BDBM11118 (2S)-1-[(2S)-2-amino-3-(4-phenylphenyl)propanoyl]pyrrolidine-2-carbonitrile::4-substituted phenylalanine cyano-(S)-pyrrolidine deriv. 5

SMILES N[C@@H](Cc1ccc(cc1)-c1ccccc1)C(=O)N1CCC[C@H]1C#N

InChI Key InChIKey=JFHXVIXBGWKRGK-OALUTQOASA-N

Data  1 KI  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 11118   

TargetDipeptidyl peptidase 4(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical

LigandPNGBDBM11118((2S)-1-[(2S)-2-amino-3-(4-phenylphenyl)propanoyl]p...)
Affinity DataKi:  13nM ΔG°:  -10.8kcal/molepH: 7.4 T: 2°CAssay Description:The progress of DPPIV inhibition by compounds was measured by recording the liberation of free pNA at 405 nm. IC50 was determined from the slope of r...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDipeptidyl peptidase 9(Homo sapiens (Human))
Chinese Academy Of Sciences

Curated by ChEMBL
LigandPNGBDBM11118((2S)-1-[(2S)-2-amino-3-(4-phenylphenyl)propanoyl]p...)
Affinity DataIC50:  9.42E+3nMAssay Description:Inhibition of 6xHis-tagged recombinant DPP9 (unknown origin) expressed in baculovirus expression system assessed as hydrolysis of Ala-Pro-aminomethyl...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDipeptidyl peptidase 8(Homo sapiens (Human))
Chinese Academy Of Sciences

Curated by ChEMBL
LigandPNGBDBM11118((2S)-1-[(2S)-2-amino-3-(4-phenylphenyl)propanoyl]p...)
Affinity DataIC50:  3.44E+3nMAssay Description:Inhibition of 6xHis-tagged recombinant DPP8 (unknown origin) expressed in baculovirus expression system assessed as hydrolysis of Ala-Pro-aminomethyl...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProlyl endopeptidase FAP(Homo sapiens (Human))
Chinese Academy Of Sciences

Curated by ChEMBL
LigandPNGBDBM11118((2S)-1-[(2S)-2-amino-3-(4-phenylphenyl)propanoyl]p...)
Affinity DataIC50:  1.41E+3nMAssay Description:Inhibition of 6xHis-tagged recombinant FAP (unknown origin) expressed in baculovirus expression system assessed as hydrolysis of Nle-Pro-aminomethylc...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed