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BDBM101739 US9695160, 33::US9796707, Compound 33

SMILES: FC(F)(F)c1ccc(N2CCN(Cc3ccccn3)CC2)c(NC(=O)c2cnc(o2)-c2ccccc2)c1

InChI Key: InChIKey=CLWSDTWEUVBGNB-UHFFFAOYSA-N

Data: 2 IC50

Find this compound or compounds like it in BindingDB or PDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 101739   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Serine/threonine-protein kinase SRPK1


(Homo sapiens (Human))
BDBM101739
PNG
(US9695160, 33 | US9796707, Compound 33)
Show SMILES FC(F)(F)c1ccc(N2CCN(Cc3ccccn3)CC2)c(NC(=O)c2cnc(o2)-c2ccccc2)c1
Show InChI InChI=1S/C27H24F3N5O2/c28-27(29,30)20-9-10-23(35-14-12-34(13-15-35)18-21-8-4-5-11-31-21)22(16-20)33-25(36)24-17-32-26(37-24)19-6-2-1-3-7-19/h1-11,16-17H,12-15,18H2,(H,33,36)
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
antibodypedia
GoogleScholar
PC cid
PC sid
UniChem

Similars

US Patent
n/an/a 4.03E+3n/an/an/an/an/an/a



The University of Nottingham

US Patent


Assay Description
Candidate compounds were screened by the Kinase-Glo assay (Promega; Koresawa and Okabe, 2004), the results of which are shown in Table 1 and Table 2....


US Patent US9796707 (2017)


BindingDB Entry DOI: 10.7270/Q2125VTM
More data for this
Ligand-Target Pair
SRSF protein kinase 1 (SRPK1)


(Homo sapiens (Human))
BDBM101739
PNG
(US9695160, 33 | US9796707, Compound 33)
Show SMILES FC(F)(F)c1ccc(N2CCN(Cc3ccccn3)CC2)c(NC(=O)c2cnc(o2)-c2ccccc2)c1
Show InChI InChI=1S/C27H24F3N5O2/c28-27(29,30)20-9-10-23(35-14-12-34(13-15-35)18-21-8-4-5-11-31-21)22(16-20)33-25(36)24-17-32-26(37-24)19-6-2-1-3-7-19/h1-11,16-17H,12-15,18H2,(H,33,36)
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
antibodypedia
GoogleScholar
PC cid
PC sid
UniChem

Similars

US Patent
n/an/a 4.03E+3n/an/an/an/an/a30



The University of Nottingham

US Patent


Assay Description
Candidate compounds were screened by the Kinase-Glo assay (Promega; Koresawa and Okabe, 2004), the results of which are shown in Table 1 and Table 2....


US Patent US9695160 (2017)


BindingDB Entry DOI: 10.7270/Q2639MW1
More data for this
Ligand-Target Pair