BDBM11833 3-[2-(aminomethyl)-1H,2H,3H,4H-pyrido[1,2-a]indol-10-yl]-4-(1H-indol-3-yl)-2,5-dihydro-1H-pyrrole-2,5-dione::BIM-10

SMILES NCC1CCn2c(C1)c(C1=C(C(=O)NC1=O)c1c[nH]c3ccccc13)c1ccccc21

InChI Key InChIKey=WCPRHIKZZFXHSD-UHFFFAOYSA-N

Data  1 Kd  1 ITC

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 11833   

TargetSerine/threonine-protein kinase pim-1(Homo sapiens (Human))
Oxford University

Curated by ChEMBL
LigandPNGBDBM11833(3-[2-(aminomethyl)-1H,2H,3H,4H-pyrido[1,2-a]indol-...)
Affinity DataKd:  72nMAssay Description:Binding affinity to non phosphorylated PIM1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

Activity Spreadsheet -- ITC Data from BindingDB

Found 1 hit for monomerid = 11833   

CellPNGBDBM11833(3-[2-(aminomethyl)-1H,2H,3H,4H-pyrido[1,2-a]indol-...)
Oxford University

SyringeSerine/threonine-protein kinase PIM(Homo sapiens (Human))
ITC DataΔG°: -9.19kcal/mole −TΔS°: -3.58kcal/mole ΔH°: -5.59kcal/mole logk: 1.38E+7
pH: 7.5 T: 10.00°C