BDBM50410855 CIN-QUIN::QUINIDEX::QUINIDINE SULFATE

SMILES COc1ccc2nccc([C@H](O)[C@H]3CC4CCN3C[C@@H]4C=C)c2c1

InChI Key InChIKey=LOUPRKONTZGTKE-NBGVHYBESA-N

Data  2 KI  7 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 9 hits for monomerid = 50410855   

TargetSolute carrier organic anion transporter family member 1A1(Rattus norvegicus)
Kitasato University

Curated by ChEMBL
LigandPNGBDBM50410855(CIN-QUIN | QUINIDEX | QUINIDINE SULFATE)
Affinity DataKi:  9.27E+3nMAssay Description:TP_TRANSPORTER: inhibition of E217betaG uptake in Oatp1-expressing LLC-PK1 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSolute carrier organic anion transporter family member 1A4(Rattus norvegicus)
Kitasato University

Curated by ChEMBL
LigandPNGBDBM50410855(CIN-QUIN | QUINIDEX | QUINIDINE SULFATE)
Affinity DataKi:  1.20E+5nMAssay Description:TP_TRANSPORTER: inhibition of Digoxin uptake in Oatp2-expressing LLC-PK1 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 2D6(Homo sapiens (Human))
Vrije Universiteit

Curated by ChEMBL
LigandPNGBDBM50410855(CIN-QUIN | QUINIDEX | QUINIDINE SULFATE)
Affinity DataIC50:  20nMAssay Description:Inhibition of human CYP2D6 expressed in Escherichia coli JM109More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium channel protein type 5 subunit alpha(Homo sapiens (Human))
University Of Oxford

Curated by ChEMBL
LigandPNGBDBM50410855(CIN-QUIN | QUINIDEX | QUINIDINE SULFATE)
Affinity DataIC50:  1.66E+4nMAssay Description:Inhibition of sodium current measured using whole-cell patch clamp experiments in HEK-293 cells stably transfected with hNaV1.5 cDNAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVoltage-dependent L-type calcium channel subunit alpha-1C(Cavia porcellus)
University Of Oxford

Curated by ChEMBL
LigandPNGBDBM50410855(CIN-QUIN | QUINIDEX | QUINIDINE SULFATE)
Affinity DataIC50:  1.56E+4nMAssay Description:Inhibition of calcium current (ICaL) measured using whole-cell patch clamp experiments in isolated guinea pig ventricular myocytesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
University Of Oxford

Curated by ChEMBL
LigandPNGBDBM50410855(CIN-QUIN | QUINIDEX | QUINIDINE SULFATE)
Affinity DataIC50:  300nMAssay Description:Inhibition of hERG K channelMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 2D6(Homo sapiens (Human))
Vrije Universiteit

Curated by ChEMBL
LigandPNGBDBM50410855(CIN-QUIN | QUINIDEX | QUINIDINE SULFATE)
Affinity DataIC50:  2.51E+4nMAssay Description:Inhibition of human recombinant CYP2D6 incubated for 5 mins by fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 2D6(Homo sapiens (Human))
Vrije Universiteit

Curated by ChEMBL
LigandPNGBDBM50410855(CIN-QUIN | QUINIDEX | QUINIDINE SULFATE)
Affinity DataIC50:  17nMAssay Description:Inhibition of recombinant CYP2D6 (unknown origin) using 7-methoxy-4-trifluoromethylcoumarin as substrateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 2D6(Homo sapiens (Human))
Vrije Universiteit

Curated by ChEMBL
LigandPNGBDBM50410855(CIN-QUIN | QUINIDEX | QUINIDINE SULFATE)
Affinity DataIC50:  2.50E+4nMAssay Description:Inhibition of recombinant human CYP2D6 preincubated for 5 mins before fluorescent substrate addition by fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed