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BDBM119231 US8673906, 1.02::US9718800, 1.02

SMILES: CC(Nc1ccccc1)c1cc(cc2c1oc(cc2=O)N1CCOCC1)C(=O)NCCN(C)C

InChI Key: InChIKey=IGUXKRRCBYGCRH-UHFFFAOYSA-N

Data: 2 IC50

Find this compound or compounds like it in BindingDB or PDB:
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Similarity at least:  must be >=0.5
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 119231   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform


(Homo sapiens (human))
BDBM119231
PNG
(US8673906, 1.02 | US9718800, 1.02)
Show SMILES CC(Nc1ccccc1)c1cc(cc2c1oc(cc2=O)N1CCOCC1)C(=O)NCCN(C)C
Show InChI InChI=1S/C26H32N4O4/c1-18(28-20-7-5-4-6-8-20)21-15-19(26(32)27-9-10-29(2)3)16-22-23(31)17-24(34-25(21)22)30-11-13-33-14-12-30/h4-8,15-18,28H,9-14H2,1-3H3,(H,27,32)
PDB
MMDB

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KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

US Patent
n/an/a 2n/an/an/an/an/a25



ASTRAZENECA AB

US Patent


Assay Description
Compounds in 100% DMSO were added to assay plates by acoustic dispensing. PI3Kβ was added in a Tris buffer (50 mM Tris pH7.4, 0.05% CHAPS, 2.1 m...


US Patent US9718800 (2017)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform


(Homo sapiens (human))
BDBM119231
PNG
(US8673906, 1.02 | US9718800, 1.02)
Show SMILES CC(Nc1ccccc1)c1cc(cc2c1oc(cc2=O)N1CCOCC1)C(=O)NCCN(C)C
Show InChI InChI=1S/C26H32N4O4/c1-18(28-20-7-5-4-6-8-20)21-15-19(26(32)27-9-10-29(2)3)16-22-23(31)17-24(34-25(21)22)30-11-13-33-14-12-30/h4-8,15-18,28H,9-14H2,1-3H3,(H,27,32)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

US Patent
n/an/a 2n/an/an/an/an/an/a



AstraZeneca AB

US Patent


Assay Description
The inhibition of PI3Kβ, PI3Kα, PI3Kγ and PI3Kδ was evaluated in a Kinase Glo based enzyme activity assay using human recombinant...


US Patent US8673906 (2014)


BindingDB Entry DOI: 10.7270/Q2280682
More data for this
Ligand-Target Pair