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38 articles for thisTarget

The following articles (labelled with PubMed ID or TBD) are for your review
PMIDDataArticle TitleOrganization
28306255 89 Development of Potent and Selective Antagonists for the UTP-Activated P2YEBI University of Bonn
24931384 66 Discovery of 4-aryl-7-hydroxyindoline-based P2Y1 antagonists as novel antiplatelet agents.EBI Bristol-Myers Squibb Research
24513044 19 Identification of 1-{2-[4-chloro-1'-(2,2-dimethylpropyl)-7-hydroxy-1,2-dihydrospiro[indole-3,4'-piperidine]-1-yl]phenyl}-3-{5-chloro-[1,3]thiazolo[5,4-b]pyridin-2-yl}urea, a potent, efficacious and orally bioavailable P2Y(1) antagonist as an antiplatelet agent.EBI Bristol-Myers Squibb
24712832 66 4-Alkyloxyimino derivatives of uridine-5'-triphosphate: distal modification of potent agonists as a strategy for molecular probes of P2Y2, P2Y4, and P2Y6 receptors.EBI National Institute of Diabetes and Digestive and Kidney Diseases
24164581 82 Conformationally constrained ortho-anilino diaryl ureas: discovery of 1-(2-(1'-neopentylspiro[indoline-3,4'-piperidine]-1-yl)phenyl)-3-(4-(trifluoromethoxy)phenyl)urea, a potent, selective, and bioavailable P2Y1 antagonist.EBI Bristol-Myers Squibb Company
23602442 28 Discovery of diarylurea P2Y(1) antagonists with improved aqueous solubility.EBI Bristol-Myers Squibb
23368907 62 Discovery of 2-(phenoxypyridine)-3-phenylureas as small molecule P2Y1 antagonists.EBI Bristol-Myers Squibb Research and Development
16250663 8 Synthesis and structure-activity relationships of suramin-derived P2Y11 receptor antagonists with nanomolar potency.EBI University of Bonn
22901672 15 UDP made a highly promising stable, potent, and selective P2Y6-receptor agonist upon introduction of a boranophosphate moiety.EBI Bar-Ilan University
21207957 163 Discovery of potent competitive antagonists and positive modulators of the P2X2 receptor.EBI University of Bonn
20146483 66 Development of potent and selective inhibitors of ecto-5'-nucleotidase based on an anthraquinone scaffold.EBI University of Bonn
20095577 25 5-OMe-UDP is a potent and selective P2Y(6)-receptor agonist.EBI Bar-Ilan University
19419204 14 Key determinants of nucleotide-activated G protein-coupled P2Y(2) receptor function revealed by chemical and pharmacological experiments, mutagenesis and homology modeling.EBI University of Bonn
18760862 8 Identification of hydrolytically stable and selective P2Y(1) receptor agonists.EBI Bar-Ilan University
18630897 36 Selective nucleoside triphosphate diphosphohydrolase-2 (NTPDase2) inhibitors: nucleotide mimetics derived from uridine-5'-carboxamide.EBI University of Bonn
18514530 100 Synthesis and potency of novel uracil nucleotides and derivatives as P2Y2 and P2Y6 receptor agonists.EBI NIDDK
17483457 58 A-803467, a potent and selective Nav1.8 sodium channel blocker, attenuates neuropathic and inflammatory pain in the rat.EBI Abbott Laboratories
18006312 42 Combinatorial synthesis of anilinoanthraquinone derivatives and evaluation as non-nucleotide-derived P2Y2 receptor antagonists.EBI University of Bonn
18232657 67 Lipophilic modifications to dinucleoside polyphosphates and nucleotides that confer antagonist properties at the platelet P2Y12 receptor.EBI Inspire Pharmaceuticals, Inc.
17079144 19 Novel nucleotide triphosphates as potent P2Y2 agonists with enhanced stability over UTP.EBI UCB-Group
17011188 45 Novel nucleotide triphosphates as potent P2Y2 agonists.EBI UCB-Group
17302398 33 Molecular modeling of the human P2Y2 receptor and design of a selective agonist, 2'-amino-2'-deoxy-2-thiouridine 5'-triphosphate.EBI National Institute of Diabetes and Digestive and Kidney Diseases
17125260 69 Synthesis and structure-activity relationships of uracil nucleotide derivatives and analogues as agonists at human P2Y2, P2Y4, and P2Y6 receptors.EBI University of Bonn
16942026 27 Structure-activity relationships of uridine 5'-diphosphate analogues at the human P2Y6 receptor.EBI National Institute of Diabetes and Digestive and Kidney Diseases
16539385 11 Diadenosine and diuridine poly(borano)phosphate analogues: synthesis, chemical and enzymatic stability, and activity at P2Y1 and P2Y2 receptors.EBI Bar-Ilan University
12213051 207 Purine and pyrimidine (P2) receptors as drug targets.EBI National Institute of Diabetes
11985476 35 Adenine nucleotide analogues locked in a Northern methanocarba conformation: enhanced stability and potency as P2Y(1) receptor agonists.EBI National Institute of Diabetes
11754592 21 Methanocarba modification of uracil and adenine nucleotides: high potency of Northern ring conformation at P2Y1, P2Y2, P2Y4, and P2Y11 but not P2Y6 receptors.EBI National Institute of Diabetes
11206448 21 Synthesis and P2Y receptor activity of a series of uridine dinucleoside 5'-polyphosphates.EBI Inspire Pharmaceuticals, Inc.
22386981 14 Synthesis and P2Y2 receptor agonist activities of uridine 5'-phosphonate analogues.EBI Ghent University
22107038 32 Boranophosphate isoster controls P2Y-receptor subtype selectivity and metabolic stability of dinucleoside polyphosphate analogues.EBI Bar-Ilan University
21528910 87 Pyrimidine nucleotides with 4-alkyloxyimino and terminal tetraphosphated-ester modifications as selective agonists of the P2Y(4) receptor.EBI NIDDK
21417463 80 Structural modifications of UMP, UDP, and UTP leading to subtype-selective agonists for P2Y2, P2Y4, and P2Y6 receptors.EBI University of Bonn
20446735 59 Pyrimidine ribonucleotides with enhanced selectivity as P2Y(6) receptor agonists: novel 4-alkyloxyimino, (S)-methanocarba, and 5'-triphosphate gamma-ester modifications.EBI National Institute of Diabetes and Digestive and Kidney Diseases
20004096 49 Identification of a new class of small molecule C5a receptor antagonists.EBI Wyeth Research
19502066 25 Molecular recognition in the P2Y(14) receptor: Probing the structurally permissive terminal sugar moiety of uridine-5'-diphosphoglucose.EBI National Institute of Diabetes and Digestive and Kidney Diseases
19419868 7 Synthesis and P2Y receptor activity of nucleoside 5'-phosphonate derivatives.EBI Ghent University
28938069 1 Molecular Recognition of Agonists and Antagonists by the Nucleotide-Activated G Protein-Coupled P2YEBI University of Bonn