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Compounds Sorted by Binding Targets per Compound

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Compounds Sorted Alphabetically

Compound Name (alphabetical)	Binding Targets	Enz. Inhib. Data							ITC Data	Alternate Compound Names
		Ki	IC50	Kd	EC50	Koff	Kon	Other
BDBM10304	Acetylcholinesterase Acyl-CoA: cholesterol acyltransferase (ACAT) Carboxylesterase 1 Caspase-3 Cholinesterases Chorismate mutase (MTB CM) Factor XIIa Human rhinovirus A protease Transthyretin	6	3	0	0	0	0	0	0	1-methyl-2,3-dihydro-1H-indole-2,3-dione CHEMBL60569 Isatin analog 8 N‐methylindol‐2,3‐dione (Compound 2)
BDBM108115	Coagulation factor X Coagulation factor XI Complement C1r subcomponent Complement C1s Factor XIIa Plasma kallikrein Plasminogen Transcription initiation factor IIA Vitamin K-dependent protein C	10	0	0	0	0	0	0	0	US8598206, Table 6, 24
BDBM11343	72 kDa type IV collagenase Carbonic Anhydrase IV Carbonic anhydrase 1 Carbonic anhydrase 2 Collagenase (ChC) Interstitial collagenase Matrix metalloproteinase 12 Matrix metalloproteinase-9 Neutrophil collagenase	10	2	0	0	0	0	0	0	(2S)-2-[benzyl(4-methoxybenzene)sulfonamido]-N-hydroxy-3-methylbutanamide Hydroxamate 24 N-4-Methoxyphenylsulfonyl-N-benzyl-L-valine hydroxamate
BDBM11365	72 kDa type IV collagenase Aldehyde dehydrogenase 1A1 Carbonic Anhydrase IV Carbonic anhydrase 1 Carbonic anhydrase 2 Collagenase (ChC) Interstitial collagenase Matrix metalloproteinase-9 Neutrophil collagenase	8	1	0	0	0	0	0	0	CHEMBL98328 Hydroxysulfonamide 46 N-hydroxymethanesulfonamide
BDBM11372	72 kDa type IV collagenase Aldehyde dehydrogenase 1A1 Carbonic Anhydrase IV Carbonic anhydrase 1 Carbonic anhydrase 2 Collagenase (ChC) Interstitial collagenase Matrix metalloproteinase-9 Neutrophil collagenase	8	1	0	0	0	0	0	0	CHEMBL55310 Hydroxysulfonamide 53 N-hydroxybenzenesulfonamide
BDBM11611	β-Carbonic anhydrase 2 (CA 2) β-Carbonic anhydrase 3 (CA 3) Astrosclerin-3 Carbonic Anhydrase (mtCA 1) Carbonic Anhydrase III Carbonic Anhydrase IV Carbonic anhydrase 1 Carbonic anhydrase 2 Carbonic anhydrase 9	15	0	0	0	0	0	0	0	β-CA inhibitor, 10 4-Amino-3,5-dibromobenzenesulfonamide 4-amino-3,5-dibromobenzene-1-sulfonamide CHEMBL306195 halogenosulfanilamide deriv. 12
BDBM119122	MurA (E. coli) MurB (E. coli) MurB (S. aureus) MurC MurC (S. aureus) MurD MurD (S. aureus) MurE MurE (E. coli)	0	9	0	0	0	0	0	0	MurA/B/C/D/E inhibitor (compound 67)
BDBM120086	Cytochrome P450 1A Cytochrome P450 2C19 Cytochrome P450 2C9 Cytochrome P450 2D6 (2D6) Cytochrome P450 3A Dual specificity mitogen-activated protein kinase kinase 1/Mitogen-activated protein kinase 1/RAF proto-oncogene serine/threonine-protein kinase MAP kinase ERK1 Mitogen-activated protein kinase 1 Potassium voltage-gated channel subfamily H member 2	1	12	0	0	0	0	0	0	US8697715, 1 US9259470, 1
BDBM12348	Cytochrome P450 1A Cytochrome P450 2A6 Cytochrome P450 2B6 Cytochrome P450 2C19 Cytochrome P450 2C8 Cytochrome P450 2C9 Cytochrome P450 2D6 Cytochrome P450 2E1 Cytochrome P450 3A	3	12	0	0	0	0	0	0	3-(pyridin-3-yl)prop-2-yn-1-amine CHEMBL360541 US8609708, 3 nicotine 3-heteroaromatic analogue 3a
BDBM13065	Carbonic Anhydrase IV Carbonic anhydrase 1 Carbonic anhydrase 2 Carbonic anhydrase 9 Cyclooxygenase Cyclooxygenase-1 (COX-1) Prostaglandin E synthase/G/H synthase 2 Prostaglandin G/H synthase (Cyclooxygenase-2) Prostaglandin G/H synthase (cyclooxygenase)	0	23	0	0	0	0	0	0	5-(4-chlorophenyl)-1-(4-methoxyphenyl)-3-(trifluoromethyl)-1H-pyrazole CHEMBL26915 SC-560
BDBM13075	Carbonic Anhydrase III Carbonic Anhydrase XIV Carbonic anhydrase Carbonic anhydrase 1 Carbonic anhydrase 13 (CA XIII) Carbonic anhydrase 2 Carbonic anhydrase 6 (CA-VI) Carbonic anhydrase V Carbonic anhydrases; II & IX	0	13	48	0	0	0	0	0	2,4-dichloro-5-sulfamoylbenzoic acid 2000-01951 Lasamide (Hsba) LeadQuest Compound 9
BDBM13814	Protein-Tyrosine Phosphatase 1B (PTP1B) Protein-Tyrosine Phosphatase 1B (PTP1B) Mutant (G117E) Protein-Tyrosine Phosphatase 1B (PTP1B) Mutant (L119V) Protein-Tyrosine Phosphatase 1B (PTP1B) Mutant (M114V) Protein-Tyrosine Phosphatase 1B (PTP1B) Mutant (V113I) Protein-Tyrosine Phosphatase 1B (PTP1B) Mutant (V113L/M114V) Protein-tyrosine phosphatase 1B T-Cell Protein-Tyrosine Phosphatase (TCPTP) Mutant (V121L) Tyrosine-protein phosphatase non-receptor type 2	0	10	0	0	0	0	0	0	({4-[(4E)-2-(1H-1,2,3-benzotriazol-1-yl)-2-[4-(methoxycarbonyl)phenyl]-5-phenylpent-4-en-1-yl]phenyl}difluoromethyl)phosphonic acid benzotriazole phenyldifluoromethylphosphonic acid compound 1
BDBM14142	Coagulation factor X Hepsin Plasminogen Prothrombin Tissue-type plasminogen activator Trypsin Trypsin-1 Urokinase (uPA) Mutant (S190A) Urokinase-type plasminogen activator	14	0	0	0	0	0	0	0	2-{5-[amino(iminiumyl)methyl]-1H-indol-2-yl}-6-phenylbenzen-1-olate 3-{5-[AMINO(IMINIO)METHYL]-1H-INDOL-2-YL}-1,1-BIPHENYL-2-OLATE) APC-8696 CA-04 CRA-8696
BDBM14152	Coagulation factor X Hepsin Plasminogen Prothrombin Tissue-type plasminogen activator Trypsin Trypsin-1 Urokinase (uPA) Mutant (S190A) Urokinase-type plasminogen activator	14	0	0	0	0	0	0	0	6-CHLORO-2-(2-HYDROXY-BIPHENYL-3-YL)-1H-INDOLE-5-CARBOXAMIDINE APC-10302 CA-14 CRA-10302 {amino[6-chloro-2-(2-hydroxy-3-phenylphenyl)-1H-indol-5-yl]methylidene}azanium
BDBM14333	Coagulation factor X Plasminogen Prothrombin Tissue-type plasminogen activator Trypsin Trypsin-1 Tryptase Urokinase (uPA) Mutant (S190A) Urokinase-type plasminogen activator	12	0	0	0	0	0	0	0	2-{5-[amino(iminiumyl)methyl]-6-fluoro-1H-1,3-benzodiazol-2-yl}-6-phenylbenzen-1-olate CA-09 CRA-10818
BDBM14350	Coagulation factor X Hepsin Plasminogen Prothrombin Tissue-type plasminogen activator Trypsin-1 Tryptase Urokinase (uPA) Mutant (S190A) Urokinase-type plasminogen activator	10	0	0	0	0	0	0	0	2-{5-[amino(iminiumyl)methyl]-6-fluoro-1H-1,3-benzodiazol-2-yl}-6-{[(1S,2S)-2-methylcyclohexyl]oxy}benzen-1-olate CA-11 CRA-11092
BDBM14480	Coagulation factor X Hepsin Plasminogen Prothrombin Tissue-type plasminogen activator Trypsin-1 Tryptase Urokinase (uPA) Mutant (S190A) Urokinase-type plasminogen activator	10	0	0	0	0	0	0	0	CA-22 [amino({4-[(3-hydroxynaphthalene-2-)amido]phenyl}amino)methylidene]azanium
BDBM14714	Coagulation factor VII Coagulation factor X Plasma kallikrein Plasminogen Prothrombin Tissue-type plasminogen activator Trypsin Urokinase-type plasminogen activator Vitamin K-dependent protein C	10	0	0	0	0	0	0	0	(2R)-N-[(3-aminobenzene)sulfonyl]-2-[(4-carbamimidoyl-3-hydroxyphenyl)amino]-2-(3,5-diethoxy-2-fluorophenyl)acetamide G17905 R-4-[2-(3-aminobenzenesulfonylamino)-1-(3,5-diethoxy-2-fluorophenyl)-2-oxoethylamino]-2-hydroxy-benzamidine.TFA
BDBM148173	Beta-secretase 1 Beta-secretase 2 Cathepsin D Cytochrome P450 1A Cytochrome P450 2C19 Cytochrome P450 2C8 Cytochrome P450 2D6 (2D6) Cytochrome P450 3A Potassium voltage-gated channel subfamily H member 2	0	11	0	0	0	0	0	0	US8962616, 1
BDBM148176	Beta-secretase 1 Beta-secretase 2 Cathepsin D Cytochrome P450 1A Cytochrome P450 2C19 Cytochrome P450 2C8 Cytochrome P450 2D6 (2D6) Cytochrome P450 3A Potassium voltage-gated channel subfamily H member 2	0	13	0	0	0	0	0	0	US8962616, 22 US8962616, 4
BDBM152692	Cereblon/Histone deacetylase 6 Histone deacetylase Histone deacetylase 1 Histone deacetylase 10 Histone deacetylase 11 Histone deacetylase 2 Histone deacetylase 3 Histone deacetylase 8 Histone deacetylase 8 (HDAC8)	0	12	0	0	0	0	0	1	Thiol-SAHA (t-SAHA)
BDBM153742	CDK2/CycE CDK7/Cyclin H/MNAT1 Cyclin-Dependent Kinase 1 (CDK1) Cyclin-Dependent Kinase 2 (CDK2) Cyclin-Dependent Kinase 4 (CDK4) Cyclin-Dependent Kinase 5 (CDK5) Cyclin-Dependent Kinase 9 (CDK9) Cyclin-dependent kinase 2 Serine/threonine-protein kinase TBK1	0	9	0	0	0	0	0	0	Oxindole (Scaffold V)
BDBM154546	Chromobox protein homolog 7 (CBX7) E3 ubiquitin-protein ligase (UHRF1) Lethal(3)malignant brain tumor-like protein 1 (L3MBTL1) Lysine-specific demethylase 5A MBT domain-containing protein 1 (MBTD1) Methyl-lysine binding protein (53BP1) PHD finger protein 1 (PHF1) PHD finger protein 19 (PHF19) PHD finger protein 23 (PHF23)	0	9	0	0	0	0	0	0	3-Bromo-N-(3-(dimethylamino)propyl)benzamide (2)
BDBM154547	Chromobox protein homolog 7 (CBX7) E3 ubiquitin-protein ligase (UHRF1) Lethal(3)malignant brain tumor-like protein 1 (L3MBTL1) Lysine-specific demethylase 5A MBT domain-containing protein 1 (MBTD1) Methyl-lysine binding protein (53BP1) PHD finger protein 1 (PHF1) PHD finger protein 19 (PHF19) PHD finger protein 23 (PHF23)	0	9	0	0	0	0	0	0	3-Bromo-N-(3-(isopropylamino)propyl)benzamide (3)
BDBM154548	Chromobox protein homolog 7 (CBX7) E3 ubiquitin-protein ligase (UHRF1) Lethal(3)malignant brain tumor-like protein 1 (L3MBTL1) Lysine-specific demethylase 5A MBT domain-containing protein 1 (MBTD1) Methyl-lysine binding protein (53BP1) PHD finger protein 1 (PHF1) PHD finger protein 19 (PHF19) PHD finger protein 23 (PHF23)	0	9	0	0	0	0	0	0	3-Bromo-N-(3-(tert-butyl(methyl)amino)propyl)benzamide (UNC2892, 4)
BDBM154549	Chromobox protein homolog 7 (CBX7) E3 ubiquitin-protein ligase (UHRF1) Lethal(3)malignant brain tumor-like protein 1 (L3MBTL1) Lysine-specific demethylase 5A MBT domain-containing protein 1 (MBTD1) Methyl-lysine binding protein (53BP1) PHD finger protein 1 (PHF1) PHD finger protein 19 (PHF19) PHD finger protein 23 (PHF23)	0	9	0	0	0	0	0	0	3-Bromo-N-(3-(tert-butoxy)propyl)benzamide (5)
BDBM154550	Chromobox protein homolog 7 (CBX7) E3 ubiquitin-protein ligase (UHRF1) Lethal(3)malignant brain tumor-like protein 1 (L3MBTL1) Lysine-specific demethylase 5A MBT domain-containing protein 1 (MBTD1) Methyl-lysine binding protein (53BP1) PHD finger protein 1 (PHF1) PHD finger protein 19 (PHF19) PHD finger protein 23 (PHF23)	0	9	0	0	0	0	0	0	3-Bromo-N-(3-(pyrrolidin-1-yl)propyl)benzamide (6)
BDBM155253	Cytochrome P450 1A Cytochrome P450 1A1 Cytochrome P450 2C19 Cytochrome P450 2C8 Cytochrome P450 2C9 Cytochrome P450 2D6 Cytochrome P450 2D6 (2D6) H3K27me2 H3K27me3	0	12	0	0	0	0	0	0	US10098888, Compound 1 US9006242, 1
BDBM155254	Cytochrome P450 1A Cytochrome P450 1A1 Cytochrome P450 2C19 Cytochrome P450 2C8 Cytochrome P450 2C9 Cytochrome P450 2D6 Cytochrome P450 2D6 (2D6) H3K27me2 H3K27me3	0	12	0	0	0	0	0	0	US10098888, Compound 2 US9006242, 2
BDBM16285	Acyl-protein thioesterase 1/2 Dipeptidyl peptidase 2 (DPP II) Dipeptidyl peptidase 4 Dipeptidyl peptidase 8/9 Dipeptidyl peptidase 9 Dipeptidyl peptidase VIII Dipeptidyl peptidase-IV (DDP-4) Fibroblast activation protein alpha Lysosomal phospholipase A1	0	38	2	0	0	0	0	0	2-({6-[(3R)-3-aminopiperidin-1-yl]-3-methyl-2,4-dioxo-1,2,3,4-tetrahydropyrimidin-1-yl}methyl)benzonitrile 2-({6-[(3R)-3-aminopiperidin-1-yl]-3-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl}methyl)benzonitrile Alogliptin SYR-322
BDBM164808	Cytoplasmic tyrosine-protein kinase BMX Receptor protein-tyrosine kinase erbB-4 Tyrosine-protein kinase BTK Tyrosine-protein kinase ITK/TSK Tyrosine-protein kinase JAK2 Tyrosine-protein kinase JAK3 Tyrosine-protein kinase Lck Tyrosine-protein kinase TEC Tyrosine-protein kinase TXK	0	15	0	0	0	0	0	0	US10604504, Example 5 US9688629, 5 US9802915, Example 22 US9920031, Example 5
BDBM165194	Rhomboid protease (AaROM) Rhomboid protease (BsYqgP) Rhomboid protease (HiGlpG) Rhomboid protease (MmRHBDL1) Rhomboid protease (MmRHBDL3) Rhomboid protease (PhROM) Rhomboid protease (PsAarA) Rhomboid protease (TmROM) Rhomboid protease (VcROM)	0	9	0	0	0	0	0	0	4‐Chloro‐7‐nitro‐3‐[(5‐phenylpentyl)oxy]isochromen‐1‐one (21)
BDBM165209	Cytoplasmic tyrosine-protein kinase BMX Receptor protein-tyrosine kinase erbB-4 Tyrosine-protein kinase BTK Tyrosine-protein kinase ITK/TSK Tyrosine-protein kinase JAK2 Tyrosine-protein kinase JAK3 Tyrosine-protein kinase Lck Tyrosine-protein kinase TEC Tyrosine-protein kinase TXK	0	14	0	0	0	0	0	0	US10604504, Example 34 US9688629, 34 US9802915, Example 34 US9920031, Example 34
BDBM176676	ERK2(L114A) ERK2(L198A/L232A) ERK2(L198A/L235A) ERK2(L232A) ERK2(L235A) ERK2(L265A) ERK2(R275A) ERK2(Y191A) Mitogen-activated protein kinase 1	0	0	9	0	0	0	0	0	US9115122, 2.3.2
BDBM178095	Cereblon/Histone deacetylase 6 Histone deacetylase 1 Histone deacetylase 2 Histone deacetylase 3 Histone deacetylase 4 Histone deacetylase 5 Histone deacetylase 7 Histone deacetylase 8 Histone deacetylase 9	3	9	0	0	0	0	0	0	BRD2492
BDBM18073	Alkaline phosphatase, tissue-nonspecific isozyme Intestinal alkaline phosphatase Intestinal alkaline phosphatase (IAP) L-type amino acid transporter 1 Large neutral amino acids transporter small subunit 1 Phospholipase A-2-activating protein Tissue non-specific alkaline phosphatase (TNAP) Voltage-gated calcium channel alpha2/delta subunit 1 X-linked inhibitor of apoptosis protein (XIAP)	2	15	0	0	0	0	0	2	(2S)-2-amino-3-phenylpropanoic acid CHEMBL301523 L-[2,3,4,5,6-3H]phenylalanine L-phenylalanine Phenylalanine
BDBM18361	β-galactosidase Acidic alpha-glucosidase Glucosylceramidase Lactase-glycosylceramidase Lysosomal acid glucosylceramidase Trehalase Uncharacterized protein alpha-Glucosidase (α-Glucosidase) alpha-Glucosidase (alpha-Glu)	1	12	0	0	0	0	0	0	(2R,3S,4R,5R,6R)-2-butyl-6-(hydroxymethyl)piperidine-3,4,5-triol alpha-1-C-Butyl-DNJ
BDBM19	Aminoacyl-tRNA synthetase Anthrax Lethal Factor (LF) Bile salt export pump Human immunodeficiency virus type 1 REV Phosphatidylcholine specific phospholipase C, PC-PLC Phosphatidylcholine-retinol O-acyltransferase Phosphoinositide specific phospholipase C, PI-PLC RNA(23-mer) Vascular endothelial growth factor receptor 2	4	3	2	0	0	0	0	9	(2S,3S,4R,5R,6R)-5-amino-2-(aminomethyl)-6-{[(2R,3S,4R,5S)-5-{[(1R,2R,3S,5R,6S)-3,5-diamino-2-{[(2R,3R,4R,5S,6R)-3-amino-6-(aminomethyl)-4,5-dihydroxyoxan-2-yl]oxy}-6-hydroxycyclohexyl]oxy}-4-hydroxy-2-(hydroxymethyl)oxolan-3-yl]oxy}oxane-3,4-diol KDR Kinase Inhibitor, 3 Neomycin Neomycin B
BDBM190404	Cytochrome P450 1A Cytochrome P450 2B6 Cytochrome P450 2C19 Cytochrome P450 2C8 Cytochrome P450 2C9 Cytochrome P450 2D6 (2D6) Cytochrome P450 2E1 Cytochrome P450 3A Cytochrome P450 3A5	0	9	0	0	0	0	0	0	US9180183, SC12
BDBM190665	Nitric Oxide Synthase, brain Mutant (D597N) Nitric Oxide Synthase, endothelial Nitric Oxide Synthase, inducible Nitric oxide synthase mutant (nNOS M336V/D597N) Nitric oxide synthase, brain Nitric oxide synthase, endothelial Nitric oxide synthase, inducible Nitric-oxide synthase, brain Nitric-oxide synthase, endothelial	15	0	0	0	0	0	0	0	US10759791, Compound 14g nNOS inhibitor, 3
BDBM190666	Nitric Oxide Synthase, brain Mutant (D597N) Nitric Oxide Synthase, endothelial Nitric Oxide Synthase, inducible Nitric oxide synthase mutant (nNOS M336V/D597N) Nitric oxide synthase, brain Nitric oxide synthase, endothelial Nitric oxide synthase, inducible Nitric-oxide synthase, brain Nitric-oxide synthase, endothelial	15	0	0	0	0	0	0	0	US10759791, Compound 14h nNOS inhibitor, 4
BDBM190667	Nitric Oxide Synthase, brain Mutant (D597N) Nitric Oxide Synthase, endothelial Nitric Oxide Synthase, inducible Nitric oxide synthase mutant (nNOS M336V/D597N) Nitric oxide synthase, brain Nitric oxide synthase, endothelial Nitric oxide synthase, inducible Nitric-oxide synthase, brain Nitric-oxide synthase, endothelial	19	2	0	0	0

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