BDBM86748 CAS_386750-22-7::Desvenlafaxine::NSC_6918664::O-Desmethylvenlafaxine::US9944618, Compound ID No. 181
SMILES CN(C)CC(c1ccc(O)cc1)C1(O)CCCCC1
InChI Key InChIKey=KYYIDSXMWOZKMP-UHFFFAOYSA-N
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 41 hits for monomerid = 86748
Affinity DataKi: 4.10nMAssay Description:SERT: This protocol was designed to measure inhibition of uptake by the human serotonin transporter. The reagents were human SERT (HEK293F) cells, fl...More data for this Ligand-Target Pair
TargetSodium-dependent serotonin transporter(Rattus norvegicus (rat))
Emory University
Curated by PDSP Ki Database
Emory University
Curated by PDSP Ki Database
TargetSodium-dependent noradrenaline transporter(Homo sapiens (Human))
Wyeth Research
Curated by PDSP Ki Database
Wyeth Research
Curated by PDSP Ki Database
TargetSodium-dependent noradrenaline transporter(Homo sapiens (Human))
Wyeth Research
Curated by PDSP Ki Database
Wyeth Research
Curated by PDSP Ki Database
TargetSodium-dependent noradrenaline transporter(Homo sapiens (Human))
Wyeth Research
Curated by PDSP Ki Database
Wyeth Research
Curated by PDSP Ki Database
Affinity DataKi: 668nMAssay Description:NET: This protocol was designed to measure inhibition of uptake by the human norepinephrine transporter. The reagents were human NET (HEK293F) cells,...More data for this Ligand-Target Pair
TargetSodium-dependent noradrenaline transporter(Homo sapiens (Human))
Wyeth Research
Curated by PDSP Ki Database
Wyeth Research
Curated by PDSP Ki Database
TargetSodium-dependent noradrenaline transporter(Homo sapiens (Human))
Wyeth Research
Curated by PDSP Ki Database
Wyeth Research
Curated by PDSP Ki Database
TargetSodium-dependent noradrenaline transporter(Homo sapiens (Human))
Wyeth Research
Curated by PDSP Ki Database
Wyeth Research
Curated by PDSP Ki Database
Affinity DataKi: 3.73E+3nMAssay Description:DAT: This protocol was designed to measure inhibition of uptake by the human dopamine transporter. The reagents were human DAT (HEK293F) cells, GBR 1...More data for this Ligand-Target Pair
TargetHistamine H2 receptor(Cavia porcellus (domestic guinea pig))
Wyeth Research
Curated by PDSP Ki Database
Wyeth Research
Curated by PDSP Ki Database
TargetMuscarinic acetylcholine receptor M5(Homo sapiens (Human))
Wyeth Research
Curated by PDSP Ki Database
Wyeth Research
Curated by PDSP Ki Database
TargetMuscarinic acetylcholine receptor M4(Homo sapiens (Human))
Wyeth Research
Curated by PDSP Ki Database
Wyeth Research
Curated by PDSP Ki Database
TargetMuscarinic acetylcholine receptor M3(Homo sapiens (Human))
Wyeth Research
Curated by PDSP Ki Database
Wyeth Research
Curated by PDSP Ki Database
TargetMuscarinic acetylcholine receptor M2(Homo sapiens (Human))
Wyeth Research
Curated by PDSP Ki Database
Wyeth Research
Curated by PDSP Ki Database
TargetMuscarinic acetylcholine receptor M1(Homo sapiens (Human))
Wyeth Research
Curated by PDSP Ki Database
Wyeth Research
Curated by PDSP Ki Database
TargetAdenosine 3'-phospho 5'-phosphosulfate transporter 1(Homo sapiens (Human))
Wyeth Research
Curated by PDSP Ki Database
Wyeth Research
Curated by PDSP Ki Database
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
University Of Oxford
Curated by ChEMBL
University Of Oxford
Curated by ChEMBL
Affinity DataIC50: 2.00E+7nMAssay Description:Inhibition of fast sodium current (INa) in HEK293 cells transfected with human Nav1.5 measured using IonWorks Quattro automated patch clamp platformMore data for this Ligand-Target Pair
TargetSodium channel protein type 5 subunit alpha(Homo sapiens (Human))
University Of Oxford
Curated by ChEMBL
University Of Oxford
Curated by ChEMBL
Affinity DataIC50: 3.16E+5nMAssay Description:Inhibition of fast sodium current (INa) in HEK293 cells transfected with human Nav1.5 measured using IonWorks Quattro automated patch clamp platformMore data for this Ligand-Target Pair
Affinity DataIC50: 1.16E+3nMAssay Description:Inhibition of uptake of tritiated norepinephrine (NE) into rat brain synaptosomesMore data for this Ligand-Target Pair
TargetSodium-dependent serotonin transporter(Rattus norvegicus (rat))
Emory University
Curated by PDSP Ki Database
Emory University
Curated by PDSP Ki Database
Affinity DataIC50: 180nMAssay Description:Inhibition of uptake of tritiated serotonin (5-HT) into rat brain synaptosomesMore data for this Ligand-Target Pair
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
University Of Oxford
Curated by ChEMBL
University Of Oxford
Curated by ChEMBL
Affinity DataIC50: 2.51E+5nMAssay Description:Inhibition of fast sodium current (INa) in Chinese Hamster Ovary (CHO) K1 cells transfected with human Nav1.5 measured using IonWorks Quattro automat...More data for this Ligand-Target Pair
TargetSodium channel protein type 5 subunit alpha(Homo sapiens (Human))
University Of Oxford
Curated by ChEMBL
University Of Oxford
Curated by ChEMBL
Affinity DataIC50: 2.00E+5nMAssay Description:Inhibition of rapid delayed inward rectifying potassium current (IKr) in Chinese hamster ovary (CHO) K1 cells stably expressing hERG measured using I...More data for this Ligand-Target Pair
TargetPotassium voltage-gated channel subfamily D member 3(Homo sapiens (Human))
University Of Oxford
Curated by ChEMBL
University Of Oxford
Curated by ChEMBL
Affinity DataIC50: 5.01E+6nMAssay Description:Inhibition of transient outward potassium current (Ito) current in Chinese Hamster Ovary (CHO) K1 cells expressing human Kv4.3 measured using IonWork...More data for this Ligand-Target Pair
TargetSodium-dependent noradrenaline transporter(Homo sapiens (Human))
Wyeth Research
Curated by PDSP Ki Database
Wyeth Research
Curated by PDSP Ki Database
Affinity DataIC50: 538nMAssay Description:Inhibition of human NET expressed in CHO cells assessed as reduction of [3H]-NE re-uptake preincubated for 10 mins followed by [3H]-NE addition measu...More data for this Ligand-Target Pair
Affinity DataIC50: 53nMAssay Description:Inhibition of human SERT expressed in CHO cells assessed as reduction of [3H]-5-HT re-uptake preincubated for 10 mins followed by [3H]-5-HT addition ...More data for this Ligand-Target Pair
Affinity DataIC50: 60nMAssay Description:Inhibition of binding of [3H]imipramine to imipramine receptor in rat brainMore data for this Ligand-Target Pair