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BDBM111994 US8618107, 308

SMILES: CN1CCC(C1)c1ccc(Nc2cc(cn(C)c2=O)-c2cc(F)cc(N3CCc4c5CCCCc5sc4C3=O)c2CO)nc1

InChI Key: InChIKey=MPJHYCDNGHGKCK-UHFFFAOYSA-N

Data: 1 IC50

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 111994   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Tyrosine-protein kinase BTK


(Homo sapiens (Human))
BDBM111994
PNG
(US8618107, 308)
Show SMILES CN1CCC(C1)c1ccc(Nc2cc(cn(C)c2=O)-c2cc(F)cc(N3CCc4c5CCCCc5sc4C3=O)c2CO)nc1
Show InChI InChI=1S/C34H36FN5O3S/c1-38-11-9-21(17-38)20-7-8-31(36-16-20)37-28-13-22(18-39(2)33(28)42)26-14-23(35)15-29(27(26)19-41)40-12-10-25-24-5-3-4-6-30(24)44-32(25)34(40)43/h7-8,13-16,18,21,41H,3-6,9-12,17,19H2,1-2H3,(H,36,37)
PDB
MMDB

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KEGG

UniProtKB/SwissProt

DrugBank
antibodypedia
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PC cid
PC sid
UniChem

Similars

US Patent
n/an/a 3.30n/an/an/an/a7.5n/a



Gilead Connecticut, Inc.

US Patent


Assay Description
A generalized procedure for a standard biochemical Btk Kinase Assay that can be used to test Formula I compounds. Alternatively, the Lanthascreen ass...


US Patent US8618107 (2013)


BindingDB Entry DOI: 10.7270/Q2T72G3C
More data for this
Ligand-Target Pair