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BDBM104231 US8575145, 108

SMILES: Fc1cc(OCC2(F)CNC2)c2nc(ccc2c1)-c1nnc2ccccn12

InChI Key: InChIKey=OIHRVTLGUCLTFU-UHFFFAOYSA-N

Data: 2 IC50

Find this compound or compounds like it in BindingDB:
Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 104231   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Serine/threonine-protein kinase pim-2


(Homo sapiens (Human))
BDBM104231
PNG
(US8575145, 108)
Show SMILES Fc1cc(OCC2(F)CNC2)c2nc(ccc2c1)-c1nnc2ccccn12
Show InChI InChI=1S/C19H15F2N5O/c20-13-7-12-4-5-14(18-25-24-16-3-1-2-6-26(16)18)23-17(12)15(8-13)27-11-19(21)9-22-10-19/h1-8,22H,9-11H2
PDB
MMDB

KEGG

UniProtKB/SwissProt
UniProtKB/TrEMBL

antibodypedia
GoogleScholar
PC cid
PC sid
UniChem

Similars

US Patent
n/an/a 489n/an/an/an/a7.422



Array BioPharma Inc

US Patent


Assay Description
The assay for the determination of PIM activity is based on the incorporation of [33P] ATP into PIM2tide substrate and capture of the radiolabeled pe...


US Patent US8575145 (2013)


BindingDB Entry DOI: 10.7270/Q2M90797
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-1


(Homo sapiens (Human))
BDBM104231
PNG
(US8575145, 108)
Show SMILES Fc1cc(OCC2(F)CNC2)c2nc(ccc2c1)-c1nnc2ccccn12
Show InChI InChI=1S/C19H15F2N5O/c20-13-7-12-4-5-14(18-25-24-16-3-1-2-6-26(16)18)23-17(12)15(8-13)27-11-19(21)9-22-10-19/h1-8,22H,9-11H2
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt
UniProtKB/TrEMBL

DrugBank
antibodypedia
GoogleScholar
PC cid
PC sid
UniChem

Similars

US Patent
n/an/a 7.30n/an/an/an/a7.422



Array BioPharma Inc

US Patent


Assay Description
The assay for the determination of PIM activity is based on the incorporation of [33P] ATP into PIM2tide substrate and capture of the radiolabeled pe...


US Patent US8575145 (2013)


BindingDB Entry DOI: 10.7270/Q2M90797
More data for this
Ligand-Target Pair