BDBM113719 US8637507, C-3

SMILES CCC1CN(C(=O)Nc2ccccc2)c2ccc(cc2O1)-c1ccc(OCC(C)(C)C(O)=O)nc1

InChI Key InChIKey=AQCJSILNHNZZTF-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 113719   

TargetDiacylglycerol O-acyltransferase 1(Homo sapiens (Human))
Merck Sharp & Dohme

US Patent
LigandPNGBDBM113719(US8637507, C-3)
Affinity DataIC50:  131nMT: 2°CAssay Description:The in vitro assay to identify DGAT1 inhibitors uses human DGAT1 enzyme expressed in Sf9 insect cells prepared as microsomes. The reaction was initia...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetDiacylglycerol O-acyltransferase 1(Homo sapiens (Human))
Merck Sharp & Dohme

US Patent
LigandPNGBDBM113719(US8637507, C-3)
Affinity DataIC50:  100nMAssay Description:Inhibition of human DGAT1 expressed in Sf9 insect cells using 1,2-dioleoyl-sn-glycerol and [14C]-palmitoyl-CoA substrate by scintillation counting an...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDiacylglycerol O-acyltransferase 1(Mus musculus (mouse))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM113719(US8637507, C-3)
Affinity DataIC50:  73nMAssay Description:Inhibition of mouse DGAT1 expressed in Sf9 insect cells using 1,2-dioleoyl-sn-glycerol and [14C]-palmitoyl-CoA substrate by scintillation counting an...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 2C9(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM113719(US8637507, C-3)
Affinity DataIC50:  500nMAssay Description:Inhibition of CYP2C9 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed