BDBM103953 US8569521, 442

SMILES Fc1ccc(F)c2c1OC[C@H]1C[C@H](CC(=O)NCC(F)(F)F)CC[C@@]21S(=O)(=O)c1ccc(cc1)C(F)(F)F

InChI Key InChIKey=UUJVQLCCCVFYKS-QCPUYCGNSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 103953   

TargetAmyloid-beta precursor protein(Homo sapiens (Human))
Merck Sharp & Dohme

US Patent
LigandPNGBDBM103953(US8569521, 442)
Affinity DataIC50:  25nMAssay Description:Gamma-secretase activity was determined as described by Zhang et al. (Biochemistry, 40(16), 5049-5055, 2001).More data for this Ligand-Target Pair
In DepthDetails US Patent