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89 articles for thisTarget


The following articles (labelled with PubMed ID or TBD) are for your review
PMIDDataArticle TitleOrganization
26638042 5 Discovery of novel hybrids of diaryl-1,2,4-triazoles and caffeic acid as dual inhibitors of cyclooxygenase-2 and 5-lipoxygenase for cancer therapy.EBI China Pharmaceutical University
25462262 98 Development and evaluation of ST-1829 based on 5-benzylidene-2-phenylthiazolones as promising agent for anti-leukotriene therapy.EBI Goethe-University Frankfurt
1848292 116 Indazolinones, a new series of redox-active 5-lipoxygenase inhibitors with built-in selectivity and oral activity.EBI ICI Pharmaceuticals Group
3806607 15 Substituted arylmethyl phenyl ethers. 1. A novel series of 5-lipoxygenase inhibitors and leukotriene antagonists.EBI TBA
 4 Cyclic aryl hydroxamic acids: synthesis and inhibition of 5-lipoxygenaseEBI TBA
22380511 73 Dynamic modeling of human 5-lipoxygenase-inhibitor interactions helps to discover novel inhibitors.EBI Peking University
9207936 198 Structure-activity relationships of N-hydroxyurea 5-lipoxygenase inhibitors.EBI Abbott Laboratories
8831759 16 1-substituted 4-aryl-5-pyridinylimidazoles: a new class of cytokine suppressive drugs with low 5-lipoxygenase and cyclooxygenase inhibitory potency.EBI SmithKline Beecham Pharmaceuticals Ltd
7932529 37 Novel dual inhibitors of 5-lipoxygenase and thromboxane A2 synthetase: synthesis and structure-activity relationships of 3-pyridylmethyl-substituted 2-amino-6-hydroxybenzothiazole derivatives.EBI Eisai Company, Ltd
8478906 25 Design of 5-(3,5-di-tert-butyl-4-hydroxyphenyl)-1,3,4-thiadiazoles, -1,3,4-oxadiazoles, and -1,2,4-triazoles as orally-active, nonulcerogenic antiinflammatory agents.EBI Warner-Lambert Company
1433181 39 Novel 1,2,4-oxadiazoles and 1,2,4-thiadiazoles as dual 5-lipoxygenase and cyclooxygenase inhibitors.EBI Warner-Lambert Company
1635053 47 5-lipoxygenase: properties, pharmacology, and the quinolinyl(bridged)aryl class of inhibitors.EBI Wyeth-Ayerst Research
2113951 134 1,2-Dihydro-1-oxopyrrolo[3,2,1-kl]phenothiazine-2-carboxamides and congeners, dual cyclooxygenase/5-lipoxygenase inhibitors with antiinflammatory activity.EBI Pfizer Inc
2104936 98 2-substituted-1-naphthols as potent 5-lipoxygenase inhibitors with topical antiinflammatory activity.EBI E.I. Du Pont de Nemours and Company, Inc.
3133478 16 4-Hydroxy-3-quinolinecarboxamides with antiarthritic and analgesic activities.EBI Centre de Recherches Roussel-Uclaf
3599023 29 Synthesis and 5-lipoxygenase inhibitory activity of 5-hydroperoxy-6,8,11,14-eicosatetraenoic acid analogues.EBI TBA
3820229 51 Hydroxamic acid inhibitors of 5-lipoxygenase.EBI TBA
3806609 30 Structural requirements for the inhibition of 5-lipoxygenase by 15-hydroxyeicosa-5,8,11,13-tetraenoic acid analogues.EBI TBA
3681891 27 Novel 1H-benzimidazol-4-ols with potent 5-lipoxygenase inhibitory activity.EBI Beecham Pharmaceuticals Research Division
 35 Antiinflammatory -benzeneethanamines. IIIEBI TBA
 22 Topical antiinflammatory dehydroabietylamine derivatives. IVEBI TBA
 39 O-alkylcarboxylate oxime and N-hydroxyurea analogs of substituted indole leukotriene biosynthesis inhibitorsEBI TBA
 19 Catechol based inhibitors of 15-lipoxygenaseEBI TBA
 42 Cmi-206: A potent dual platelet activating factor antagonist and 5-lipoxygenase inhibitorEBI TBA
 8 Synthesis and pharmacological profile of two novel heterocyclic chromanols, CP-80,798 and CP-85,958, as potent LTD4 receptor antagonistsEBI TBA
 76 2,4,5- triarylimidazole inhibitors of IL-1 biosynthesisEBI TBA
 14 A novel series of highly potent 5-lipoxygenase inhibitors; 2-aryldienylbenzoxazolesEBI TBA
 13 Design of pyrrolo-1,4-benzoxazine derivatives as inhibitors of 5-lipoxygenase and PAF antagonists with anthihistaminic propertiesEBI TBA
 12 4-[5-(2,3-dihydroxyphenyl)pentyloxy]-2-hydroxy-3-propylbenzoic acid (Ro 24-0553): an orally active 5-lipoxygenase inhibitor with antiinflammatory activityEBI TBA
 11 Cyclooxygenase and 5-lipoxygenase inhibitory activity of 2,6 di-t-butylphenols linked by a sulfur atom to 1,3,4-thiadiazoles and 1,3,4-oxadiazolesEBI TBA
 24 Vinylogous hydroxamic acids: 5-lipoxygenase inhibitorsEBI TBA
 11 Synthesis and cyclooxygenase and 5-lipoxygenase inhibitory activity of some thiazolidene-4-one analogs of meclofenamic acidEBI TBA
 17 Development of L-689,065 - the prototype of a new class of potent 5-lipoxygenase inhibitorsEBI TBA
 16 Synthesis of reversed hydroxamic acids of indomethacin: dual inhibitors of cyclooxygenase and 5-lipoxygenaseEBI TBA
 21 1-Phenyl-[2H]-tetrahydropyridazin-3-one, A-53612, a selective orally active 5-lipoxygenase inhibitorEBI TBA
 19 Structural analysis of 2-aryl-1,3-dione compounds as inhibitors of 5-lipoxygenaseEBI TBA
 14 Conversion of NSAIDS into balanced dual inhibitors of cyclooxygenase and 5-lipoxygenaseEBI TBA
10514305 4 Novel and known constituents from Buddleja species and their activity against leukocyte eicosanoid generation.EBI Peking Union Medical College and Chinese Academy of Medical Sciences
17336065 12 Indole derivatives as potent inhibitors of 5-lipoxygenase: design, synthesis, biological evaluation, and molecular modeling.EBI Chinese Academy of Sciences
15081022 20 5-lipoxygenase inhibitors with histamine H(1) receptor antagonist activity.EBI UCB Pharma SA
11277534 3 N-Aminoindoline derivatives as inhibitors of 5-lipoxygenase.EBI Université de Lille 2
31331653 16 5-Lipoxygenase as a drug target: A review on trends in inhibitors structural design, SAR and mechanism based approach.EBI School of Advanced Sciences
10230624 110 N-hydroxyurea and hydroxamic acid inhibitors of cyclooxygenase and 5-lipoxygenase.EBI The R. W. Johnson Pharmaceutical Research Institute
30877972 89 Design, synthesis and evaluation of novel diaryl-1,5-diazoles derivatives bearing morpholine as potent dual COX-2/5-LOX inhibitors and antitumor agents.EBI Nanjing University
9599246 28 (+/-)-trans-2-[3-methoxy-4-(4-chlorophenylthioethoxy)-5-(N-methyl-N- hydroxyureidyl)methylphenyl]-5-(3,4, 5-trimethoxyphenyl)tetrahydrofuran (CMI-392), a potent dual 5-lipoxygenase inhibitor and platelet-activating factor receptor antagonist.EBI University of Virginia
9544212 37 New cyclooxygenase-2/5-lipoxygenase inhibitors. 2. 7-tert-butyl-2,3-dihydro-3,3-dimethylbenzofuran derivatives as gastrointestinal safe antiinflammatory and analgesic agents: variations of the dihydrobenzofuran ring.EBI Procter & Gamble Pharmaceuticals
9484493 11 Design, synthesis, and biological evaluation of conformationally constrained aci-reductone mimics of arachidonic acid.EBI OXIS International, Inc.
9057869 25 Nonsteroidal anti-inflammatory drugs as scaffolds for the design of 5-lipoxygenase inhibitors.EBI Abbott Laboratories
8978834 33 Bicyclic N-hydroxyurea inhibitors of 5-lipoxygenase: pharmacodynamic, pharmacokinetic, and in vitro metabolic studies characterizing N-hydroxy-N-(2,3-dihydro-6-(phenylmethoxy)-3-benzofuranyl)urea.EBI SmithKline Beecham Pharmaceuticals Ltd
8831760 108 5-Lipoxygenase inhibitors: synthesis and structure-activity relationships of a series of 1-aryl-2H,4H-tetrahydro-1,2,4-triazin-3-ones.EBI Abbott Laboratories
8809171 13 (E)-3-[6-[[(2,6-dichlorophenyl)thio]methyl]-3-(2-phenylethoxy)-2- pyridinyl]-2-propenoic acid: a high-affinity leukotriene B4 receptor antagonist with oral antiinflammatory activity.EBI SmithKline Beecham Pharmaceuticals Ltd
8568814 23 Dibenzoxepinone hydroxylamines and hydroxamic acids: dual inhibitors of cyclooxygenase and 5-lipoxygenase with potent topical antiinflammatory activity.EBI Hoechst-Roussel Pharmaceuticals Inc
8515419 29 1,3,4-Oxadiazole, 1,3,4-thiadiazole, and 1,2,4-triazole analogs of the fenamates: in vitro inhibition of cyclooxygenase and 5-lipoxygenase activities.EBI Warner-Lambert Company
8410991 88 Substituted thiopyrano[2,3,4-c,d]indoles as potent, selective, and orally active inhibitors of 5-lipoxygenase. Synthesis and biological evaluation of L-691,816.EBI Merck Frosst Centre for Therapeutic Research
8295221 28 Synthesis and biological evaluation of 5-[[3,5-bis(1,1-dimethylethyl)- 4-hydroxyphenyl]methylene]oxazoles, -thiazoles, and -imidazoles: novel dual 5-lipoxygenase and cyclooxygenase inhibitors with antiinflammatory activity.EBI Warner-Lambert Company
8254620 62 3,4-Dihydroxychalcones as potent 5-lipoxygenase and cyclooxygenase inhibitors.EBI Tokushima Bunri University
8151626 4 Antiinflammatory 4,5-diarylpyrroles: synthesis and QSAR.EBI DuPont Pharmaceuticals Company
7932593 24 Synthesis and 5-lipoxygenase inhibitory activities of some novel 2-substituted 5-benzofuran hydroxamic acids.EBI R. W. Johnson Pharmaceutical Research Institute
7739006 2 Synthesis and antiinflammatory activity of certain 5,6,7,8-tetrahydroquinolines and related compounds.EBI Wyeth Research (U.K.) Ltd.
3806620 16 Leukotriene D4 antagonists and 5-lipoxygenase inhibitors. Synthesis of benzoheterocyclic [(methoxyphenyl)amino]oxoalkanoic acid esters.EBI TBA
3783588 51 Syntheses of 5,6,7- and 5,7,8-trioxygenated 3',4'-dihydroxyflavones having alkoxy groups and their inhibitory activities against arachidonate 5-lipoxygenase.EBI TBA
3669019 11 In vivo characterization of hydroxamic acid inhibitors of 5-lipoxygenase.EBI Abbott Laboratories
29609119 9 Benzopyrroloxazines containing a bridgehead nitrogen atom as promising scaffolds for the achievement of biologically active agents.EBI University of Calabria
3336029 8 Orally active hydroxamic acid inhibitors of leukotriene biosynthesis.EBI Abbott Laboratories
3172130 35 Structure-activity analysis of a class of orally active hydroxamic acid inhibitors of leukotriene biosynthesis.EBI Abbott Laboratories
3090264 28 Synthesis of [[(naphthalenylmethoxy)- and [[(quinolinylmethoxy)phenyl]amino]oxoalkanoic acid esters. A novel series of leukotriene D4 antagonists and 5-lipoxygenase inhibitors.EBI TBA
28835803 14 Evaluation of Oxetan-3-ol, Thietan-3-ol, and Derivatives Thereof as Bioisosteres of the Carboxylic Acid Functional Group.EBI University of Pennsylvania
2878078 43 Synthesis and antiallergic activity of a novel series of 5-lipoxygenase inhibitors.EBI TBA
2542553 31 Synthesis and structure-activity relationships of a novel class of 5-lipoxygenase inhibitors. 2-(Phenylmethyl)-4-hydroxy-3,5-dialkylbenzofurans: the development of L-656,224.EBI Merck Frosst Canada Inc.
2502629 90 Differential effects of a series of hydroxamic acid derivatives on 5-lipoxygenase and cyclooxygenase from neutrophils and 12-lipoxygenase from platelets and their in vivo effects on inflammation and anaphylaxis.EBI Rorer Central Research
2498516 4 N-[(arylmethoxy)phenyl] and N-[(arylmethoxy)naphthyl] sulfonamides: potent orally active leukotriene D4 antagonists of novel structure.EBI Wyeth-Ayerst Research
2319562 12 Design, synthesis, and 5-lipoxygenase-inhibiting properties of 1-thio-substituted butadienes.EBI Molecular Therapeutics Inc.
2308149 221 Hydroxamic acid inhibitors of 5-lipoxygenase: quantitative structure-activity relationships.EBI Abbott Laboratories
2213827 73 Penta- and hexadienoic acid derivatives: a novel series of 5-lipoxygenase inhibitors.EBI Centre de Recherches de Vitry
28720504 63 Synthesis of novel hybrids of pyrazole and coumarin as dual inhibitors of COX-2 and 5-LOX.EBI Nanjing University
2115586 29 Nonsteroidal antiinflammatory drug hydroxamic acids. Dual inhibitors of both cyclooxygenase and 5-lipoxygenase.EBI Warner-Lambert Company
2104935 10 N-[(arylmethoxy)phenyl] carboxylic acids, hydroxamic acids, tetrazoles, and sulfonyl carboxamides. Potent orally active leukotriene D4 antagonists of novel structure.EBI Wyeth-Ayerst Research
2066989 89 4-hydroxythiazole inhibitors of 5-lipoxygenase.EBI Abbott Laboratories
2016727 30 Novel caffeic acid derivatives: extremely potent inhibitors of 12-lipoxygenase.EBI Institute for Bio-Medical Research
1992126 54 Dual inhibitors of thromboxane A2 synthase and 5-lipoxygenase with scavenging activity of active oxygen species. Synthesis of a novel series of (3-pyridylmethyl)benzoquinone derivatives.EBI Takeda Chemical Industries, Ltd
1903450 34 5-Lipoxygenase inhibitors: the synthesis and structure-activity relationships of a series of 1-phenyl-3-pyrazolidinones.EBI Sterling Research Group
1847426 56 Styrylpyrazoles, styrylisoxazoles, and styrylisothiazoles. Novel 5-lipoxygenase and cyclooxygenase inhibitors.EBI Warner-Lambert Company
1648621 55 (Methoxyalkyl)thiazoles: a new series of potent, selective, and orally active 5-lipoxygenase inhibitors displaying high enantioselectivity.EBI ICI Pharmaceuticals Group
1507204 18 Novel 1-(pyridylphenyl)-1-phenyl-2-imidazolylethanols with topical antiinflammatory activity.EBI DuPont Pharmaceuticals Company
1433212 59 Synthesis, chemical, and biological properties of vinylogous hydroxamic acids: dual inhibitors of 5-lipoxygenase and IL-1 biosynthesis.EBI DuPont Pharmaceuticals Company
1313879 21 Development of 2,3-dihydro-6-(3-phenoxypropyl)-2-(2-phenylethyl)-5-benzofuranol (L-670,630) as a potent and orally active inhibitor of 5-lipoxygenase.EBI Merck Frosst Centre for Therapeutic Research