BindingDB BDBM50005246 1-Phenylpropan-2-amin::1-phenyl-2-aminopropane::1-phenylpropan-2-amine::AMP ASPARTATE::AMPHETAMINE::AMPHETAMINE SULFATE::Amfetamine::Amphetamin::DEXTROAMP SACCHARATE::alpha-methylbenzeneethaneamine::alpha-methylphenylethylamine::amfetaminum::beta-Phenylisopropylamin::beta-aminopropylbenzene::beta-phenylisopropylamine::desoxynorephedrine

BDBM50005246 1-Phenylpropan-2-amin::1-phenyl-2-aminopropane::1-phenylpropan-2-amine::AMP ASPARTATE::AMPHETAMINE::AMPHETAMINE SULFATE::Amfetamine::Amphetamin::DEXTROAMP SACCHARATE::alpha-methylbenzeneethaneamine::alpha-methylphenylethylamine::amfetaminum::beta-Phenylisopropylamin::beta-aminopropylbenzene::beta-phenylisopropylamine::desoxynorephedrine

SMILES CC(N)Cc1ccccc1

InChI Key InChIKey=KWTSXDURSIMDCE-UHFFFAOYSA-N

Data 47 KI 7 IC50 1 Kd

PDB links: 4 PDB IDs match this monomer.

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 55 hits for monomerid = 50005246

Sodium-dependent noradrenaline transporter(Homo sapiens (Human))
National Institute On Drug Abuse

Curated by PDSP K_i Database

PNG

BDBM50005246(1-Phenylpropan-2-amin | 1-phenyl-2-aminopropane | ...)

Ki: 7.10nMMore data for this Ligand-Target Pair

Reactome pathway KEGG
UniProtKB/SwissProt
DrugBank antibodypedia GoogleScholar

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Sodium-dependent dopamine transporter(Homo sapiens (Human))
National Institute On Drug Abuse

Curated by PDSP K_i Database

PNG

BDBM50005246(1-Phenylpropan-2-amin | 1-phenyl-2-aminopropane | ...)

Ki: 24.8nMMore data for this Ligand-Target Pair

NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
DrugBank GoogleScholar

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Sodium-dependent dopamine transporter(Rattus norvegicus (rat))
Nih

Curated by PDSP K_i Database

PNG

BDBM50005246(1-Phenylpropan-2-amin | 1-phenyl-2-aminopropane | ...)

Ki: 34nMMore data for this Ligand-Target Pair

Reactome pathway KEGG
UniProtKB/SwissProt
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Norepinephrine transporter(RAT)
Nih

Curated by PDSP K_i Database

PNG

BDBM50005246(1-Phenylpropan-2-amin | 1-phenyl-2-aminopropane | ...)

Ki: 38.9nMMore data for this Ligand-Target Pair

UniProtKB/TrEMBL
GoogleScholar

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Norepinephrine transporter(RAT)
Nih

Curated by PDSP K_i Database

PNG

BDBM50005246(1-Phenylpropan-2-amin | 1-phenyl-2-aminopropane | ...)

Ki: 58nMMore data for this Ligand-Target Pair

UniProtKB/TrEMBL
GoogleScholar

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Norepinephrine transporter(RAT)
Nih

Curated by PDSP K_i Database

PNG

BDBM50005246(1-Phenylpropan-2-amin | 1-phenyl-2-aminopropane | ...)

Ki: 59nMMore data for this Ligand-Target Pair

UniProtKB/TrEMBL
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Sodium-dependent dopamine transporter(Homo sapiens (Human))
National Institute On Drug Abuse

Curated by PDSP K_i Database

PNG

BDBM50005246(1-Phenylpropan-2-amin | 1-phenyl-2-aminopropane | ...)

Ki: 116nMMore data for this Ligand-Target Pair

NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
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Sodium-dependent dopamine transporter(Homo sapiens (Human))
National Institute On Drug Abuse

Curated by PDSP K_i Database

PNG

BDBM50005246(1-Phenylpropan-2-amin | 1-phenyl-2-aminopropane | ...)

Ki: 190nMMore data for this Ligand-Target Pair

NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
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Sodium-dependent dopamine transporter(Rattus norvegicus (rat))
Nih

Curated by PDSP K_i Database

PNG

BDBM50005246(1-Phenylpropan-2-amin | 1-phenyl-2-aminopropane | ...)

Ki: 400nMMore data for this Ligand-Target Pair

Reactome pathway KEGG
UniProtKB/SwissProt
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Alpha-2C adrenergic receptor(RAT)
University Of California

Curated by PDSP K_i Database

PNG

BDBM50005246(1-Phenylpropan-2-amin | 1-phenyl-2-aminopropane | ...)

Ki: 992nMMore data for this Ligand-Target Pair

PDB Reactome pathway KEGG
UniProtKB/SwissProt
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Sodium-dependent serotonin transporter(Rattus norvegicus (rat))
Novo Industri

Curated by PDSP K_i Database

PNG

BDBM50005246(1-Phenylpropan-2-amin | 1-phenyl-2-aminopropane | ...)

Ki: 1.00E+3nMMore data for this Ligand-Target Pair

PDB Reactome pathway KEGG
UniProtKB/SwissProt
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Sodium-dependent dopamine transporter(Rattus norvegicus (rat))
Nih

Curated by PDSP K_i Database

PNG

BDBM50005246(1-Phenylpropan-2-amin | 1-phenyl-2-aminopropane | ...)

Ki: 1.00E+3nMMore data for this Ligand-Target Pair

Reactome pathway KEGG
UniProtKB/SwissProt
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Sodium-dependent serotonin transporter(Rattus norvegicus (rat))
Novo Industri

Curated by PDSP K_i Database

PNG

BDBM50005246(1-Phenylpropan-2-amin | 1-phenyl-2-aminopropane | ...)

Ki: 1.00E+3nMMore data for this Ligand-Target Pair

PDB Reactome pathway KEGG
UniProtKB/SwissProt
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Norepinephrine transporter(RAT)
Nih

Curated by PDSP K_i Database

PNG

BDBM50005246(1-Phenylpropan-2-amin | 1-phenyl-2-aminopropane | ...)

Ki: 1.00E+3nMMore data for this Ligand-Target Pair

UniProtKB/TrEMBL
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Alpha-1A adrenergic receptor(Rattus norvegicus (Rat))
TBA

Curated by PDSP K_i Database

PNG

BDBM50005246(1-Phenylpropan-2-amin | 1-phenyl-2-aminopropane | ...)

Ki: 1.60E+3nMMore data for this Ligand-Target Pair

PDB Reactome pathway KEGG
UniProtKB/SwissProt
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Alpha-1A adrenergic receptor(Rattus norvegicus (Rat))
TBA

Curated by PDSP K_i Database

PNG

BDBM50005246(1-Phenylpropan-2-amin | 1-phenyl-2-aminopropane | ...)

Ki: 2.20E+3nMMore data for this Ligand-Target Pair

PDB Reactome pathway KEGG
UniProtKB/SwissProt
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Alpha-2C adrenergic receptor(RAT)
University Of California

Curated by PDSP K_i Database

PNG

BDBM50005246(1-Phenylpropan-2-amin | 1-phenyl-2-aminopropane | ...)

Ki: 2.41E+3nMMore data for this Ligand-Target Pair

PDB Reactome pathway KEGG
UniProtKB/SwissProt
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Sodium-dependent dopamine transporter(Rattus norvegicus (rat))
Nih

Curated by PDSP K_i Database

PNG

BDBM50005246(1-Phenylpropan-2-amin | 1-phenyl-2-aminopropane | ...)

Ki: 2.90E+3nMMore data for this Ligand-Target Pair

Reactome pathway KEGG
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Sodium-dependent serotonin transporter(Rattus norvegicus (rat))
Novo Industri

Curated by PDSP K_i Database

PNG

BDBM50005246(1-Phenylpropan-2-amin | 1-phenyl-2-aminopropane | ...)

Ki: 3.83E+3nMMore data for this Ligand-Target Pair

PDB Reactome pathway KEGG
UniProtKB/SwissProt
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5-hydroxytryptamine receptor 1A(Homo sapiens (Human))
Sri International

Curated by PDSP K_i Database

PNG

BDBM50005246(1-Phenylpropan-2-amin | 1-phenyl-2-aminopropane | ...)

Ki: 6.61E+3nMMore data for this Ligand-Target Pair

PDB Reactome pathway
UniProtKB/SwissProt
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5-hydroxytryptamine receptor 1A/1B/1D/1F(RAT)
TBA

Curated by ChEMBL

PNG

BDBM50005246(1-Phenylpropan-2-amin | 1-phenyl-2-aminopropane | ...)

Ki: 7.66E+3nMAssay Description:Evaluated for binding affinity towards rat cortical membranes at 5-hydroxytryptamine 1 receptor binding site by using [3H]-5-HT as a radioligand.More data for this Ligand-Target Pair

PDB MMDB Reactome pathway
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5-hydroxytryptamine receptor 1A/1B/1D/1F(RAT)
TBA

Curated by ChEMBL

PNG

BDBM50005246(1-Phenylpropan-2-amin | 1-phenyl-2-aminopropane | ...)

Ki: 7.66E+3nMAssay Description:Binding affinity for 5-hydroxytryptamine 1 receptor of rat prefrontal cortexMore data for this Ligand-Target Pair

PDB MMDB Reactome pathway
UniProtKB/SwissProt
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Sodium-dependent serotonin transporter(Rattus norvegicus (rat))
Novo Industri

Curated by PDSP K_i Database

PNG

BDBM50005246(1-Phenylpropan-2-amin | 1-phenyl-2-aminopropane | ...)

Ki: >1.00E+4nMMore data for this Ligand-Target Pair

PDB Reactome pathway KEGG
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5-hydroxytryptamine receptor 2A(Rattus norvegicus (rat))
Sri International

Curated by PDSP K_i Database

PNG

BDBM50005246(1-Phenylpropan-2-amin | 1-phenyl-2-aminopropane | ...)

Ki: >1.00E+4nMMore data for this Ligand-Target Pair

PDB Reactome pathway KEGG
UniProtKB/SwissProt
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D(3) dopamine receptor(Homo sapiens (Human))
Sri International

Curated by PDSP K_i Database

PNG

BDBM50005246(1-Phenylpropan-2-amin | 1-phenyl-2-aminopropane | ...)

Ki: >1.00E+4nMMore data for this Ligand-Target Pair

PDB Reactome pathway
UniProtKB/SwissProt
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D(2) dopamine receptor(Homo sapiens (Human))
Sri International

Curated by PDSP K_i Database

PNG

BDBM50005246(1-Phenylpropan-2-amin | 1-phenyl-2-aminopropane | ...)

Ki: >1.00E+4nMMore data for this Ligand-Target Pair

PDB Reactome pathway KEGG
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D(1A) dopamine receptor(Homo sapiens (Human))
Sri International

Curated by PDSP K_i Database

PNG

BDBM50005246(1-Phenylpropan-2-amin | 1-phenyl-2-aminopropane | ...)

Ki: >1.00E+4nMMore data for this Ligand-Target Pair

PDB Reactome pathway KEGG
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5-hydroxytryptamine receptor 3A(Mus musculus (house mouse))
Sri International

Curated by PDSP K_i Database

PNG

BDBM50005246(1-Phenylpropan-2-amin | 1-phenyl-2-aminopropane | ...)

Ki: >1.00E+4nMMore data for this Ligand-Target Pair

PDB Reactome pathway KEGG
UniProtKB/SwissProt
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Sodium-dependent dopamine transporter(Homo sapiens (Human))
National Institute On Drug Abuse

Curated by PDSP K_i Database

PNG

BDBM50005246(1-Phenylpropan-2-amin | 1-phenyl-2-aminopropane | ...)

Ki: >1.00E+4nMMore data for this Ligand-Target Pair

NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
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Alpha-1A adrenergic receptor(Rattus norvegicus (Rat))
TBA

Curated by PDSP K_i Database

PNG

BDBM50005246(1-Phenylpropan-2-amin | 1-phenyl-2-aminopropane | ...)

Ki: 1.00E+4nMMore data for this Ligand-Target Pair

PDB Reactome pathway KEGG
UniProtKB/SwissProt
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Beta-2 adrenergic receptor(Homo sapiens (Human))
TBA

Curated by PDSP K_i Database

PNG

BDBM50005246(1-Phenylpropan-2-amin | 1-phenyl-2-aminopropane | ...)

Ki: >1.00E+4nMMore data for this Ligand-Target Pair

PDB MMDB Reactome pathway KEGG
UniProtKB/SwissProt
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Beta-2 adrenergic receptor(Homo sapiens (Human))
TBA

Curated by PDSP K_i Database

PNG

BDBM50005246(1-Phenylpropan-2-amin | 1-phenyl-2-aminopropane | ...)

Ki: >1.00E+4nMMore data for this Ligand-Target Pair

PDB MMDB Reactome pathway KEGG
UniProtKB/SwissProt
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Sigma non-opioid intracellular receptor 1(RAT)
TBA

Curated by PDSP K_i Database

PNG

BDBM50005246(1-Phenylpropan-2-amin | 1-phenyl-2-aminopropane | ...)

Ki: >1.00E+4nMMore data for this Ligand-Target Pair

PDB
UniProtKB/SwissProt
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5-hydroxytryptamine receptor 2C(Rattus norvegicus (Rat))
Sri International

Curated by PDSP K_i Database

PNG

BDBM50005246(1-Phenylpropan-2-amin | 1-phenyl-2-aminopropane | ...)

Ki: >1.00E+4nMMore data for this Ligand-Target Pair

PDB Reactome pathway KEGG
UniProtKB/SwissProt
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5-hydroxytryptamine receptor 2A(Rattus norvegicus (rat))
Sri International

Curated by PDSP K_i Database

PNG

BDBM50005246(1-Phenylpropan-2-amin | 1-phenyl-2-aminopropane | ...)

Ki: >1.00E+4nMAssay Description:Displacement of [3H]ketanserin from rat 5HT2A expressed in mouse NIH/3T3 cell membranes after 30 mins by scintillation counting methodMore data for this Ligand-Target Pair

PDB Reactome pathway KEGG
UniProtKB/SwissProt
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Serotonin 2 (5-HT2) receptor(RAT)
Virginia Commonwealth University

Curated by ChEMBL

PNG

BDBM50005246(1-Phenylpropan-2-amin | 1-phenyl-2-aminopropane | ...)

Ki: >1.00E+4nMAssay Description:Compound was tested for binding affinity towards 5-hydroxytryptamine 2 (5-hydroxytryptamine-2) receptor from frontal cortical regions of male Sprague...More data for this Ligand-Target Pair

PDB
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5-hydroxytryptamine receptor 2C(Rattus norvegicus (Rat))
Sri International

Curated by PDSP K_i Database

PNG

BDBM50005246(1-Phenylpropan-2-amin | 1-phenyl-2-aminopropane | ...)

Ki: >1.00E+4nMAssay Description:Compound was tested for binding affinity towards 5-hydroxytryptamine 1C receptor from frontal cortical regions of male Sprague-Dawley rat homogenates...More data for this Ligand-Target Pair

PDB Reactome pathway KEGG
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5-hydroxytryptamine receptor 2A(Rattus norvegicus (rat))
Sri International

Curated by PDSP K_i Database

PNG

BDBM50005246(1-Phenylpropan-2-amin | 1-phenyl-2-aminopropane | ...)

Ki: >1.00E+4nMAssay Description:Displacement of [3H]-ketanserin from NIH3T3 cells stably expressing rat 5-hydroxytryptamine 2A receptorMore data for this Ligand-Target Pair

PDB Reactome pathway KEGG
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5-hydroxytryptamine receptor 2C(Rattus norvegicus (Rat))
Sri International

Curated by PDSP K_i Database

PNG

BDBM50005246(1-Phenylpropan-2-amin | 1-phenyl-2-aminopropane | ...)

Ki: >1.00E+4nMAssay Description:Displacement of [3H]-mesulergine from A9 cells stably expressing rat 5-hydroxytryptamine 2C receptorMore data for this Ligand-Target Pair

PDB Reactome pathway KEGG
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Alpha-1A adrenergic receptor(Rattus norvegicus (Rat))
TBA

Curated by PDSP K_i Database

PNG

BDBM50005246(1-Phenylpropan-2-amin | 1-phenyl-2-aminopropane | ...)

Ki: 1.20E+4nMMore data for this Ligand-Target Pair

PDB Reactome pathway KEGG
UniProtKB/SwissProt
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Amine oxidase [flavin-containing] A(Rattus norvegicus (rat))
University Of Chile

Curated by ChEMBL

PNG

BDBM50005246(1-Phenylpropan-2-amin | 1-phenyl-2-aminopropane | ...)

Ki: 1.22E+4nMAssay Description:Inhibition of MAOA in rat brain mitochondriaMore data for this Ligand-Target Pair

PDB MMDB Reactome pathway
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Serotonin 2 (5-HT2) receptor(RAT)
Virginia Commonwealth University

Curated by ChEMBL

PNG

BDBM50005246(1-Phenylpropan-2-amin | 1-phenyl-2-aminopropane | ...)

Ki: 4.30E+4nMAssay Description:Binding affinity to rat cortical membranes at 5-hydroxytryptamine 2 (5-HT2) receptor using [3H]KET as a radioligandMore data for this Ligand-Target Pair

PDB
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Serotonin 2 (5-HT2) receptor(RAT)
Virginia Commonwealth University

Curated by ChEMBL

PNG

BDBM50005246(1-Phenylpropan-2-amin | 1-phenyl-2-aminopropane | ...)

Ki: 4.30E+4nMAssay Description:Displacement of [3H]ketanserin from rat prefrontal cortex 5-hydroxytryptamine 2 receptorMore data for this Ligand-Target Pair

PDB
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Sigma non-opioid intracellular receptor 1(RAT)
TBA

Curated by PDSP K_i Database

PNG

BDBM50005246(1-Phenylpropan-2-amin | 1-phenyl-2-aminopropane | ...)

Ki: >5.00E+4nMAssay Description:Binding affinity towards sigma opioid receptor was determined in rat cerebral homogenate using [3H]haloperidol as radioligandMore data for this Ligand-Target Pair

PDB
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Phenylethanolamine N-methyltransferase(Bos taurus (bovine))
TBA

Curated by ChEMBL

PNG

BDBM50005246(1-Phenylpropan-2-amin | 1-phenyl-2-aminopropane | ...)

Ki: 7.40E+5nMAssay Description:Inhibitory activity against bovine adrenal norepinephrine N-methyl-transferase was determinedMore data for this Ligand-Target Pair

PDB
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Phenylethanolamine N-methyltransferase(Bos taurus (bovine))
TBA

Curated by ChEMBL

PNG

BDBM50005246(1-Phenylpropan-2-amin | 1-phenyl-2-aminopropane | ...)

Ki: 7.40E+5nMAssay Description:Inhibitory activity against Norepinephrine N-methyltransferase of bovine adrenal glandsMore data for this Ligand-Target Pair

PDB
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Phenylethanolamine N-methyltransferase(Bos taurus (bovine))
TBA

Curated by ChEMBL

PNG

BDBM50005246(1-Phenylpropan-2-amin | 1-phenyl-2-aminopropane | ...)

Ki: 7.40E+5nMAssay Description:The inhibitory constant(Ki) value for Norepinephrine N-methyltransferase was calculatedMore data for this Ligand-Target Pair

PDB
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Sodium-dependent dopamine transporter(Rattus norvegicus (rat))
Nih

Curated by PDSP K_i Database

PNG

BDBM50005246(1-Phenylpropan-2-amin | 1-phenyl-2-aminopropane | ...)

IC50: 960nMAssay Description:Inhibition of [3H]dopamine uptake at dopamine transporter expressed in rat striatal homogenate after 5 mins by scintillation counting analysisMore data for this Ligand-Target Pair

Reactome pathway KEGG
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Sodium-dependent serotonin transporter(MOUSE)
TBA

Curated by ChEMBL

PNG

BDBM50005246(1-Phenylpropan-2-amin | 1-phenyl-2-aminopropane | ...)

IC50: 4.50E+4nMAssay Description:Inhibition of 5-HT transporter in NMRI albino mouse brain assessed as [3H]5-HT accumulation in hypothalamus after 5 minsMore data for this Ligand-Target Pair

PDB Reactome pathway
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Sodium-dependent noradrenaline transporter(MOUSE)
TBA

Curated by ChEMBL

PNG

BDBM50005246(1-Phenylpropan-2-amin | 1-phenyl-2-aminopropane | ...)

IC50: 1.00E+3nMAssay Description:Inhibition of noradrenaline transporter in NMRI albino mouse brain assessed as [3H]NA accumulation in hypothalamus after 5 minsMore data for this Ligand-Target Pair

Reactome pathway KEGG
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Displayed 1 to 50 (of 55 total ) | Next | Last >>

Filter my 55 hits

Targets 24▿
- Sodium-dependent dopamine transporter 9
- Sodium-dependent serotonin transporter 5
- Alpha-1A adrenergic receptor 4
- Norepinephrine transporter 4
- 5-hydroxytryptamine receptor 2C 3
- 5-hydroxytryptamine receptor 2A 3
- Serotonin 2 (5-HT2) receptor 3
- Phenylethanolamine N-methyltransferase 3
- 5-hydroxytryptamine receptor 1A/1B/1D/1F 2
- Alpha-2C adrenergic receptor 2
- Sigma non-opioid intracellular receptor 1 2
- Sodium-dependent noradrenaline transporter 2
- Beta-2 adrenergic receptor 2
- Solute carrier family 22 member 3 1
- D(3) dopamine receptor 1
- Amine oxidase [flavin-containing] A 1
- D(2) dopamine receptor 1
- 5-hydroxytryptamine receptor 2B 1
- 5-hydroxytryptamine receptor 1A 1
- D(1A) dopamine receptor 1
- 5-hydroxytryptamine receptor 3A 1
- Transporter 1
- Cytochrome P450 2A6 1
- Cytochrome P450 2A5 1
- ...
Publications 25▿
- NIDA Res Monogr 178: 440-66 (1998) 7
- Eur J Pharmacol 166: 493-504 (1989) 6
- Mol Pharmacol 13: 454-73 (1977) 4
- J Pharmacol Exp Ther 301: 1097-102 (2002) 3
- Synapse 39: 32-41 (2001) 3
- Mol Pharmacol 45: 125-35 (1994) 3
- J Med Chem 19: 725-7 (1976) 2
- J Med Chem 30: 1-12 (1987) 2
- J Med Chem 48: 440-9 (2005) 2
- Mol Pharmacol 12: 568-80 (1976) 2
- J Med Chem 21: 78-82 (1978) 2
- J Med Chem 43: 3074-84 (2000) 2
- J Med Chem 29: 194-9 (1986) 2
- J Med Chem 35: 734-40 (1992) 2
- J Pharmacol Exp Ther 241: 1092-8 (1987) 2
- J Pharmacol Exp Ther 307: 138-45 (2003) 2
- Bioorg Med Chem 17: 2452-60 (2009) 1
- J Med Chem 24: 1414-21 (1982) 1
- J Med Chem 25: 1204-8 (1983) 1
- J Med Chem 25: 1248-50 (1983) 1
- J Med Chem 25: 1198-204 (1983) 1
- J Med Chem 60: 2605-2628 (2017) 1
- Proc Natl Acad Sci U S A 81: 4983-7 (1984) 1
- J Med Chem 34: 1094-8 (1991) 1
- J Biol Chem 273: 32776-86 (1998) 1
Institutions 12▿
- TBA 19
- Sri International 7
- Novo Industri 6
- Virginia Commonwealth University 6
- Harvard University 3
- Nih 3
- University Of Toronto 3
- University Of Kuopio 2
- University Of California 2
- National Institute On Drug Abuse 2
- Medical College Of Georgia 1
- University Of Chile 1
Affinity: 7.1 to 7.4E+5 nM▿
- Ki 47
- IC50 7
- Kd 1
- Affinity ≤ nM
Xtal structures: 0
Docked structures: 0
Catalog Cmpds: 1