BDBM60928 BDBM50130192::L-3,4-dihydroxyphenylalanine::L-DOPA::US11021454, Compound L-dopa::dihydroxyphenylalanine

SMILES N[C@@H](Cc1ccc(O)c(O)c1)C(O)=O

InChI Key InChIKey=WTDRDQBEARUVNC-LURJTMIESA-N

Data  10 IC50

PDB links: 29 PDB IDs match this monomer.

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 10 hits for monomerid = 60928   

TargetPC4 and SFRS1-interacting protein(Homo sapiens (Human))
The Scripps Research Institute Molecular Screening Center

Curated by PubChem BioAssay
LigandPNGBDBM60928(BDBM50130192 | L-3,4-dihydroxyphenylalanine | L-DO...)
Affinity DataIC50:  662nMAssay Description:Source (MLPCN Center Name): The Scripps Research Institute Molecular Screening Center (SRIMSC) Affiliation: Ohio State University Assay Provider: Mam...More data for this Ligand-Target Pair
In DepthDetails PCBioAssay
TargetPC4 and SFRS1-interacting protein(Homo sapiens (Human))
The Scripps Research Institute Molecular Screening Center

Curated by PubChem BioAssay
LigandPNGBDBM60928(BDBM50130192 | L-3,4-dihydroxyphenylalanine | L-DO...)
Affinity DataIC50:  526nMAssay Description:Source (MLPCN Center Name): The Scripps Research Institute Molecular Screening Center (SRIMSC) Affiliation: Ohio State University Assay Provider: Mam...More data for this Ligand-Target Pair
In DepthDetails PCBioAssay
TargetTyrosinase(Homo sapiens (Human))
University Of California

Curated by ChEMBL
LigandPNGBDBM60928(BDBM50130192 | L-3,4-dihydroxyphenylalanine | L-DO...)
Affinity DataIC50:  8.40E+6nMAssay Description:Inhibitory activity against mushroom tyrosinaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSolute carrier family 15 member 1(Homo sapiens (Human))
The University Of Michigan

Curated by ChEMBL
LigandPNGBDBM60928(BDBM50130192 | L-3,4-dihydroxyphenylalanine | L-DO...)
Affinity DataIC50:  1.41E+8nMAssay Description:TP_TRANSPORTER: inhibition of Gly-Sar uptake (Gly-Sar: 20 uM) in PEPT1-expressing CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMedDrugBank

TargetXanthine dehydrogenase/oxidase(Homo sapiens (Human))
China Pharmaceutical University

US Patent
LigandPNGBDBM60928(BDBM50130192 | L-3,4-dihydroxyphenylalanine | L-DO...)
Affinity DataIC50: >6.00E+4nMAssay Description:11.1 Preparation of Reagents and Standard Solutions(1) 75 mM phosphate buffer (PB, pH 7.4): containing KH2PO4 0.0956 g, K2HPO4 0.6946 g, EDTA 1.862 m...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetBile salt export pump(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM60928(BDBM50130192 | L-3,4-dihydroxyphenylalanine | L-DO...)
Affinity DataIC50: >1.33E+5nMAssay Description:Inhibition of human BSEP overexpressed in Sf9 cell membrane vesicles assessed as uptake of [3H]-taurocholate in presence of ATP measured after 15 to ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetATP-binding cassette sub-family C member 3(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM60928(BDBM50130192 | L-3,4-dihydroxyphenylalanine | L-DO...)
Affinity DataIC50: >1.33E+5nMAssay Description:Inhibition of human MRP3 overexpressed in Sf9 insect cell membrane vesicles assessed as uptake of [3H]-estradiol-17beta-D-glucuronide in presence of ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetATP-binding cassette sub-family C member 2(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM60928(BDBM50130192 | L-3,4-dihydroxyphenylalanine | L-DO...)
Affinity DataIC50: >1.33E+5nMAssay Description:Inhibition of human MRP2 overexpressed in Sf9 cell membrane vesicles assessed as uptake of [3H]-estradiol-17beta-D-glucuronide in presence of ATP and...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLarge neutral amino acids transporter small subunit 1(Homo sapiens (Human))
University Of Florida

Curated by ChEMBL
LigandPNGBDBM60928(BDBM50130192 | L-3,4-dihydroxyphenylalanine | L-DO...)
Affinity DataIC50:  1.00E+5nMAssay Description:Inhibition of LAT1-mediated [14C]-L-leucine uptake in human MCF7 cells after 5 mins by liquid scintillation counting methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetATP-binding cassette sub-family C member 4(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM60928(BDBM50130192 | L-3,4-dihydroxyphenylalanine | L-DO...)
Affinity DataIC50: >1.33E+5nMAssay Description:Inhibition of human MRP4 overexpressed in Sf9 cell membrane vesicles assessed as uptake of [3H]-estradiol-17beta-D-glucuronide in presence of ATP and...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed