BDBM11865 N-Hydroxy-4-{[(4-phenoxyphenyl)sulfonyl]methyl}-piperidine-4-carboxamide Hydrochloride::N-hydroxy-4-{[(4-phenoxybenzene)sulfonyl]methyl}piperidine-4-carboxamide hydrochloride::beta-sulfone 7b

SMILES ONC(=O)C1(CS(=O)(=O)c2ccc(Oc3ccccc3)cc2)CCNCC1

InChI Key InChIKey=KNFQAZOHJDVGHS-UHFFFAOYSA-N

Data  6 KI

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 11865   

TargetNeutrophil collagenase(Homo sapiens (Human))
Pfizer

LigandPNGBDBM11865(N-Hydroxy-4-{[(4-phenoxyphenyl)sulfonyl]methyl}-pi...)
Affinity DataKi:  2.40nMAssay Description:Inhibitors were assayed against purified hMMP-1, hMMP-2, hMMP-3, hMMP-8, hMMP-9, and hMMP-13 using an enzyme assay based on cleavage of the quenched ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target72 kDa type IV collagenase(Homo sapiens (Human))
Pfizer

LigandPNGBDBM11865(N-Hydroxy-4-{[(4-phenoxyphenyl)sulfonyl]methyl}-pi...)
Affinity DataKi:  2.80nMAssay Description:Inhibitors were assayed against purified hMMP-1, hMMP-2, hMMP-3, hMMP-8, hMMP-9, and hMMP-13 using an enzyme assay based on cleavage of the quenched ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCollagenase 3(Homo sapiens (Human))
Pfizer

LigandPNGBDBM11865(N-Hydroxy-4-{[(4-phenoxyphenyl)sulfonyl]methyl}-pi...)
Affinity DataKi:  8nMAssay Description:Inhibitors were assayed against purified hMMP-1, hMMP-2, hMMP-3, hMMP-8, hMMP-9, and hMMP-13 using an enzyme assay based on cleavage of the quenched ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMatrix metalloproteinase-9(Homo sapiens (Human))
Pfizer

LigandPNGBDBM11865(N-Hydroxy-4-{[(4-phenoxyphenyl)sulfonyl]methyl}-pi...)
Affinity DataKi:  30nMAssay Description:Inhibitors were assayed against purified hMMP-1, hMMP-2, hMMP-3, hMMP-8, hMMP-9, and hMMP-13 using an enzyme assay based on cleavage of the quenched ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetStromelysin-1(Homo sapiens (Human))
Pfizer

LigandPNGBDBM11865(N-Hydroxy-4-{[(4-phenoxyphenyl)sulfonyl]methyl}-pi...)
Affinity DataKi:  158nMAssay Description:Inhibitors were assayed against purified hMMP-1, hMMP-2, hMMP-3, hMMP-8, hMMP-9, and hMMP-13 using an enzyme assay based on cleavage of the quenched ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetInterstitial collagenase(Homo sapiens (Human))
Pfizer

LigandPNGBDBM11865(N-Hydroxy-4-{[(4-phenoxyphenyl)sulfonyl]methyl}-pi...)
Affinity DataKi:  2.40E+3nM ΔG°:  -7.66kcal/molepH: 7.5 T: 2°CAssay Description:Inhibitors were assayed against purified hMMP-1, hMMP-2, hMMP-3, hMMP-8, hMMP-9, and hMMP-13 using an enzyme assay based on cleavage of the quenched ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed