BDBM50395626 ACT-064992::MACITENTAN
SMILES CCCNS(=O)(=O)Nc1ncnc(OCCOc2ncc(Br)cn2)c1-c1ccc(Br)cc1
InChI Key InChIKey=JGCMEBMXRHSZKX-UHFFFAOYSA-N
Data 11 IC50
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 11 hits for monomerid = 50395626
Affinity DataIC50: 0.5nMAssay Description:Displacement of [I125]ET1 from recombinant ETA receptor expressed in CHO cells after 2 hrs by TopCount analysisMore data for this Ligand-Target Pair
Affinity DataIC50: 391nMAssay Description:Displacement of [I125]ET1 from recombinant ETB receptor expressed in CHO cells after 2 hrs by TopCount analysisMore data for this Ligand-Target Pair
Affinity DataIC50: 3.40nMAssay Description:Antagonist activity at human ETA receptor expressed in CHO cells in presence of ET1More data for this Ligand-Target Pair
Affinity DataIC50: 3.40nMAssay Description:Antagonist activity at human ETA receptor expressed in CHO cells in presence of ET1More data for this Ligand-Target Pair
Affinity DataIC50: 0.5nMAssay Description:Displacement of [125I]-ET-1 from human ETA receptor expressed in CHO cell membranes after 2 hrs by scintillation countingMore data for this Ligand-Target Pair
TargetSodium/bile acid cotransporter(Homo sapiens (Human))
Southwest Jiaotong University
Curated by ChEMBL
Southwest Jiaotong University
Curated by ChEMBL
Affinity DataIC50: 1.00E+7nMAssay Description:Inhibition of human recombinant NTCP expressed in CHO cells assessed as reduction in [3H]taurocholate uptake preincubated for 1 hr by radioactive sci...More data for this Ligand-Target Pair
Affinity DataIC50: 391nMAssay Description:Displacement of [125I]-ET-1 from human ETB receptor expressed in CHO cell membranes after 2 hrs by scintillation countingMore data for this Ligand-Target Pair
Affinity DataIC50: 391nMAssay Description:Displacement of [125I]-ET-1 from human ETB receptor expressed in CHO cell membranes after 2 hrs by scintillation countingMore data for this Ligand-Target Pair
Affinity DataIC50: 987nMAssay Description:Antagonist activity at human ETB receptor expressed in CHO cells in presence of ET1More data for this Ligand-Target Pair
Affinity DataIC50: 987nMAssay Description:Antagonist activity at human ETB receptor expressed in CHO cells in presence of ET1More data for this Ligand-Target Pair
Affinity DataIC50: 0.5nMAssay Description:Displacement of [125I]-ET-1 from human ETA receptor expressed in CHO cell membranes after 2 hrs by scintillation countingMore data for this Ligand-Target Pair