BDBM11548 CHEMBL100570::N-hydroxy-2-[(4-methoxy-1,1-biphenyl-4-yl)methyl]isothiazolidine-3-carboxamide 1,1-dioxide::N-hydroxy-2-{[4-(4-methoxyphenyl)phenyl]methyl}-1,1-dioxo-1,2-thiazolidine-3-carboxamide::Sultam Hydroxamate 15a

SMILES COc1ccc(cc1)-c1ccc(CN2C(CCS2(=O)=O)C(=O)NO)cc1

InChI Key InChIKey=RNCWXNOSFWYLTA-UHFFFAOYSA-N

Data  15 KI  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 17 hits for monomerid = 11548   

Target72 kDa type IV collagenase(Homo sapiens (Human))
Bristol-Myers Squibb

LigandPNGBDBM11548(CHEMBL100570 | N-hydroxy-2-[(4-methoxy-1,1-bipheny...)
Affinity DataKi:  3.80nMAssay Description:The enzymatic activities of MMPs were determined with recombinant human version catalytic domains and a fluorogenic peptide substrate. Fluorescence m...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target72 kDa type IV collagenase(Homo sapiens (Human))
Bristol-Myers Squibb

LigandPNGBDBM11548(CHEMBL100570 | N-hydroxy-2-[(4-methoxy-1,1-bipheny...)
Affinity DataKi:  3.80nMAssay Description:Inhibition of MMP-2 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails PubMed
Target72 kDa type IV collagenase(Homo sapiens (Human))
Bristol-Myers Squibb

LigandPNGBDBM11548(CHEMBL100570 | N-hydroxy-2-[(4-methoxy-1,1-bipheny...)
Affinity DataKi:  3.80nMAssay Description:Inhibition of MMP2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target72 kDa type IV collagenase(Homo sapiens (Human))
Bristol-Myers Squibb

LigandPNGBDBM11548(CHEMBL100570 | N-hydroxy-2-[(4-methoxy-1,1-bipheny...)
Affinity DataKi:  3.80nMAssay Description:Binding affinity to MMP2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMatrix metalloproteinase-9(Homo sapiens (Human))
The M. S. University Of Baroda

Curated by ChEMBL
LigandPNGBDBM11548(CHEMBL100570 | N-hydroxy-2-[(4-methoxy-1,1-bipheny...)
Affinity DataKi:  46.7nMAssay Description:Inhibition of MMP9More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMatrix metalloproteinase-9(Homo sapiens (Human))
The M. S. University Of Baroda

Curated by ChEMBL
LigandPNGBDBM11548(CHEMBL100570 | N-hydroxy-2-[(4-methoxy-1,1-bipheny...)
Affinity DataKi:  46.7nMAssay Description:The enzymatic activities of MMPs were determined with recombinant human version catalytic domains and a fluorogenic peptide substrate. Fluorescence m...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMatrix metalloproteinase-9(Homo sapiens (Human))
The M. S. University Of Baroda

Curated by ChEMBL
LigandPNGBDBM11548(CHEMBL100570 | N-hydroxy-2-[(4-methoxy-1,1-bipheny...)
Affinity DataKi:  47nMAssay Description:Binding affinity to MMP9More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMatrix metalloproteinase-9(Homo sapiens (Human))
The M. S. University Of Baroda

Curated by ChEMBL
LigandPNGBDBM11548(CHEMBL100570 | N-hydroxy-2-[(4-methoxy-1,1-bipheny...)
Affinity DataKi:  47nMAssay Description:Inhibition of MMP-9 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails PubMed
TargetCollagenase 3(Homo sapiens (Human))
The M. S. University Of Baroda

Curated by ChEMBL
LigandPNGBDBM11548(CHEMBL100570 | N-hydroxy-2-[(4-methoxy-1,1-bipheny...)
Affinity DataKi:  55nMAssay Description:Inhibition of MMP13More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCollagenase 3(Homo sapiens (Human))
The M. S. University Of Baroda

Curated by ChEMBL
LigandPNGBDBM11548(CHEMBL100570 | N-hydroxy-2-[(4-methoxy-1,1-bipheny...)
Affinity DataKi:  55nMAssay Description:Binding affinity to MMP13More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCollagenase 3(Homo sapiens (Human))
The M. S. University Of Baroda

Curated by ChEMBL
LigandPNGBDBM11548(CHEMBL100570 | N-hydroxy-2-[(4-methoxy-1,1-bipheny...)
Affinity DataKi:  55nMAssay Description:Inhibition of MMP-13 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails PubMed
TargetCollagenase 3(Homo sapiens (Human))
The M. S. University Of Baroda

Curated by ChEMBL
LigandPNGBDBM11548(CHEMBL100570 | N-hydroxy-2-[(4-methoxy-1,1-bipheny...)
Affinity DataKi:  55nMAssay Description:The enzymatic activities of MMPs were determined with recombinant human version catalytic domains and a fluorogenic peptide substrate. Fluorescence m...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetInterstitial collagenase(Homo sapiens (Human))
Bristol-Myers Squibb

LigandPNGBDBM11548(CHEMBL100570 | N-hydroxy-2-[(4-methoxy-1,1-bipheny...)
Affinity DataKi: >4.95E+3nM ΔG°: >-7.23kcal/molepH: 7.5 T: 2°CAssay Description:The enzymatic activities of MMPs were determined with recombinant human version catalytic domains and a fluorogenic peptide substrate. Fluorescence m...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetInterstitial collagenase(Homo sapiens (Human))
Bristol-Myers Squibb

LigandPNGBDBM11548(CHEMBL100570 | N-hydroxy-2-[(4-methoxy-1,1-bipheny...)
Affinity DataKi: >4.95E+3nMAssay Description:Binding affinity to MMP1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetInterstitial collagenase(Homo sapiens (Human))
Bristol-Myers Squibb

LigandPNGBDBM11548(CHEMBL100570 | N-hydroxy-2-[(4-methoxy-1,1-bipheny...)
Affinity DataKi:  4.95E+3nMAssay Description:Inhibition of MMP-1 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails PubMed
TargetDisintegrin and metalloproteinase domain-containing protein 17(Homo sapiens (Human))
The M. S. University Of Baroda

Curated by ChEMBL
LigandPNGBDBM11548(CHEMBL100570 | N-hydroxy-2-[(4-methoxy-1,1-bipheny...)
Affinity DataIC50: >1.00E+3nMAssay Description:Inhibition of TACEMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDisintegrin and metalloproteinase domain-containing protein 17(Homo sapiens (Human))
The M. S. University Of Baroda

Curated by ChEMBL
LigandPNGBDBM11548(CHEMBL100570 | N-hydroxy-2-[(4-methoxy-1,1-bipheny...)
Affinity DataIC50: >1.00E+3nMAssay Description:Inhibitory activity against TACEMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed