BDBM103827 SPI-02::US11041859, Code SPI-02::US9791447, Compound SPI-02

SMILES Cc1cc(ccc1\N=N\c1c(N)ccc2cc(ccc12)S(O)(=O)=O)-c1ccc(\N=N\c2c(N)c(cc3cc(ccc23)S(O)(=O)=O)S(O)(=O)=O)c(C)c1

InChI Key InChIKey=OFGVQLJUXSRVEG-HVMBLDELSA-N

Data  17 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 17 hits for monomerid = 103827   

TargetSentrin-specific protease 1(Homo sapiens (Human))
Beckman Research Institute Of The City Of Hope

LigandPNGBDBM103827(SPI-02 | US11041859, Code SPI-02 | US9791447, Comp...)
Affinity DataIC50:  2.65E+4nMpH: 7.4Assay Description:Assays were performedby incubating SENPs with various concentrations of the inhibitor (0−60 μM) at RT for 10 min in assay buffer (50 mM Tr...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSentrin-specific protease 7(Homo sapiens (Human))
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM103827(SPI-02 | US11041859, Code SPI-02 | US9791447, Comp...)
Affinity DataIC50:  2.70E+3nMAssay Description:Inhibition of His-tagged human SENP7 expressed in Escherichia coli (DE3) using YFP-SUMO-ECFP as substrate incubated for 15 mins by Coomassie staining...More data for this Ligand-Target Pair
In DepthDetails PubMed
TargetSentrin-specific protease 1(Homo sapiens (Human))
Beckman Research Institute Of The City Of Hope

LigandPNGBDBM103827(SPI-02 | US11041859, Code SPI-02 | US9791447, Comp...)
Affinity DataIC50:  2.08E+3nMpH: 7.4Assay Description:Assays were performedby incubating SENPs with various concentrations of the inhibitor (0−60 μM) at RT for 10 min in assay buffer (50 mM Tr...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSentrin-specific protease 2(Homo sapiens (Human))
Beckman Research Institute Of The City Of Hope

LigandPNGBDBM103827(SPI-02 | US11041859, Code SPI-02 | US9791447, Comp...)
Affinity DataIC50:  2.70E+3nMpH: 7.4Assay Description:Assays were performedby incubating SENPs with various concentrations of the inhibitor (0−60 μM) at RT for 10 min in assay buffer (50 mM Tr...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSentrin-specific protease 1(Homo sapiens (Human))
Beckman Research Institute Of The City Of Hope

LigandPNGBDBM103827(SPI-02 | US11041859, Code SPI-02 | US9791447, Comp...)
Affinity DataIC50:  2.10E+3nMAssay Description:The binding of SPI-01 to the enzyme-substrate complex was investigated. CSP analysis was carried out on the 40 kDa complex of 15N-labeled full length...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetSentrin-specific protease 2(Homo sapiens (Human))
Beckman Research Institute Of The City Of Hope

LigandPNGBDBM103827(SPI-02 | US11041859, Code SPI-02 | US9791447, Comp...)
Affinity DataIC50:  2.00E+3nMAssay Description:The binding of SPI-01 to the enzyme-substrate complex was investigated. CSP analysis was carried out on the 40 kDa complex of 15N-labeled full length...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetSentrin-specific protease 7(Homo sapiens (Human))
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM103827(SPI-02 | US11041859, Code SPI-02 | US9791447, Comp...)
Affinity DataIC50:  2.70E+3nMAssay Description:The binding of SPI-01 to the enzyme-substrate complex was investigated. CSP analysis was carried out on the 40 kDa complex of 15N-labeled full length...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetSentrin-specific protease/Small ubiquitin-related modifier 1(Homo sapiens (Human))
City Of Hope

US Patent
LigandPNGBDBM103827(SPI-02 | US11041859, Code SPI-02 | US9791447, Comp...)
Affinity DataIC50:  2.65E+4nMAssay Description:The inhibitors confer the non-competitive inhibitory mechanism, as shown by nuclear magnetic resonance (NMR) and quantitative enzyme kinetic analysis...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetSentrin-specific protease 2/Small ubiquitin-related modifier 1(Homo sapiens (Human))
City Of Hope

US Patent
LigandPNGBDBM103827(SPI-02 | US11041859, Code SPI-02 | US9791447, Comp...)
Affinity DataIC50:  3.42E+3nMAssay Description:The inhibitors confer the non-competitive inhibitory mechanism, as shown by nuclear magnetic resonance (NMR) and quantitative enzyme kinetic analysis...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetSmall ubiquitin-related modifier 1/2(Homo sapiens (Human))
City Of Hope

US Patent
LigandPNGBDBM103827(SPI-02 | US11041859, Code SPI-02 | US9791447, Comp...)
Affinity DataIC50:  2.08E+3nMAssay Description:The inhibitors confer the non-competitive inhibitory mechanism, as shown by nuclear magnetic resonance (NMR) and quantitative enzyme kinetic analysis...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetSentrin-specific protease/Small ubiquitin-related modifier 2(Homo sapiens (Human))
City Of Hope

US Patent
LigandPNGBDBM103827(SPI-02 | US11041859, Code SPI-02 | US9791447, Comp...)
Affinity DataIC50:  2.70E+3nMAssay Description:The inhibitors confer the non-competitive inhibitory mechanism, as shown by nuclear magnetic resonance (NMR) and quantitative enzyme kinetic analysis...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetSentrin-specific protease 1(Homo sapiens (Human))
Beckman Research Institute Of The City Of Hope

LigandPNGBDBM103827(SPI-02 | US11041859, Code SPI-02 | US9791447, Comp...)
Affinity DataIC50:  2.10E+3nMAssay Description:The inhibitors confer the non-competitive inhibitory mechanism, as shown by nuclear magnetic resonance (NMR) and quantitative enzyme kinetic analysis...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetSentrin-specific protease 2(Homo sapiens (Human))
Beckman Research Institute Of The City Of Hope

LigandPNGBDBM103827(SPI-02 | US11041859, Code SPI-02 | US9791447, Comp...)
Affinity DataIC50:  2.00E+3nMAssay Description:The inhibitors confer the non-competitive inhibitory mechanism, as shown by nuclear magnetic resonance (NMR) and quantitative enzyme kinetic analysis...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetSentrin-specific protease 7(Homo sapiens (Human))
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM103827(SPI-02 | US11041859, Code SPI-02 | US9791447, Comp...)
Affinity DataIC50:  2.70E+3nMAssay Description:The inhibitors confer the non-competitive inhibitory mechanism, as shown by nuclear magnetic resonance (NMR) and quantitative enzyme kinetic analysis...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetSentrin-specific protease 1(Homo sapiens (Human))
Beckman Research Institute Of The City Of Hope

LigandPNGBDBM103827(SPI-02 | US11041859, Code SPI-02 | US9791447, Comp...)
Affinity DataIC50:  2.10E+3nMAssay Description:Inhibition of His-tagged human SENP1 (419 to 644 residues) expressed in Escherichia coli (DE3) using YFP-SUMO-ECFP as substrate incubated for 15 mins...More data for this Ligand-Target Pair
In DepthDetails PubMed
TargetSentrin-specific protease 2(Homo sapiens (Human))
Beckman Research Institute Of The City Of Hope

LigandPNGBDBM103827(SPI-02 | US11041859, Code SPI-02 | US9791447, Comp...)
Affinity DataIC50:  2.00E+3nMAssay Description:Inhibition of His-tagged human SENP2 (364 to 589 residues) expressed in Escherichia coli (DE3) using YFP-SUMO-ECFP as substrate incubated for 15 mins...More data for this Ligand-Target Pair
In DepthDetails PubMed
TargetSentrin-specific protease 2(Homo sapiens (Human))
Beckman Research Institute Of The City Of Hope

LigandPNGBDBM103827(SPI-02 | US11041859, Code SPI-02 | US9791447, Comp...)
Affinity DataIC50:  3.42E+3nMpH: 7.4Assay Description:Assays were performedby incubating SENPs with various concentrations of the inhibitor (0−60 μM) at RT for 10 min in assay buffer (50 mM Tr...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed