BDBM11363 2-{[(2-chlorophenyl)methyl](2,3,4,5,6-pentafluorobenzene)sulfonamido}-N-hydroxypropanamide::Hydroxamate 44::hydroxamate deriv. B21

SMILES CC(N(Cc1ccccc1Cl)S(=O)(=O)c1c(F)c(F)c(F)c(F)c1F)C(=O)NO

InChI Key InChIKey=VDDKIBQLKXMKIW-UHFFFAOYSA-N

Data  11 KI  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 12 hits for monomerid = 11363   

TargetNeutrophil collagenase(Homo sapiens (Human))
Universita Degli Studi

LigandPNGBDBM11363(2-{[(2-chlorophenyl)methyl](2,3,4,5,6-pentafluorob...)
Affinity DataKi:  1.30nMAssay Description:Initial rates for the hydrolysis of the thioester substrate AcProLeuGly-S-LeuLeuGlyOEt, coupled to the reaction with 5,5-dithiobis(2-nitrobenzoic aci...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target72 kDa type IV collagenase(Homo sapiens (Human))
Pomona College

Curated by ChEMBL
LigandPNGBDBM11363(2-{[(2-chlorophenyl)methyl](2,3,4,5,6-pentafluorob...)
Affinity DataKi:  1.5nMAssay Description:Inhibition of MMP2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target72 kDa type IV collagenase(Homo sapiens (Human))
Pomona College

Curated by ChEMBL
LigandPNGBDBM11363(2-{[(2-chlorophenyl)methyl](2,3,4,5,6-pentafluorob...)
Affinity DataKi:  1.5nMAssay Description:Initial rates for the hydrolysis of the thioester substrate AcProLeuGly-S-LeuLeuGlyOEt, coupled to the reaction with 5,5-dithiobis(2-nitrobenzoic aci...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMatrix metalloproteinase-9(Homo sapiens (Human))
Pomona College

Curated by ChEMBL
LigandPNGBDBM11363(2-{[(2-chlorophenyl)methyl](2,3,4,5,6-pentafluorob...)
Affinity DataKi:  1.70nMAssay Description:Inhibition of MMP9More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMatrix metalloproteinase-9(Homo sapiens (Human))
Pomona College

Curated by ChEMBL
LigandPNGBDBM11363(2-{[(2-chlorophenyl)methyl](2,3,4,5,6-pentafluorob...)
Affinity DataKi:  1.70nMAssay Description:Initial rates for the hydrolysis of the thioester substrate AcProLeuGly-S-LeuLeuGlyOEt, coupled to the reaction with 5,5-dithiobis(2-nitrobenzoic aci...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCollagenase ColG(Clostridium histolyticum)
Universita Degli Studi

LigandPNGBDBM11363(2-{[(2-chlorophenyl)methyl](2,3,4,5,6-pentafluorob...)
Affinity DataKi:  5nMAssay Description:The rate of hydrolysis was determined from the change in absorbance at 324 nm using an extinction coefficient, 24700 M-1 cm-1 for FALGPA. Initial vel...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCollagenase ColG(Clostridium histolyticum)
Universita Degli Studi

LigandPNGBDBM11363(2-{[(2-chlorophenyl)methyl](2,3,4,5,6-pentafluorob...)
Affinity DataKi:  5nMAssay Description:The rate of hydrolysis was determined from the change in absorbance at 324 nm using an extinction coefficient, 24700 M-1 cm-1 for FALGPA. Initial vel...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetInterstitial collagenase(Homo sapiens (Human))
Universita Degli Studi

LigandPNGBDBM11363(2-{[(2-chlorophenyl)methyl](2,3,4,5,6-pentafluorob...)
Affinity DataKi:  10nMAssay Description:Initial rates for the hydrolysis of the thioester substrate AcProLeuGly-S-LeuLeuGlyOEt, coupled to the reaction with 5,5-dithiobis(2-nitrobenzoic aci...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCarbonic anhydrase 4(Bos taurus (bovine))
Universita Degli Studi

LigandPNGBDBM11363(2-{[(2-chlorophenyl)methyl](2,3,4,5,6-pentafluorob...)
Affinity DataKi: >200nMAssay Description:Initial rates of 4-nitrophenyl acetate hydrolysis catalyzed by different CA isozymes were monitored spectrophotometrically at 400 nm. A molar absorpt...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCarbonic anhydrase 2(Homo sapiens (Human))
Universita Degli Studi

LigandPNGBDBM11363(2-{[(2-chlorophenyl)methyl](2,3,4,5,6-pentafluorob...)
Affinity DataKi: >200nMAssay Description:Initial rates of 4-nitrophenyl acetate hydrolysis catalyzed by different CA isozymes were monitored spectrophotometrically at 400 nm. A molar absorpt...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCarbonic anhydrase 1(Homo sapiens (Human))
Universita Degli Studi

LigandPNGBDBM11363(2-{[(2-chlorophenyl)methyl](2,3,4,5,6-pentafluorob...)
Affinity DataKi: >200nMAssay Description:Initial rates of 4-nitrophenyl acetate hydrolysis catalyzed by different CA isozymes were monitored spectrophotometrically at 400 nm. A molar absorpt...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetInterstitial collagenase(Homo sapiens (Human))
Universita Degli Studi

LigandPNGBDBM11363(2-{[(2-chlorophenyl)methyl](2,3,4,5,6-pentafluorob...)
Affinity DataIC50:  10nMAssay Description:Inhibition of MMP1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed