BDBM118599 US8653263, 252

SMILES Cc1nc([nH]c(=O)n1)N1CC2CN(CC2C1)C(=O)c1c(F)cccc1-n1nccn1

InChI Key InChIKey=AIVGDPBTPXPSDJ-UHFFFAOYSA-N

Data  2 KI

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   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 118599   

TargetOrexin/Hypocretin receptor type 1(Homo sapiens (Human))
Janssen Pharmaceutica NV

US Patent
LigandPNGBDBM118599(US8653263, 252)
Show SMILES Cc1nc([nH]c(=O)n1)N1CC2CN(CC2C1)C(=O)c1c(F)cccc1-n1nccn1
Show InChI InChI=1S/C19H19FN8O2/c1-11-23-18(25-19(30)24-11)27-9-12-7-26(8-13(12)10-27)17(29)16-14(20)3-2-4-15(16)28-21-5-6-22-28/h2-6,12-13H,7-10H2,1H3,(H,23,24,25,30)
Affinity DataKi:  1.00E+4nMAssay Description:The in vitro affinity of the compounds for the human orexin-1 and orexin-2 receptors was determined by competitive radioligand binding using [3H]SB S...More data for this Ligand-Target Pair
TargetOrexin receptor type 2(Homo sapiens (Human))
Janssen Pharmaceutica NV

US Patent
LigandPNGBDBM118599(US8653263, 252)
Show SMILES Cc1nc([nH]c(=O)n1)N1CC2CN(CC2C1)C(=O)c1c(F)cccc1-n1nccn1
Show InChI InChI=1S/C19H19FN8O2/c1-11-23-18(25-19(30)24-11)27-9-12-7-26(8-13(12)10-27)17(29)16-14(20)3-2-4-15(16)28-21-5-6-22-28/h2-6,12-13H,7-10H2,1H3,(H,23,24,25,30)
Affinity DataKi:  1.00E+4nMAssay Description:The in vitro affinity of the compounds for the human orexin-1 and orexin-2 receptors was determined by competitive radioligand binding using [3H]SB S...More data for this Ligand-Target Pair