BDBM10585 3-Chloro-6,7,10,11-tetrahydro-9-methyl-12-{{8-[(1,2,3,4-tetrahydroacridin-9-yl)amino]octyl}amino}-7,11-methanocycloocta[b]quinoline dihydrochloride::7-chloro-15-methyl-N-[8-(1,2,3,4-tetrahydroacridin-9-ylamino)octyl]-10-azatetracyclo[11.3.1.0^{2,11}.0^{4,9}]heptadeca-2(11),3,5,7,9,14-hexaen-3-amine dihydrochloride::CHEMBL2011488::Huprine-Tacrine Heterodimer 17c
SMILES CC1=CC2CC(C1)c1c(C2)nc2cc(Cl)ccc2c1NCCCCCCCCNc1c2CCCCc2nc2ccccc12
InChI Key InChIKey=XXFJVXFGCDTSND-UHFFFAOYSA-N
Data 6 IC50
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 6 hits for monomerid = 10585
Affinity DataIC50: 0.330nMpH: 8.0 T: 2°CAssay Description:The cholinesterase assays were performed using colorimetric method reported by Ellman. Enzyme activity was determined by measuring the absorbance at...More data for this Ligand-Target Pair
Affinity DataIC50: 4.74nMAssay Description:The cholinesterase assays were performed using colorimetric method reported by Ellman. Enzyme activity was determined by measuring the absorbance at...More data for this Ligand-Target Pair
Affinity DataIC50: 74nMAssay Description:Inhibition of human serum BChE using butyrylthiocholine iodide as substrate preincubated for 20 mins prior substrate addition measured after 5 mins b...More data for this Ligand-Target Pair
Affinity DataIC50: 6.13E+4nMAssay Description:Inhibition of human recombinant AChE-induced Abeta1-40 aggregation by thioflavin T fluorescence methodMore data for this Ligand-Target Pair
Affinity DataIC50: 69nMAssay Description:Inhibition of bovine AChE-induced coumarin-tagged PrP106-126 aggregation after 48 hrs by fluorescence microscopyMore data for this Ligand-Target Pair
Affinity DataIC50: 1.40nMAssay Description:Inhibition of human recombinant AChE using acetylthiocholine iodide as substrate preincubated for 20 mins prior substrate addition measured after 5 m...More data for this Ligand-Target Pair