBI Sandoz Pharma Ltd.
1613746 48 Synthesis and muscarinic receptor activity of ester derivatives of 2-substituted 2-azabicyclo[2.2.1]heptan-5-ol and -6-ol.EBI Research Triangle Institute
1588567 18 Synthesis and pharmacological investigation of the enantiomers of muscarone and allomuscarone.EBI Istituto Chimico-Farmaceutico dell'Università
1578480 26 Synthesis and in vitro characterization of novel amino terminally modified oxotremorine derivatives for brain muscarinic receptors.EBI Abbott Laboratories
1507212 42 Urea and 2-imidazolidone derivatives of the muscarinic agents oxotremorine and N-methyl-N-(1-methyl-4-pyrrolidino-2-butynyl)acetamide.EBI University of Uppsala
1507203 96 Synthesis and cholinergic properties of N-aryl-2-[[[5-[(dimethylamino)methyl]-2-furanyl]methyl]thio]ethylamino analogs of ranitidine.EBI University of South Carolina
23548908 1 Inhibition of isoleucyl-tRNA synthetase as a potential treatment for human African Trypanosomiasis.BDB University of Washington
26390252 12 Characterization of DDR2 Inhibitors for the Treatment of DDR2 Mutated Nonsmall Cell Lung Cancer.BDB Dana-Farber Cancer Institute
26218629 26 Small Molecule Inhibitors of 8-Oxoguanine DNA Glycosylase-1 (OGG1).BDB Oregon Health & Science University
26214585 23 Virtual Screening for UDP-Galactopyranose Mutase Ligands Identifies a New Class of Antimycobacterial Agents.BDB University of Wisconsin-Madison
26364932 22 Structure and Inhibition of Microbiome -Glucuronidases Essential to the Alleviation of Cancer Drug Toxicity.BDB University of North Carolina at Chapel Hill
25590533 245 Identification of a fragment-like small molecule ligand for the methyl-lysine binding protein, 53BP1.BDB University of North Carolina at Chapel Hill
26051755 2 New monomeric and dimeric uridinyl derivatives as inhibitors of chitin synthase.BDB Silesian University of Technology