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BDBM119238 US8673906, 2.06::US9718800, 2.06

SMILES: CC(Nc1cccc(Cl)c1F)c1cc(cc2c1oc(cc2=O)N1CCOCC1)C(=O)N1CCC(O)CC1

InChI Key: InChIKey=QWELDBADLWQWPE-UHFFFAOYSA-N

Data: 2 IC50

Find this compound or compounds like it in BindingDB or PDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 119238   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform


(Homo sapiens (Human))
BDBM119238
PNG
(US8673906, 2.06 | US9718800, 2.06)
Show SMILES CC(Nc1cccc(Cl)c1F)c1cc(cc2c1oc(cc2=O)N1CCOCC1)C(=O)N1CCC(O)CC1
Show InChI InChI=1S/C27H29ClFN3O5/c1-16(30-22-4-2-3-21(28)25(22)29)19-13-17(27(35)32-7-5-18(33)6-8-32)14-20-23(34)15-24(37-26(19)20)31-9-11-36-12-10-31/h2-4,13-16,18,30,33H,5-12H2,1H3
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
PC cid
PC sid
UniChem

Similars

US Patent
n/an/a 6n/an/an/an/an/a25



ASTRAZENECA AB

US Patent


Assay Description
Compounds in 100% DMSO were added to assay plates by acoustic dispensing. PI3Kβ was added in a Tris buffer (50 mM Tris pH7.4, 0.05% CHAPS, 2.1 m...


US Patent US9718800 (2017)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform


(Homo sapiens (Human))
BDBM119238
PNG
(US8673906, 2.06 | US9718800, 2.06)
Show SMILES CC(Nc1cccc(Cl)c1F)c1cc(cc2c1oc(cc2=O)N1CCOCC1)C(=O)N1CCC(O)CC1
Show InChI InChI=1S/C27H29ClFN3O5/c1-16(30-22-4-2-3-21(28)25(22)29)19-13-17(27(35)32-7-5-18(33)6-8-32)14-20-23(34)15-24(37-26(19)20)31-9-11-36-12-10-31/h2-4,13-16,18,30,33H,5-12H2,1H3
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
PC cid
PC sid
UniChem

Similars

US Patent
n/an/a 6n/an/an/an/an/an/a



AstraZeneca AB

US Patent


Assay Description
The inhibition of PI3Kβ, PI3Kα, PI3Kγ and PI3Kδ was evaluated in a Kinase Glo based enzyme activity assay using human recombinant...


US Patent US8673906 (2014)


BindingDB Entry DOI: 10.7270/Q2280682
More data for this
Ligand-Target Pair