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51 articles for thisTarget


The following articles (labelled with PubMed ID or TBD) are for your review
PMIDDataArticle TitleOrganization
7902871 35 o-phenylphenols: potent and orally active leukotriene B4 receptor antagonists.EBI Lilly Research Laboratories
9873433 109 trans-3-Benzyl-4-hydroxy-7-chromanylbenzoic acid derivatives as antagonists of the leukotriene B4 (LTB4) receptor.EBI Pfizer Inc
10821712 18 Quantized surface complementarity diversity (QSCD): a model based on small molecule-target complementarity.EBI NeoGenesis, Inc.
8759636 1 Structure-activity relationships of (E)-3-(1,4-benzoquinonyl)-2-[(3-pyridyl)-alkyl]-2-propenoic acid derivatives that inhibit both 5-lipoxygenase and thromboxane A2 synthetase.EBI Eisai Company Ltd.
8709092 21 Modulators of leukotriene biosynthesis and receptor activation.EBI Abbott Laboratories
7932529 37 Novel dual inhibitors of 5-lipoxygenase and thromboxane A2 synthetase: synthesis and structure-activity relationships of 3-pyridylmethyl-substituted 2-amino-6-hydroxybenzothiazole derivatives.EBI Eisai Company, Ltd.
8230121 15 Synthesis of structural analogs of leukotriene B4 and their receptor binding activity.EBI SmithKline Beecham Pharmaceuticals
 14 Synthesis and pharmacologic activity of hydroxyacetophenone-substituted benzophenone/xanthone leukotriene B4 receptor antagonistsEBI TBA
20380377 70 Discovery of novel and potent leukotriene B4 receptor antagonists. Part 1.EBI Roche Research Center
8496700 16 The Role of Receptor Binding in Drug DiscoveryEBI TBA
8383730 7 New Leukotriene B4 Receptor Antagonist: Leucettamine A and Related Imidazole Alkaloids from the Marine Sponge Leucetta microraphisEBI TBA
 15 N-aryl cinnamides: A novel class of rigid and highly potent leukotriene B4 receptor antagonistsEBI TBA
 1 3-Amino-1,2-benzisoxazoles: A new family of potent inhibitors of LTB4 binding to the human neutrophilsEBI TBA
 6 Synthesis and pharmacological profile of new 1,3-disubstituted cyclohexanes as leukotriene B4 receptor antagonistsEBI TBA
 25 Synthesis and in vitro profile of 7-substituted quinoline chromanols as novel, non-acidic LTB4 antagonistsEBI TBA
 24 2-alkyl-4-ethyl-5-[6-methyl-6-(2H-tetrazol-5-yl)heptyloxy]phenol leukotriene B4 receptor antagonistsEBI TBA
 11 Synthesis and pharmacological activity of SC-53228, a leukotriene B4 receptor antagonist with high intrinsic potency and selectivityEBI TBA
 10 Structural analogues of LY292728, a highly potent xanthone dicarboxylic acid leukotriene B4 receptor antagonist: spatial positioning of the secondary acid groupEBI TBA
 12 Acid unit modifications of 1,2,4,5-substituted hydroxyacetophenones and the effect on in vitro and in vivo LTB4 receptor antagonismEBI TBA
 10 Ortho-alkoxyphenol leukotriene B4 receptor antagonists: effect of a chroman carboxylic acid.EBI TBA
 16 Ortho-alkoxyphenol leukotriene B4 receptor antagonistsEBI TBA
 1 Enantioselective total synthesis and pharmacologic profile of 12-deoxy-12(S)-methyl leukotriene B4EBI TBA
16190770 8 Synthesis of leukotriene B4 antagonists labeled with In-111 or Tc-99m to image infectious and inflammatory foci.EBI Bristol-Myers Squibb Medical Imaging
14643356 32 Structure-activity relationships of indole cytosolic phospholipase A(2)alpha inhibitors: substrate mimetics.EBI Wyeth Research
10782692 8 Leukotriene B4 photoaffinity probes: design, synthesis and evaluation of new arylazide-1,3-disubstituted cyclohexanes.EBI UPRESA-CNRS 5074
9888841 1 Carboxy-substituted cinnamides: a novel series of potent, orally active LTB4 receptor antagonists.EBI Novartis Pharmaceuticals Corporation
8809171 13 (E)-3-[6-[[(2,6-dichlorophenyl)thio]methyl]-3-(2-phenylethoxy)-2- pyridinyl]-2-propenoic acid: a high-affinity leukotriene B4 receptor antagonist with oral antiinflammatory activity.EBI SmithKline Beecham Pharmaceuticals
8809164 5 Structure-activity relationships study of two series of leukotriene B4 antagonists: novel indolyl and naphthyl compounds substituted with a 2-[methyl(2-phenethyl)amino]-2-oxoethyl side chain.EBI Rhône-Poulenc Rorer Central Research
8809163 3 A novel series of [2-[methyl(2-phenethyl)amino]-2-oxoethyl] benzene-containing leukotriene B4 antagonists: initial structure-activity relationships.EBI Rhone-Poulenc Rorer Central Research
8410983 7 (E)-3-[[[[6-(2-carboxyethenyl)-5-[[8-(4- methoxyphenyl)octyl]oxy]-2-pyridinyl]-methyl]thio]methyl]benzoic acid: a novel high-affinity leukotriene B4 receptor antagonist.EBI SmithKline Beecham Pharmaceuticals
8389876 11 Design, synthesis, and pharmacological evaluation of potent xanthone dicarboxylic acid leukotriene B4 receptor antagonists.EBI Lilly Research Laboratories
8254628 17 Biphenylyl-substituted xanthones: highly potent leukotriene B4 receptor antagonists.EBI Lilly Research Laboratories
8230123 7 Synthesis and LTB4 receptor antagonist activities of the naturally occurring LTB4 receptor antagonist Leucettamine A and related analogues.EBI Smithkline Beecham Pharmaceuticals
8230122 32 Trisubstituted pyridine leukotriene B4 receptor antagonists: synthesis and structure-activity relationships.EBI SmithKline Beecham Pharmaceuticals
8057289 17 Leukotriene B4 (LTB4) receptor antagonists: a series of (hydroxyphenyl)pyrazoles.EBI Lilly Research Laboratories
7932560 19 (E)-3-[[[[6-(2-carboxyethenyl)-5-[[8-(4- methoxyphenyl)octyl]oxy]-2-pyridinyl]-methyl]thio]methyl]benzoic acid and related compounds: high affinity leukotriene B4 receptor antagonists.EBI SmithKline Beecham Pharmaceuticals
7932545 3 (+)-1-(3S,4R)-[3-(4-phenylbenzyl)-4-hydroxychroman-7-yl]cyclopentane carboxylic acid, a highly potent, selective leukotriene B4 antagonist with oral activity in the murine collagen-induced arthritis model.EBI Pfizer Inc.
7699700 23 Second-generation leukotriene B4 receptor antagonists related to SC-41930: heterocyclic replacement of the methyl ketone pharmacophore.EBI Searle Research and Development
7473568 5 Synthetic and structure/activity studies on acid-substituted 2-arylphenols: discovery of 2-[2-propyl-3-[3-[2-ethyl-4-(4-fluorophenyl)-5- hydroxyphenoxy]-propoxy]phenoxy]benzoic acid, a high-affinity leukotriene B4 receptor antagonist.EBI Lilly Research Laboratories
2542550 1 7-[3-(4-acetyl-3-methoxy-2-propylphenoxy)propoxy]-3,4-dihydro-8- propyl-2H-1-benzopyran-2-carboxylic acid: an orally active selective leukotriene B4 receptor antagonist.EBI G.D. Searle and Co.
2170648 2 Benzophenone dicarboxylic acid antagonists of leukotriene B4. 2. Structure-activity relationships of the lipophilic side chain.EBI Lilly Research Laboratories
1333012 106 omega-[(4,6-Diphenyl-2-pyridyl)oxy]alkanoic acid derivatives: a new family of potent and orally active LTB4 antagonists.EBI Centre de Recherche de Vitry-Alfortville
1333011 29 omega-[(4-Phenyl-2-quinolyl)oxy]alkanoic acid derivatives: a new family of potent LTB4 antagonists.EBI Centre de Recherche de Vitry-Alfortville
1331462 9 4-[2-[Methyl(2-phenethyl)amino]-2-oxoethyl]-8-(phenylmethoxy)-2- naphthalenecarboxylic acid: a high affinity, competitive, orally active leukotriene B4 receptor antagonist.EBI Rhone-Poulenc Rorer Central Research
1324316 22 Omega-[(omega-arylalkyl)thienyl]alkanoic acids: from specific LTA4 hydrolase inhibitors to LTB4 receptor antagonists.EBI Centre de Recherche de Vitry-Alfortville
1313879 21 Development of 2,3-dihydro-6-(3-phenoxypropyl)-2-(2-phenylethyl)-5-benzofuranol (L-670,630) as a potent and orally active inhibitor of 5-lipoxygenase.EBI Merck Frosst Centre For Therapeutic Research