BDBM12080 6-Chloro-4-Cyclohexylthio-3-propyl-1H-quinol-2-one::6-chloro-4-(cyclohexylsulfanyl)-3-propyl-1,2-dihydroquinolin-2-one::quinolone-based inhibitor 5

SMILES CCCc1c(SC2CCCCC2)c2cc(Cl)ccc2[nH]c1=O

InChI Key InChIKey=CLKFNGKDJYMUPK-UHFFFAOYSA-N

Data  3 IC50

PDB links: 1 PDB ID matches this monomer.

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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 12080   

TargetGag-Pol polyprotein [588-1027]/[588-1147](Human immunodeficiency virus type 1)
University Of Oxford

LigandPNGBDBM12080(6-Chloro-4-Cyclohexylthio-3-propyl-1H-quinol-2-one...)
Affinity DataIC50:  240nMpH: 7.8 T: 2°CAssay Description:The IC50 of reverse transcriptase is the concentration that inhibits 50% of recombinant HIV-1 RT RNA-directed DNA polymerase activity in vitro.More data for this Ligand-Target Pair
TargetGag-Pol polyprotein [588-1127,L687I]/[588-1147,L687I](Human immunodeficiency virus type 1)
University Of Oxford

LigandPNGBDBM12080(6-Chloro-4-Cyclohexylthio-3-propyl-1H-quinol-2-one...)
Affinity DataIC50:  1.61E+3nMpH: 7.8 T: 2°CAssay Description:The IC50 of reverse transcriptase is the concentration that inhibits 50% of recombinant HIV-1 RT RNA-directed DNA polymerase activity in vitro.More data for this Ligand-Target Pair
TargetGag-Pol polyprotein [588-1127,Y768C]/[588-1147,Y768C](Human immunodeficiency virus type 1)
University Of Oxford

LigandPNGBDBM12080(6-Chloro-4-Cyclohexylthio-3-propyl-1H-quinol-2-one...)
Affinity DataIC50:  860nMpH: 7.8 T: 2°CAssay Description:The IC50 of reverse transcriptase is the concentration that inhibits 50% of recombinant HIV-1 RT RNA-directed DNA polymerase activity in vitro.More data for this Ligand-Target Pair