BDBM11425 2-(3-Hydroxyphenyl)-3-[(2-propynylamino)methyl]-2H-thieno[3,2-e]-1,2-thiazine-6-sulfonamide 1,1-dioxide hydrochloride::2-(3-hydroxyphenyl)-1,1-dioxo-3-[(prop-2-yn-1-ylamino)methyl]-2H-1,7,2-thieno[3,2-e][1,2]thiazine-6-sulfonamide hydrochloride::2H-Thieno[3,2-e]-1,2-thiazine-6-sulfonamide 1,1-dioxide 33::Compound 17p8

SMILES NS(=O)(=O)c1cc2C=C(CNCC#C)N(c3cccc(O)c3)S(=O)(=O)c2s1

InChI Key InChIKey=BISUIZWGJFAJFB-UHFFFAOYSA-N

Data  1 KI  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 11425   

TargetCarbonic anhydrase 2(Homo sapiens (Human))
Alcon Research

LigandPNGBDBM11425(2-(3-Hydroxyphenyl)-3-[(2-propynylamino)methyl]-2H...)
Affinity DataKi:  0.160nMAssay Description:Inhibitor binding to CA II was determined using a fluorescence competition assay. Displacement of dansylamide and binding of the inhibitor was determ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCarbonic anhydrase 4(Homo sapiens (Human))
Alcon Research

LigandPNGBDBM11425(2-(3-Hydroxyphenyl)-3-[(2-propynylamino)methyl]-2H...)
Affinity DataIC50:  6.25nMAssay Description:The assay measured the rate of CO2 hydration by determining the addition rate of a NaOH solution using a Radiometer VIT 90 titration system. The enzy...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCarbonic anhydrase 2(Homo sapiens (Human))
Alcon Research

LigandPNGBDBM11425(2-(3-Hydroxyphenyl)-3-[(2-propynylamino)methyl]-2H...)
Affinity DataIC50:  0.600nMAssay Description:The assay measured the rate of CO2 hydration by determining the addition rate of a NaOH solution using a Radiometer VIT 90 titration system. The enzy...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed