BDBM11866 N-Hydroxy-1-(3-methoxybenzyl)-4-{[(4-phenoxyphenyl)-sulfonyl]methyl}piperidine-4-carboxamide Hydrochloride::N-hydroxy-1-[(3-methoxyphenyl)methyl]-4-{[(4-phenoxybenzene)sulfonyl]methyl}piperidine-4-carboxamide hydrochloride::beta-sulfone 7c

SMILES COc1cccc(CN2CCC(CS(=O)(=O)c3ccc(Oc4ccccc4)cc3)(CC2)C(=O)NO)c1

InChI Key InChIKey=WDPVPUZANMBBLA-UHFFFAOYSA-N

Data  6 KI

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 11866   

Target72 kDa type IV collagenase(Homo sapiens (Human))
Pfizer

LigandPNGBDBM11866(N-Hydroxy-1-(3-methoxybenzyl)-4-{[(4-phenoxyphenyl...)
Affinity DataKi:  0.200nMAssay Description:Inhibitors were assayed against purified hMMP-1, hMMP-2, hMMP-3, hMMP-8, hMMP-9, and hMMP-13 using an enzyme assay based on cleavage of the quenched ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCollagenase 3(Homo sapiens (Human))
Pfizer

LigandPNGBDBM11866(N-Hydroxy-1-(3-methoxybenzyl)-4-{[(4-phenoxyphenyl...)
Affinity DataKi:  0.400nMAssay Description:Inhibitors were assayed against purified hMMP-1, hMMP-2, hMMP-3, hMMP-8, hMMP-9, and hMMP-13 using an enzyme assay based on cleavage of the quenched ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeutrophil collagenase(Homo sapiens (Human))
Pfizer

LigandPNGBDBM11866(N-Hydroxy-1-(3-methoxybenzyl)-4-{[(4-phenoxyphenyl...)
Affinity DataKi:  0.400nMAssay Description:Inhibitors were assayed against purified hMMP-1, hMMP-2, hMMP-3, hMMP-8, hMMP-9, and hMMP-13 using an enzyme assay based on cleavage of the quenched ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMatrix metalloproteinase-9(Homo sapiens (Human))
Pfizer

LigandPNGBDBM11866(N-Hydroxy-1-(3-methoxybenzyl)-4-{[(4-phenoxyphenyl...)
Affinity DataKi:  1.10nMAssay Description:Inhibitors were assayed against purified hMMP-1, hMMP-2, hMMP-3, hMMP-8, hMMP-9, and hMMP-13 using an enzyme assay based on cleavage of the quenched ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetStromelysin-1(Homo sapiens (Human))
Pfizer

LigandPNGBDBM11866(N-Hydroxy-1-(3-methoxybenzyl)-4-{[(4-phenoxyphenyl...)
Affinity DataKi:  18.1nMAssay Description:Inhibitors were assayed against purified hMMP-1, hMMP-2, hMMP-3, hMMP-8, hMMP-9, and hMMP-13 using an enzyme assay based on cleavage of the quenched ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetInterstitial collagenase(Homo sapiens (Human))
Pfizer

LigandPNGBDBM11866(N-Hydroxy-1-(3-methoxybenzyl)-4-{[(4-phenoxyphenyl...)
Affinity DataKi:  330nM ΔG°:  -8.84kcal/molepH: 7.5 T: 2°CAssay Description:Inhibitors were assayed against purified hMMP-1, hMMP-2, hMMP-3, hMMP-8, hMMP-9, and hMMP-13 using an enzyme assay based on cleavage of the quenched ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed