BDBM119256 US8673906, 3.16::US9718800, 3.16

SMILES CC(Nc1cc(C)cc(F)c1)c1cc(cc2c1oc(cc2=O)N1CCOCC1)C(=O)N(C)C

InChI Key InChIKey=XJSKZRBOYRXUSG-UHFFFAOYSA-N

Data  7 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 7 hits for monomerid = 119256   

LigandPNGBDBM119256(US8673906, 3.16 | US9718800, 3.16)
Affinity DataIC50:  5nMAssay Description:The inhibition of PI3Kβ, PI3Kα, PI3Kγ and PI3Kδ was evaluated in a Kinase Glo based enzyme activity assay using human recombinant...More data for this Ligand-Target Pair
In DepthDetails US Patent
LigandPNGBDBM119256(US8673906, 3.16 | US9718800, 3.16)
Affinity DataIC50:  2.20E+3nMAssay Description:Inhibition of human recombinant PI3Kgamma using PIP2 by Kinase-Glo Plus assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM119256(US8673906, 3.16 | US9718800, 3.16)
Affinity DataIC50:  110nMAssay Description:Inhibition of human recombinant PI3Kdelta using PIP2 by Kinase-Glo Plus assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM119256(US8673906, 3.16 | US9718800, 3.16)
Affinity DataIC50:  5nMT: 2°CAssay Description:Compounds in 100% DMSO were added to assay plates by acoustic dispensing. PI3Kβ was added in a Tris buffer (50 mM Tris pH7.4, 0.05% CHAPS, 2.1 m...More data for this Ligand-Target Pair
In DepthDetails US Patent
LigandPNGBDBM119256(US8673906, 3.16 | US9718800, 3.16)
Affinity DataIC50:  15nMAssay Description:Inhibition of human recombinant PI3Kbeta using PIP2 by Kinase-Glo Plus assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM119256(US8673906, 3.16 | US9718800, 3.16)
Affinity DataIC50:  130nMAssay Description:Inhibition of human recombinant PI3Kalpha using PIP2 by Kinase-Glo Plus assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM119256(US8673906, 3.16 | US9718800, 3.16)
Affinity DataIC50:  49nMAssay Description:Inhibition of PI3Kbeta in PTEN-null human MDA-MB-468 cells assessed as inhibition of Akt phosphorylation after 2 hrsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed