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39 articles for thisTarget


The following articles (labelled with PubMed ID or TBD) are for your review
PMIDDataArticle TitleOrganization
323484 8 Thymidylate synthetase inhibitors. Synthesis of N-substituted 5-aminomethyl-2'-deoxyuridine 5'-phosphates.EBI TBA
17275316 11 The effect of 5-substitution in the pyrimidine ring of dUMP on the interaction with thymidylate synthase: molecular modeling and QSAR.EBI Polish Academy of Sciences
9154971 15 Folate-based inhibitors of thymidylate synthase: synthesis and antitumor activity of gamma-linked sterically hindered dipeptide analogues of 2-desamino-2-methyl-N10-propargyl-5,8-dideazafolic acid (ICI 198583).EBI The Institute of Cancer Research
1372358 18 Syntheses and thymidylate synthase inhibitory activity of the poly-gamma-glutamyl conjugates of N-[5-[N-(3,4-dihydro-2-methyl-4-oxoquinazolin-6-ylmethyl)-N-methylamino ]-2-thenoyl]-L-glutamic acid (ICI D1694) and other quinazoline antifolates.EBI Institute of Cancer Research
3339615 51 Inhibition of murine thymidylate synthase and human dihydrofolate reductase by 5,8-dideaza analogues of folic acid and aminopterin.EBI Medical University of South Carolina
11714600 10 Cyclopenta[g]quinazoline-based antifolates: the effect of the chirality at the 6-position on the inhibition of thymidylate synthase (TS).EBI CRC Laboratory
11101356 23 5-Substituted N(4)-hydroxy-2'-deoxycytidines and their 5'-monophosphates: synthesis, conformation, interaction with tumor thymidylate synthase, and in vitro antitumor activity.EBI Polish Academy of Sciences
8917645 20 Synthesis and biological activity of aromatic amino acid phosphoramidates of 5-fluoro-2'-deoxyuridine and 1-beta-arabinofuranosylcytosine: evidence of phosphoramidase activity.EBI University of Minnesota
7932557 25 The synthesis and thymidylate synthase inhibitory activity of L-gamma-L-linked dipeptide and L-gamma-amide analogues of 2-desamino-2-methyl-N10-propargyl-5,8-dideazafolic acid (ICI 198583).EBI Institute of Cancer Research
1447744 2 A dideazatetrahydrofolate analogue lacking a chiral center at C-6, N-[4-[2-(2-amino-3,4-dihydro-4-oxo-7H-pyrrolo[2,3-d]pyrimidin-5- yl)ethyl]benzoyl]-L-glutamic acid, is an inhibitor of thymidylate synthase.EBI Princeton University
1495009 32 Quinoline antifolate thymidylate synthase inhibitors: variation of the C2- and C4-substituents.EBI ICI Pharmaceuticals
2033585 37 Quinazoline antifolate thymidylate synthase inhibitors: heterocyclic benzoyl ring modifications.EBI ICI Pharmaceuticals
2362285 23 Potent inhibition of thymidylate synthase by two series of nonclassical quinazolines.EBI Warner-Lambert Company
3373483 39 Linear free energy relationship studies of enzyme active site binding: thymidylate synthase.EBI University of Kansas
3470522 16 Folate analogues as inhibitors of thymidylate synthase.EBI TBA
3100797 21 Folate analogues. 25. Synthesis and biological evaluation of N10-propargylfolic acid and its reduced derivatives.EBI TBA
21330014 28 Synthesis and biological evaluation of unsaturated keto and exomethylene D-arabinopyranonucleoside analogs: novel 5-fluorouracil analogs that target thymidylate synthase.EBI University of Thessaly
 8 Carboxylic acid bioisosteres of γ-linked dipeptide analogues of the folate-based thymidylate synthase (TS) inhibitor, 2-desamino-2-methyl-N10-propargyl-5,8-dideazafolic acid (ICI 198583)EBI TBA
12166942 4 The design and synthesis of water-soluble analogues of CB30865, a quinazolin-4-one-based antitumor agent.EBI Institute of Cancer Research
11728193 12 Synthesis and biological studies of novel nucleoside phosphoramidate prodrugs.EBI Purdue University
10821704 22 Design and synthesis of Cyclopenta[g]quinazoline-based antifolates as inhibitors of thymidylate synthase and potential antitumor agents(,).EBI Institute of Cancer Research
10508430 38 Design and synthesis of potent non-polyglutamatable quinazoline antifolate thymidylate synthase inhibitors.EBI AstraZeneca
8576912 34 Quinazoline antifolates thymidylate synthase inhibitors: lipophilic analogues with modification to the C2-methyl substituent.EBI Zeneca Pharma
8568829 22 Quinazoline antifolate thymidylate synthase inhibitors: gamma-linked L-D, D-D, and D-L dipeptide analogues of 2-desamino-2-methyl-N10-propargyl-5,8-dideazafolic acid (ICI 198583).EBI Institute of Cancer Research
8246229 4 2-Thio derivatives of dUrd and 5-fluoro-dUrd and their 5'-monophosphates: synthesis, interaction with tumor thymidylate synthase, and in vitro antitumor activity.EBI Polish Academy of Sciences
7699716 41 Quinazoline antifolate thymidylate synthase inhibitors: replacement of glutamic acid in the C2-methyl series.EBI Zeneca Pharmaceuticals
7086836 1 Inhibition by 5-(substituted-benzyl)-2,4-diaminopyrimidines of murine tumor (L5178Y) cell cultures sensitive to and resistant to methotrexate. Further evidence for the sensitivity of resistant cells to hydrophobic drugs.EBI TBA
4045922 4 Quinazoline antifolates inhibiting thymidylate synthase: variation of the N10 substituent.EBI TBA
3754284 13 Quinazoline antifolates inhibiting thymidylate synthase: benzoyl ring modifications.EBI TBA
3599032 22 Folate analogues. 30. Synthesis and biological evaluation of N10-propargyl-5,8-dideaza-5,6,7,8-tetrahydrofolic acid and related compounds.EBI TBA
3027341 10 5-Quinone derivatives of 2'-deoxyuridine 5'-phosphate: inhibition and inactivation of thymidylate synthase, antitumor cell, and antiviral studies.EBI TBA
2704030 16 Quinazoline antifolates inhibiting thymidylate synthase: 2-desamino derivatives with enhanced solubility and potency.EBI Institute of Cancer Research
2231608 41 Quinazoline antifolate thymidylate synthase inhibitors: benzoyl ring modifications in the C2-methyl series.EBI ICI Pharmaceuticals
2231607 10 Quinazoline antifolate thymidylate synthase inhibitors: 2'-fluoro-N10-propargyl-5,8-dideazafolic acid and derivatives with modifications in the C2 position.EBI Institute of Cancer Research
2231606 39 Quinazoline antifolate thymidylate synthase inhibitors: alkyl, substituted alkyl, and aryl substituents in the C2 position.EBI ICI Pharmaceuticals Mereside
2066994 25 Quinazoline antifolate thymidylate synthase inhibitors: bridge modifications and conformationally restricted analogues in the C2-methyl series.EBI ICI Pharmaceuticals
2002476 5 Quinazoline antifolates inhibiting thymidylate synthase: 4-thio-substituted analogues.EBI Institute of Cancer Research
1635061 4 N-[4-[[(3,4-dihydro-4-oxo-1,2,3-benzotriazin-6- yl)methyl]amino]benzoyl]-L-glutamic acid, a novel A-ring analogue of 2-desamino-5,8-dideazafolic acid.EBI Harvard Medical School
1613755 12 Quinazoline antifolate thymidylate synthase inhibitors: difluoro-substituted benzene ring analogues.EBI Institute of Cancer Research