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Compounds Sorted by Binding Targets per Compound

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429   443   447   515   
Compounds Sorted Alphabetically
Compound Name (alphabetical)
Binding Targets
Enz. Inhib. Data
ITC Data
Alternate Compound Names
  • Cytoplasmic tyrosine-protein kinase BMX
  • EGF-R Tyrosine Kinase Mutant (T790M)
  • JAK3
  • Nuclear receptor subfamily 2 group C member 2 (TAK1)
  • Peptidyl-prolyl cis-trans isomerase FKBP1B/Serine/threonine-protein kinase mTOR
  • Tyrosine-protein kinase BTK
  • Tyrosine-protein kinase Blk
  • Tyrosine-protein kinase ITK/TSK
  • Tyrosine-protein kinase JAK3
  • Tyrosine-protein kinase TEC
1 Ki 20 IC50
  • BMX-IN-1
  • N-[5-[9-[4-(methanesulfonamido)phenyl]-2-oxobenzo[h][1,
  • US10000483, Compound I-14
  • 5-hydroxytryptamine 1D receptor (5HT1D)
  • Cytochrome P450 1A
  • Cytochrome P450 2C19
  • Cytochrome P450 2C9
  • Cytochrome P450 2D6 (2D6)
  • Cytochrome P450 3A
  • Nitric oxide synthase, brain
  • Nitric oxide synthase, endothelial
  • Nitric oxide synthase, inducible
  • Nitric-oxide synthase, brain
13 IC50
  • CHEMBL1957350
  • US8586620, 46
  • CDK2/CycE
  • Cyclin-Dependent Kinase 1 (CDK1)
  • Cyclin-Dependent Kinase 2 (CDK2)
  • Cyclin-Dependent Kinase 5 (CDK5)
  • Cyclin-Dependent Kinase 7 (CDK7)
  • Cyclin-Dependent Kinase 9 (CDK9)
  • Cyclin-dependent kinase 2
  • Cyclin-dependent kinase 4/G1/S-specific cyclin-E1
  • Cyclin-dependent kinase 9
  • Cyclin-dependent-like kinase 5
12 IC50
  • US8592581, 1
  • Coagulation factor X
  • Coagulation factor XI
  • Complement C1r subcomponent
  • Complement C1s
  • Factor XIIa
  • Plasma kallikrein
  • Plasminogen
  • Tissue-type plasminogen activator
  • Transcription initiation factor IIA
  • Vitamin K-dependent protein C
11 Ki
  • US8598206, Table 6, 5
  • Coagulation factor X
  • Coagulation factor XI
  • Complement C1r subcomponent
  • Complement C1s
  • Factor XIIa
  • Plasma kallikrein
  • Plasminogen
  • Tissue-type plasminogen activator
  • Transcription initiation factor IIA
  • Vitamin K-dependent protein C
11 Ki
  • US8598206, Table 6, 8
  • Coagulation factor X
  • Coagulation factor XI
  • Complement C1r subcomponent
  • Complement C1s
  • Factor XIIa
  • Plasma kallikrein
  • Plasminogen
  • Tissue-type plasminogen activator
  • Transcription initiation factor IIA
  • Vitamin K-dependent protein C
11 Ki
  • US8598206, Table 6, 11
  • Coagulation factor X
  • Coagulation factor XI
  • Complement C1r subcomponent
  • Complement C1s
  • Factor XIIa
  • Plasma kallikrein
  • Plasminogen
  • Tissue-type plasminogen activator
  • Transcription initiation factor IIA
  • Vitamin K-dependent protein C
11 Ki
  • US8598206, Table 6, 13
  • Coagulation factor X
  • Coagulation factor XI
  • Complement C1r subcomponent
  • Complement C1s
  • Factor XIIa
  • Plasma kallikrein
  • Plasminogen
  • Tissue-type plasminogen activator
  • Transcription initiation factor IIA
  • Vitamin K-dependent protein C
11 Ki
  • US8598206, Table 6, 14
  • Coagulation factor X
  • Coagulation factor XI
  • Complement C1r subcomponent
  • Complement C1s
  • Factor XIIa
  • Plasma kallikrein
  • Plasminogen
  • Tissue-type plasminogen activator
  • Transcription initiation factor IIA
  • Vitamin K-dependent protein C
10 Ki
  • US8598206, Table 6, 15
  • Coagulation factor X
  • Coagulation factor XI
  • Complement C1r subcomponent
  • Complement C1s
  • Factor XIIa
  • Plasma kallikrein
  • Plasminogen
  • Tissue-type plasminogen activator
  • Transcription initiation factor IIA
  • Vitamin K-dependent protein C
11 Ki
  • US8598206, Table 6, 16
  • Coagulation factor X
  • Coagulation factor XI
  • Complement C1r subcomponent
  • Complement C1s
  • Factor XIIa
  • Plasma kallikrein
  • Plasminogen
  • Tissue-type plasminogen activator
  • Transcription initiation factor IIA
  • Vitamin K-dependent protein C
21 Ki
  • US8598206, 117
  • US8598206, 123
  • Coagulation factor X
  • Coagulation factor XI
  • Complement C1r subcomponent
  • Complement C1s
  • Factor XIIa
  • Plasma kallikrein
  • Plasminogen
  • Tissue-type plasminogen activator
  • Transcription initiation factor IIA
  • Vitamin K-dependent protein C
21 Ki
  • US8598206, 118
  • US8598206, 122
  • Coagulation factor X
  • Coagulation factor XI
  • Complement C1r subcomponent
  • Complement C1s
  • Factor XIIa
  • Plasma kallikrein
  • Plasminogen
  • Tissue-type plasminogen activator
  • Transcription initiation factor IIA
  • Vitamin K-dependent protein C
10 Ki
  • US8598206, Table 6, 3
  • Coagulation factor X
  • Coagulation factor XI
  • Complement C1r subcomponent
  • Complement C1s
  • Factor XIIa
  • Plasma kallikrein
  • Plasminogen
  • Tissue-type plasminogen activator
  • Transcription initiation factor IIA
  • Vitamin K-dependent protein C
11 Ki
  • US8598206, Table 6, 2
  • Axin-1/Glycogen synthase kinase-3 beta
  • Cyclin-Dependent Kinase 1 (CDK1)
  • Cyclin-Dependent Kinase 5 (CDK5)
  • Dual specificty protein kinase CLK1
  • Dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A
  • Dual-specificity tyrosine-phosphorylation regulated kinase 1A
  • Glycogen Synthase Kinase-3, beta
  • Mitogen-activated protein kinase kinase kinase 14
  • cAMP-Dependent Protein Kinase (PKA)
  • cGMP-Dependent Protein Kinase
12 IC50
  • 4-(1H-indol-3-yl)pyrimidin-2-amine
  • Meridianin G
  • Chitinase (chiA1)
  • Chitinase 1
  • Chitinase B
  • Chitinase Mutant (A217G)
  • Chitinase Mutant (D175A)
  • Chitinase Mutant (E322A)
  • Chitinase Mutant (M243A)
  • Chitinase Mutant (R301K)
  • Chitinase Mutant (T138A)
  • Endochitinase B1
1 Ki 5 IC50 7 Kd
  • (2R,5S,8S,11S,15S)-8-benzyl-2,7-dimethyl-5-[3-({[(methylcarbamoyl)amino]methanimidoyl}amino)propyl]-3,6,9,13,17-pentaoxo-1,4,7,10,14-pentaazacycloheptadecane-11,15-dicarboxylic acid
  • Argifin
  • Chitinase 1
  • Chitinase B
  • Chitinase Mutant (A217G)
  • Chitinase Mutant (D175A)
  • Chitinase Mutant (E322A)
  • Chitinase Mutant (M243A)
  • Chitinase Mutant (R301K)
  • Chitinase Mutant (T138A)
  • Chitinase Mutant (Y245F)
  • Endochitinase B1
1 Ki 3 IC50 8 Kd
  • 4-[(1S,4R,10S,13S,16S,18R)-10-{3-[(acetamidomethanimidoyl)amino]propyl}-18-hydroxy-16-(1H-imidazol-4-ylmethyl)-3,9,12,15,20-pentaoxo-2,8,11,14,17-pentaazatricyclo[15.2.1.0^{4,8}]icosan-13-yl]butanoic acid
  • Argadin
  • CHEMBL445236
  • 1,3-beta-glucan synthase component GLS2
  • 5-hydroxytryptamine receptor 1A
  • Alpha-1A adrenergic receptor
  • Axin-1/Glycogen synthase kinase-3 beta
  • Cytochrome P450 3A
  • Dopamine receptor
  • Mitogen-activated protein kinase kinase kinase kinase 4
  • Serine/threonine-protein kinase pim-1
  • Serine/threonine-protein kinase pim-2
  • Serine/threonine-protein kinase pim-3
5 Ki 9 IC50
  • US8614206, 139
  • 72 kDa type IV collagenase
  • Carbonic Anhydrase IV
  • Carbonic anhydrase 1
  • Carbonic anhydrase 2
  • Collagenase (ChC)
  • Interstitial collagenase
  • Matrix metalloproteinase 12
  • Matrix metalloproteinase-9
  • Neutrophil collagenase
  • Stromelysin-1
11 Ki 2 IC50
  • 2-[benzyl(4-methoxybenzene)sulfonamido]-N-hydroxypropanamide
  • CHEMBL316169
  • Hydroxamate 18
  • Cytochrome P450 1A
  • Cytochrome P450 2A6
  • Cytochrome P450 2B6
  • Cytochrome P450 2C19
  • Cytochrome P450 2C8
  • Cytochrome P450 2C9
  • Cytochrome P450 2D6 (2D6)
  • Cytochrome P450 2E1
  • Cytochrome P450 3A
  • Dipeptidyl peptidase 4
1 Ki 20 IC50
  • (1S,3S,5S)-2-[(2S)-2-amino-2-(3,5-dihydroxyadamantan-1-yl)acetyl]-2-azabicyclo[3.1.0]hexane-3-carbonitrile; 2,2,2-trifluoroacetic acid
  • (S)-3,5-Dihydroxyadamantylglycine-L-cis-4,5-methanoprolinenitrile TFA salt
  • BMS-477118
  • Saxagliptin analogue 28
  • Anthrax Lethal Factor (LF)
  • DNA (cytosine-5)-methyltransferase 1
  • DNA (cytosine-5)-methyltransferase 1 (DNMT1)
  • DNA (cytosine-5)-methyltransferase 3-like
  • DNA (cytosine-5)-methyltransferase 3B
  • DNMT3B-DNMT3L complex
  • Genome polyprotein
  • HTH-type transcriptional regulator mgrA (MgrA)
  • Human immunodeficiency virus type 1 integrase
  • Protein-tyrosine phosphatase 1B
1 Ki 18 IC50
  • 5-[(3-carboxy-4-hydroxyphenyl)methyl]-2-hydroxybenzoic acid
  • CHEMBL115145
  • MgrA inhibitor, 1
  • chemical diversity library compound 4
  • 72 kDa type IV collagenase
  • Collagenase 3
  • Interstitial collagenase
  • Matrix metalloproteinase 10
  • Matrix metalloproteinase 14
  • Matrix metalloproteinase-12 (MMP12)
  • Matrix metalloproteinase-7 (MMP7)
  • Matrix metalloproteinase-9
  • Neutrophil collagenase
  • Stromelysin-1
10 Ki
  • US8691753, 3
  • 72 kDa type IV collagenase
  • Collagenase 3
  • Interstitial collagenase
  • Matrix metalloproteinase 10
  • Matrix metalloproteinase 14
  • Matrix metalloproteinase-12 (MMP12)
  • Matrix metalloproteinase-7 (MMP7)
  • Matrix metalloproteinase-9
  • Neutrophil collagenase
  • Stromelysin-1
10 Ki
  • US8691753, 14
  • 72 kDa type IV collagenase
  • Collagenase 3
  • Interstitial collagenase
  • Matrix metalloproteinase 10
  • Matrix metalloproteinase 14
  • Matrix metalloproteinase-12 (MMP12)
  • Matrix metalloproteinase-7 (MMP7)
  • Matrix metalloproteinase-9
  • Neutrophil collagenase
  • Stromelysin-1
10 Ki
  • US8691753, 40
  • 72 kDa type IV collagenase
  • Collagenase 3
  • Interstitial collagenase
  • Matrix metalloproteinase 10
  • Matrix metalloproteinase 14
  • Matrix metalloproteinase-12 (MMP12)
  • Matrix metalloproteinase-7 (MMP7)
  • Matrix metalloproteinase-9
  • Neutrophil collagenase
  • Stromelysin-1
18 Ki
  • US8691753, 61
  • US8691753, 72
  • 72 kDa type IV collagenase
  • Collagenase 3
  • Interstitial collagenase
  • Matrix metalloproteinase 10
  • Matrix metalloproteinase 14
  • Matrix metalloproteinase-12 (MMP12)
  • Matrix metalloproteinase-7 (MMP7)
  • Matrix metalloproteinase-9
  • Neutrophil collagenase
  • Stromelysin-1
10 Ki
  • US8691753, 80
  • 72 kDa type IV collagenase
  • Collagenase 3
  • Interstitial collagenase
  • Matrix metalloproteinase 10
  • Matrix metalloproteinase 14
  • Matrix metalloproteinase-12 (MMP12)
  • Matrix metalloproteinase-7 (MMP7)
  • Matrix metalloproteinase-9
  • Neutrophil collagenase
  • Stromelysin-1
18 Ki
  • US8691753, 95
  • US8691753, 96
  • 72 kDa type IV collagenase
  • Collagenase 3
  • Interstitial collagenase
  • Matrix metalloproteinase 10
  • Matrix metalloproteinase 14
  • Matrix metalloproteinase-12 (MMP12)
  • Matrix metalloproteinase-7 (MMP7)
  • Matrix metalloproteinase-9
  • Neutrophil collagenase
  • Stromelysin-1
10 Ki
  • US8691753, 99
  • 72 kDa type IV collagenase
  • Collagenase 3
  • Interstitial collagenase
  • Matrix metalloproteinase 10
  • Matrix metalloproteinase 14
  • Matrix metalloproteinase-12 (MMP12)
  • Matrix metalloproteinase-7 (MMP7)
  • Matrix metalloproteinase-9
  • Neutrophil collagenase
  • Stromelysin-1
10 Ki
  • US8691753, 101
  • 72 kDa type IV collagenase
  • Collagenase 3
  • Interstitial collagenase
  • Matrix metalloproteinase 10
  • Matrix metalloproteinase 14
  • Matrix metalloproteinase-12 (MMP12)
  • Matrix metalloproteinase-7 (MMP7)
  • Matrix metalloproteinase-9
  • Neutrophil collagenase
  • Stromelysin-1
10 Ki
  • US8691753, 103
  • 72 kDa type IV collagenase
  • Collagenase 3
  • Interstitial collagenase
  • Matrix metalloproteinase 10
  • Matrix metalloproteinase 14
  • Matrix metalloproteinase-12 (MMP12)
  • Matrix metalloproteinase-7 (MMP7)
  • Matrix metalloproteinase-9
  • Neutrophil collagenase
  • Stromelysin-1
10 Ki
  • US8691753, 106
  • 72 kDa type IV collagenase
  • Collagenase 3
  • Interstitial collagenase
  • Matrix metalloproteinase 10
  • Matrix metalloproteinase 14
  • Matrix metalloproteinase-12 (MMP12)
  • Matrix metalloproteinase-7 (MMP7)
  • Matrix metalloproteinase-9
  • Neutrophil collagenase
  • Stromelysin-1
10 Ki
  • US8691753, 95 bis
  • CDK2/CycE
  • Cyclin-Dependent Kinase 1 (CDK1)
  • Cyclin-Dependent Kinase 4 (CDK4)
  • Cyclin-Dependent Kinase 7 (CDK7)
  • Cyclin-Dependent Kinase 9 (CDK9)
  • Cyclin-dependent kinase 1
  • Cyclin-dependent kinase 2
  • Cyclin-dependent kinase 4
  • Cyclin-dependent kinase 7
  • Cyclin-dependent kinase 9
10 IC50
  • AAP1742
  • Carbonic anhydrase
  • Carbonic anhydrase 1
  • Carbonic anhydrase 12
  • Carbonic anhydrase 13 (CA XIII)
  • Carbonic anhydrase 2
  • Carbonic anhydrase 4
  • Carbonic anhydrase 6 (CA-VI)
  • Carbonic anhydrase 7
  • Carbonic anhydrase I
  • LDL-associated phospholipase A2
14 Ki 2 IC50 10 Kd
  • CHEMBL27601
  • benzenesulfonamide
  • hCA inhibitor, 6
  • Coagulation factor IX
  • Coagulation factor VII
  • Coagulation factor X
  • Coagulation factor XI
  • Plasma kallikrein
  • Plasminogen
  • Prothrombin
  • Tissue-type plasminogen activator
  • Trypsin
  • Vitamin K-dependent protein C
31 Ki
  • 1-(3-Aminobenzisoxazol-5-yl)-3-trifluoromethyl-N-[2-fluoro-4-[(2-dimethylaminomethyl)imidazol-1-yl]phenyl]-1H-pyrazole-5-carboxyamide Hydrochloride Salt
  • 1-(3-amino-1,2-benzoxazol-5-yl)-N-(4-{2-[(dimethylamino)methyl]-1H-imidazol-1-yl}-2-fluorophenyl)-3-(trifluoromethyl)-1H-pyrazole-5-carboxamide
  • BMS-561389
  • CHEMBL206335
  • CHEMBL558198
  • DPC 906
  • Razaxaban
  • High affinity nerve growth factor receptor
  • JAK1 (aa 866-1154)
  • JAK2 (aa 808-1132)
  • JAK3 (aa 781-1124)
  • Non-receptor tyrosine-protein kinase TYK2
  • Tyk2
  • Tyrosine-protein kinase JAK1
  • Tyrosine-protein kinase JAK1 (866-1154)
  • Tyrosine-protein kinase JAK2
  • Tyrosine-protein kinase JAK3
32 IC50
  • US10251889, Example 30
  • US10758542, Example 30
  • US8791123, 30
  • US9782415, Example 30
  • US9796724, Example 30
  • High affinity nerve growth factor receptor
  • JAK1 (aa 866-1154)
  • JAK2 (aa 808-1132)
  • JAK3 (aa 781-1124)
  • Non-receptor tyrosine-protein kinase TYK2
  • Tyk2
  • Tyrosine-protein kinase JAK1
  • Tyrosine-protein kinase JAK1 (866-1154)
  • Tyrosine-protein kinase JAK2
  • Tyrosine-protein kinase JAK3
32 IC50
  • US10251889, Example 52
  • US10758542, Example 52
  • US8791123, 52
  • US9782415, Example 52
  • US9796724, Example 52
  • High affinity nerve growth factor receptor
  • JAK1 (aa 866-1154)
  • JAK2 (aa 808-1132)
  • JAK3 (aa 781-1124)
  • Non-receptor tyrosine-protein kinase TYK2
  • Tyk2
  • Tyrosine-protein kinase JAK1
  • Tyrosine-protein kinase JAK1 (866-1154)
  • Tyrosine-protein kinase JAK2
  • Tyrosine-protein kinase JAK3
32 IC50
  • US10251889, Example 91
  • US10758542, Example 91
  • US8791123, 91
  • US9782415, Example 91
  • US9796724, Example 91
  • High affinity nerve growth factor receptor
  • JAK1 (aa 866-1154)
  • JAK2 (aa 808-1132)
  • JAK3 (aa 781-1124)
  • Non-receptor tyrosine-protein kinase TYK2
  • Tyk2
  • Tyrosine-protein kinase JAK1
  • Tyrosine-protein kinase JAK1 (866-1154)
  • Tyrosine-protein kinase JAK2
  • Tyrosine-protein kinase JAK3
32 IC50
  • US10251889, Example 93
  • US10758542, Example 93
  • US8791123, 93
  • US9782415, Example 93
  • US9796724, Example 93
  • High affinity nerve growth factor receptor
  • JAK1 (aa 866-1154)
  • JAK2 (aa 808-1132)
  • JAK3 (aa 781-1124)
  • Non-receptor tyrosine-protein kinase TYK2
  • Tyk2
  • Tyrosine-protein kinase JAK1
  • Tyrosine-protein kinase JAK1 (866-1154)
  • Tyrosine-protein kinase JAK2
  • Tyrosine-protein kinase JAK3
32 IC50
  • US10251889, Example 98
  • US10758542, Example 98
  • US8791123, 98
  • US9782415, Example 98
  • US9796724, Example 98
  • High affinity nerve growth factor receptor
  • JAK1 (aa 866-1154)
  • JAK2 (aa 808-1132)
  • JAK3 (aa 781-1124)
  • Non-receptor tyrosine-protein kinase TYK2
  • Tyk2
  • Tyrosine-protein kinase JAK1
  • Tyrosine-protein kinase JAK1 (866-1154)
  • Tyrosine-protein kinase JAK2
  • Tyrosine-protein kinase JAK3
32 IC50
  • US10251889, Example 106
  • US10758542, Example 106
  • US8791123, 106
  • US9782415, Example 106
  • US9796724, Example 106
  • High affinity nerve growth factor receptor
  • JAK1 (aa 866-1154)
  • JAK2 (aa 808-1132)
  • JAK3 (aa 781-1124)
  • Non-receptor tyrosine-protein kinase TYK2
  • Tyk2
  • Tyrosine-protein kinase JAK1
  • Tyrosine-protein kinase JAK1 (866-1154)
  • Tyrosine-protein kinase JAK2
  • Tyrosine-protein kinase JAK3
32 IC50
  • US10251889, Example 114
  • US10758542, Example 114
  • US8791123, 114
  • US9782415, Example 114
  • US9796724, Example 114
  • High affinity nerve growth factor receptor
  • JAK1 (aa 866-1154)
  • JAK2 (aa 808-1132)
  • JAK3 (aa 781-1124)
  • Non-receptor tyrosine-protein kinase TYK2
  • Tyk2
  • Tyrosine-protein kinase JAK1
  • Tyrosine-protein kinase JAK1 (866-1154)
  • Tyrosine-protein kinase JAK2
  • Tyrosine-protein kinase JAK3
32 IC50
  • US10251889, Example 123
  • US10758542, Example 123
  • US8791123, 123
  • US9782415, Example 123
  • US9796724, Example 123
  • High affinity nerve growth factor receptor
  • JAK1 (aa 866-1154)
  • JAK2 (aa 808-1132)
  • JAK3 (aa 781-1124)
  • Non-receptor tyrosine-protein kinase TYK2
  • Tyk2
  • Tyrosine-protein kinase JAK1
  • Tyrosine-protein kinase JAK1 (866-1154)
  • Tyrosine-protein kinase JAK2
  • Tyrosine-protein kinase JAK3
32 IC50
  • US10251889, Example 124
  • US10758542, Example 124
  • US8791123, 124
  • US9782415, Example 124
  • US9796724, Example 124
  • High affinity nerve growth factor receptor
  • JAK1 (aa 866-1154)
  • JAK2 (aa 808-1132)
  • JAK3 (aa 781-1124)
  • Non-receptor tyrosine-protein kinase TYK2
  • Tyk2
  • Tyrosine-protein kinase JAK1
  • Tyrosine-protein kinase JAK1 (866-1154)
  • Tyrosine-protein kinase JAK2
  • Tyrosine-protein kinase JAK3
32 IC50
  • US10251889, Example 140
  • US10758542, Example 140
  • US8791123, 140
  • US9782415, Example 140
  • US9796724, Example 140
  • High affinity nerve growth factor receptor
  • JAK1 (aa 866-1154)
  • JAK2 (aa 808-1132)
  • JAK3 (aa 781-1124)
  • Non-receptor tyrosine-protein kinase TYK2
  • Tyk2
  • Tyrosine-protein kinase JAK1
  • Tyrosine-protein kinase JAK1 (866-1154)
  • Tyrosine-protein kinase JAK2
  • Tyrosine-protein kinase JAK3
25 IC50
  • US10758542, Example 190
  • US8791123, 190
  • US9782415, Example 190
  • US9796724, Example 190
  • High affinity nerve growth factor receptor
  • JAK1 (aa 866-1154)
  • JAK2 (aa 808-1132)
  • JAK3 (aa 781-1124)
  • Non-receptor tyrosine-protein kinase TYK2
  • Tyk2
  • Tyrosine-protein kinase JAK1
  • Tyrosine-protein kinase JAK1 (866-1154)
  • Tyrosine-protein kinase JAK2
  • Tyrosine-protein kinase JAK3
40 IC50
  • US10251889, Example 195
  • US10758542, Example 194
  • US8791123, 194
  • US9782415, Example 194
  • US9796724, Example 194
  • Cyclin-dependent kinase 2
  • Cyclin-dependent kinase 4
  • Proto-oncogene tyrosine-protein kinase Src
  • Receptor tyrosine-protein kinase erbB-2
  • Tyrosine-protein kinase Fgr
  • Tyrosine-protein kinase Fyn
  • Tyrosine-protein kinase HCK
  • Tyrosine-protein kinase JAK3
  • Tyrosine-protein kinase Lck
  • Vascular endothelial growth factor receptor 2
10 IC50
  • BMS-354825 2-Heteroarylamino-thiazole Analog 12m
  • CHEMBL364623
  • N-(2-Chloro-6-methylphenyl)-2-[(2,6-dimethyl-4-pyrimidinyl)-amino]-1,3-thiazole-5-carboxamide
  • N-(2-chloro-6-methylphenyl)-2-[(2,6-dimethylpyrimidin-4-yl)amino]-1,3-thiazole-5-carboxamide
  • Axin-1/Glycogen synthase kinase-3 beta
  • CDK2/Cyclin E/G1/S-specific cyclin E2
  • Cyclin B/Cyclin-Dependent Kinase 1 (CDK1)/G2/mitotic-specific cyclin B2/G2/mitotic-specific cyclin B3
  • Cyclin-Dependent Kinase 4 (CDK4)
  • Mixed Lineage Kinase 1 (MLK1)
  • Mixed Lineage Kinase 3 (MLK3)
  • PKC alpha and beta-2
  • Protein kinase C alpha type
  • Protein kinase C, gamma
  • cAMP-dependent protein kinase (PKA)
10 IC50
  • 3,13-diazahexacyclo[14.8.0.0^{2,10}.0^{4,9}.0^{11,15}.0^{17,22}]tetracosa-1(16),2(10),4(9),5,7,11(15),17(22),18,20,23-decaene-12,14-dione
  • 6H,14H-Naphthyl[3,4-a]pyrrolo[3,4-c]carbazole-5,7(5H,7H)-dione
  • CHEMBL332575
  • Imide Analog 12
  • Beta-secretase 1
  • Coagulation factor III/Factor VIIa (fVIIa)
  • Neutrophil cytosol factor 1
  • Nitric oxide synthase, brain
  • Nitric oxide synthase, endothelial
  • Nitric oxide synthase, inducible
  • Trypsin
  • Tryptase
  • Tyrosine-protein kinase TEC
  • Urokinase-type plasminogen activator
5 Ki 4 IC50 2 Kd 1 Other
  • 1-amino-isoquinoline
  • CHEMBL62083
  • Fragment 17
  • fragment 1 (J. med. chem.,50,1116)
  • isoquinolin-1-amine
  • Nitric Oxide Synthase, brain Mutant (D597N)
  • Nitric Oxide Synthase, endothelial
  • Nitric Oxide Synthase, inducible
  • Nitric oxide synthase (bsNOS)
  • Nitric oxide synthase mutant (nNOS M336V/D597N)
  • Nitric oxide synthase, brain
  • Nitric oxide synthase, endothelial
  • Nitric oxide synthase, inducible
  • Nitric-oxide synthase, brain
  • Nitric-oxide synthase, endothelial
18 Ki 1 Kd
  • 4-methyl-6-[2-(5-{methyl[2-(methylamino)ethyl]amino}pyridin-3-yl)ethyl]pyridin-2-amine (14)
  • US10759791, Compound 5
  • US9951014, Name 14b
  • nNOS inhibitor, 2
  • Phosphodiesterase (TcrPDEC)
  • Phosphodiesterase 1
  • Phosphodiesterase 2A
  • Phosphodiesterase 3
  • Phosphodiesterase 3 (PDE3)
  • Phosphodiesterase 4
  • Phosphodiesterase Type 3 (PDE3A)
  • Phosphodiesterase Type 3 (PDE3B)
  • cGMP-inhibited 3',5'-cyclic phosphodiesterase B
  • cGMP-specific 3',5'-cyclic phosphodiesterase
11 IC50
  • CHEMBL34431
  • Cilostamide
  • N-Cyclohexyl-N-methyl-4-(2-oxo-1,2-dihydro-quinolin-6-yloxy)-butyramide
  • N-cyclohexyl-N-methyl-4-[(2-oxo-1,2-dihydroquinolin-6-yl)oxy]butanamide
  • Chromobox protein homolog 7 (CBX7)
  • E3 ubiquitin-protein ligase (UHRF1)
  • Lethal(3)malignant brain tumor-like protein 1 (L3MBTL1)
  • Lysine-specific demethylase 5A
  • MBT domain-containing protein 1 (MBTD1)
  • Methyl-lysine binding protein (53BP1)
  • PHD finger protein 1 (PHF1)
  • PHD finger protein 19 (PHF19)
  • PHD finger protein 23 (PHF23)
  • Tumor suppressor p53-binding protein 1
10 IC50 2 Kd
  • 3-Bromo-N-(3-(tert-butylamino)propyl)benzamide (UNC2170, 1)
  • Chromobox protein homolog 7 (CBX7)
  • E3 ubiquitin-protein ligase (UHRF1)
  • Lethal(3)malignant brain tumor-like protein 1 (L3MBTL1)
  • Lethal(3)malignant brain tumor-like protein 3 (L3MBTL3)
  • Lysine-specific demethylase 5A
  • MBT domain-containing protein 1 (MBTD1)
  • Methyl-lysine binding protein (53BP1)
  • PHD finger protein 1 (PHF1)
  • PHD finger protein 19 (PHF19)
  • PHD finger protein 23 (PHF23)
10 IC50
  • 3-Bromo-N-(3-(tert-butylamino)propyl)benzenesulfonamide (7)
  • Chromobox protein homolog 7 (CBX7)
  • E3 ubiquitin-protein ligase (UHRF1)
  • Lethal(3)malignant brain tumor-like protein 1 (L3MBTL1)
  • Lethal(3)malignant brain tumor-like protein 3 (L3MBTL3)
  • Lysine-specific demethylase 5A
  • MBT domain-containing protein 1 (MBTD1)
  • Methyl-lysine binding protein (53BP1)
  • PHD finger protein 1 (PHF1)
  • PHD finger protein 19 (PHF19)
  • PHD finger protein 23 (PHF23)
10 IC50
  • N1-(3-Bromobenzyl)-N3-(tert-butyl)propane-1,3-diamine (8)
  • Chromobox protein homolog 7 (CBX7)
  • E3 ubiquitin-protein ligase (UHRF1)
  • Lethal(3)malignant brain tumor-like protein 1 (L3MBTL1)
  • Lethal(3)malignant brain tumor-like protein 3 (L3MBTL3)
  • Lysine-specific demethylase 5A
  • MBT domain-containing protein 1 (MBTD1)
  • Methyl-lysine binding protein (53BP1)
  • PHD finger protein 1 (PHF1)
  • PHD finger protein 19 (PHF19)
  • PHD finger protein 23 (PHF23)
10 IC50
  • (3-Bromophenyl)(3-(tert-butyl)imidazolidin-1-yl)methanone (9)
  • Chromobox protein homolog 7 (CBX7)
  • E3 ubiquitin-protein ligase (UHRF1)
  • Lethal(3)malignant brain tumor-like protein 1 (L3MBTL1)
  • Lethal(3)malignant brain tumor-like protein 3 (L3MBTL3)
  • Lysine-specific demethylase 5A
  • MBT domain-containing protein 1 (MBTD1)
  • Methyl-lysine binding protein (53BP1)
  • PHD finger protein 1 (PHF1)
  • PHD finger protein 19 (PHF19)
  • PHD finger protein 23 (PHF23)
10 IC50
  • (3-Bromophenyl)(4-(tert-butyl)piperazin-1-yl)methanone (10)
  • Chromobox protein homolog 7 (CBX7)
  • E3 ubiquitin-protein ligase (UHRF1)
  • Lethal(3)malignant brain tumor-like protein 1 (L3MBTL1)
  • Lethal(3)malignant brain tumor-like protein 3 (L3MBTL3)
  • Lysine-specific demethylase 5A
  • MBT domain-containing protein 1 (MBTD1)
  • Methyl-lysine binding protein (53BP1)
  • PHD finger protein 1 (PHF1)
  • PHD finger protein 19 (PHF19)
  • PHD finger protein 23 (PHF23)
10 IC50
  • 3-Bromo-N-(4-(tert-butylamino)butyl)benzamide (11)
  • Chromobox protein homolog 7 (CBX7)
  • E3 ubiquitin-protein ligase (UHRF1)
  • Lethal(3)malignant brain tumor-like protein 1 (L3MBTL1)
  • Lethal(3)malignant brain tumor-like protein 3 (L3MBTL3)
  • Lysine-specific demethylase 5A
  • MBT domain-containing protein 1 (MBTD1)
  • Methyl-lysine binding protein (53BP1)
  • PHD finger protein 1 (PHF1)
  • PHD finger protein 19 (PHF19)
  • PHD finger protein 23 (PHF23)
10 IC50
  • 3-Bromo-N-(5-(tert-butylamino)pentyl)benzamide (12)
  • Chromobox protein homolog 7 (CBX7)
  • E3 ubiquitin-protein ligase (UHRF1)
  • Lethal(3)malignant brain tumor-like protein 1 (L3MBTL1)
  • Lethal(3)malignant brain tumor-like protein 3 (L3MBTL3)
  • Lysine-specific demethylase 5A
  • MBT domain-containing protein 1 (MBTD1)
  • Methyl-lysine binding protein (53BP1)
  • PHD finger protein 1 (PHF1)
  • PHD finger protein 19 (PHF19)
  • PHD finger protein 23 (PHF23)
10 IC50
  • 3-Bromo-N-(2-(tert-butylamino)ethyl)benzamide (13)
  • Chromobox protein homolog 7 (CBX7)
  • E3 ubiquitin-protein ligase (UHRF1)
  • Lethal(3)malignant brain tumor-like protein 1 (L3MBTL1)
  • Lethal(3)malignant brain tumor-like protein 3 (L3MBTL3)
  • Lysine-specific demethylase 5A
  • MBT domain-containing protein 1 (MBTD1)
  • Methyl-lysine binding protein (53BP1)
  • PHD finger protein 1 (PHF1)
  • PHD finger protein 19 (PHF19)
  • PHD finger protein 23 (PHF23)
10 IC50
  • N-(3-(Tert-butylamino)propyl)benzamide (14)
  • Chromobox protein homolog 7 (CBX7)
  • E3 ubiquitin-protein ligase (UHRF1)
  • Lethal(3)malignant brain tumor-like protein 1 (L3MBTL1)
  • Lethal(3)malignant brain tumor-like protein 3 (L3MBTL3)
  • Lysine-specific demethylase 5A
  • MBT domain-containing protein 1 (MBTD1)
  • Methyl-lysine binding protein (53BP1)
  • PHD finger protein 1 (PHF1)
  • PHD finger protein 19 (PHF19)
  • PHD finger protein 23 (PHF23)
10 IC50
  • 4-Bromo-N-(3-(tert-butylamino)propyl)benzamide (15)
  • Chromobox protein homolog 7 (CBX7)
  • E3 ubiquitin-protein ligase (UHRF1)
  • Lethal(3)malignant brain tumor-like protein 1 (L3MBTL1)
  • Lethal(3)malignant brain tumor-like protein 3 (L3MBTL3)
  • Lysine-specific demethylase 5A
  • MBT domain-containing protein 1 (MBTD1)
  • Methyl-lysine binding protein (53BP1)
  • PHD finger protein 1 (PHF1)
  • PHD finger protein 19 (PHF19)
  • PHD finger protein 23 (PHF23)
10 IC50
  • 2-Bromo-N-(3-(tert-butylamino)propyl)benzamide (16)
  • Chromobox protein homolog 7 (CBX7)
  • E3 ubiquitin-protein ligase (UHRF1)
  • Lethal(3)malignant brain tumor-like protein 1 (L3MBTL1)
  • Lethal(3)malignant brain tumor-like protein 3 (L3MBTL3)
  • Lysine-specific demethylase 5A
  • MBT domain-containing protein 1 (MBTD1)
  • Methyl-lysine binding protein (53BP1)
  • PHD finger protein 1 (PHF1)
  • PHD finger protein 19 (PHF19)
  • PHD finger protein 23 (PHF23)
10 IC50
  • N-(3-(Tert-butylamino)propyl)-3-chlorobenzamide (17)
  • Chromobox protein homolog 7 (CBX7)
  • E3 ubiquitin-protein ligase (UHRF1)
  • Lethal(3)malignant brain tumor-like protein 1 (L3MBTL1)
  • Lethal(3)malignant brain tumor-like protein 3 (L3MBTL3)
  • Lysine-specific demethylase 5A
  • MBT domain-containing protein 1 (MBTD1)
  • Methyl-lysine binding protein (53BP1)
  • PHD finger protein 1 (PHF1)
  • PHD finger protein 19 (PHF19)
  • PHD finger protein 23 (PHF23)
10 IC50
  • N-(3-(Tert-butylamino)propyl)-3-fluorobenzamide (18)
  • Chromobox protein homolog 7 (CBX7)
  • E3 ubiquitin-protein ligase (UHRF1)
  • Lethal(3)malignant brain tumor-like protein 1 (L3MBTL1)
  • Lethal(3)malignant brain tumor-like protein 3 (L3MBTL3)
  • Lysine-specific demethylase 5A
  • MBT domain-containing protein 1 (MBTD1)
  • Methyl-lysine binding protein (53BP1)
  • PHD finger protein 1 (PHF1)
  • PHD finger protein 19 (PHF19)
  • PHD finger protein 23 (PHF23)
10 IC50
  • N-(3-(Tert-butylamino)propyl)-4-(trifluoromethyl)benzamide (22)
  • Chromobox protein homolog 7 (CBX7)
  • E3 ubiquitin-protein ligase (UHRF1)
  • Lethal(3)malignant brain tumor-like protein 1 (L3MBTL1)
  • Lethal(3)malignant brain tumor-like protein 3 (L3MBTL3)
  • Lysine-specific demethylase 5A
  • MBT domain-containing protein 1 (MBTD1)
  • Methyl-lysine binding protein (53BP1)
  • PHD finger protein 1 (PHF1)
  • PHD finger protein 19 (PHF19)
  • PHD finger protein 23 (PHF23)
10 IC50
  • N-(3-(Tert-butylamino)propyl)-3-nitrobenzamide (23)
  • Chromobox protein homolog 7 (CBX7)
  • E3 ubiquitin-protein ligase (UHRF1)
  • Lethal(3)malignant brain tumor-like protein 1 (L3MBTL1)
  • Lethal(3)malignant brain tumor-like protein 3 (L3MBTL3)
  • Lysine-specific demethylase 5A
  • MBT domain-containing protein 1 (MBTD1)
  • Methyl-lysine binding protein (53BP1)
  • PHD finger protein 1 (PHF1)
  • PHD finger protein 19 (PHF19)
  • PHD finger protein 23 (PHF23)
10 IC50
  • 4-Bromo-N-(3-(tert-butylamino)propyl)picolinamide (24)
  • Chromobox protein homolog 7 (CBX7)
  • E3 ubiquitin-protein ligase (UHRF1)
  • Lethal(3)malignant brain tumor-like protein 1 (L3MBTL1)
  • Lethal(3)malignant brain tumor-like protein 3 (L3MBTL3)
  • Lysine-specific demethylase 5A
  • MBT domain-containing protein 1 (MBTD1)
  • Methyl-lysine binding protein (53BP1)
  • PHD finger protein 1 (PHF1)
  • PHD finger protein 19 (PHF19)
  • PHD finger protein 23 (PHF23)
10 IC50
  • N-(3-(Tert-butylamino)propyl)-4-(trifluoromethyl)picolinamide (25)
  • CDK4/CDK1
  • Cyclin-dependent kinase 2
  • Cyclin-dependent protein kinase 2 (CDK2 A144G)
  • Cyclin-dependent protein kinase 2 (CDK2 C118I)
  • Cyclin-dependent protein kinase 2 (CDK2 F80M)
  • Cyclin-dependent protein kinase 2 (CDK2 F80T)
  • Cyclin-dependent protein kinase 2 (CDK2 WT)
  • Cyclin-dependent protein kinase 2 variant (CDK2 A144C)
  • Cyclin-dependent protein kinase 2 variant (CDK2 C118L)
  • Cyclin-dependent protein kinase 2 variant (CDK2 C118L/A144C)
8 IC50 6 Kd
4 ΔG°
  • K03861 (1)
  • Cytochrome P450 1A
  • Cytochrome P450 1A1
  • Cytochrome P450 2C19
  • Cytochrome P450 2C8
  • Cytochrome P450 2C9
  • Cytochrome P450 2D6
  • Cytochrome P450 2D6 (2D6)
  • H3K27me2
  • H3K27me3
  • Histone-lysine N-methyltransferase EZH2
13 IC50
  • US10098888, Compound 105
  • US9006242, 105
  • Dual specificity protein kinase TTK
  • IRE1α
  • Interferon-induced, double-stranded RNA-activated protein kinase
  • Mitogen-activated protein kinase 10
  • Mitogen-activated protein kinase 14
  • Mitogen-activated protein kinase 8
  • Mitogen-activated protein kinase 9
  • TPA: Essential protein of the mitochondrial intermembrane space
  • Tyrosine-protein kinase JAK3
  • c-Jun N-terminal kinase, JNK
19 IC50 3 Kd
  • 14,15-diazatetracyclo[7.6.1.0^{2,7}.0^{13,16}]hexadeca-1(15),2(7),3,5,9(16),10,12-heptaen-8-one
  • CHEMBL7064
  • ChemBiol10705 Compound 4
  • JMC517015 Compound 2
  • SP 600125
  • SP-600125
  • SP600125
  • cid_8515
  • dibenzo[cd,g]indazol-6(2H)-one
  • Caspase-1
  • Caspase-10
  • Caspase-2
  • Caspase-3
  • Caspase-4
  • Caspase-5
  • Caspase-6
  • Caspase-7
  • Caspase-8
  • Caspase-9
20 IC50
  • US10167313, Compound 53
  • US9045524, 53
  • Caspase-1
  • Caspase-10
  • Caspase-2
  • Caspase-3
  • Caspase-4
  • Caspase-5
  • Caspase-6
  • Caspase-7
  • Caspase-8
  • Caspase-9
10 IC50
  • US9045524, 111
  • Caspase-1
  • Caspase-10
  • Caspase-2
  • Caspase-3
  • Caspase-4
  • Caspase-5
  • Caspase-6
  • Caspase-7
  • Caspase-8
  • Caspase-9
10 IC50
  • US9045524, 123
  • 1,3-beta-glucan synthase component GLS2
  • ATP-sensitive inward rectifier potassium channel 1
  • Cytochrome P450 2C9
  • Cytochrome P450 2D6 (2D6)
  • Cytochrome P450 3A
  • Inward rectifier potassium channel 2
  • Inward rectifier potassium channel 4
  • Renal Outer Medullary Potassium (ROMK)
  • Sodium channel protein type 2 alpha subunit
  • Voltage-gated calcium channel
13 IC50
  • US9056859, 72
  • Axin-1/Glycogen synthase kinase-3 beta
  • Cyclin-dependent kinase 1
  • Cyclin-dependent kinase 2
  • Cyclin-dependent kinase 3 (CDK3)
  • Cyclin-dependent kinase 6
  • Cyclin-dependent kinase 7
  • Cyclin-dependent kinase 9
  • Cyclin-dependent-like kinase 5
  • Glycogen synthase kinase-3
  • Interleukin-1 receptor-associated kinase 1
10 IC50
  • US9067888, 34
  • Angiopoietin-1 receptor
  • Fibroblast growth factor receptor 1
  • Insulin-like growth factor I receptor
  • Macrophage colony-stimulating factor 1 receptor (CSF1R)
  • Mast/stem cell growth factor receptor Kit
  • Mitogen-activated protein kinase 14
  • Mitogen-activated protein kinase 8
  • Proto-oncogene tyrosine-protein kinase Src
  • Tyrosine-protein kinase Lck
  • Vascular endothelial growth factor receptor 2
1 Ki 10 IC50
  • 2-aminobenzoxazole, 22
  • 4-({2-[(4-chloro-3-{[(2S)-1-methylpyrrolidin-2-yl]methoxy}phenyl)amino]-1,3-benzoxazol-5-yl}oxy)-N-methylpyridine-2-carboxamide
  • Cereblon/BCR/ABL
  • Ephrin type-A receptor 2 (EPHA2)
  • Epidermal growth factor receptor
  • Ferrochelatase R115L (FECH)
  • Proto-oncogene tyrosine-protein kinase receptor Ret
  • Serine/threonine-protein kinase D2
  • Serine/threonine-protein kinase GAK
  • Serine/threonine-protein kinase SIK2
  • Tyrosine kinase non-receptor protein 2
  • Tyrosine-protein kinase ABL2
10 Kd
  • (3R,4R)-4-amino-1-[[4-(3-methoxyanilino)pyrrolo[2,1-f][1,2,4]triazin-5-yl]methyl]piperidin-3-ol
  • BMS-690514
  • Peptidyl-prolyl cis-trans isomerase FKBP1B/Serine/threonine-protein kinase mTOR
  • Phosphatidylinositol 3-kinase catalytic subunit type 3
  • Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform
  • Phosphatidylinositol 4-kinase alpha (PI4KA)
  • Phosphatidylinositol 4-kinase beta
  • Phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit alpha
  • Phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit beta
  • Phosphoinositide 3-Kinase (PI3K), delta
  • Tyrosine-protein kinase STK16 (STK16)
  • p110α/p85α
10 IC50
  • STK16-IN-1
  • Dihydrofolate Reductase (DHFR)
  • Dihydrofolate reductase
  • Dihydrofolate reductase (DHFR)
  • GAR transformylase
  • Glycinamide ribonucleotide formyltransferase (GARFTase)
  • Proton-coupled folate transporter
  • Serine hydroxymethyltransferase, cytosolic
  • Thymidylate Synthase (TS)
  • Thymidylate synthase
  • Thymidylate synthase (EC 2.1.1.45) (TS) (TSase)
13 Ki 88 IC50 1 Kd
  • (2S)-2-{[4-(2-{2-amino-4-oxo-1H,4H,7H-pyrrolo[2,3-d]pyrimidin-5-yl}ethyl)phenyl]formamido}pentanedioic acid
  • LY231514
  • PEMETREXED
  • Pemetrexed
  • Androgen Receptor
  • Bile acid transporter
  • CFTR inhibitory factor, Cif
  • Peroxisome proliferator-activated receptor
  • Proliferating cell nuclear antigen
  • Retinoic acid receptor RXR-alpha/gamma
  • Solute carrier organic anion transporter family member 1C1
  • Thyroid hormone receptor alpha
  • Thyroid hormone receptor beta
  • thyroid beta
1 Ki 11 IC50 2 Kd 2 EC50
  • 2-[4-(4-hydroxy-3-iodophenoxy)-3,5-diiodophenyl]acetic acid
  • CHEMBL41632
  • TRIAC
  • Tiratricol
  • Triiodothyroacetic acid, 3
  • US10322118, Entry Tiratricol
  • Sodium channel alpha subunit
  • Sodium channel protein type 2 alpha subunit
  • Sodium channel protein type 5 subunit alpha
  • Sodium channel protein type 7 subunit alpha
  • Sodium channel protein type 8 subunit alpha
  • Sodium channel protein type 9 subunit alpha
  • Sodium channel protein type XI alpha subunit
  • Voltage-gated sodium channel subunit alpha Nav1.4
  • Voltage-gated sodium channel subunit alpha Nav1.4 (I757A)
  • Voltage-gated sodium channel subunit alpha Nav1.4 (M1240A)
13 IC50
  • US9174999, Table 1, Compound 1
  • Lysine-specific demethylase 5A
  • Lysine-specific demethylase 5A (KDM5A(aa 1-1090)-Flag)
  • Lysine-specific demethylase 5A (KDM5A(aa 1-588)ΔAP)
  • Lysine-specific demethylase 5A (KDM5A(aa 1-739)ΔAP(2C-2S))
  • Lysine-specific demethylase 5B
  • Lysine-specific demethylase 5B (KDM5B(aa 1-604)ΔAP)
  • Lysine-specific demethylase 5B (KDM5B(aa 1-755)ΔAP)
  • Lysine-specific demethylase 5C
  • Lysine-specific demethylase 5C (KDM5C(aa 1-789)ΔAP)
  • Lysine-specific demethylase 5D (KDM5D(aa 1-760)ΔAP)
13 IC50 2 Kd
  • 6-isopropyl-5-methyl-7-oxo-4,7-dihydropyrazolo[1,5-a]pyrimidine-3-carbonitrile (N8)
  • Lysine-specific demethylase 4C
  • Lysine-specific demethylase 5A
  • Lysine-specific demethylase 5A (KDM5A(aa 1-1090)-Flag)
  • Lysine-specific demethylase 5A (KDM5A(aa 1-588)ΔAP)
  • Lysine-specific demethylase 5B
  • Lysine-specific demethylase 5B (KDM5B(aa 1-604)ΔAP)
  • Lysine-specific demethylase 5B (KDM5B(aa 1-755)ΔAP)
  • Lysine-specific demethylase 5C
  • Lysine-specific demethylase 5C (KDM5C(aa 1-789)ΔAP)
  • Lysine-specific demethylase 5D (KDM5D(aa 1-760)ΔAP)
9 IC50 2 Kd
  • 8-(1-methyl-1Himidazol-4-yl)-2-(4,4,4-trifluorobutoxy)pyrido[3,4-d]pyrimidin-4-ol (N10)
  • Amine oxidase (flavin-containing) A
  • Amine oxidase [flavin-containing] B
  • Cytochrome P450 1A
  • Cytochrome P450 2C19
  • Cytochrome P450 2C9
  • Cytochrome P450 2D6 (2D6)
  • Cytochrome P450 2E1
  • Cytochrome P450 3A
  • Monoamine Oxidase Type B (MAO-B)
  • Monoamine oxidase
2 Ki 12 IC50
  • 7-(3-chlorobenzyloxy)-4-(methylamino)methyl-coumarin, 2
  • 7-[(3-chlorophenyl)methoxy]-4-[(methylamino)methyl]-2H-chromen-2-one
  • C18
  • CHEMBL593763
  • 5-lipoxygenase/FLAP
  • Bile salt export pump
  • Cannabinoid receptor 1
  • Cannabinoid receptor 2
  • Cyclooxygenase-1 (COX-1)
  • Transient receptor potential cation channel subfamily M member 8
  • Transient receptor potential cation channel subfamily V member 1
  • Tyrosyl-tRNA synthetase
  • Vanilloid receptor
  • Voltage-gated potassium channel subfamily A member 1/beta-1
14 Ki 8 IC50 22 EC50
  • (6E)-N-[(4-hydroxy-3-methoxyphenyl)methyl]-8-methylnon-6-enamide
  • (E)-N-[(4-hydroxy-3-methoxyphenyl)methyl]-8-methylnon-6-enamide
  • CAP
  • CHEMBL294199
  • Capsaicin
  • Zostrix
  • 1,3-beta-glucan synthase component GLS2
  • Beta-hexosaminidase subunit beta (Hex B)
  • Cytochrome P450 2C9
  • Cytochrome P450 2D6
  • Cytochrome P450 3A
  • L-type calcium channel alpha-1c/beta-2/alpha2delta-1
  • N-acetyl-beta-D-glucosaminidase (O-GlcNAcase)
  • Nuclear receptor subfamily 1 group I member 2
  • Protein O-GlcNAcase
  • Sodium channel protein type 5 subunit alpha
4 Ki 6 IC50 3 EC50
  • US9243020, 2
  • US9815861, Example 2
  • Cereblon/Histone deacetylase 6
  • Histone deacetylase 1
  • Histone deacetylase 10
  • Histone deacetylase 2
  • Histone deacetylase 3
  • Histone deacetylase 4
  • Histone deacetylase 5
  • Histone deacetylase 7
  • Histone deacetylase 8
  • Histone deacetylase 9
18 IC50
  • US9265734, RGFA8
  • US9796664, Compound RGFA8
  • Cereblon/Histone deacetylase 1
  • Histone deacetylase 1
  • Histone deacetylase 2
  • Histone deacetylase 3
  • Histone deacetylase 3/Nuclear receptor corepressor 2 (HDAC3/NCoR2)
  • Histone deacetylase 4
  • Histone deacetylase 5
  • Histone deacetylase 7
  • Histone deacetylase 8
  • Leukotriene A4 hydrolase
2 Ki 16 IC50
  • US9265734, R01
  • US9796664, Compound R01
  • CNR1
  • Delta-type opioid receptor
  • Kappa-type opioid receptor
  • Mu-type opioid receptor
  • Norepinephrine transporter
  • OPRD1
  • Opioid receptors; mu & delta
  • Opioid receptors; mu and delta
  • Sodium-dependent serotonin transporter
  • neuropeptides B/W receptor 1
42 Ki 4 IC50 3 Kd 12 EC50
  • (4S,7S,13S)-13-[(2S)-2-amino-3-(4-hydroxyphenyl)propanamido]-7-benzyl-3,3,14,14-tetramethyl-6,9,12-trioxo-1,2-dithia-5,8,11-triazacyclotetradecane-4-carboxylic acid
  • CHEMBL31421
  • DPDPE
  • DPDPE-Cl
  • DPDPE-OH
  • Enkephalin, [Tyrosyl-2,6-3H(N)]- (2-D-Penicillamine, 5-D-Penicillamine)
  • [3H]DPDPE
  • Cytochrome P450
  • Metabotropic glutamate receptor 1
  • Metabotropic glutamate receptor 2
  • Metabotropic glutamate receptor 3
  • Metabotropic glutamate receptor 4
  • Metabotropic glutamate receptor 6
  • Metabotropic glutamate receptor 7
  • Metabotropic glutamate receptor 8
  • Pregnane X receptor
  • mGluR2 and G alpha 16
15 IC50 1 EC50
  • US9278960, 2-7
  • US9663506, Example 2-7
  • 5-hydroxytryptamine receptor 2B
  • 5-hydroxytryptamine receptor 2C
  • 5-hydroxytryptamine receptor 6
  • 5-hydroxytryptamine receptor 7
  • Cytochrome P450 1A
  • Cytochrome P450 2A6
  • Cytochrome P450 2C19
  • Cytochrome P450 2C9
  • Cytochrome P450 2D6 (2D6)
  • Cytochrome P450 3A
8 Ki 6 IC50 3 EC50
  • 2-[1-({6-chloroimidazo[2,1-b][1,3]thiazole-5-}sulfonyl)-1H-indol-3-yl]ethan-1-amine
  • N1-(6-chloroimidazo[2,1-b][1,3]thiazole-5-sulfonyl)tryptamine
  • SAX-187
  • WAY-181187
  • Bile salt export pump
  • Canalicular multispecific organic anion transporter 1
  • Canalicular multispecific organic anion transporter 2
  • Cytochrome P450 3A
  • DNA Gyrase
  • DNA Topoisomerase IV
  • DNA gyrase subunit A
  • DNA gyrase subunit B
  • DNA topoisomerase II
  • Multidrug resistance-associated protein 4
15 IC50
  • 1-ethyl-7-methyl-4-oxo-1,4-dihydro-1,8-naphthyridine-3-carboxylic acid
  • Nalidixic Acid
  • Nalidixin
  • NegGram
  • Nevigramon
  • US9138393, Nalidixic acid
  • US9144538, Nalidixic acid
  • DNA-dependent protein kinase (DNAPK)
  • Phosphatidylinositol 3-kinase catalytic subunit type 3
  • Phosphatidylinositol 3-kinase p110β (p110β)
  • Phosphatidylinositol 3-kinase p110γ (p110γ)
  • Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform (PI3K alpha)
  • Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform
  • Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform
  • Phosphatidylinositol-4-phosphate 5-kinase alpha (PIP5Kα)
  • Phosphatidylinositol-4-phosphate 5-kinase beta (PIP5Kβ)
  • Serine/threonine-protein kinase mTOR (mTOR)
11 IC50
  • GS-9820
  • 1,3-beta-glucan synthase component GLS2
  • Cytochrome P450 1A
  • Cytochrome P450 2C19
  • Cytochrome P450 2C9
  • Cytochrome P450 2D6
  • Cytochrome P450 3A
  • Gag-Pol polyprotein
  • Human immunodeficiency virus type 1 reverse transcriptase
  • Reverse Transcriptase
  • Reverse transcriptase
24 IC50 2 EC50
  • Rilpivirine
  • Ephrin receptor
  • Ephrin type-A receptor 3 ligand binding domain (EphA3-LBD)
  • Ephrin type-A receptor 4 ligand binding domain (D61G/E62G-EphA4-LBD)
  • Ephrin type-A receptor 4 ligand binding domain (EphA4-LBD)
  • Ephrin type-A receptor 4 ligand binding domain (I159A-EphA4-LBD)
  • Ephrin type-A receptor 4 ligand binding domain (I59A-EphA4-LBD)
  • Ephrin type-A receptor 4 ligand binding domain (I59G-EphA4-LBD)
  • Ephrin type-A receptor 4 ligand binding domain (I67A-EphA4-LBD)
  • Ephrin type-A receptor 4 ligand binding domain (M164A-EphA4-LBD)
  • Ephrin type-A receptor 4 ligand binding domain (M60A-EphA4-LBD)
1 Ki 10 Kd
9 ΔG°
  • 123C4
  • 26S Proteasome regulatory subunit Rpn11 (Rpn11)
  • 72 kDa type IV collagenase
  • AMSH-like protease
  • BRISC complex
  • COP9 signalosome complex subunit 5 (Csn5)
  • Carbonic anhydrase 1
  • Cereblon/Histone deacetylase 6
  • Glyoxalase 1 (GLO1)
  • Matrix metalloproteinase-12 (MMP12)
  • STAM-binding protein (AMSH)
12 IC50
  • Capzimin
  • US10005735, Compound 12
  • Acetylcholinesterase
  • Acyl coenzyme A:cholesterol acyltransferase
  • Acyl-CoA: cholesterol acyltransferase (ACAT)
  • Carboxylesterase
  • Carboxylesterase 1
  • Carboxylesterase 2
  • Cholinesterases
  • Cholinesterases; ACHE & BCHE
  • Factor XIIa
  • Fatty-acid amide hydrolase 1
26 Ki 11 IC50
  • 1,2-diphenylethane-1,2-dione
  • Benzil
  • CHEMBL189886
  • Diphenylethane-1,2-dione
  • Botulinum Neurotoxin Type A
  • Cereblon/Histone deacetylase 6
  • Histone deacetylase 1
  • Histone deacetylase 2
  • Histone deacetylase 3
  • Histone deacetylase 4
  • Histone deacetylase 5
  • Histone deacetylase 7
  • Histone deacetylase 8
  • Histone deacetylase 9
10 IC50
  • (2E)-N-hydroxy-3-(4-methoxyphenyl)prop-2-enamide
  • Cinnamic hydroxamate deriv., 13
  • US10188756, Compound CN87
  • Aldehyde oxidase
  • Catalase
  • D-Aspartate Oxidase (DDO)
  • D-amino-acid oxidase
  • HM74 nicotinic acid GPCR
  • Hydroxycarboxylic acid receptor 2
  • Multidrug and toxin extrusion protein 1
  • Nicotinamidase (SpNic)
  • Tyrosinase
  • Xanthine dehydrogenase/oxidase
5 Ki 24 IC50 38 EC50
  • CHEMBL573
  • Niacin
  • Nicotinic Acid
  • [5, 6-3H]-niacin
  • pyridine-3-carboxylic acid
  • wampocap
  • Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A
  • Cyclooxygenase
  • Cyclooxygenase-1 (COX-1)
  • Phosphodiesterase 11 (PDE11)
  • Phosphodiesterase 2A (PDE2A)
  • Phosphodiesterase 3 (PDE3)
  • Phosphodiesterase 9A
  • cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A
  • cGMP-inhibited 3',5'-cyclic phosphodiesterase B
  • cGMP-specific 3',5'-cyclic phosphodiesterase
16 IC50
  • US9388139, 12
  • 5'-AMP-activated protein kinase subunit beta-1
  • 5'-AMP-activated protein kinase subunit gamma-1
  • 5'-AMP-activated protein kinase Complex 1
  • 5'-AMP-activated protein kinase catalytic subunit alpha-1/beta-1/gamma-1
  • 5-hydroxytryptamine receptor 2B
  • AMPK alpha1/beta2/gamma1
  • AMPK alpha2/beta1/gamma1
  • AMPK alpha2/beta2/gamma3
  • Phosphodiesterase 3
  • Prkaa1/Prkab2/Prkag1
2 IC50 3 Kd 19 EC50
  • US9394285, 1
  • RNA polymerase (NS5B)
  • RNA-directed RNA polymerase (NS5B)
  • RNA-directed RNA polymerase (NS5B)(C316Y)
  • RNA-directed RNA polymerase (NS5B)(L392I)
  • RNA-directed RNA polymerase (NS5B)(M414T)
  • RNA-directed RNA polymerase (NS5B)(M423T)
  • RNA-directed RNA polymerase (NS5B)(P495L)
  • RNA-directed RNA polymerase (NS5B)(S282T)
  • RNA-directed RNA polymerase (NS5B)(V494A)
  • Serine protease NS3/ RNA-directed RNA polymerase NS5B (NS3-NS5B)
2 IC50 11 Kd 1 EC50 11 Koff 11 Kon
  • US9427440, 1
  • Cytochrome P450 125 (CYP125)
  • Cytochrome P450 142 (CYP142)
  • Cytochrome P450 144 (CYP144)
  • Cytochrome P450 144 (CYP144A1-TRV)
  • Cytochrome P450 1A1
  • Cytochrome P450 2B1
  • Cytochrome P450 3A
  • Indoleamine 2,3-dioxygenase
  • Lanosterol 14-alpha demethylase
  • Peptidyl-prolyl cis-trans isomerase FKBP1B/Serine/threonine-protein kinase mTOR
13 IC50 6 Kd
  • 4-PIM
  • 4-Phenylimidazole
  • 4-phenyl-1H-imidazole
  • 4-phenylimidazole, 4-PI
  • CHEMBL14145
  • US9138393, 4-Phenyl- imidazole
  • US9144538, 4-Phenylimidazole
  • 1,3-beta-glucan synthase component GLS2
  • Cytochrome P450 1A
  • Cytochrome P450 2C19
  • Cytochrome P450 2C8
  • Cytochrome P450 2C9
  • Cytochrome P450 2D6
  • Cytochrome P450 3A
  • P2X purinoceptor
  • P2X purinoceptor 7
  • P2X purinoceptor 7 (P2X7)
12 Ki 25 IC50
  • US10112937, Example 158
  • US10150765, Example 158
  • US10703749, Example 158
  • US9464084, 158
  • Beta-1 adrenergic receptor
  • Beta-2 adrenergic receptor
  • Beta-3 adrenergic receptor
  • Bile salt export pump
  • Canalicular multispecific organic anion transporter 1
  • Canalicular multispecific organic anion transporter 2
  • D(2) dopamine receptor
  • D(3) dopamine receptor
  • Galanin receptor 3
  • Multidrug resistance-associated protein 4
21 Ki 10 IC50 7 Kd 46 EC50
  • 1-hydroxy-2-naphthoic acid;4-[1-hydroxy-2-[6-(4-phenylbutoxy)hexylamino]ethyl]-2-methylol-phenol
  • 4-(1-hydroxy-2-{[6-(4-phenylbutoxy)hexyl]amino}ethyl)-2-(hydroxymethyl)phenol
  • Aeromax
  • Salmeterol
  • Serevent
  • salmeterol xinafoate
  • 1,3-beta-glucan synthase component GLS2
  • Cytochrome P450
  • Sodium channel alpha subunit
  • Sodium channel protein type 1 subunit alpha/beta-1/beta-2
  • Sodium channel protein type 2 alpha subunit
  • Sodium channel protein type 4 subunit alpha/beta-1/beta-2
  • Sodium channel protein type 5 subunit alpha/beta-1/beta-2
  • Sodium channel protein type 8 subunit alpha
  • Sodium channel protein type 9 subunit alpha
  • Sodium channel subunit beta-2
32 IC50
  • US9493448, 122
  • US9493448, 154
  • US9493448, 48
  • US9597330, Example 34
  • US9845313, Example 154
  • Aurora kinase B
  • Cyclin-Dependent Kinase 2 (CDK2)
  • Cyclin-Dependent Kinase 5 (CDK5)
  • Cyclin-Dependent Kinase 9 (CDK9)
  • Dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A
  • Glycogen synthase kinase-3
  • Protein Kinase C
  • Receptor-interacting serine/threonine-protein kinase 3
  • Serine/threonine-protein kinase haspin
  • Serine/threonine-protein kinase pim-1
10 IC50
  • (Arylindolyl)maleimide deriv. 27
  • 3-(1-methyl-1H-indol-3-yl)-4-{1-methyl-1H-pyrrolo[2,3-b]pyridin-3-yl}-2,5-dihydro-1H-pyrrole-2,5-dione
  • 4-hydroxy-2-oxoglutarate aldolase, mitochondrial
  • Beta-lactamase 2
  • Beta-lactamase L1
  • Class B carbapenemase VIM-13
  • Dihydrodipicolinate synthase
  • Glutamate receptor ionotropic, NMDA 1
  • Histone Lysine Demethylase
  • Metallo-beta-lactamase VIM-2 (VIM-2)
  • Metallo-beta-lactamase type 2
  • VIM-1
3 Ki 8 IC50
  • CHEMBL284104
  • Dipicolinate
  • pyridine carboxylate, 6d
  • pyridine-2,6-dicarboxylic acid
  • 1,3-beta-glucan synthase component GLS2
  • JAK1 (aa 866-1154)
  • JAK2 (aa 808-1132)
  • JAK2 (aa 831-1132)
  • JAK3 (aa 781-1124)
  • JAK3 (aa 811-1124)
  • Tyrosine-protein kinase JAK1
  • Tyrosine-protein kinase JAK1 (aa 866-1154)
  • Tyrosine-protein kinase JAK2
  • Tyrosine-protein kinase JAK3
17 IC50
  • (2R)-N-(3-{5-chloro- 2-[(3-methoxy-1- methyl-1H-pyrazol-4- yl)amino]pyrimidin-4- yl}-1H-indol-7-yl)-2- (4-methylpiperazin-1- yl)propanamide
  • US10167276, Example 36
  • US10654835, Example 36
  • US9714236, 36
  • Apurinic-apyrimidinic endonuclease 1 (APE-1)
  • Cdc25C
  • Dual specificity phosphatase Cdc25B
  • Dual specificity protein phosphatase (VHR)
  • Dual specificity protein phosphatase 6
  • Phosphatidylglycerophosphatase and protein-tyrosine phosphatase 1
  • Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN
  • Protein-tyrosine phosphatase 1B
  • Receptor-type tyrosine-protein phosphatase beta (PTPβ)
  • phosphatase Cdc25
2 Ki 11 IC50
  • (2E)-3-{3-[dihydroxy(oxo)--stibanyl]phenyl}prop-2-enoic acid
  • Compound 13778
  • 3-Phosphoinositide-Dependent Protein Kinase 1 (PDK1) Mutant (A162V)
  • 3-Phosphoinositide-Dependent Protein Kinase 1 (PDK1) Mutant (E166D)
  • 3-Phosphoinositide-Dependent Protein Kinase 1 (PDK1) Mutant (L159M)
  • 3-Phosphoinositide-Dependent Protein Kinase 1 (PDK1) Mutant (T222A)
  • 3-Phosphoinositide-Dependent Protein Kinase 1 (PDK1) Mutant (V143T)
  • 3-Phosphoinositide-Dependent Protein Kinase 1 (PDK1) Mutant (V143T/T222A)
  • 3-phosphoinositide-dependent protein kinase 1 (aa 51-359)
  • Calcium/calmodulin-dependent protein kinase type II subunit delta
  • Phosphorylase Kinase
  • cAMP-Dependent Protein Kinase (PKA)
13 IC50
  • 3-[1-(3-aminopropyl)-1H-indol-3-yl]-4-(1H-indol-3-yl)-2,5-dihydro-1H-pyrrole-2,5-dione
  • BIM-3
  • Bisindolyl deriv. 19
  • Cyclooxygenase-1 (COX-1)
  • Intestinal fatty acid-binding protein (hIFABP)
  • Liver fatty acid binding protein (human L-FABP T94A)
  • Liver fatty acid binding protein (human L-FABP T94T)
  • Liver fatty acid binding protein (rat L-FABP)
  • Peroxisome proliferator-activated receptor
  • Peroxisome proliferator-activated receptor alpha
  • Peroxisome proliferator-activated receptor alpha (PPAR alpha)
  • Peroxisome proliferator-activated receptor delta
  • Peroxisome proliferator-activated receptor gamma
7 Ki 15 IC50 15 Kd 33 EC50
  • 2-(4-(4-Chlorobenzoyl)phenoxy)-2-methylpropionic acid
  • 2-{4-[(4-chlorophenyl)carbonyl]phenoxy}-2-methylpropanoic acid
  • CHEMBL981
  • FENOFIBRIC ACID
  • FIBRICOR
  • Fenofibrate
  • LF 153
  • alpha-1081
  • procetofenic acid
  • Bile salt export pump
  • Bile salt export pump (BSEP)
  • Intestinal fatty acid-binding protein (hIFABP)
  • Liver fatty acid binding protein (rat L-FABP)
  • Organic anion-transporting polypeptide 1D1 (Oatp1d1)
  • Peroxisome proliferator-activated receptor
  • Peroxisome proliferator-activated receptor alpha
  • Peroxisome proliferator-activated receptor alpha (PPAR alpha)
  • Peroxisome proliferator-activated receptor delta
  • Peroxisome proliferator-activated receptor gamma
3 Ki 3 IC50 36 EC50
  • 2-(4-{2-[(4-chlorophenyl)formamido]ethyl}phenoxy)-2-methylpropanoic acid
  • Azufibrat
  • Bezafibrate
  • CHEMBL264374
  • Cedur
  • Sklerofibrat
  • Acid ceramidase (AC)
  • Cannabinoid receptor 1
  • Cannabinoid receptor 2
  • G-protein coupled receptor 119 (GPR119)
  • Glucose-dependent insulinotropic receptor
  • Liver fatty acid binding protein (FABP1)
  • Peroxisome proliferator-activated receptor
  • Peroxisome proliferator-activated receptor alpha (PPAR alpha)
  • Transient receptor potential cation channel subfamily V member 1
  • Vanilloid receptor
10 Ki 2 IC50 17 EC50
  • CHEMBL280065
  • N-oleoylethanolamine
  • Oleamide MEA
  • Oleoyl monoethanolamide
  • Oleoylethanolamide (OEA)
  • Bcl-2-like protein 1
  • Induced myeloid leukemia cell differentiation protein Mcl-1
  • Low molecular weight phosphotyrosine protein phosphatase
  • MPI protein
  • NS3
  • Runt-Related Transcription Factor 1 Isoform AML1C
  • Valosin-containing protein
  • exonuclease V (RecBCD complex), alpha chain
  • large T antigen
  • lens epithelium-derived growth factor p75
14 IC50 1 EC50
  • 2-[(6,7-dihydroxy-2-keto-chromen-4-yl)methylthio]-3-(3-methoxyphenyl)quinazolin-4-one
  • 2-[(6,7-dihydroxy-2-oxo-1-benzopyran-4-yl)methylthio]-3-(3-methoxyphenyl)-4-quinazolinone
  • 2-[(6,7-dihydroxy-2-oxochromen-4-yl)methylsulfanyl]-3-(3-methoxyphenyl)quinazolin-4-one
  • 2-[[6,7-bis(oxidanyl)-2-oxidanylidene-chromen-4-yl]methylsulfanyl]-3-(3-methoxyphenyl)quinazolin-4-one
  • MLS000409303
  • SMR000247593
  • cid_5691857
  • 5-hydroxytryptamine receptor 1A
  • Alpha-1A adrenergic receptor
  • BZLF2
  • Bfl-1
  • D(2) dopamine receptor
  • DRD1
  • P-glycoprotein 1
  • P-glycoprotein 1 and 3 (MDR1a/MDR1b)
  • Rho-associated protein kinase 2
  • Serotonin (5-HT) receptor
10 Ki 4 IC50 1 EC50
  • ERGOCORNINE
  • MLS000069342
  • SMR000058938
  • cid_73453
  • ATP-binding cassette sub-family G member 2
  • Cytochrome P450 1A
  • Cytochrome P450 2C19
  • Cytochrome P450 2C9
  • Cytochrome P450 2D6
  • Cytochrome P450 3A
  • Indoleamine 2,3-dioxygenase
  • Indoleamine 2,3-dioxygenase 1
  • Indoleamine 2,3-dioxygenase 2
  • Tryptophan 2,3-dioxygenase
30 IC50 3 Kd
  • 3-(5-fluoro-1H-indol-3- yl)pyrrolidine-2,5-dione
  • US9603836, Compound 1
  • US9603836, Compound 1a
  • US9949951, 1a
  • 5-hydroxytryptamine receptor 1A
  • 5-hydroxytryptamine receptor 2C
  • D(2) dopamine receptor
  • Rho-associated protein kinase 2
  • Serotonin (5-HT) receptor
  • Serotonin 1B/1D receptor
  • Serotonin 2 (5-HT2) receptor
  • Sodium-dependent serotonin transporter
  • Sphingosine 1-phosphate receptor 3
  • cAMP-dependent protein kinase (PKA)
8 Ki 4 IC50 4 EC50
  • 3-(1,2,3,6-tetrahydropyridin-4-yl)-1H-indole
  • CHEMBL2011570
  • CHEMBL27811
  • MLS000093715
  • SMR000029333
  • cid_2761023
  • 5-hydroxytryptamine receptor 1A
  • Dual Specificity Protein Phosphatase 1
  • Dual specificity phosphatase Cdc25B
  • Heat shock protein HSP 90-alpha
  • MKP-3
  • Mitogen-activated protein kinase 10
  • Serotonin (5-HT) receptor
  • Sphingosine 1-phosphate receptor 1
  • Sphingosine 1-phosphate receptor 2
  • Sphingosine 1-phosphate receptor 3
16 IC50 3 EC50
  • (5-acetamido-4-acetyloxy-2,1,3-benzoxadiazol-7-yl) acetate
  • (5-acetamido-4-acetyloxy-2,1,3-benzoxadiazol-7-yl) ethanoate
  • Acetic acid 7-acetoxy-5-acetylamino-benzo[1,2,5]oxadiazol-4-yl ester
  • MLS000077136
  • SMR000008576
  • acetic acid (5-acetamido-4-acetyloxy-2,1,3-benzoxadiazol-7-yl) ester
  • acetic acid (6-acetamido-7-acetoxy-benzofurazan-4-yl) ester
  • cid_597363
  • 5-hydroxytryptamine receptor 1A
  • DNA damage-inducible transcript 3 protein
  • Galanin receptor 3
  • Nuclear receptor ROR-alpha
  • Serotonin (5-HT) receptor
  • Sphingosine 1-phosphate receptor 1
  • Sphingosine 1-phosphate receptor 2
  • Sphingosine 1-phosphate receptor 3
  • Steroidogenic Factor 1
  • XBP1
13 IC50 3 EC50
  • 1-[1,1-bis(trifluoromethyl)propyl]-3-[5-(trifluoromethyl)-1,3,4-thiadiazol-2-yl]urea
  • 1-[5-(trifluoromethyl)-1,3,4-thiadiazol-2-yl]-3-[1,1,1-trifluoro-2-(trifluoromethyl)butan-2-yl]urea
  • 1-[5-(trifluoromethyl)-1,3,4-thiadiazol-2-yl]-3-[1,1,1-tris(fluoranyl)-2-(trifluoromethyl)butan-2-yl]urea
  • MLS000038681
  • SMR000040781
  • cid_659822
  • Complement C1s
  • DNA damage-inducible transcript 3 protein
  • Dopamine receptor D2L/neurotensin receptor NTS1
  • Nuclear receptor ROR-alpha
  • STAT3
  • Serotonin (5-HT) receptor
  • Sphingosine 1-phosphate receptor 3
  • Steroidogenic Factor 1
  • Transcription Factor STAT1
  • XBP1
13 IC50 1 EC50
  • 2-(3,4-dimethoxyphenyl)-N-[3-[5-(3-methylphenyl)-1,3,4-oxadiazol-2-yl]phenyl]acetamide
  • 2-(3,4-dimethoxyphenyl)-N-[3-[5-(3-methylphenyl)-1,3,4-oxadiazol-2-yl]phenyl]ethanamide
  • 2-(3,4-dimethoxyphenyl)-N-[3-[5-(m-tolyl)-1,3,4-oxadiazol-2-yl]phenyl]acetamide
  • 2-(3,4-dimethoxyphenyl)-N-{3-[5-(3-methylphenyl)-1,3,4-oxadiazol-2-yl]phenyl}acetamide
  • MLS000052465
  • SMR000081883
  • cid_2233014
  • Bcl-2-like protein 1
  • Dual Specificity Protein Phosphatase 1
  • Dual specificity phosphatase Cdc25B
  • Genome polyprotein
  • Heat Shock 70kDa Protein 1
  • Hematopoietic protein-tyrosine phosphatase (HEPTP)
  • Induced myeloid leukemia cell differentiation protein Mcl-1
  • MKP-3
  • core protein
  • heat shock 70kDa protein 8 isoform 1
25 IC50
  • (5Z)-5-(5-bromo-2-methoxybenzylidene)-2-(2-furyl)[1,3]thiazolo[3,2-b][1,2,4]triazol-6(5H)-one
  • 5-(5-bromo-2-methoxy-benzylidene)-2-(2-furyl)thiazolo[3,2-b][1,2,4]triazol-6-one
  • 5-[(5-bromanyl-2-methoxy-phenyl)methylidene]-2-(furan-2-yl)-[1,3]thiazolo[3,2-b][1,2,4]triazol-6-one
  • 5-[(5-bromo-2-methoxyphenyl)methylidene]-2-(2-furanyl)-6-thiazolo[3,2-b][1,2,4]triazolone
  • 5-[(5-bromo-2-methoxyphenyl)methylidene]-2-(furan-2-yl)-[1,3]thiazolo[3,2-b][1,2,4]triazol-6-one
  • MLS000043560
  • SMR000020576
  • cid_3236807
  • Heat Shock 70kDa Protein 1
  • Human immunodeficiency virus type 1 REV
  • Lysosomal acid glucosylceramidase
  • POsterior Segregation family member (pos-1)
  • RecName: Full=Zinc finger protein mex-5
  • Sphingosine 1-phosphate receptor 3
  • defective in Germ Line Development family member (gld-1)
  • diphosphomevalonate decarboxylase
  • heat shock 70kDa protein 8 isoform 1
  • poly(A) binding protein, cytoplasmic 1
9 IC50 2 EC50
  • 4-amino-2-phenyl-isoindoline-1,3-quinone
  • 4-amino-2-phenylisoindole-1,3-dione
  • 4-azanyl-2-phenyl-isoindole-1,3-dione
  • CHEMBL269410
  • MLS000104009
  • SMR000015725
  • cid_3448473
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