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BDBM11572 1b-ortho-F::5-(aminomethyl)-6-(2-fluorophenyl)-2-phenylpyrimidin-4-amine::Aminomethylpyrimidine 1bj

SMILES: NCc1c(N)nc(nc1-c1ccccc1F)-c1ccccc1

InChI Key: InChIKey=JGZBQNSUNNURPM-UHFFFAOYSA-N

Data: 1 IC50

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 11572   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Dipeptidyl peptidase 4


(Homo sapiens (Human))
BDBM11572
PNG
(1b-ortho-F | 5-(aminomethyl)-6-(2-fluorophenyl)-2-...)
Show SMILES NCc1c(N)nc(nc1-c1ccccc1F)-c1ccccc1
Show InChI InChI=1S/C17H15FN4/c18-14-9-5-4-8-12(14)15-13(10-19)16(20)22-17(21-15)11-6-2-1-3-7-11/h1-9H,10,19H2,(H2,20,21,22)
PDB
MMDB

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Article
PubMed
n/an/a 1.40E+4n/an/an/an/a7.522



Hoffmann-La Roche Inc



Assay Description
DPP-IV inhibitors were measured for their ability to inhibit DPP-IV mediated cleavage of Ala-Pro-7-amido-4-trifluoromethylcoumarin in a fluorogenic a...


Bioorg Med Chem Lett 14: 1491-3 (2004)


Article DOI: 10.1016/j.bmcl.2004.01.019
BindingDB Entry DOI: 10.7270/Q22B8W7M
More data for this
Ligand-Target Pair