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BDBM119242 US8673906, 3.02

SMILES: CC(N(C)c1ccc(F)cc1)c1cc(cc2c1oc(cc2=O)N1CCOCC1)C(=O)N(C)CCN(C)C

InChI Key: InChIKey=AWZVLYNJFARKIK-UHFFFAOYSA-N

Data: 1 IC50

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 119242   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform


(Homo sapiens (Human))
BDBM119242
PNG
(US8673906, 3.02)
Show SMILES CC(N(C)c1ccc(F)cc1)c1cc(cc2c1oc(cc2=O)N1CCOCC1)C(=O)N(C)CCN(C)C
Show InChI InChI=1S/C28H35FN4O4/c1-19(32(5)22-8-6-21(29)7-9-22)23-16-20(28(35)31(4)11-10-30(2)3)17-24-25(34)18-26(37-27(23)24)33-12-14-36-15-13-33/h6-9,16-19H,10-15H2,1-5H3
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
PC cid
PC sid
UniChem

Similars

US Patent
n/an/a 11n/an/an/an/an/an/a



AstraZeneca AB

US Patent


Assay Description
The inhibition of PI3Kβ, PI3Kα, PI3Kγ and PI3Kδ was evaluated in a Kinase Glo based enzyme activity assay using human recombinant...


US Patent US8673906 (2014)


BindingDB Entry DOI: 10.7270/Q2280682
More data for this
Ligand-Target Pair